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1.
Romanian Journal of Infectious Diseases ; 24:76-78, 2021.
Article in English | Scopus | ID: covidwho-2156265

ABSTRACT

The COVID-19 pandemic has changed the lives of millions of people across the globe. As of November 2021, WHO has reported more than 250 million confirmed cases of SARS-CoV-2 infection with more than 5 million deaths. Despite the continuous efforts being made by the medical community to address the fundamental questions posed by the SARS-CoV-2 infection in pregnant women and its impact over the mother and the offspring. The aim of this paper is to assess the evidence accumulated since the emergence of the pandemic concerning the impact of SARS-CoV-2 infection on the mother and fetus, especially addressing the risks of intrauterine death in SARS-CoV-2 positive mothers. We searched different databases up to November 2021 for variations of the sentence: "SARS-CoV-2 infection and COV-ID-19 and pregnancy and fetal death, stillbirth, intrauterine death". The changing physiological and immune responses during pregnancy make a pregnant woman more prone to developing severe forms of COVID-19, causing sometimes serious pregnancy complications such as fetal loss. At times mild general symptoms related to COVID-19 can cause serious fetal complications, suggesting that placental changes are responsible for fetal outcome. Infection with non-Delta variant increases the risk of fetal loss in the third trimester two times compared to healthy population, while Delta variant increases this risk four times. The exact mechanism of vertical transmission is still to be established and these aspects need further research especially assessing COVID-19 variant particularities. © 2021, Amaltea Medical Publishing House. All rights reserved.

2.
Romanian Journal of Infectious Diseases ; 23(3):179-182, 2020.
Article in English | Scopus | ID: covidwho-2156247

ABSTRACT

The ongoing coronavirus disease 2019 (COVID-19) outbreak was declared a pandemic by the World Health organization in early March 2020. The disease typically presents with viral respiratory symptoms that could progress to acute respiratory dis-tress syndrome. Emerging evidence suggests different possible dermatologic manifestations of COVID-19, including: acral lesions (pernio-like, pseudo-chillblain), vesicular eruptions, macular and papular exanthema, urticaria, livedoid, purpuric and petechial rashes. However, specific skin manifestations of the COVID-19 disease have not yet been clearly established and the relationship between the appearance of skin lesions and SARS-CoV-2 infection is still unclear. These highly variable skin changes could represent a direct con-sequence of the viral infection, an immunological response to viral nucleotides, adverse reactions to drugs frequently used for the treatment of COVID-19, or other disorders. In a global effort to comprehend the exact cutaneous features of COVID-19, several international dermatological societies have initiated nationwide studies to analyze COVID-19 cutaneous manifestations during this pandemic. This paper represents a literature review of the scientific data available on the clinical characteristics and symptoms of the cutaneous manifestations associated with COVID-19. Such findings are extremely useful in establishing if dermatological manifestations in COVID-19 patients could harbor a diagnostic significance and subsequently be used as prognostic factors for outcomes of COVID-19. © 2020, Amaltea Medical Publishing House. All rights reserved.

3.
Open Bioinformatics Journal ; 15 (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2098963

ABSTRACT

Background: The COVID-19 pandemic has presented a series of new challenges to governments and healthcare systems. Testing is one important method for monitoring and controlling the spread of COVID-19. Yet with a serious discrepancy in the resources available between rich and poor countries, not every country is able to employ widespread testing. Methods and Objective: Here, we have developed machine learning models for predicting the prevalence of COVID-19 cases in a country based on multilinear regression and neural network models. The models are trained on data from US states and tested against the reported infections in European countries. The model is based on four features: Number of tests, Population Percentage, Urban Population, and Gini index. Result(s): The population and the number of tests have the strongest correlation with the number of infections. The model was then tested on data from European countries for which the correlation coefficient between the actual and predicted cases R2 was found to be 0.88 in the multi-linear regression and 0.91 for the neural network model Conclusion(s): The model predicts that the actual prevalence of COVID-19 infection in countries where the number of tests is less than 10% of their populations is at least 26 times greater than the reported numbers. Copyright © 2022 Hashim et al.

