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1.
Fertility and Sterility ; 116(3 SUPPL):e296-e297, 2021.
Article in English | EMBASE | ID: covidwho-1880690

ABSTRACT

OBJECTIVE: The current COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), poses several catastrophic threat s globally including those on economy, lifestyle and health. Although the respiratory tract is the primary proliferation site of the virus, its effects on other organs and organ systems is devastating. One of the potential tar-gets for SARS-CoV-2 invasion is the male reproductive system owing to the presence of viral receptors i.e., ACE2 and TMPRSS2 in the testis. Currently there are differing views in literature on whether SARS-CoV-2 infection has any short term and long term effects on male fertility. This pilot study was aimed to assess the impact of viral infection on crucial reproductive processes at the molecular level even after recovery. MATERIALS AND METHODS: We performed a label free quantitative proteomic analysis of semen procured from 17 COVID-19 recovered and 10 healthy fertile individuals using high resolution mass spectrometry. RESULTS: Our proteomic analysis resulted in the identification of 48 differentially expressed proteins of which 27 were upregulated and 21 were downregulated in recovered individuals. Further bio-informatic analysis revealed the dysregulation of several biological processes linked to male reproductive functions. Pathways like regulation of cell motility, regulation of adhesion, sperm-egg recognition, response to testosterone, extracellular matrix adhesion and endopeptidase activity were found to be downregulated in the recovered group. Moreover, the down regulation of two candidate proteins;Semenogelin 1 and Prosaposin which are related to male fertility were also validated using targeted proteomic approach CONCLUSIONS: This extensive proteomic study sheds light on the possible effects of SARS-CoV2 infection on reproductive functions and subsequently on male fertility even after apparent recovery from viral infection. IMPACT STATEMENT: The semen proteomic analysis of the COVID-19 recovered patients portrays a clear scenario of alteration of reproductive function in response to viral infection after clinical recovery, thus corroborating a possibility of virus-mediated impact on male infertility. A similar kind of study on large cohort will also direct the way to combat the viral effect on male reproductive function. This study would guide clinicians in counselling couples affected by COVID-19 as to the possible short term and long term effects on male reproductive potential.

2.
Journal of the American College of Cardiology ; 79(9):1784-1784, 2022.
Article in English | Web of Science | ID: covidwho-1849088
3.
3rd International Conference on Advances in Computing, Communication Control and Networking, ICAC3N 2021 ; : 2021-2026, 2021.
Article in English | Scopus | ID: covidwho-1774599

ABSTRACT

Computer based intelligence innovations and apparatuses assume a key job in each part of the COVID-19 emergency reaction. Understanding the infection and quickening clinical exploration on medications and medicines is one of the factor. Recognizing and diagnosing the infection, and anticipating its advancement helping with forestalling or easing back the infection's spread through reconnaissance and contact following reacting to the wellbeing emergency through customized data and learning checking the recuperation and improving early admonition instruments. To help encourage the utilization of AI all through the emergency, strategy creators ought to energize the sharing of clinical, sub-atomic, and logical datasets and models on synergistic stages to help AI specialists assemble successful instruments for the clinical network, and ought to guarantee that scientists approach the essential processing limit. To understand the full guarantee of AI to battle COVID-19, arrangement producers must guarantee that AI frameworks are reliable and lined up with the OECD AI Principles: they should regard human rights and protection;be straightforward, logical, vigorous, secure and safe;and on-screen characters engaged with their turn of events and utilize ought to stay responsible. Before the world was even mindful of the danger presented by the coronavirus (COVID-19), manmade reasoning (AI) frameworks had distinguished the episode of an obscure kind of pneumonia in the People's Republic of China (in the future "China"). By analyzing different aspects, the intelligent system plays the vital role to generate COVID-19 awareness and which ultimately reduce the infection to others. Proposed paper focus on awareness. © 2021 IEEE.

