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European Journal of Molecular and Clinical Medicine ; JOUR:2014-2021, 9(6).
Article in English | EMBASE | ID: covidwho-2083735

ABSTRACT

Mucormycosis is a fungal infection primarily affecting immunocompromised individuals. We have observed sudden rise of mucormycosis cases in post COVID 19 patients. Here we have reported 600 cases of mucormycosis associated with COVID 19.Liposomal amphotericin B was compared with conventional amphotericin B for antifungal therapy in mucormycosis, double-blind, multicentre trial.The two drugs were equivalent in overall efficacy. However, the liposomal amphotericin B treatment group had fewer proven fungal infections, fewer infusion-related side effects and less nephrotoxicity. Patient data from that study were analysed to compare the pharmacoeconomics of liposomal versus conventional amphotericin B therapy.Data from 600 patients were collected and analysed. Hospital costs from first dose were significantly higher for all patients who received liposomal amphotericin B. The mean duration of therapy was 10.8 days for liposomal amphotericin B (300 patients) and 10.3 days for conventional amphotericin B (300 patients). The composite rates of successful treatment were similar (50 percent for liposomal amphotericin B and 49 percent for conventional amphotericin B. The outcomes were similar with liposomal amphotericin B and conventional amphotericin B with respect to survival (93 percent and 90 percent, respectively. With the liposomal preparation significantly, fewer patients had infusion-related fever (17 percent vs. 46 percent), chills or rigors (18 percent vs. 55 percent), and other reactions, including hypotension, hypertension, and hypoxia. Nephrotoxic effects (defined by a serum creatinine level two times the upper limit of normal) were significantly less frequent among patients treated with liposomal amphotericin B (18 percent) than among those treated with conventional amphotericin B (37 percent, p<0.001). Copyright © 2022 Ubiquity Press. All rights reserved.

2.
National Journal of Community Medicine ; 13(3):195-199, 2022.
Article in English | Scopus | ID: covidwho-1836714

ABSTRACT

Background: Coronavirus disease is an infectious disease caused by newly discovered coronavirus (SARS-CoV-2), which spread rapidly throughout the world. Vaccines will provide a lasting solution by enhancing immunity and containing disease spread. This study was conducted to find out vaccination status among Covid-19 positive patients and correlate severity of infections with vaccination status. Methodology: This cross sectional study was carried out among 1218 Covid-19 positive patients that were positive after the launch of Covid-19 vaccine, selected by purposive sampling method. Data was collected using pretested semi structured proforma. Results: Covid-19 vaccination coverage was very low (10.03%) in Covid-19 positive patients, for single dose it was 8.38% and for two doses it was 1.65%. Asymptomatic and mild cases were more in vaccinated compared to unvaccinated, it was statistically significant. Though hospitalization in vaccinated was less it was not significant. There was no death among vaccinated cases. Conclusion: Vaccination coverage were very low, this needs to improve. Vaccine was significantly reduces the severity of infection. It is recommended to vaccinate all eligible population as early as possible which will help in reducing severe and hospitalized cases and ultimately reducing the impact of Covid-19 pandemic. © 2022, MedSci Publications. All rights reserved.

3.
2nd International Conference on Recent Advances in Manufacturing, RAM 2021 ; : 799-811, 2022.
Article in English | Scopus | ID: covidwho-1826300

ABSTRACT

Supply chain processes (SCM) encompass a wide spectrum of functions that facilitate the flow of a raw material till its finished product stage. The most vital aim of SCM lies in establishing a link between all the facilities of a company such as manufacturing, transporting, channelizing and delivering goods and enhancing business processes by making them more flexible, more agile and, consequently, more competitive. This unpleasant coronavirus pandemic has adversely affected almost all supply chain networks around the globe and has highlighted the shortcomings of the existing supply chains. This research study makes an attempt to find the disruptions in supply chain caused by COVID-19 by using Interpretive Structural Modeling (ISM) and provides a few solutions for the same. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

4.
Journal of Experimental Biology and Agricultural Sciences ; 8(Special Issue 1):S57-S65, 2020.
Article in English | Scopus | ID: covidwho-994748

ABSTRACT

The COVID-19 outbreak originated from Wuhan, China has spread over the world, causing a “Global Pandemic”. We analyzed daily confirmed cases and deaths from different countries to understand the progression of the ongoing pandemic in different parts around the world. The data indicated that the pandemic is in different stages in different countries, where they are either at the end of the second wave or middle or early phase of it or still in the middle of the first wave of infection, and they can be divided into four groups. Type 1 countries such as UK, France, Spain, and the Netherlands are currently witnessing the second wave of infection with an exponential increase in daily cases. Countries such as Australia, United States, Japan, and Poland are currently in the declining stage of second-wave, grouped as Type 2 countries. Type 3 countries such as Germany, Italy, Belgium, and Russia are recently seeing the second wave with slowly rising of confirmed cases. Type 4 countries including India, Brazil, Argentina, and Mexico are currently fighting against the first wave of COVID-19. These countries have a chance to learn from the countries which have overcome the second wave successfully. To be ahead of the epidemic curve and preventing it, countries need to make future plans on family, hospital, and community levels. Isolation of the highly vulnerable elderly people and young children, preventing social or public gathering, following the guidelines of COVID-19 prevention including wearing face masks regularly can save countries from devastating effects of the second wave of pandemic COVID-19. © 2020, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

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