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2.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009576

ABSTRACT

Background: We provide care for the rural, low-income, and underserved population of Oroville. The community has a vaccination rate of 50% and booster rate of over 20% in the 3rd year of the ongoing global SARS-CoV-2 pandemic in 2022. During this period, a subset of our cancer patients benefited from the use of immune checkpoint inhibitors. Methods: This is a cross-sectional observational study of the effectiveness of a mRNA-based vaccine in medical care workers compared to patients with systemic malignancies treated with immunomodulation of PD-1 and CTLA-4 inhibitors. The study was approved by the hospital IRB. We evaluated the total anti-Spike protein antibody titer using a commercial semi-quantitative assay, Labcorp Test #164090. All subjects received 3 doses of the mRNA vaccine. We excluded anyone who was administered therapeutic monoclonal antibodies (mAb) or had a recent infection within 120 days. Results: Subjects with systemic malignancies were significantly older, p = 0.0001 by t-test: median age: 76, range: 64-82, compared to health care workers: median age: 52, range: 21-75. Accrual had to be prematurely stopped upon the arrival of Omicron wave in the community. Out of the seven subjects treated with immunomodulation, six received nivolumab, including two in combination with ipilimumab. One subject received pembrolizumab. Six of the subjects had metastatic disease: one was treated adjuvantly for locally advanced esophageal adenocarcinoma. The rest had NSCLC and one case of urothelioma. We divided the groups to those who had the highest titer of antibody versus everybody else and found a similar distribution in both groups using the Chi2 test. The vast majority of the healthcare workers, 24/27 or 89%, had above the upper limit antibody titer. Patients with systemic malignancy, 5/7 or 71%, had above the upper limit antibody titer p = N.S. Conclusions: Three doses of the mRNA vaccine provided high titers irrespective of frailty or age. We hypothesize that immunomodulation could favorably affect vaccination response.

3.
Nursing Practice Today ; 9(3):221-233, 2022.
Article in English | Scopus | ID: covidwho-1994696

ABSTRACT

Background & Aim: This study aims to examine the perception of artificial insemination interviews experienced by prospective nursing graduates who have experienced artificial insemination interviews at medical institutions using focus groups and provide necessary data to increase the efficiency of artificial insemination interviews. Methods & Materials: This study was conducted to examine nursing students' artificial insemination interview experience during COVID-19 by performing a focus group interview and qualitative content analysis. The focus group interview was carried out on November 17, 2021, to understand nursing students' artificial insemination interview experience during COVID-19, selecting a total of 14 senior nursing students. Results: As a result of analyzing the artificial insemination interview experiences of nursing students who participated in this study, 35 codes, grouped into eight subcategories, were derived. They are also classified into three categories 1) Finding your way in the dark, 2) Confronting artificial intelligence, and 3) Going beyond artificial intelligence. The eight subcategories derived are as follows: 1) Vagueness, 2) Find your way, 3) The fight between artificial intelligence and me, 4) Strong questions about interview evaluation, 5) New experience, 6) Learn your own tricks for artificial insemination interviews, 7) Setting up the environment for artificial insemination interview, 8) Establishment of information system for artificial insemination interview. Conclusion: Based on the results of this study, an educational program should be developed based on the main data obtained from the artificial insemination interview experience so that nursing college students can adapt to the artificial insemination interview. © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.

