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1.
Int J Appl Earth Obs Geoinf ; 112: 102905, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1926593

ABSTRACT

Coronavirus disease 2019 (COVID-19) has crucially influenced anthropogenic activities, which in turn impacts upon the environment. In this study, we investigated the variations on aerosol optical depth (AOD) at 550 nm over the Bohai Sea and Yellow Sea during the COVID-19 lockdown (from February to March in 2020) of China mainland based on Moderate-resolution Imaging Spectroradiometer (MODIS) observation by comparing with historical AOD records (2011-2019). Our results show that with the lockdown implementation, the decade-low AOD levels are achieved in February and March 2020 (0.39 ± 0.18 and 0.37 ± 0.19, respectively), which are 22% and 28% (p < 0.01) lower than the average AOD between 2011 and 2019 (0.50 ± 0.08 and 0.52 ± 0.05, respectively). After the lockdown restrictions were relaxed and industrial production gradually resumed, the AOD in April 2020 rebounded to the historical average level. Besides, compared with historical observations (2011-2019), the AOD temporal variability from February to April 2020 showed different pattern, with the decade-high increase from March to April (+0.11) and decade-low increase from February to March (-0.01). Independent observations and simulation, including fine particulate matter (PM2.5) from ground-based measurements, wind field from Cross-Calibrated Multi-Platform, satellite-derived aerosol type, and back trajectories calculation by Hybird Single Paricle Lagrangian Intergrated Trajectory (HYSPLIT) model, indicated that the above abnormal AOD variation can be attributed to reduction of anthropogenic emissions during the COVID-19 lockdown period. The results of this paper, therefore, indicate that aerosols over the Bohai and Yellow Seas are strongly influenced by human activities, and the public health events such as the epidemic may alter the intensity of human activities and thus the spatio-temporal pattern of aerosol over ocean. With the global spread of the epidemic and the corresponding significant changes in human behavior patterns (restrictions on human activities, etc.), more studies should be carried out in the future about the aerosol variability and its potential impact on the marine environment.

2.
Chinese Journal of Dermatovenereology ; 36(5):550-552, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-1903930

ABSTRACT

Objective: To analyse the prevalence and characteristics about viral warts on the hands of Tibetan adolescents in Ganzi County.

3.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324211

ABSTRACT

Objective: The observational study was intended to explore the weight changes and risk factors of weight gain during the self-quarantine and find available methods to lose weight. Method: This was an online retrospective observational study investigating the weight changes before and after home confinement. A total of 530 participants completed the online questionnaire. diet, sleep, self-reported depression, disease history and exercise information possibly relating to weight changes were incorporated into the questionnaire. The differences among four groups (underweight, normal weight, overweight and obesity) in BMI change and weight change were compared, and the risk factors of weight gain was also analyzed by multiple linear regression analysis. Result: Participants were mostly between 21-50 years old, getting an average weight change of 0.82±3.31kg, and an average BMI change of 0.35 [-0.37, 1.00]. 43.77% of them gained weight by 2.99±2.29kg averagely. People with normal weight were easier to gain weight than obese group (p=0.001). There were differences in food intake (p<0.001), eating habits(p<0.001), taste preference (p=0.047), daily exercise step change(p=0.007), exercise (p=0.02) between non-weight gain group and weight gain group. The multiple linear regression revealed that weight gains were associated with sex (p=0.002), food intake (p=0.004), current daily exercise step (p=0.009) and self-reported depression (p=0.002) and weight loss was related to food intake (p=0.004) and pre-BMI (p=0.001). Conclusion: Eating irregularly, increasing food intake, self-reported depression and decreased daily steps were risk factors of weight gain, yet weight loss was related to decreased food intake and pre-BMI.

4.
Am J Chin Med ; 48(5): 1035-1049, 2020.
Article in English | MEDLINE | ID: covidwho-1352580

ABSTRACT

In December 2019, coronavirus disease-2019 (COVID-19) broke out in Wuhan and other places. Seven versions of the Diagnosis and Treatment Program for Coronavirus Disease-2019 successively issued by the Chinese government have designated traditional Chinese medicine (TCM) as a necessary medical strategy. Based on the changes in TCM diagnosis and treatment strategies in these seven versions of Diagnosis and Treatment Program for Coronavirus Disease-2019, this paper collected data reported by the Chinese government media; analyzed the understanding of the etiology, pathogenesis, syndrome differentiation, treatment methods, and prescriptions of COVID-19 by TCM and evaluated the clinical efficacy of TCM strategies. COVID-19 is associated with TCM disease of pestilence, and its pathogenesis can be summarized as an "epidemic pathogen invading the body, followed by entering the internal organs and transforming into heat, resulting in pathogen trapping in the interior and healthy qi collapsing, and deficiency of qi and yin". Pathological processes should be emphasized in syndrome differentiation. The manifestations of qi deficiency and yin deficiency are exhibited during the recovery period. TCM strategies represented by Qing Fei Pai Du Tang have shown apparent advantages in improving symptoms, promoting virus clearance, and shortening hospitalization, as well as surprising efficacy of zero patient progressing from mild to severe cases in a TCM cabin hospital. Clinical data illustrate the effectiveness of TCM strategies proposed by the Chinese government. This major epidemic may bring new opportunities for TCM development.