6.
17th International Scientific Conference on eLearning and Software for Education, eLSE 2021 ; : 452-459, 2021.
Article in English | Scopus | ID: covidwho-1786313

ABSTRACT

In post pandemic times when looking forward to the normality is the focus of everyone’s attention, research areas abound in papers spinning around the same topic-COVID-19. From disinformation to a mired economy, to the effects on global mobility, education, health, social and political aspects, all papers observe, analyze, count and draw conclusions on what COVID-19 meant for the whole world. Studies vary from a national level approach to the international, continental and global, with a specialist or generalist approach, from analyses on figures from economy and tourism to lexical analyses on occurrences of news topics or frequently used words, to measure society in terms of psychological unrest and confidence, after an invariable introductory section about the context and time COVID-19 first started and where it initiated, to stages of the virus spread and sectors affected. Looked at on the long term, education along with general and mental health are among the most frequently brought under lenses mainly due to the long term isolation consequences on social evolution. In this context, the present paper aims at highlighting the need for a recalibration of the educational process, to tune in with a virtual area, to accommodate a differently represented type of student and a variety of pedagogical approaches to adapt the syllabus and tailor activities to facilitate learning in an environment which has been recently re-purposed to fit and last, to answer and to teach. The universal tool-bag is extremely generous, the technological support products are abundant in apps designed for educational purposes, while the key to set it all in motion is creativity, attention to students’ needs, a proper selection of the pedagogical resorts and of the content, in a close combination with specificities of online communication in such contexts. A comparison will be drawn between two apps used for formal synchronous learning, three types of student, and four components in class management, all having one goal, the knowledge transfer. © 2021, National Defence University - Carol I Printing House. All rights reserved.

7.
Advances in Social Work ; 21(4):1064-1082, 2021.
Article in English | Scopus | ID: covidwho-1737465

ABSTRACT

Escalating conflicts, climate change, rising inequality, a global pandemic: Complex emergencies are leading to a reconfiguration of the world as we know it. Rapid flow of information allows increased visibility and understanding of the impact of these crises on the most vulnerable. Yet at the same time, marginalized communities are rendered invisible, and their fundamental human rights are being erased. In such contexts, providing a framework that engages communities and ensures that they are at the core of any capacity building endeavor is an important professional mandate for international social work and social development. This paper introduces the Strengths and Participation to Accomplish Capacity and Empowerment (SPACE) conceptual framework for capacity building and community engagement in international social work practice. This conceptual framework builds on both the strengths perspective and empowerment theories, and promotes a rights-based approach for international social work and social development. SPACE was first used to design and implement a training-of-trainers program in two communities in Guatemala. The training’s effectiveness in building capacity was evidenced by the impactful networks strengthened or developed as a result of the training in developing COVID-related responses. Further applications of this framework can improve international social work practice and advance rights-based approaches to sustainable development. © 2021 Authors,.

8.
Osteoporosis International ; 32(SUPPL 1):S384-S384, 2021.
Article in English | Web of Science | ID: covidwho-1710626
9.
Balneo and Prm Research Journal ; 12(4):301-305, 2021.
Article in English | Web of Science | ID: covidwho-1689788

ABSTRACT

Introduction: A great variety of medical issues can occur after the COVID-19 infection including fatigue, muscle weakness, locomotor disability, self-care dysfunction, polyneuropathy, persistent dyspnea on exertion and a hypercoagulable state. Materials and methods: This paper presents the case of a nonsmoker 49-year-old male with right lung lower lobe lobectomy for post tuberculosis bronchiectasis and diabetes mellitus, who developed multiple serious physicals, neurological, hematological and respiratory consequences, related to critical COVID-19 infection and prolonged hospitalization, Results: A favorable evolution of the patient's respiratory sequels and motor impairment on both lower limbs was noticed after a complex individualized rehabilitation program started in the post COVID-19 Rehabilitation Department of Balneal and Rehabilitation Sanatorium, Techirghiol, Romania, consisting in better functional parameters and exercise tolerance, significant improvement in daily activities, remission of exertional dyspnea, social and family reintegration. Conclusions: multidisciplinary approach and complex individualized programs of rehabilitation is required after a critical form of COVID in a patients known with tuberculosis, and other complex pathologies, in order to restore physical function and mobility and optimize respiratory parameters.