5.
Environ. Sci.-Wat. Res. Technol. ; : 14, 2022.
Article in English | Web of Science | ID: covidwho-1795655

ABSTRACT

As a class of endocrine disrupting compounds (EDCs), corticosteroids (CSs) have attracted increasing attention due to their large excretion masses and toxic effects. However, compared to the very well-studied estrogens and androgens, few studies have been made dealing with the removal of CSs at environmentally relevant concentrations using advanced water and wastewater treatment processes. In this study, degradation performances of 26 natural and synthetic CSs in secondary effluent at environmentally relevant concentrations were comparatively investigated during UV/free chlorine (UV/Cl-2), UV/monochloramine (UV/NH2Cl) and UV/hydrogen peroxide (UV/H2O2) treatments. The 26 CSs could be divided into two groups: UV sensitive CSs, which have two double bonds in ring A (Delta(1,4)), and UV insensitive CSs, which have only one double bond in ring A (Delta(4)). The UV sensitive CSs could be effectively removed (removal efficiency >60%) by a UV dose of 100 mJ cm(-2) while the UV insensitive CSs could be removed (removal efficiency >40%) by a UV dose of 800 mJ cm(-2). The removal efficiencies of UV insensitive CSs increased with the increase of UV dose. Most of the CSs were poorly removed by sole Cl-2, NH2Cl, or H2O2 treatment (removal efficiency <40%). However, the addition of Cl-2, NH2Cl, and H2O2 promoted the UV degradation of CSs, especially for UV-insensitive CSs. UV photolysis would be the predominant mechanism in the UV/Cl-2, UV/NH2Cl, and UV/H2O2 processes for removing CSs in water. Besides the UV photolysis, HO radicals also functioned for CS removal. Compared with the insignificant effects of reactive chlorine species (RCS), the reactive nitrogen species (RNS) showed obvious selectivity in CS degradation. This study expanded the UV induced oxidation performances of CSs, which lays a foundation for exploring degradation mechanisms and eliminating the pollution from CSs.

6.
J Adolesc Health ; 70(6): 985-988, 2022 06.
Article in English | MEDLINE | ID: covidwho-1783448

ABSTRACT

PURPOSE: Young adult anxiety/depression (mental health) symptoms have increased from prior to the COVID-19 pandemic. This study assessed young adult (aged 18-25 years) anxiety/depressive symptoms, mental health care utilization (prescription drug use, counseling, and/or either), and unmet counseling/therapy needs utilizing the national Household Pulse Survey data from June to July 2021. METHODS: Young adult (n = 2,809) rates and subgroup differences in mental health symptoms (Generalized Anxiety Disorder-2 and/or Patient Health Questionnaire-2) were assessed, as were mental health care utilization and unmet counseling/therapy needs. RESULTS: In total, 48% of young adults had mental health symptoms. Among those, 39% received treatment and 36% reported unmet mental health counseling/therapy needs. DISCUSSION: These findings highlight young adults' ongoing mental health needs and low services receipt. Interventions and further research to reduce barriers to seeking and utilizing mental health care and to increase the capacity of providers to deliver culturally appropriate mental health care are needed.


Subject(s)
COVID-19 , Mental Health Services , Adolescent , Adult , Anxiety/therapy , Anxiety Disorders/therapy , Depression/therapy , Humans , Pandemics , Young Adult
7.
Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753546

ABSTRACT

The Navy Supply Corps Office of Personnel (OP) issued a new policy emphasizing that O-4s complete an operational assignment or overseas tour during their time serving as an O-4. This change poses a challenge to career planning by Supply Officers, the nature of which has yet to be investigated. To this end, this research aims to analyze and critically evaluate perspectives of Supply Corps officers enrolled as students at NPS on career developmentrelated issues. An independently developed, web-based, anonymous survey was disseminated to Supply Corps officers at NPS and analyzed through the lens of expectancy theory. The survey consisted of 23 closed-ended questions gauging career development perspectives related to the detailing process, promotion opportunities, incentives, retention, professional certifications, communication, and work-life balance. Forty-one NPS students returned the completed survey to the researchers, which represented a 60.29 percent response rate. Survey results suggest that operational emphasis could impact retention, family planning, lack of personnel to fill critical acquisition billets, and erosion of trust in leadership. Additionally, survey results identify retention bonuses, acquisition billet guarantee, geographic preference, and expansion of the Training with Industry program as possible incentives for O-4s to complete operational tours.

