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American Journal of Hematology ; JOUR:S21-S22, 97.
Article in English | Web of Science | ID: covidwho-2084298
3.
Chest ; 162(4):A1122, 2022.
Article in English | EMBASE | ID: covidwho-2060775

ABSTRACT

SESSION TITLE: Medications and Pulmonary Rehabilitation in COVID-19 Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/18/2022 01:30 pm - 02:30 pm PURPOSE: The use of inhaled epoprostenol (iEPO) has demonstrated improvement in outcomes for patients with pulmonary hypertension and right heart failure. iEPO has been used as a rescue therapy for acute respiratory distress syndrome (ARDS) and has been shown to improve oxygenation, reduce shunting, and decrease pulmonary artery pressures. However, pulmonary vasodilators do not improve mortality in patients with ARDS. Furthermore, there is currently little data on the efficacy of iEPO via high flow nasal cannula (HFNC) for ARDS patients. Here, we describe our experience with iEPO in our patients with COVID-19-related ARDS on HFNC in a Northern California county hospital. METHODS: From March 2020 to December 2021, 74 patients with COVID-19 infection and related ARDS were placed on HFNC and received iEPO, at a public tertiary care center. A positive response to iEPO was defined as an increase P/F ratio of 10%, increase in PaO2 of 20%, decrease in FiO2, or reduced flow rate within 24 hours of initiation of iEPO. Non-parametric statistics were used to compare groups. RESULTS: 21 women and 53 men with COVID ARDS ranging from 30-86 years of age (mean age 60.1 ± 13.9) received iEPO while on HFNC. The mean hospital length of stay was 36.3 ± 43 days. All patients received steroids and 83.8% received antibiotics. 55.4% of all patients in the study (n=41) progressed to mechanical ventilation and 58.1% (n=43) survived to discharge, mean age 57 ± 14 years. 20.3% (n=15) of patients showed a response to iEPO. Patients who responded to iEPO were significantly less likely to progress to mechanical ventilation (13% vs 66%, p=0.0003) and more likely to survive to discharge (93% vs 49%, p=0.0021). CONCLUSIONS: Among patients with COVID ARDS on HFNC, patients who respond to iEPO are less likely to progress to mechanical ventilation and more likely to survive to discharge. Our study is limited by small sample size and lack of randomization. Use of iEPO in the right subset COVID ARDS on HFNC may improve outcomes. CLINICAL IMPLICATIONS: Patients on HFNC selected for initiation of iEPO had a poor overall prognosis, with 41.9% not surviving to discharge and 55.4% requiring mechanical ventilation. iEPO response correlates with not requiring mechanical ventilation and with increased likelihood of survival to discharge. DISCLOSURES: No relevant relationships by Heng Duong No relevant relationships by Craig Ivie No relevant relationships by Neharika Khurana No relevant relationships by Connie Park No relevant relationships by Natasha Puri No relevant relationships by Adam Thompson No relevant relationships by John Wehner

4.
J Korean Med Sci ; 37(36): e272, 2022 Sep 19.
Article in English | MEDLINE | ID: covidwho-2039653

ABSTRACT

BACKGROUND: This study aimed to explore clinical correlates of fear of progression (FoP) among patients with cancer during the coronavirus disease 2019 (COVID-19) pandemic and examine the mediation effect of cancer-related dysfunctional beliefs about sleep (C-DBS). METHODS: Medical charts of patients with cancer who visited a psycho-oncology clinic between July and November 2021 were reviewed. Baseline socio-demographic and cancer-related variables were collected. Patients' self-report questionnaires, regarding FoP, depression (Patient Health Questionnaire-9 items; PHQ-9), viral anxiety (Stress and Anxiety to Viral Epidemics-6 items; SAVE-6), C-DBS, and other distress, were investigated. Pearson's correlation and linear regression were performed to examine the risk factors of FoP. Mediation effect analysis with the bootstrap method with 2,000 resamples was implemented. RESULTS: A total of 231 patients were included in the analysis. Linear regression revealed that FoP was predicted by age (ß = -0.14, P = 0.003), PHQ-9 (ß = 0.48, P < 0.001), SAVE-6 (ß = 0.34, P < 0.001), and C-DBS (ß = 0.15, P = 0.005). FoP was directly influenced by SAVE-6 and mediated by C-DBS, while it was directly influenced by PHQ-9 with no mediation effect. CONCLUSION: During the COVID-19 pandemic, the FoP of patients with cancer was associated with younger age, depression, viral anxiety, and C-DBS. Depression and viral anxiety directly influenced FoP, while C-DBS mediated the association between viral anxiety and FoP. Therefore, oncology healthcare professionals are recommended to assess C-DBS of their patients when they are highly distressed from FoP.