10.
15th International Conference on Business Excellence (ICBE) - Digital Economy and New Value Creation ; 15:434-443, 2021.
Article in English | Web of Science | ID: covidwho-1674233

ABSTRACT

In this article, we try to see if there is a direct link between this health crisis and global warming and if there is something to take away and use at a different level. We are living in complicated times, a sanitary crisis which is followed by an economic one, the amplitude is remained to see, but clearly, both are very damaging. In both cases, being able to rely on the best available scientific knowledge is essential for decision-making. But these cases are quite different because in the case of climate change, apparently, the solution consists in embracing a new social, economic, and energy model. Unfortunately, this aspect is missing from the measures aimed to slow down the COVID-19 pandemic. If certain decisions taken to solve the pandemic seem initially to be directed through the direction of climate protection, others seem rather to going in the opposite direction, so there is no immediate equivalence from one problem to another, and we should not mislead ourselves about possible positive consequences of this health crisis in terms of climate. Nevertheless, perfect communication, coordinated and targeted, clear and honest, has to go hand in hand with the actions taken, to obtain the best and fast results. Despite this situation, we don't have to forget that that humanity is in the middle of another crisis, global warming, which will affect even more, at all levels, not only humankind, and for a longer period.

11.
Romanian Journal of Oral Rehabilitation ; 13(3):92-102, 2021.
Article in English | Web of Science | ID: covidwho-1610336

ABSTRACT

The aim of this study is to determine the prevalence of malocclusions in a group of schoolchildren from both urban and rural areas of Gorj County, Romania The study included 1007 schoolchildren aged between 6 and 14 years old, who were enrolled in randomly selected public schools from Gorj County. The data were collected from December 2019 to February 2020, based on the project "Educafie pentru sanatate orala. Cercetari privind anomaliile dento-maxilare si leziunile odonto-parodontale la scolarii din Oltenia", in which several institutions were involved. The study was interrupted before it was completed due to the COVID-19 pandemic outbreak. In data collection and centralization we used: Angle's classification of malocclusions and the distribution of malocclusions according to gender, age groups and origin. We obtained a prevalence of 35.35% for malocclusions. Of the total number of schoolchildren with malocclusions, the highest prevalence was recorded for those included in Angle's class I (60.37% for males and 65.63% for females). We found the highest prevalence of malocclusions in female gender (36.64%). Regarding the origin, there is a higher prevalence of malocclusions in urban areas (37.86%). Due to the strong impact of malocclusions on the quality of life, it is necessary to apply preventive measures to avoid psychological implications.

13.
Research and Practice in Thrombosis and Haemostasis ; 5(SUPPL 2), 2021.
Article in English | EMBASE | ID: covidwho-1509096