8.
Journal of Korean Ophthalmological Society ; 63(2):126-133, 2022.
Article in Korean | Scopus | ID: covidwho-1742192

ABSTRACT

Purpose: To analyze the change in the weekly incidence of epidemic keratoconjunctivitis (EKC) per 1,000 outpatients during the coronavirus disease 2019 (COVID-19) pandemic by comparing the mean weekly proportion of EKC of 2020 with that from 2016 to 2019. Methods: Using data from the Korea Disease Control and Prevention Agency for 2016-2020, we analyzed the weekly proportion of EKC per 1,000 outpatients. The data were also analyzed according to age, semester and vacation periods, region, and social distancing stages. For the Daegu data, we also analyzed the effects of social distancing in an area. Results: The mean weekly proportion of EKC per 1,000 outpatients in 2020 was lower than in previous years for all ages (2016-2019 19.77 ± 7.17 , 2020 7.28 ± 2.97 ;p 0.001). During the semester, the mean difference between 2016-2019 and 2020 was significant, particularly for preschool children. In Daegu, the weekly proportion of EKC per 1,000 outpatients during the extra 12-18 weeks of social distancing was significantly lower (2016-2019, 18.78 ± 6.61 ;2020, 8.94 ± 2.92 ;p 0.001). Conclusions: The public health interventions implemented during the COVID-19 outbreak not only reduced the prevalence of COVID-19 but also reduced the prevalence of EKC. Therefore, maintaining hygiene principles and standard precautions may help prevent EKC. © 2022 Korean Ophthalmological Society (KOS). All rights reserved.

9.
Korean Chemical Engineering Research ; 60(1):86-92, 2022.
Article in Korean | Web of Science | ID: covidwho-1716135

ABSTRACT

Recently, the bio-healthcare market is enlarging worldwide due to various reasons such as the COVID-19 pandemic. Among them, biometric measurement and analysis technology are expected to bring about future technological innovation and socio-economic ripple effect. Existing systems require a large-capacity battery to drive signal processing, wireless transmission part, and an operating system in the process. However, due to the limitation of the battery capacity, it causes a spatio-temporal limitation on the use of the device. This limitation can act as a cause for the disconnection of data required for the user's health care monitoring, so it is one of the major obstacles of the health care device. In this study, we report the concept of a standalone healthcare monitoring module, which is based on both triboelectric effects and electromagnetic effects, by converting biomechanical energy into suitable electric energy. The proposed system can be operated independently without an external power source. In particular, the wireless foot pressure measurement monitoring system, which is rationally designed triboelectric sensor (TES), can recognize the user's walking habits through foot pressure measurement. By applying the triboelectric effects to the contact-separation behavior that occurs during walking, an effective foot pressure sensor was made, the performance of the sensor was verified through an electrical output signal according to the pressure, and its dynamic behavior is measured through a signal processing circuit using a capacitor. In addition, the biomechanical energy dissipated during walking is harvested as electrical energy by using the electromagnetic induction effect to be used as a power source for wireless transmission and signal processing. Therefore, the proposed system has a great potential to reduce the inconvenience of charging caused by limited battery capacity and to overcome the problem of data disconnection.

10.
Annals of Applied Sport Science ; 9(4), 2021.
Article in English | Scopus | ID: covidwho-1675719

ABSTRACT

Background. Depression is one of the major public health concerns among older adults. Participation in preferred leisure activities has been found to be effective for reducing the symptoms of depression among this population. Objectives. The purpose of this study was to conduct a meta-analysis of the association between leisure participation and depression. Methods. A systematic review of PubMed, Academic Search Complete, PsycINFO, and Google Scholar yielded 12 studies published between 2010 and 2020 (total participants = 10,681) that met the criteria for a meta-analysis. Comprehensive Meta-Analysis Software (CMA) was used to conduct the data analysis, and the correlation coefficient r was used as the effect size. Results. The average effect size across all 12 studies was -.221 (Fisher’s Z = -5.696, P <.001), indicating that participation in leisure activities had a significant negative effect on depression for the elderly. In addition, the Q-value (116.003, P <.001) and the I-squared value (90.517) proved substantial heterogeneity between the 12 studies in the meta-analysis. The symmetrical funnel plot produced by the CMA analysis demonstrated a possible absence of publication bias. Conclusion. This meta-analytic study reinforced the effectiveness of leisure participation in reducing the symptoms of depression among older adults © 2021, Annals of Applied Sport Science. All Rights Reserved.