Subject(s)
COVID-19 , Neoplasms , Disease Progression , Fear , Humans , Pandemics , Sleep
5.
Urban Climate ; 45, 2022.
Article in English | Scopus | ID: covidwho-2036587

ABSTRACT

In this study, we performed a comprehensive assessment of the vertical CO2 concentration in the urban atmosphere using measurements at two different heights (113 m and 420 m) in Seoul, South Korea. The difference in CO2 concentration between the two altitudes (△CO2 = CO2 at 113 m minus CO2 at 420 m) showed a significant diurnal variation, with the highest at 07:00 (19.9 ppm) and the lowest at 16:00 (3.9 ppm). When the planetary boundary layer (PBL) rose above the two sites (daytime), the CO2 concentrations at the two altitudes were highly correlated (r = 0.87) with low △CO2. In contrast, when the PBL was located between the two sites (night time), the correlation coefficient of the CO2 concentration between the two altitudes decreased by 0.55 with a high △CO2. To explain the cause of this variation in △CO2 according to PBL, we performed Weather Research and Forecasting-stochastic time-inverted Lagrangian transport (WRF-STILT) simulations. Simulations showed that CO2 measurements at two different heights were influenced by the same nearby urban areas during the daytime. However, the site above the PBL only measured the CO2 of air transported from the outside downtown area during the night time. Consequently, the observed night time △CO2 is explained by the difference in air mass between the two measurements owing to PBL variations. The night time △CO2 further implicates the local attribution of observed CO2 below the PBL by removing the effect from the remote area. Because of this unique night time characteristic of △CO2, we evaluated the changes in CO2 concentration in Seoul during the COVID-19 period. Compared to the pre-COVID-19 period, △CO2 clearly decreased from 26.5 ppm to 6.2 ppm with the implementation of social distancing, thus confirming the decreasing local influence of CO2 concentrations. Our findings highlight the potential of atmospheric CO2 monitoring at high altitudes as an observation-based method to assess the effectiveness of local carbon management. © 2022 Elsevier B.V.

6.
Innovation in Aging ; 5:187-187, 2021.
Article in English | Web of Science | ID: covidwho-2012244
7.
Innovation in Aging ; 5:129-130, 2021.
Article in English | Web of Science | ID: covidwho-2012243
8.
Innovation in Aging ; 5:261-261, 2021.
Article in English | Web of Science | ID: covidwho-2012012
9.
Innovation in Aging ; 5:860-861, 2021.
Article in English | Web of Science | ID: covidwho-2011125
10.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009586

ABSTRACT

Background: COVID-19 has contributed to healthcare inequity amongst minorities and lower socioeconomic populations, while complicating present anti-cancer treatment regimens. Due to their immunocompromised status, cancer patients are at an increased risk of severe SARS-CoV-2 infection. While sentiment analysis via SM has seen vast growth among healthcare professional, deeper connection and management has been lacking. Given the higher usage of SM impressions and the increase in healthcare disparities especially at the intersection of oncology and COVID-19, the aim of this study was to develop a platform that can: (1) show that the relationships highlighted within these tweets can be realized in biomolecular interactions-specifically within the interaction between solid tumors and COVID-19;(2) use SM data to connect patients with clinical trials. Methods: To determine this relationship, ontologies, which are groupings of terms and related identifiers, such as genes, were created for general search terms, utilizing the Human Phenotype Ontology. They were then combined with “COVID-19” and used as search terms in Twitter's Standard Search tool. The keywords with the most matches were then queried through clinicaltrials.gov and European Bioinformatics Institute's (EBI) Protein Search Tool to find relevant clinical trials and proteins. Finally, the proteins found by the EBI protein search were run through the SwissModel Tool to find relevant protein structures before being used in binding using Polar+'s Binding Platform from Iff Technologies, which provides K values related to 50% inhibition for each medication or immunotherapy. This produced a set of disease-specific keywords that are related to top tweets, clinical trials, protein structures, and binding concentration values in relevant biomolecular pathways for the keyword set “Tumor COVID-19”. Results: The example shown in Table is produced via our platform, with keywords with tweet numbers greater than 95% of all tweets with connected keywords used. Conclusions: By utilizing SM with highly relevant keywords, this platform can combat healthcare inequity by connecting patients and their tweets to clinical trials and enhance literacy about their medical conditions, while providing a greater understanding of the biomolecular pathways involved.