ABSTRACT

Background : COVID-19 frequently associated thrombotic complication that could determine severe evolution. Inflammation was proved as important pathogenic mechanism of thrombosis. Aims : The main objective was to evaluate the role of inflammation in increased risk of thrombosis in COVID 19 patients. Methods : Our study was prospective and included all patients diagnosed with COVID 19 between April-September 2020 in Hematology, Pneumology and Intensive Care Unit from Colentina Clinical Hospital (285 patients). The diagnosis was established using molecular test for SARS-Cov2. Results : Thrombotic complication was presented in 56 COVID-19 patients (19, 65%), The higher incidence of thrombosis was observed in severe form of COVID-19: stage 3 (66%) and stage 2 (26.3%), Comorbidities: diabetes mellitus, obesity and arterial hypertension were presented in majority of COVID 19 patients with thrombosis. Acute thrombosis (stroke, myocardial infarction or pulmonary embolism) was diagnosed in 14 patients;all of them were admitted in Intensive care unit due severe form of COVID-19. Inflammatory markers including C reactive protein (CRP), procalcitonin, ferritin are significantly increased in COVID-19 group with acute thrombosis compared with COVID -19 patients with thrombosis in medical history CRP 148.86 mg/L (2.96-386.5) vs. 58.24 mg/L (min 0.25, max 212.98) P = 0.005;procalcitonin 0.93 ng/ml (0.04-784) vs 0.18 (min 0.02, max 14.1) P = 0.02;ferritin 702 ng/ml (min 102, max 4070) vs. 1195 ng/ml (min 358, max 12800) P = 0.03. There is no significant difference between haematological parameters in COVID-19 patients with acute thrombosis or in their medical history. D Dimers are significant increased in patients with acute thrombosis 4.79 ug/ml (0.51-20) vs patients with medical history of thrombosis 2.12 (0.31-20), P = 0.02. The level of protein C, protein S and antitrombine III, antiphospholipid antibodies are not significant modified in the both groups. Conclusions : The assessment of inflammation parameters are very important in COVID-19 patients especially those with a history of thrombosis or who have significant comorbidities (diabetes mellitus, arterial hypertension or obesity).

14.
Journal of Mind and Medical Sciences ; 8(2):9, 2021.
Article in English | Web of Science | ID: covidwho-1485650

ABSTRACT

Objective. This study aimed at identifying the stress and anxiety levels among physicians and nurses working in Romanian hospitals during the COVID-19 pandemic Methods and Results. We conducted an online survey with a questionnaire completed by 169 healthcare providers aged between 25 and 69 years from COVID and non-COVID hospitals. There were 87.6% physicians and 12.4% nurses, with 61.5% women and 38.5% men. Clinicians experienced high levels of stress in 2.7% of the cases, medium stress in 68.9% of the cases, and low stress in 28.4% of the cases. Women experienced more stress (2.9% high level, 66.3% medium level) than men (1.5% high level, 64.6% medium level), while men are more anxious (73.8% high level, 26.2% medium level) than women (63.6% high level, 33.7% medium level). In both COVID and non-COVID healthcare providers, the stress score directly correlates with the anxiety score. Overall, during this period, the responders felt stressed and anxious (p=0.001). Conclusions. The COVID-19 pandemic is a strong reason for increased stress and anxiety among physicians and nurses. Men are more anxious and women more stressed. The stress and anxiety scores are different according to the hospital type.

15.
IBIMA Business Review ; 2021, 2021.
Article in English | Scopus | ID: covidwho-1395176

ABSTRACT

In the context of the COVID-19 pandemic outbreak, fiscal policies become essential in combating the crisis effects on both the labour market and the business sector. Thus, finding the most effective fiscal policy solutions to ensure a smoother economic recovery from the pandemic effects becomes a major concern worldwide. As compared to more developed countries, developing economies tend to have harder and usually longer recovery periods from economic crises. Therefore, this paper aims to study the changes in fiscal policies in correlation with the evolutions and transformations of the labour market for a case of a developing country. Evidence for the case of Romania is provided, where labour force participation is very low and youth unemployment is among the highest in Europe. This paper discusses the national legislative framework of fiscal policies and the recent labour market changes. Forecasts of moderate levels of economic growth are radically changed following the outbreak of the COVID-19 pandemic in early 2020. Copyright © 2021. Madalina Ecaterina POPESCU, Larisa STANILA, Ana-Maria GATEA and Amalia CRISTESCU. Distributed under Creative Commons Attribution 4.0 International CC-BY 4.0

