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1.
Saúde Soc ; 29(4):e200412-e200412, 2020.
Article in Portuguese | LILACS (Americas), Grey literature | ID: grc-745671

ABSTRACT

Resumo Este artigo trata de uma pesquisa quantitativa, descritiva e analítica da população brasileira em isolamento social (IS) durante pandemia do novo coronavírus, com o objetivo de identificar preditores de estresse psicossocial com dados recolhidos por questionário on-line nas redes sociais em abril de 2020. Do total de 3.836 pessoas participantes, prevaleceram: mulheres (2.821;73,5%);faixa etária de 30 a 39 anos (1.101;28,7%);com pós-graduação (2075;54,1%);estando em IS (3.447;89,9%). Houve diferença significativa pelo fato de as pessoas estarem em IS: sentir medo de serem infectadas pelo coronavírus (p<0,001);preocupação se alguém precisava sair de casa (p<0,001);rotina modificada após o IS, destacando "entretanto conseguiram se adaptar à nova realidade", comparado aos que "tiveram a rotina alterada sem conseguir se adaptar" (p<0,001);tristeza ou preocupação, fazendo outras atividades como exercício físico, práticas religiosas, atividades lúdicas (p<0,001);e não pensaram numa solução para esse problema (p<0,001);além de mudança no padrão de sono (p=0,006). Os achados revelam a necessidade de discussão ampliada dos determinantes sociais da saúde, que devem envolver não só a doença, mas levar em consideração as relações sociais, as manifestações culturais e a economia, que podem impactar a saúde mental das pessoas. This is a quantitative, descriptive, and analytical study of the Brazilian population in social isolation (SI) during the novel coronavirus pandemic whose aim was to identify predictive factors for psychosocial stress using data collected by a social media-based online questionnaire administered in April 2020. Among the 3,836 participants, most were women (2,821;73.5%), aged from 30 to 39 years (1,101;28.7%), with post-graduate education (2,075;54.1%), and in SI (3,447;89.9%). We found significant differences between individuals who were in SI and those who were not regarding: feeling afraid of being infected by the coronavirus (p<0.001) and worried if someone had to leave the house (p<0.001);changes in routine after self-isolating in those who managed to adapt to the new reality compared to those who could not adapt (p<0.001);feeling sad and worried while doing other activities, such as physical exercise, religious practices, or recreational activities (p<0.001);inability to imagine a solution to this problem (p<0.001), and changes in sleep pattern (p=0.006). Our findings indicate the need for further discussions about the social determinants of health, addressing not only the disease per se, but also social relations, cultural manifestations, and the economy, which may impact people's mental health.

2.
Comput Struct Biotechnol J ; 19: 759-766, 2021.
Article in English | MEDLINE | ID: covidwho-1036889

ABSTRACT

The recent emergence of the novel SARS-CoV-2 in China and its rapid spread in the human population has led to a public health crisis worldwide. Like in SARS-CoV, horseshoe bats currently represent the most likely candidate animal source for SARS-CoV-2. Yet, the specific mechanisms of cross-species transmission and adaptation to the human host remain unknown. Here we show that the unsupervised analysis of conservation patterns across the ß-CoV spike protein family, using sequence information alone, can provide valuable insights on the molecular basis of the specificity of ß-CoVs to different host cell receptors. More precisely, our results indicate that host cell receptor usage is encoded in the amino acid sequences of different CoV spike proteins in the form of a set of specificity determining positions (SDPs). Furthermore, by integrating structural data, in silico mutagenesis and coevolution analysis we could elucidate the role of SDPs in mediating ACE2 binding across the Sarbecovirus lineage, either by engaging the receptor through direct intermolecular interactions or by affecting the local environment of the receptor binding motif. Finally, by the analysis of coevolving mutations across a paired MSA we were able to identify key intermolecular contacts occurring at the spike-ACE2 interface. These results show that effective mining of the evolutionary records held in the sequence of the spike protein family can help tracing the molecular mechanisms behind the evolution and host-receptor adaptation of circulating and future novel ß-CoVs.