11.
21st IEEE/ACIS International Fall Virtual Conference on Computer and Information Science, ICIS 2021 ; 1003 SCI:62-74, 2022.
Article in English | Scopus | ID: covidwho-1605822

ABSTRACT

Libraries are encountering certain challenges derived from changes on their business environment. With the advent of COVID-19 pandemic, digital and online functions of university libraries in Korea is suggested as an alternative for the future. Thus, it is significant to assess libraries’ business efficiency focusing on digital function while it is able to acquire valuable factors for future strategy. Therefore, the study adopts DEA (Data Envelopment Analysis), a widely accepted analysis model for measuring efficiency. Moreover, the study derived appropriate factors for efficiency assessment in digital service of university library by literature review. Through this, factors regarding efficiency in university libraries can be measured. We hope this study could contribute to identify inefficient factors in university libraries as well as gaining basic data for developing improvement strategy for future. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

12.
European Heart Journal ; 42(SUPPL 1):2890, 2021.
Article in English | EMBASE | ID: covidwho-1554265

ABSTRACT

Background: Heart disease is the leading non-obstetric cause of maternal death during pregnancy. In this field, the emergence of pandemic COVID-19 has caused the worst-case scenario considering that pregnant women are more susceptible to viral infections, and preexisting cardiac disease is the most prevalent co-morbidity among COVID-19 deaths. Purpose: To assess the maternal and fetal outcomes of COVID-19 during pregnancy of women with heart diseases. Methods: During the year 2020, among 82 pregnant women with heart disease followed consecutively at the Instituto do Coração-InCor, seven of them with an average age of 33.2 years had COVID-19 during their pregnancies. The underlying heart diseases were rheumatic valve disease (5 pt), congenital heart disease (1 pt) and one case with acute myocarditis, without preexisting cardiopathy. The prescription (antibiotics, inotropes, corticosteroids and others) used was according to the clinical conditions required for each patient, however subcutaneous or intravenous heparin was used in all patients. Results: Only one case had an uneventful maternal-fetal course, the other six women required hospitalization / ICU for an average of 25.3 days, including the need for mechanical ventilation in two of them. Serious complications were related to respiratory failure (ADRS), recurrent atrial flutter with hemodynamic instability, acute pulmonary edema, and cardiogenic shock associated with sepsis which caused two maternal deaths. There were two emergency mitral valve interventional, percutaneous balloon valvuloplasty and valve bioprosthesis replacement, respectively. There were five premature births with an average gestational age of 34.2 weeks of gestation, which resulted in one stillbirth. Pathological findings of three placental and the six-months follow-up of the babies did not confirm vertical transmission of COVID-19. Conclusions: The uncertain evolution given of the overlapping complications of three conditions-COVID-19, pregnancy, and heart disease-implies an increased risk for women with heart diseases of childbearing age, for whom pregnancy should be discouraged and planned after vaccination.