5.
Journal of the American Society of Nephrology ; 32:56-57, 2021.
Article in English | EMBASE | ID: covidwho-1490020

ABSTRACT

Background: Acute kidney injury (AKI) is a frequent extrapulmonary manifestation of COVID-19 and is associated with increased morbidity and mortality. We investigated alterations in the urine metabolome associated with AKI among patients with COVID-19, with the hypothesis that changes in nicotinamide adenine dinucleotide (NAD+) metabolism described in ischemic, toxic, and inflammatory AKI will be also associated with AKI in patients with COVID-19. Methods: This is a case-control study among two adult populations with COVID-19: critically ill patients hospitalized in Boston, Massachusetts, and a general hospitalized patient population in Birmingham, Alabama. Cases had AKI stages 2 or 3 by Kidney Disease Improving Global Outcomes (KDIGO) criteria. Controls had no AKI by KDIGO criteria. Metabolites were measured by liquid chromatography -mass spectrometry. Results: 14 cases and 14 controls were included from Boston, and 8 cases and 10 controls included from Birmingham. Urinary quinolinate to tryptophan ratio, an indicator which increases with impaired NAD+ biosynthesis, was higher among cases than controls at each location and pooled across locations (median [IQR]: 1.34 [0.59-2.96] in cases, 0.31 [0.13-1.63] in controls, unadjusted p = 0.0013;p=0.03 in analyses adjusted for age and sex). We identified alterations in tryptophan, nicotinamide, and other components of energy metabolism as well as decreases in purine metabolites which contributed to a distinct urinary metabolomic signature that could reliably differentiate patients with and without AKI (supervised random forest class error: 1/14 for AKI and 1/14 for no AKI groups in Boston, 0/8 for AKI and 0/10 for no AKI groups in Birmingham). Conclusions: Conserved urinary metabolic alterations spanning multiple biochemical pathways distinguish AKI vs. non-AKI in the context of COVID-related hospitalization at two large academic medical centers. AKI is further associated with derangements in NAD+ biosynthesis that suggest impaired energy metabolism in the kidney. Augmenting renal NAD+ by administering biosynthetic precursors may present a novel therapeutic opportunity to mitigate COVID-19 associated AKI.

7.
Vascular Medicine ; 26(5):NP3-NP4, 2021.
Article in English | Web of Science | ID: covidwho-1464481
8.
MEDLINE; 2020.
Preprint in English | MEDLINE | ID: ppcovidwho-290700

ABSTRACT

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections and ARDS, but their benefit has not been assessed in COVID-19. Thus, we sought to determine whether antecedent statin use is associated with lower in-hospital mortality in patients hospitalized for COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 st through May 12 th , 2020 with study period ending on June 11 th , 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline socio-demographic and clinical characteristics, and outpatient medications. The primary endpoint included in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, demographic, baseline, and outpatient medication information were well balanced. Statin use was significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.48, 95% CI 0.36 a" 0.64, p<0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 was associated with lower inpatient mortality. Randomized clinical trials evaluating the utility of statin therapy in patients with COVID-19 are needed.

9.
Ann R Coll Surg Engl ; 103(7): 478-480, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1288679

ABSTRACT

BACKGROUND: There is limited evidence on perioperative outcomes of surgical patients during the COVID-19 pandemic to inform continued operating into the winter period. METHODS: We retrospectively analysed the rate of 30-day COVID-19 transmission and mortality of all surgical patients in the three hospitals in our trust in the East of England during the first lockdown in March 2020. All patients who underwent a swab were swabbed on or 24 hours prior to admission. RESULTS: There were 4,254 patients and an overall 30-day mortality of 0.99%. The excess surgical mortality in our region was 0.29%. There were 39 patients who were COVID-19 positive within 30 days of admission, 12 of whom died. All 12 were emergency admissions with a length of stay longer than 24 hours. There were three deaths among those who underwent day case surgery, one of whom was COVID-19 negative, and the other two were not swabbed but not suspected to have COVID-19. There were two COVID-19 positive elective cases and none in day case elective or emergency surgery. There were no COVID-19 positive deaths in elective or day case surgery. CONCLUSIONS: There was a low rate of COVID-19 transmission and mortality in elective and day case operations. Our data have allowed us to guide patients in the consent process and provided the evidence base to restart elective and day case operating with precautions and regular review. A number of regions will be similarly affected and should perform a review of their data for the winter period and beyond.