3.
Saúde Soc ; 29(4):e200412-e200412, 2020.
Article in Portuguese | LILACS (Americas) | ID: covidwho-1022703

ABSTRACT

Resumo Este artigo trata de uma pesquisa quantitativa, descritiva e analítica da população brasileira em isolamento social (IS) durante pandemia do novo coronavírus, com o objetivo de identificar preditores de estresse psicossocial com dados recolhidos por questionário on-line nas redes sociais em abril de 2020. Do total de 3.836 pessoas participantes, prevaleceram: mulheres (2.821;73,5%);faixa etária de 30 a 39 anos (1.101;28,7%);com pós-graduação (2075;54,1%);estando em IS (3.447;89,9%). Houve diferença significativa pelo fato de as pessoas estarem em IS: sentir medo de serem infectadas pelo coronavírus (p<0,001);preocupação se alguém precisava sair de casa (p<0,001);rotina modificada após o IS, destacando "entretanto conseguiram se adaptar à nova realidade", comparado aos que "tiveram a rotina alterada sem conseguir se adaptar" (p<0,001);tristeza ou preocupação, fazendo outras atividades como exercício físico, práticas religiosas, atividades lúdicas (p<0,001);e não pensaram numa solução para esse problema (p<0,001);além de mudança no padrão de sono (p=0,006). Os achados revelam a necessidade de discussão ampliada dos determinantes sociais da saúde, que devem envolver não só a doença, mas levar em consideração as relações sociais, as manifestações culturais e a economia, que podem impactar a saúde mental das pessoas. This is a quantitative, descriptive, and analytical study of the Brazilian population in social isolation (SI) during the novel coronavirus pandemic whose aim was to identify predictive factors for psychosocial stress using data collected by a social media-based online questionnaire administered in April 2020. Among the 3,836 participants, most were women (2,821;73.5%), aged from 30 to 39 years (1,101;28.7%), with post-graduate education (2,075;54.1%), and in SI (3,447;89.9%). We found significant differences between individuals who were in SI and those who were not regarding: feeling afraid of being infected by the coronavirus (p<0.001) and worried if someone had to leave the house (p<0.001);changes in routine after self-isolating in those who managed to adapt to the new reality compared to those who could not adapt (p<0.001);feeling sad and worried while doing other activities, such as physical exercise, religious practices, or recreational activities (p<0.001);inability to imagine a solution to this problem (p<0.001), and changes in sleep pattern (p=0.006). Our findings indicate the need for further discussions about the social determinants of health, addressing not only the disease per se, but also social relations, cultural manifestations, and the economy, which may impact people's mental health.

4.
Saúde Soc ; 29(4): e200412, 2020. tab
Article in Portuguese | WHO COVID, LILACS (Americas) | ID: covidwho-1011305

ABSTRACT

Resumo Este artigo trata de uma pesquisa quantitativa, descritiva e analítica da população brasileira em isolamento social (IS) durante pandemia do novo coronavírus, com o objetivo de identificar preditores de estresse psicossocial com dados recolhidos por questionário on-line nas redes sociais em abril de 2020. Do total de 3.836 pessoas participantes, prevaleceram: mulheres (2.821; 73,5%); faixa etária de 30 a 39 anos (1.101; 28,7%); com pós-graduação (2075;54,1%); estando em IS (3.447; 89,9%). Houve diferença significativa pelo fato de as pessoas estarem em IS: sentir medo de serem infectadas pelo coronavírus (p<0,001); preocupação se alguém precisava sair de casa (p<0,001); rotina modificada após o IS, destacando "entretanto conseguiram se adaptar à nova realidade", comparado aos que "tiveram a rotina alterada sem conseguir se adaptar" (p<0,001); tristeza ou preocupação, fazendo outras atividades como exercício físico, práticas religiosas, atividades lúdicas (p<0,001); e não pensaram numa solução para esse problema (p<0,001); além de mudança no padrão de sono (p=0,006). Os achados revelam a necessidade de discussão ampliada dos determinantes sociais da saúde, que devem envolver não só a doença, mas levar em consideração as relações sociais, as manifestações culturais e a economia, que podem impactar a saúde mental das pessoas.


Abstract This is a quantitative, descriptive, and analytical study of the Brazilian population in social isolation (SI) during the novel coronavirus pandemic whose aim was to identify predictive factors for psychosocial stress using data collected by a social media-based online questionnaire administered in April 2020. Among the 3,836 participants, most were women (2,821; 73.5%), aged from 30 to 39 years (1,101; 28.7%), with post-graduate education (2,075;54.1%), and in SI (3,447; 89.9%). We found significant differences between individuals who were in SI and those who were not regarding: feeling afraid of being infected by the coronavirus (p<0.001) and worried if someone had to leave the house (p<0.001); changes in routine after self-isolating in those who managed to adapt to the new reality compared to those who could not adapt (p<0.001); feeling sad and worried while doing other activities, such as physical exercise, religious practices, or recreational activities (p<0.001); inability to imagine a solution to this problem (p<0.001), and changes in sleep pattern (p=0.006). Our findings indicate the need for further discussions about the social determinants of health, addressing not only the disease per se, but also social relations, cultural manifestations, and the economy, which may impact people's mental health.


Subject(s)
Humans , Male , Female , Social Isolation , Stress, Psychological , Coronavirus Infections , Qualitative Research , Pandemics
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