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Medical Journal of Wuhan University ; 41(4):533-536, 2020.
Article | COVIDWHO | ID: covidwho-616545


Objective: To analyze the epidemiological and clinical characteristics of severe and critical coronavirus disease 2019(COVID-19) and provide evidence for the discovery and management of COVID-19 cases in these types Methods: A retrospective observation on the severe or critical COVID-19 cases in Renmin Hospital of Wuhan University was made from January 2020 to February 2020 Epidemiological and clinical data were collected and analyzed Results: Forty severe cases and 10 critical cases were included, and most cases came from Wuchang District of Wuhan City 90% of them were familial clustering The average age was 57 6 years old The average length of stay was 17 days The main clinical manifestations were fever (100%) and cough (90%) The majority of laboratory examinations showed normal white blood cells (72%), decreased lymphocytes (30%), increased inflammatory factors (73 9%), accompanied by liver and kidney dysfunction (10% and 14%) and decreased cellular immune function (42 3% and 37 8%) 44% of the patients had moderate or severe hypoxemia at the time of admission and need high-flow nasal cannula, noninvasive ventilation or even mechanic ventilation Conclusion: The main symptoms of severe and critical COVID-2019 are fever and cough, and increased inflammation and immune function suppression are common Hypoxemia is severe, and these patients need higher respiratory support technology © 2020, Editorial Board of Medical Journal of Wuhan University All right reserved