11.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009581

ABSTRACT

Background: Mammography screening significantly reduces breast-cancer related mortality;however, many women fail to undergo screening as recommended by national guidelines. No-shows are responsible for a significant proportion of delayed or missed cancer screening exams. Further, no-shows disproportionately affect underserved and minority populations. We previously identified a high no-show rate for screening mammograms among patients seeking care our institution. African American (AA) women were almost three times more likely to no-show than non-Hispanic white women. The racial disparity in no-shows persisted after adjustment for socioeconomic factors. The objective of this survey study was to identify reasons for missed mammogram screening appointments among AA women. Methods: We conducted a survey (via mail or telephone) of AA women who missed their screening mammogram appointment in summer 2021. Using a structured survey instrument, we collected information on patient-specific and health service barriers. Patient-specific barriers included procedure-related concerns (e.g., concern about discomfort), cognitive-emotional factors (e.g., fear of finding cancer), and changes in health status. Health service barriers included logistical factors (e.g., transportation), cost (e.g., lack of insurance) and scheduling problems (e.g., forgot about appointment or scheduled at an inconvenient time). Here we describe the most common reasons for missed appointments and compared women who reported patient-specific versus health service barriers. Results: 255 women who no-showed for their appointment were contacted and 91 participated in the study survey (35.6% response rate). Most respondents (90%) attributed their no-show to at least one of the listed barriers. Nineteen (7.5%) attributed their no-show to COVID-19, but only 1 person reported this as their only barrier. Scheduling issues were the most commonly reported barriers (57.8%), followed by transportation (38.9%). Three-quarters of respondents reported health service barriers, while only 40.7% reported patient-related barriers. The most common patient-related barriers were cognitiveemotional (25%), changes in health status (20.9%) and procedure-related concerns (15.6%). The majority of respondents (82.6%) were interested in rescheduling their mammogram. Conclusions: Most appointment no-shows among surveyed AA women resulted from potentially preventable scheduling and transportation issues. Relatively few respondents reported cognitive-emotional or procedure-related concerns. Further, the majority of respondents were interested in rescheduling their mammogram;which suggests that these women remain motivated to undergo breast cancer screening. Programs which address preventable health-service related issues may help these women keep their appointments.

12.
Journal of Web Engineering ; 21(5):1419-1433, 2022.
Article in English | Web of Science | ID: covidwho-1998051

ABSTRACT

To fix network congestion resulting from the increase in high volume traffic in data-intensive science and the increase in internet traffic due to COVID19, there has been a necessity of traffic engineering through traffic prediction. For this, there have been various attempts from a statistical method such as ARIMA to machine learning including LSTM and GRU. This study aimed to collect and learn KREOENT backbone and subscribers' traffic volume through diverse machine learning techniques (e.g., SVR, LSTM, GRU, etc.) and predict maximum traffic on the following day.

13.
Int J Environ Res Public Health ; 19(16)2022 08 12.
Article in English | MEDLINE | ID: covidwho-1987761

ABSTRACT

We aimed to explore the reliability and validity of viral anxiety rating scales (developed for the general population) among healthcare workers. In addition, we compared the psychometric properties of rating scales in accordance with the Generalized Anxiety Scale-7 items (GAD-7) during this COVID-19 pandemic. The viral anxiety of 330 healthcare workers was measured with Stress and Anxiety to Viral Epidemics-9 items (SAVE-9), SAVE-6, Coronavirus Anxiety Scale (CAS), Fear of COVID-19 Scale (FCV-19S), and COVID-19 Anxiety Scale (CAS-7). Factor analyses, item response theory, and Rasch model analyses were conducted to confirm the construct validities of the scales and compare the psychometric properties of rating scales. The receiver operating curve (ROC) analysis examined the cutoff scores of rating scales in accordance with a mild degree of generalized anxiety. The SAVE-9, SAVE-6, CAS, FCV-19S, and CAS-7 scales showed good reliability of internal consistency among healthcare workers. Their construct validity and convergent validity of each scale were similarly good. Furthermore, in comparing the psychometric properties of rating scales, we observed that the CAS scale was the most discriminating and difficult among the scales. The CAS and FCV-19S provided more information and were more efficient than the SAVE-9, SAVE-6, and CAS-7 scales when they were used to measure healthcare workers' viral anxiety. Viral anxiety rating scales can be applied to healthcare workers with good reliability and validity.


