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Journal of Pharmaceutical Negative Results ; 13:3929-3940, 2022.
Article in English | EMBASE | ID: covidwho-2206739


Tinospora cordifolia commonly known as giloy is used in traditional Ayurvedic medicine and the Indian system of medicine (ISM) since times immemorial. The plant is designated as Rasayana in ayurveda and is very well known for building up the immune system and body's defence against definite infecting micro-organisms. There are 40 species but 4 species are found in India. It is a herbaceous perennial vine that belongs to the family Menispermaceae. It is widely used as a unique ingredient of various natural medicine and traditionally use for numerous ailments like fever, vomiting, diabetes, jaundice, anaemia, polyuria and skin diseases etc. It has antimicrobial activity, anticancer activity, anti-diabetic activity, anti-inflammatory, antioxidant, and immunomodulatory properties. Giloy is also used in the treatment of coronaviruses because giloy built a strong immunity in the human body against covid-19. A variety of active components derived from the plant like alkaloids, steroids, diterpenoid lactones, aliphatic, and glycosides have been isolated from the different parts of the plant, like root, stem, leaves and whole plant. The current study explores and establishes the biological and medicinal properties and phytochemistry of Tinospora cordifolia. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

27th National Conference on Communications, NCC 2022 ; : 291-296, 2022.
Article in English | Scopus | ID: covidwho-1973500


Motivated by various health care applications and many other novel fields of Molecular Communication (MC), it has become an important field of research since the last decade. This paper proposes a molecular communication-based model for the spread of the SARS-CoV2 virus in the human body. The virus uses the ACE2 receptor as a gateway to enter the blood vessels, organs and then replicate itself. In response to the infection, the immune system synthesizes pro-inflammatory cytokines such as IL6, IL2, and TNFa. This active bodily response may be further compromised by the generation of anti-inflammatory cytokines such as IL4 and IL10. We also propose a mathematical model using a Markov state transition for a flow-based molecular communication system which contributes to the detection of these pro-inflammatory cytokines level and gives a further inference about the infection in the body by taking multiple cytokines into account. © 2022 IEEE.

Biocell ; 46(10):2201-2208, 2022.
Article in English | Web of Science | ID: covidwho-1918326


Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their application in regenerative medicine and COVID-19 treatment. Different approaches to evaluate the future of biomaterials and stem cell properties have been developed. However, misconceptions and ethical issues still exist, such as MSCs being non-angiogenic, anti-apoptotic, and immunoregulatory competencies. Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. These issues generate questions related to ethical and moral issues. However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. They are capable of secreting a broad range of biomolecules such as proteins, nucleic acids, exosomes, microRNAs, and membrane vesicles, collectively known as secretomes. Secretomes are released in response to the surrounding microenvironment. In this article, we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.