13.
14.
Annals of Allergy, Asthma & Immunology ; 127(5):S20-S20, 2021.
Article in English | PMC | ID: covidwho-1509536
15.
Research and Practice in Thrombosis and Haemostasis ; 5(SUPPL 2), 2021.
Article in English | EMBASE | ID: covidwho-1509054

ABSTRACT

Background : SARS-CoV-2 virus infection (COVID-19) is associated with high rates of venous thromboembolism (VTE). Immune mediated thrombosis has been implicated as a driving factor. Aims : To characterize coagulopathy by assessing thrombin generation kinetics and Von Willebrand Factor (VWF) and to characterize thromboinflammation through neutrophil extracellular trap (NET) formation in COVID-19 patients (pts). Methods : We collected plasma samples from 67 COVID-19 pts in the Emergency Department (ED) and 38 healthy volunteers (HV). Plasma thrombin generation kinetics were assessed using Calibrated Automated Thrombogram (CAT) and expressed as lag time (LT), peak height (PH), time to peak (ttPeak), and endogenous thrombin potential (ETP-total thrombin generated). NET formation was quantified through citrullinated nucleosome ELISA (H3NUC). VWF antigen/activity levels were determined by latex immunoassay. Factor VIII levels were performed using one-stage optical clot detection. VTE events were tracked through electronic medical records. This study was approved by the Institutional Review Board and patients were consented. Mann-Whitney test was performed, P < 0.05 considered significant. Results : Subject characteristics are described in Table 1. Of the 67 pts, 50.7% required admission and 31.3% supplemental oxygen. COVID-19 pts had longer LT and ttPeak, greater H3NUC, VWF antigen and activity level, and Factor VIII levels as compared to HV (Table 2). Admitted pts had longer LT (4.33 min [3.67, 5.67];3.33 min [3.00, 4.00], P < 0.001), ttPeak (7.73 min [6.84, 8.50];7.15 min [6.05, 7.75], P = 0.011), greater VWF antigen (247 IU/dL [208, 298];168 IU/ dL [103, 222], P < 0.001), activity (196 IU/dL [164, 238];130 IU/dL [94, 172], P < 0.001), and Factor VIII (159 IU/dL [129, 194];119 IU/dL [88, 169], P = 0.023) as compared to those not admitted. Conclusions : Symptomatic COVID-19 pts have prolonged initiation of thrombin generation, especially those requiring admission. Greater VWF activity and NETosis suggest systemic thromboinflammation in COVID-19 associated coagulopathy.

16.
Morbidity and Mortality Weekly Report ; 69(50):1895-1901, 2020.
Article in English | GIM | ID: covidwho-1502896

ABSTRACT

During the COVID-19 public health emergency, health centers have provided and continue to provide testing and follow-up care to medically underserved populations;these centers are capable of reaching areas disproportionately affected by the pandemic. HRSA administers a weekly, voluntary Health Center COVID-19 Survey section section to track health center COVID-19 testing capacity and the impact of COVID-19 on operations, patients, and personnel. Potential respondents can include up to 1,382 HRSA-funded health centers. To assess health centers' capacity to reach racial and ethnic minority groups at increased risk for COVID-19 and to provide access to testing, CDC and HRSA analyzed survey data for the weeks June 2-5 October 2020 to describe all patients tested (3,194,838) and those who received positive SARS-CoV-2 test results (308,780) by race/ethnicity and state of residence. Among persons with known race/ethnicity who received testing (2,506,935), 36% were Hispanic/Latino (Hispanic), 38% were non-Hispanic White (White), and 20% were non-Hispanic Black (Black);among those with known race/ethnicity with positive test results, 56% were Hispanic, 24% were White, and 15% were Black. Improving health centers' ability to reach groups at increased risk for COVID-19 might reduce transmission by identifying cases and supporting contact tracing and isolation. Efforts to improve coordination of COVID-19 response-related activities between state and local public health departments and HRSA-funded health centers can increase access to testing and follow-up care for populations at increased risk for COVID-19.