Subject(s)
COVID-19 , Anxiety/diagnosis , Anxiety/epidemiology , COVID-19/epidemiology , Health Personnel , Humans , Pandemics , Psychiatric Status Rating Scales , Psychometrics , Reproducibility of Results
14.
Lecture Notes on Data Engineering and Communications Technologies ; 145:596-606, 2022.
Article in English | Scopus | ID: covidwho-1971540

ABSTRACT

Healthcare workers face the risk and the danger of contracting several infectious diseases. In order to prevent from the risk of being infected by blood, contact, respiratory droplets, etc., healthcare workers need to use Personal Protective Equipment (PPE). Because of the increasing demand for quality PPE after COVID-19 pandemic, it is important for healthcare institutions to determine the best supplier. Evaluation of suppliers is a complex decision, which contains a number of alternative suppliers and conflicting criteria. The conflicts between supplier evaluation factors require institutions to make a compromise choice among alternative suppliers. Therefore, the main aim of this study is to develop an analytic supplier evaluation model for PPE procurement to healthcare institutions. To that end, a hybrid multi-criteria decision making (MCDM) model based on Analytic Hierarchy Process (AHP) and VIse KriterijumsaOptimiz acija I Kompromisno Resenje (VIKOR) is proposed. A case study for surgical mask procurement to a hospital is presented to demonstrate the applicability of the proposed model. The application results show that the proposed model is a useful decision support tool for PPE procurements to policy-makers of healthcare institutions. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

15.
Alexandria Engineering Journal ; 61(12):11787-11802, 2022.
Article in English | Web of Science | ID: covidwho-1914097

ABSTRACT

The fractional derivative is an advanced category of mathematics for real-life problems. This work focus on the investigation of 2nd wave of the Corona virus in India. We develop a time fractional order COVID-19 model with effects of the disease which consist of a system of fractional differential equations. The fractional-order COVID-19 model is investigated with AtanganaBaleanu-Caputo fractional derivative. Also, the deterministic mathematical model for the Omicron effect is investigated with different fractional parameters. The fractional-order system is analyzed qualitatively as well as verified sensitivity analysis. Fixed point theory is used to prove the existence and uniqueness of the fractional-order model. Analyzed the model locally as well as globally using Lyapunov first and second derivative. Boundedness and positive unique solutions are verified for the fractional-order model of infection of disease. The concept of fixed point theory is used to interrogate the problem and confine the solution. Solutions are derived to investigate the influence of fractional operator which shows the impact of the disease on society. Simulation has been made to understand the behavior of the virus.(c) 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/).

16.
Psychiatry Investig ; 19(6): 411-417, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1856670

ABSTRACT

OBJECTIVE: In this study, we aimed to develop a Korean version of the Coronavirus Reassurance-Seeking Behaviors Scale (CRBS) and to explore its reliability and validity among the general population in South Korea. METHODS: Using an online survey conducted during November 9-15, 2021, we collected the demographic data of 400 individuals and their responses to rating scales such as the CRBS, the Stress and Anxiety to Viral Epidemics-6 items (SAVE-6), the Generalized Anxiety Disorder-7 items (GAD-7), and the Patient Health Questionnaire-9 items (PHQ-9). We conducted factor analyses and utilized item response theory to confirm the validity and reliability of the Korean version of the CRBS. RESULTS: Factor analyses revealed that the single factor model of the Korean version of the CRBS showed a good fit with the CRBS (χ2=5.475, df=5, p value=0.361, χ2/df=1.095, CFI=0.999, TLI=0.998, RMSEA=0.015). Multigroup CFA results indicated that the CRBS measures reassurance-seeking behaviors consistently across variables of sex, depression, general anxiety, and viral anxiety. The CRBS also exhibited good convergent validity with the SAVE-6 (r=0.431, p<0.001), GAD-7 (r=0.574, p<0.001), and PHQ-9 (r=0.575, p<0.001). CONCLUSION: The CRBS is a reliable and valid rating scale that measures reassurance-seeking behavior in relation to viral epidemics.

