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Int J Infect Dis ; 108: 231-236, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1202384


OBJECTIVE: Evaluate the real-world accuracy of Myxovirus resistance protein A (MxA) detected by the rapid, point-of-care FebriDx test during the second-wave pandemic in Italy in patients with acute respiratory infection (ARI) and a clinical suspicion of COVID-19. DESIGN AND METHODS: Prospective, observational, diagnostic accuracy study whereby hospitalized patients with ARI were consecutively enrolled in a single tertiary care center in Italy from August 1, 2020 to January 31, 2021. RESULTS: COVID-19 was diagnosed in 136/200 (68.0%) patients and Non-COVID-19 was diagnosed in 64/200 (32.0%) patients. COVID-19 patients were younger and had a lower Charlson comorbidity index compared to Non-COVID-19 patients (p < 0.001). Concordance between FebriDx, MxA and rt-PCR for SARS-CoV-2 (gold standard) was good (k 0.93, 95% CI 0.87-0.99). Overall sensitivity and specificity were 97.8% [95% CI 93.7-99.5] and 95.3% [95% CI 86.9%-99.0%], respectively. FebriDx demonstrated a negative predictive value of 95.3% (95% CI 86.9-99.0) for an observed disease prevalence of 68%. CONCLUSIONS: FebriDx MxA showed high diagnostic accuracy to identify COVID-19 and could be considered as a real-time triage tool to streamline the management of suspected COVID-19 patients. FebriDx also detected bacterial etiology in Non-COVID-19 patients suggesting good performance to distinguish bacterial from viral respiratory infection.

COVID-19 , SARS-CoV-2 , COVID-19 Testing , Humans , Italy/epidemiology , Point-of-Care Testing , Prospective Studies , Sensitivity and Specificity
Cytokine ; 141: 155456, 2021 05.
Article in English | MEDLINE | ID: covidwho-1062308


OBJECTIVES: Olfactory and gustatory dysfunction (OD/GD) are now recognized as typical symptoms of COVID-19 infection. However, their pathogenesis remains unclear and no clear prognostic factors have been identified. We have analyzed a cohort of mild/moderate hospitalized patients to identify possible clinical or immunological predictors of recovery from OD/GD. METHODS: Clinical and biological parameters were reviewed along with associated comorbidities. Chemosensory Complaint Score was administered on admission and 30 days after the first negative swab. Unpaired Wilcoxon and chi-squared tests were used to compare the variables in the patients who recovered versus those who did not. RESULTS: From a cohort of 119 hospitalized patients, 43 (36%) reported OD/GD on admission. 60.6% had a full recovery from OD and 69.2% from GD. Only the concentration of IL-10 on admission emerged as significantly associated with recovery of taste (p = 0.041) while allergic respiratory disease was more prevalent in the group who did not recover from OD (p = 0.049) and GD (p = 0.007). CONCLUSION: These findings suggest that COVID-19 associated OD/GD is an inflammatory-mediated condition and that clinical and immunological parameters could predict the evolution of these symptoms.

COVID-19/complications , COVID-19/immunology , Interleukin-10/blood , Olfaction Disorders/etiology , Olfaction Disorders/immunology , Pandemics , SARS-CoV-2 , Taste Disorders/etiology , Taste Disorders/immunology , Biomarkers/blood , COVID-19/blood , Cohort Studies , Female , Humans , Inflammation Mediators/blood , Inflammation Mediators/immunology , Interleukin-10/immunology , Male , Middle Aged , Olfaction Disorders/blood , Prognosis , Recovery of Function/immunology , Severity of Illness Index , Taste Disorders/blood
Euro Surveill ; 25(17)2020 04.
Article in English | MEDLINE | ID: covidwho-142724


We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical disease unit in Florence, Italy, over 30 days after the start of the COVID-19 outbreak in Italy. A 12% reduction in the rate of intensive care unit transfer was observed after the implementation of intensity care measures in the regular ward such as increasing the nurse/patient ratio, presence of critical care physicians and using high flow nasal cannulae oxygenation.

Coronavirus Infections/mortality , Coronavirus Infections/therapy , Coronavirus , Intensive Care Units/organization & administration , Pandemics , Pneumonia, Viral/mortality , Pneumonia, Viral/therapy , Age Distribution , Aged , Betacoronavirus , COVID-19 , Cannula , Cohort Studies , Comorbidity , Contact Tracing , Coronavirus Infections/diagnosis , Critical Care , Disease Outbreaks , Female , Humans , Italy/epidemiology , Male , Middle Aged , Patient Transfer , Pneumonia, Viral/diagnosis , Respiratory Care Units , SARS-CoV-2 , Sex Distribution , Treatment Outcome