17.
Federal Reserve Bank of St Louis Review ; 103(4):367-383, 2021.
Article in English | Web of Science | ID: covidwho-1498183

ABSTRACT

The destructive economic impact of the COVID-19 pandemic was distributed unequally across the population. A worker's gender, race and ethnicity, age, education, industry, and occupation all mattered. We analyze the initial negative effect and its lingering effect through the recovery phase, across demographic and socioeconomic groups. The initial negative impact on employment was larger for women, minorities, the less educated, and the young whether or not we account for the industries and occupations they worked in. By February 2021, however, the differential effects across groups had gotten much smaller overall and had entirely vanished once the different industries and occupations they work in are taken into account. In particular, the differential effects between men and women vanished with or without the industry and occupation compositions taken into account, indicating that women's progress in the labor market over the past decades has not been wiped out by the pandemic. Across race and ethnicity, Hispanics and Asians were the worse hit but made up most of the lost ground, while the initial impact on Blacks was smaller but their recovery was slower.

18.
Aerosol and Air Quality Research ; 21(9):14, 2021.
Article in English | Web of Science | ID: covidwho-1497589

ABSTRACT

In March 2020, the average concentration of PM2.5 in Seoul decreased by 44% compared to that in March 2019 (from 45 mu g m(-3) to 25 mu g m(-3)). In this study, the synoptic and local meteorological conditions during the period with reduced PM2.5 concentrations were analyzed. The synoptic meteorological conditions during March 2020 show a common characteristic of strong zonal flow and winds. Therefore, air circulation was active and meteorological conditions were unfavorable to long-range transboundary transport. Local meteorological conditions such as wind and turbulent motion at the surface were sensitive to PM2.5 concentrations. Our analyses indicate that the greatly reduced PM2.5 concentrations were mainly influenced by synoptic rather than local conditions. Decreased demand for heating of buildings due to warmer temperatures in March 2020, the economic slowdown following the outbreak of COVID-19, and the implementation of guidelines aimed at controlling particulate matter (PM) were other important causes of reduced PM2.5 emissions. A decrease in long-range transboundary transport contributed to the reduced PM2.5 concentrations.

19.
Journal of the American Society of Nephrology ; 32:405, 2021.
Article in English | EMBASE | ID: covidwho-1489695

ABSTRACT

Background: The therapeutic pipeline in autosomal dominant polycystic kidney disease (ADPKD) has grown, generating a need for more patient participation in clinical trials. To facilitate US ADPKD patient enrollment and to encourage the utilization of patient-reported outcomes in trial design, the PKD Foundation (PKDF) designed a national ADPKD Registry. Methods: The ADPKD Registry is hosted on a secure, online platform (IQVIA, oc-meridian.com/pkdcure). Participants are consented through the online system and complete a series of modules. The Core Questionnaire includes diagnosis, latest kidney function tests, and comorbidities. Family history, diet and lifestyle, quality of life, and complications of liver cysts, and vascular outcomes are queried. Results: Between 9/4/19 and 5/1/21, 1,580 ADPKD patients have registered and completed the Core Questionnaire. Participants have a median age of 49 years, 73% have not reached ESKD, and 79% reported a family history of the disease. Currently, the cohort is 71% female, 93% Caucasian, 4.8% Hispanic/Latino and 2.5% African American. Strategic efforts are in development to increase diversity in the cohort. Nearly three quarters of participants had not previously participated in research, with only 27% indicating that they had been in another PKD study or clinical trial. All participants have consented to be contacted about future studies. Many will likely qualify for ongoing trials based on completed module data. Thus far, the Registry platform has made over 2,200 participants contacts regarding six clinical studies, with some individual overlap due to similar eligibility criteria. Conclusions: The ADPKD Registry is a longitudinal research tool intended to capture ADPKD patient-reported data and is designed to impact research in multiple ways. It will allow for a range of research questions related to the clinical management of ADPKD from early disease through dialysis and post-transplant outcomes. Additionally, modules on health care access & utilization and COVID-19 impact will help the PKDF better understand the challenges of this community.

20.
Annals of Allergy, Asthma & Immunology ; 127(5):S20-S20, 2021.
Article in English | CINAHL | ID: covidwho-1460571
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