ABSTRACT
Background:COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). Serologic assays for SARS- CoV-2, play an important role in understanding the immune status of post covid health care workers who are at highest risk of infection. In this infection, IgM and IgG antibodies can arise nearly simultaneously in serum within 2 to 3 weeks after illness onset. Around day 14 after symptom onset, IgG will rise above detection levels and will generally continue to rise for 28 - 35 days after symptom onset, peaking around or after clinical recovery. IgG typically has a long half-life and will remain above detectable thresholds for months after the resolution of infection. Most widely used treatment strategies include steroids, antivirals and antibiotics. Aim of the study is to assess the effect of treatment strategies on IgG antibodies against SARS-CoV-2 among covid infected Health care workers Methods:All the post covid HCWs (60-75 days after detection) were categorized into 4 groups on the basis of treatment strategies. 1st group (30) – combination of antiviral and steroid therapy, 2nd group (30) – only steroids, 3rd group (15) – only antivirals, 4th group (15)– only antibiotics (asymptomatic). All the groups were treated with multivitamins and VitC along with above mentioned therapy. Qualitative IgG ELISA using Merilisa kits was adopted to assess the prevalence of IgG antibodies against SARS-CoV-2 to know the pattern of IgG antibody titres. Results:90 samples were collected for this study, which were subjected to qualitative ELISA. Out of these highest IgG titres were found in patients only on antibiotics followed by only on antivirals, followed by steroid and antiviral combi- nation and least was found in patients only on steroids. Conclusions:This study showed that administration of steroids results in early weaning of antibodies. Re -infection could be more in these cases
ABSTRACT
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.
ABSTRACT
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.