Subject(s)
Ambulatory Surgical Procedures/mortality , COVID-19/epidemiology , Elective Surgical Procedures/mortality , Emergency Treatment/mortality , Ambulatory Surgical Procedures/standards , Ambulatory Surgical Procedures/statistics & numerical data , COVID-19/complications , COVID-19/diagnosis , COVID-19/transmission , COVID-19 Testing/standards , COVID-19 Testing/statistics & numerical data , Elective Surgical Procedures/standards , Elective Surgical Procedures/statistics & numerical data , Emergency Service, Hospital/standards , Emergency Service, Hospital/statistics & numerical data , Emergency Treatment/standards , Emergency Treatment/statistics & numerical data , England/epidemiology , Female , Hospital Mortality , Humans , Incidence , Infection Control/standards , Infection Control/statistics & numerical data , Length of Stay/statistics & numerical data , Male , Pandemics/prevention & control , Pandemics/statistics & numerical data , Patient Admission/standards , Patient Admission/statistics & numerical data , Retrospective Studies , SARS-CoV-2/isolation & purification , State Medicine/standards , State Medicine/statistics & numerical data
10.
British Journal of Surgery ; 108:2, 2021.
Article in English | Web of Science | ID: covidwho-1254477
12.
Journal of the American Association of Nurse Practitioners ; 23:23, 2021.
Article in English | MEDLINE | ID: covidwho-1209981

ABSTRACT

ABSTRACT: Millions of deaths worldwide have been attributed to the novel coronavirus (COVID-19). As case counts increased in the United States and resurgence occurred in Europe, health care systems across the country prepared for the influx of acutely ill patients. In response to this, our cardiology consult service was called to aid in the management of COVID-19 patients. We describe our experiences and the changes that were implemented.

13.
Indian Journal of Critical Care Medicine ; 25(SUPPL 1):S62, 2021.
Article in English | EMBASE | ID: covidwho-1200265

ABSTRACT

Introduction: Traditionally, central lines are put blindly using anatomical landmarks, which often result in complications, such as, difficulty in access, misplaced lines, pneumothorax, bleeding from inadvertent arterial punctures, etc. •Ultrasonography provides “real-time” imaging, i.e., the needle can be visualized entering the vein that may result in a less associated complication. Objectives: To perform a study regarded •Ease of cannulation. •Time consumed. Materials and methods: Twenty-five critical care patients at the intensive care units of SVP Hospital, Ahmedabad, who needed central venous cannulation, with informed written consent. Results: Out of 25 patients, all (100%) cannulated successfully. In only 1 patient, carotid artery was punctured and was cannulated in second attempt. •96% of patients are cannulated in the first attempt. •Complication rate is 4%. Discussions: After three or more attempts at insertion, mechanical complications increase by six times compared with a single attempt. In the USG-guided approach, most patients are cannulated in the first attempt compared to a conventional method. In the USG technique, access time required is much less. In most patients where Trendelenburg's position may be difficult where USG comes like a gift. Conclusion:: We came to the conclusion that the USG approach took less time, required less attempts, and had a lower incidence of complications for cannulation of the internal jugular vein as compared to a conventional method.