16.
HemaSphere ; 5(SUPPL 2):383, 2021.
Article in English | EMBASE | ID: covidwho-1393444

ABSTRACT

Background: The severe acute respiratory syndrome coronavirus-2 (SARSCoV-2) was first reported in Wuhan, China in December2019 and represented the pathogen agent that induced COVID-19. The onset and evolution of COVID -19 is severe when is associated with another comorbidities. Patients with acute leukemia present high risk for severe form of COVID-19 Aims: The main objective was to evaluate the particularities of COVID-19 in patients with acute leukemia. Methods: Our study was prospective and included 49 patients with acute leukemia (27 male median age 64 and22 female median age 54,5) who also were SARS CoV2 positive between April2020- February2021 admitted in Hematology and Intensive Care Unit Departments of Colentina Clinical Hospital Bucharest. The diagnosis was established using molecular test for SARS-Cov2 Results: In the group was included 32 patients diagnosed with acute myeloid leukemia (AML), 9 patients with acute lymphoid leukemia (ALL), 6 patients with acut promyelocytic leukemia and2 patients with acute bifenotypic leukemia. Severe form of COVID-19 with ICU addmission was diagnosed in16 patients (32,17%), almost all of them (15 patients) had unfavourable evolution compared with non-ICU patients group with only1 deceased patient, p<0.0001. The recent chemotherapy followed by severe aplasia was the main negative factor that impacted patient evolution (rho=0.508, p=0.0002),13 patients admitted in ICU Department and12 patients in non-ICU. Severe pneumonia (more than 30% lung field) was diagnosed in17 patients with recent chemotherapy and 4 untreated patients. The type of leukemia or refractory status have not any impact of patient evolution. Antiviral therapy - Remdesivir rapidly introduced in patient's therapy was followed by favourable evolution. Summary/Conclusion: Patients with acute leukemia are negatively impacted by intensive chemotherapy during COVID-19 evolution. The key for good prognosis of these patients during COVID-19 are rapid diagnosis and antiviral therapy at the onset of the disease.

17.
Proceedings of the Romanian Academy. Series B, Chemistry, Life Sciences and Geosciences ; 23(1):108-114, 2021.
Article in English | GIM | ID: covidwho-1279171

ABSTRACT

The COVID-19 disease brought numerous hospitalizations and deaths worldwide, which exerted implications not only for health care professionals of different specialties, but also for the general population in need of medical attention - and psoriasis patients make no exception. The COVID-19 pandemic raised multiple issues of concern such as whether immunosuppressant, including biologic therapy may increase the risk of patients with psoriasis to develop the viral infection or to progress more severely;the possibility of a disease flare-up after discontinuation of immunosuppressive therapy;the safety of COVID-19 vaccination in immunocompromised patients including those on immunosuppressive medications. In this review, we aim to bring attention to the coronavirus vaccination among psoriasis population, a fundamental point of interest for dermatologists, rheumatologists and general practitioners, according to the available guidelines and recommendations. Patient education with respect to SARS-CoV-2 vaccination is of great importance and proper counseling by healthcare professionals is essential for a better understanding of the use of vaccines while on immunosuppressive or biologic therapy.