17.
Annals of Behavioral Medicine ; 56(SUPP 1):S165-S165, 2022.
Article in English | Web of Science | ID: covidwho-1848622
18.
Annals of Behavioral Medicine ; 56(SUPP 1):S255-S255, 2022.
Article in English | Web of Science | ID: covidwho-1848368
19.
J Korean Med Sci ; 37(17): e129, 2022 May 02.
Article in English | MEDLINE | ID: covidwho-1834342

ABSTRACT

BACKGROUND: The aim of this study is to explore whether high school students' adherence to physical distancing was associated with health beliefs, social norms, and psychological factors during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: Overall, 300 high school students participated in this anonymous online survey conducted from October 18-24, 2021. The survey included rating scales such as attitude toward physical distancing during the pandemic, Stress and Anxiety to Viral Epidemics-6 items (SAVE-6), Patient Health Questionnaire-9 items, Satisfaction with Life Scale, and Connor Davidson Resilience Scale 2-items. RESULTS: The results revealed that perceived susceptibility or severity (ß = -0.13, P = 0.038), perceived benefit (ß = 0.32, P < 0.001), descriptive social norms (ß = 0.10, P = 0.041), social injunctive norms (ß = 0.19, P < 0.001), and SAVE-6 (ß = 0.24, P < 0.001) predicted students' adherence to physical distancing (adjusted R² = 0.42, F = 19.2, P < 0.001). Social injunctive norms and personal injunctive norms directly influenced adherence to physical distancing. Viral anxiety, measured by SAVE-6, mediated the association between social injunctive norms and adherence to physical distancing, and perceived benefits mediated the relationship between personal injunctive norms and adherence to physical distancing. The influence of perceived susceptibility or severity on adherence to physical distancing was entirely mediated by perceived benefits or viral anxiety. CONCLUSION: Explaining the rationale or benefits of physical distancing may be important in increasing adherence to physical distancing among high school students.


Subject(s)
COVID-19 , Physical Distancing , Anxiety/epidemiology , Anxiety/psychology , Anxiety Disorders , COVID-19/epidemiology , COVID-19/prevention & control , Humans , Students/psychology
20.
Front Psychiatry ; 13: 807312, 2022.
Article in English | MEDLINE | ID: covidwho-1792887

ABSTRACT

Objective: This study examined the psychometric properties of the French-Canadian version of the Stress and Anxiety to Viral Epidemics-6 items (SAVE-6) scale for assessing the anxiety response to the viral epidemic among the general population in Quebec, Canada. Methods: A total of 590 participants responded to a confidential online survey between September 28 and October 18, 2020. Confirmatory Factor Analysis (CFA) was conducted to explore the factor structure of the scale. Psychometric properties were assessed using the Item Response Theory (IRT) approach. To explore the convergent validity, a Pearson correlation analysis between the SAVE-6 scale and the depression (Patient Health Questionnaire-2, PHQ-2) or anxiety subscale (Generalized Anxiety Disorder-2, GAD-2) of the Patient Health Questionnaire-4 items scale was conducted. Findings: The French-Canadian version of the SAVE-6 scale was clustered into a single factor. The CFA of the SAVE-6 scale showed a good model fit (CFI = 0.985, TLI = 0.976, RMSEA = 0.051, RSMR = 0.048), and the multi-group CFA revealed that the SAVE-6 scale can measure anxiety response in the same way across gender or the presence of elevated depressive and anxiety symptoms. It showed good internal consistency (Cronbach's alpha = 0.76, McDonald's Omega = 0.77) and significant correlation with the PHQ-2 score and GAD-2 score. The IRT model suggested the efficiency in discrimination among individuals in this latent trait. Conclusion: The French-Canadian version of the SAVE-6 scale is a valid and reliable rating scale, which can measure the general population's anxiety response to the viral epidemic.

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