Subject(s)
Coronavirus Infections/diagnosis , Coronavirus Infections/therapy , Medicine, Chinese Traditional/methods , Pneumonia, Viral/diagnosis , Pneumonia, Viral/therapy , Animals , Betacoronavirus , COVID-19 , China , Coronavirus Infections/drug therapy , Coronavirus Infections/virology , Drugs, Chinese Herbal/administration & dosage , Humans , Pandemics , Pneumonia, Viral/drug therapy , Pneumonia, Viral/virology , SARS-CoV-2
5.
BMC Endocr Disord ; 21(1): 111, 2021 May 27.
Article in English | MEDLINE | ID: covidwho-1244921

ABSTRACT

BACKGROUND: Low free triiodothyronine (FT3) levels are related to a poor prognosis deterioration in patients with COVID-19 presenting with non-thyroidal illness syndrome (NTI). This study was designed to explore whether free thyroxin (FT4) or thyroid stimulating hormone (TSH) levels affected the mortality of patients with COVID-19 presenting with NTI. METHODS: Patients with COVID-19 complicated with NTI who were treated at our hospital were included in this retrospective study. Patients were divided into low TSH and normal TSH groups, as well as low and normal-high FT4 group, according to the reference range of TSH or FT4 levels. The 90-day mortality and critical illness rates were compared among patients with low and normal TSH levels, as well as among patients with low FT4 levels and normal-high FT4 levels; in addition, differences in demographic and laboratory data were compared. A Kaplan-Meier analysis and Cox proportional hazards models were used to assess the associations of TSH and FT4 levels with mortality. RESULTS: One hundred fifty patients with low FT3 levels and without a history of thyroid disease were included, 68% of whom had normal FT4 and TSH levels. Critical illness rates (74.07% VS 37.40%, P = 0.001) and mortality rates (51.85% VS 22.76%, P = 0.002) were significantly higher in the low TSH group than in the normal TSH group. Although no significant difference in the critical illness rate was found (P = 0.296), the mortality rate was significantly higher in the low FT4 group (P = 0.038). Low TSH levels were independently related to 90-day mortality (hazard ratio = 2.78, 95% CI:1.42-5.552, P = 0.003). CONCLUSIONS: Low FT4 and TSH concentrations were associated with mortality in patients with COVID-19 presenting with NTI; moreover, low TSH levels were an independent risk factor for mortality in these patients.


Subject(s)
COVID-19/epidemiology , COVID-19/mortality , Euthyroid Sick Syndromes/epidemiology , SARS-CoV-2 , Thyrotropin/blood , Thyroxine/blood , Adult , Aged , Aged, 80 and over , COVID-19/blood , Cohort Studies , Comorbidity , Euthyroid Sick Syndromes/blood , Female , Humans , Male , Middle Aged , Prognosis , Proportional Hazards Models , Retrospective Studies , Risk Factors , Thyrotropin/deficiency , Thyroxine/deficiency
6.
Curr Med Sci ; 41(1): 46-50, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1081788

ABSTRACT

Positive nucleic acid (NA) results have been found in recovered and discharged COVID-19 patients, but the proportion is unclear. This study was designed to analyze the recurrent positive rate of NA results after consecutively negative results, and the relationship between the specific antibody production and positive NA rate. According to Strengthening the Reporting of Observational Studies in Epidemiology guidelines, data of inpatients in Sino-French New City Branch of Tongji Hospital between Jan. 28 and Mar. 6, 2020 were collected. A total of 564 COVID-19 patients over 14 years old who received the examinations of NA and antibodies against SARS-CoV-2 were included. Days of viral shedding and specific antibodies were recorded and assessed. Among NA tests in respiratory samples (throat swabs, nasopharyngeal swabs, sputum and flushing fluid in alveoli), the patients with all-negative NA results accounted for 17.20%, those with single-positive results for 46.63%, and those with multiple-positive results for 36.17% respectively. Besides, the recurrent positive NA results after consecutively negative results appeared in 66 patients (11.70%). For multiple-positive patients, median viral shedding duration was 20 days (range: 1 to 57 days). Of the 205 patients who received 2 or more antibody tests, 141 (68.78%) had decreased IgG and IgM concentrations. IgM decreased to normal range in 24 patients, with a median of 44 days from symptom onset. Viral shedding duration was not significantly correlated with gender, age, disease severity, changes in pulmonary imaging, and antibody concentration. It is concluded that antibody level and antibody change had no significant correlation with the positive rate of NA tests and the conversion rate after continuous negative NA tests. In order to reduce the recurrent positive proportion after discharge, 3 or more consecutive negative NA test results with test interval more than 24 h every time are suggested for the discharge or release from quarantine.