18.
Thorax ; 76(SUPPL 1):A59-A60, 2021.
Article in English | EMBASE | ID: covidwho-1194253

ABSTRACT

Introduction COVID-19 mortality rates are high, particularly in patients requiring invasive ventilatory support, developing a cytokine storm, or experiencing thromboembolic disease. Our goal was to determine if traffic-light driven, personalised care was associated with improved survival in acute hospital settings. Methods Outcomes were evaluated during two implementation phases of a real-time clinical decision support tool that had been developed as part of a Trust's COVID-19 response, using a reporting and bioinformatics team to support Clinical and Operational teams. Following optimisation, the tool defined patients' clinical status in terms of risk of preventable complications based on blood test results (Ddimer, C reactive protein and ferritin). Feedback to wardbased clinicians enabled rapid modification of care pathways, in the first phase following a daily review, and in the second phase, in real-time (dashboard updated every 10 minutes). Results 1039 COVID-19 positive patients were admitted by 21/05/2020. Focusing on the first 939 completed encounters to death or home discharge (median age 69ys;60% [563/939] male), 568/939 (60.4%) received thromboembolism risk flags, and 212/939 (22.5%) cytokine storm flags. The maximum thromboembolism flag discriminated completed encounter mortality between no flag (9.97% [37/371]);medium-risk (28.5% [68/239]);high-risk (51.2% [105/205]);and suspected thromboembolism (52.4% [65/124]), Kruskal Wallis p<0.0001. 173 of 535 consecutive COVID-19 positive patients whose hospital encounter completed before real-time introduction died (32.3% [95% confidence intervals 28.0, 36.0]), compared to 46 of 200 (23.0% [95% CI 17.1, 28.9]) admitted after implementation of real-time traffic light flags (p=0.013). The realtime cohort were older (median age 72ys compared to 67ys, p=0.037), and were more likely to flag at risk of thromboembolism on admission. However, adjusted for age/sex, the probability of death was 0.33 (95% confidence intervals 0.30, 0.37) before real-time implementation, and 0.22 (0.17, 0.27) after real-time implementation (p<0.001). In subgroup analyses, older patients, males, and patients with hypertension (p£0.01) and/or diabetes (p=0.05) derived the greatest benefit from admission under the real-time traffic light system. Conclusion Personalised early interventions were associated with a reduction in mortality. We suggest benefit predominantly resulted from early triggers to review/enhance anticoagulation management, without exposing lower-risk patients to potential risks of full anticoagulation therapy.

20.
Clinical Lymphoma, Myeloma and Leukemia ; 20:S228, 2020.
Article in English | EMBASE | ID: covidwho-989493

ABSTRACT

Context: Coronavirus disease 2019 (COVID-19) is a highly infectious disease. A small proportion of COVID patients are positive for SARS-CoV-2 for long time. We report a COVID-19 patient with prolonged presence of SARS-CoV-2 RNA. Objective: In this study we evaluate the unexpected evolution of patients with CLL diagnosed with COVID-19. Design and Setting: We have a prospective study that included all CLL patients admitted in the Hematology Department of Colentina Clinical Hospital, during April-June 2020. Patients or other participants: The study group included 3 CLL patients. All patients were SARS-CoV-2 positive by molecular test. Results: 1st patient: A 53-year-old male diagnosed with COVID on 25th March, 2020, at the onset presented fever, headache, and associated anal abscess. The patient had a history of diabetes mellitus and CLL (starting 2014). The CLL patient was monitored as a “watch and wait” patient until 2019 when started on Ibrutinib (was stopped on 16th March, 2020). He received antiviral+hydroxychloroquine associated with antibiotics Piperacilin/Tazobactam and Linezolid with favourable evolution and resolution of anal abscess. During surgical monitoring (week 3), patient presented fever, chills, cough and dyspnea. CT scan revealed bilateral COVID pneumonia and associated Klebsiella pneumonie infection in sputum by Biofire exam. Antibiotics treatment (Vancomycin, Colimicin, and Meropenem), antifungal treatment (Caspofungin), and Tocilizumab 640 mg was started with favourable evolution but patient is still SARS-CoV-2-positive (50 days). The long-time of positive SARS-CoV-2 status although the patient received COVID treatment including Tocilizumab is not an usual evolution for COVID patient 2nd and 3rd patients watch and wait CLL patients with positive SARS-CoV-2 test and ongoing evolution during 2 weeks. Compared with the rest of patients, including AML or MPN patients (negativity of SARS-CoV-2 test was obtained in maximum 2 weeks), CLL patients had long evolution. Conclusions: These cases suggest that a small proportion of COVID patients like CLL patients may have prolonged positivity for SARS-CoV-2 RNA although the evolution is not severe.

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