14.
Pharmacy Education ; 20(2):136-144, 2020.
Article in English | Web of Science | ID: covidwho-1100558

ABSTRACT

The University of Southern California School of Pharmacy has offered a residential summer course for international undergraduate pharmacy students for many years, with a focus on clinical therapeutics. In 2020, the COVID-19 pandemic made it impossible to offer the on-campus course. After some discussion, the course was moved online, with the goals of maintaining links with international partners and providing students with a virtual study abroad experience. This article describes the planning and implementation of this course, which was held for two weeks in July 2020 for 19 students from South Korea, Taiwan and Saudi Arabia. The course included an integrated science and clinical approach to diabetes and drug-drug interactions. The facilitation of active learning and problem-solving in transnational student groups through Zoom meetings are described. A post-course survey of students provided positive feedback on the content and online delivery of the course.

15.
IOP Conference Series: Materials Science and Engineering ; 1022, 2021.
Article in English | Scopus | ID: covidwho-1096465

ABSTRACT

COVID-19 is real a worldwide terrific problem. This paper focuses on the different aspects of data analytics and visualization by using various datasets supported by authorized sources. It also discusses the practical aspects using open source tools and python library support. Here chapter focuses on comparative analysis also. It also visualize analytical aspects by different aspects such as country wise, date wise and so on. In this paper, the COVID infected cases and its reaction on people will be discussed. This case study will predict the COVID-19 infected cases and death ratio with symptoms in future. This paper focus on data visualization, data analytics and comparative study based on practical aspects. Machine Learning plays a vital role to predict the cases by providing learning instances. © 2021 Institute of Physics Publishing. All rights reserved.

17.
Circulation ; 142:2, 2020.
Article in English | Web of Science | ID: covidwho-1089430
18.
Journal of Cardiac Failure ; 26(10):S74, 2020.
Article in English | EMBASE | ID: covidwho-871794

ABSTRACT

Introduction: Cardiovascular comorbidities confer worse outcomes for patients with Coronavirus disease 2019 (COVID-19), but the impact of heart failure (HF) with preserved (HFpEF) and reduced (HFrEF) ejection fraction has not been well characterized. The aim herein is to examine outcomes in COVID-19 patients with and without HF. Methods: Patients (n = 437) consecutively admitted with COVID-19 were categorized according to the presence vs. absence of HF and subcategorized according to HFpEF and HFrEF (EF <50%). The primary outcome was inpatient mortality with independent correlates were identified with logistic regression. Secondary outcomes included acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), and need for mechanical ventilation. Results: The median cohort patient age was 68 (56-76) years, 43% (n = 189) were female, and 41% (n = 179) were Caucasian. HF was present in 29.7% (n = 130) of patients of which 43.8% (n = 57) had HFrEF and 56.2% (N = 73) had HFpEF. Patients with HF were more likely to be of older age and have more comorbidities. Overall inpatient mortality in the cohort was 12.3%. Compared to patients without HF (7.6%), patients with HFpEF (39.1%) and HFrEF (23.5%) had higher inpatient mortality (p<0.05) and were more likely to develop AKI, require mechanical ventilation, and have worse ARDS (figure 1). ACE/ARB and/or hydroxychloroquine were not associated with mortality (p >0.05) and there were no differences in inflammatory markers (ferritin, D-dimer, CRP, LDH). Independent predictors of inpatient mortality included: HFpEF (adjOR 2.55 (1.37-4.76)), age > 65 years (adjOR 3.00 (1.66-5.43), African American race (adjOR 1.82 (1.00-3.30)), Other race (adjOR 2.34 (1.02-5.37), p = 0.043), cerebrovascular disease (adjOR 3.07 (1.54-6.10), p = 0.001), and chronic hypoxic respiratory failure [adjOR 3.02 (1.19-7.62], p = 0.019)], whereas HFrEF was not (adjOR 1.58 (0.77-3.23). Discussion: HF is prevalent in patients admitted with COVID-19. Patients with HFpEF had 2.6-fold higher mortality than those without HF and greater burdens of inpatient complications. Patients with HFpEF with COVID19 may warrant closer outpatient monitoring and a lower threshold for admission.

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