Subject(s)
Antibodies, Viral/analysis , COVID-19/diagnosis , SARS-CoV-2/physiology , Adult , Aged , Aged, 80 and over , COVID-19/immunology , Female , Guidelines as Topic , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Middle Aged , Respiratory System/virology , Retrospective Studies , SARS-CoV-2/immunology , Virus Shedding
7.
SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-5288

ABSTRACT

A review on discussion of prevention and treatment of new coronavirus pneumonia (COVID-19) from Traditional Chinese Medicine concept

8.
World Neurosurg ; 148: e209-e217, 2021 04.
Article in English | MEDLINE | ID: covidwho-1003130

ABSTRACT

BACKGROUND: The occurrence of coronavirus disease 2019 (COVID-19) has overwhelmed the blood supply chain worldwide and severely influenced clinical procedures with potential massive blood loss, such as clipping surgery for aneurysmal subarachnoid hemorrhage (aSAH). Whether acute normovolemic hemodilution (ANH) is safe and effective in aneurysm clipping remains largely unknown. METHODS: Patients with aSAH who underwent clipping surgery within 72 hours from bleeding were included. The patients in the ANH group received 400 mL autologous blood collection, and the blood was returned as needed during surgery. The relationships between ANH and perioperative allogeneic blood transfusion, postoperative outcome, and complications were analyzed. RESULTS: Sixty-two patients with aSAH were included between December 2019 and June 2020 (20 in the ANH group and 42 in the non-ANH group). ANH did not reduce the need of perioperative blood transfusion (3 [15%] vs. 5 [11.9%]; P = 0.734). However, ANH significantly increased serum hemoglobin levels on postoperative day 1 (11.5 ± 2.5 g/dL vs. 10.3 ± 2.0 g/dL; P = 0.045) and day 3 (12.1 ± 2.0 g/dL vs. 10.7 ± 1.3 g/dL; P = 0.002). Multivariable analysis indicated that serum hemoglobin level on postoperative day 1 (odds ratio, 0.895; 95% confidence interval, 0.822-0.973; P = 0.010) was an independent risk factor for unfavorable outcome, and receiver operating characteristic curve analysis showed that it had a comparable predictive power to World Federation of Neurosurgical Societies grade (Z = 0.275; P > 0.05). CONCLUSIONS: ANH significantly increased postoperative hemoglobin levels, and it may hold the potential to improve patients' outcomes. Routine use of ANH should be considered in aneurysm clipping surgery.


Subject(s)
Aneurysm, Ruptured/surgery , Blood Transfusion, Autologous/methods , Bloodless Medical and Surgical Procedures/methods , Hemodilution/methods , Intracranial Aneurysm/surgery , Neurosurgical Procedures/methods , Subarachnoid Hemorrhage/surgery , Adult , Aged , Blood Transfusion/statistics & numerical data , COVID-19 , Female , Hemoglobins/metabolism , Humans , Male , Middle Aged , Perioperative Care , SARS-CoV-2 , Surgical Instruments
9.
BMC Infect Dis ; 20(1): 963, 2020 Dec 21.
Article in English | MEDLINE | ID: covidwho-992450

ABSTRACT

BACKGROUND: COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe and critical patients, helping to identify severe or critical patients early. METHODS: In this cross-sectional study, 100 patients were included and divided into mild, severe or critical groups according to disease condition. Correlation of peripheral blood inflammation-related indicators with disease criticality was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. RESULTS: Significantly, disease severity was associated with age (R = -0.564, P < 0.001), interleukin-2 receptor (IL2R) (R = -0.534, P < 0.001), interleukin-6 (IL-6) (R = -0.535, P < 0.001), interleukin-8 (IL-8) (R = -0.308, P < 0.001), interleukin-10 (IL-10) (R = -0.422, P < 0.001), tumor necrosis factor α (TNFα) (R = -0.322, P < 0.001), C-reactive protein (CRP) (R = -0.604, P < 0.001), ferroprotein (R = -0.508, P < 0.001), procalcitonin (R = -0.650, P < 0.001), white cell counts (WBC) (R = -0.54, P < 0.001), lymphocyte counts (LC) (R = 0.56, P < 0.001), neutrophil count (NC) (R = -0.585, P < 0.001) and eosinophil counts (EC) (R = 0.299, P < 0.001). With IL2R > 793.5 U/mL or CRP > 30.7 ng/mL, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. CONCLUSIONS: Inflammation is closely related to severity of COVID-19, and IL-6 and TNFα might be promising therapeutic targets.


Subject(s)
COVID-19/diagnosis , Inflammation/complications , Adult , Aged , Area Under Curve , C-Reactive Protein/metabolism , COVID-19/immunology , Cross-Sectional Studies , Female , Humans , Inflammation/immunology , Interleukin-10/blood , Interleukin-6/blood , Interleukin-8/blood , Leukocyte Count , Lymphocyte Count , Male , Middle Aged , Procalcitonin/blood , ROC Curve , Retrospective Studies , Severity of Illness Index , Tumor Necrosis Factor-alpha/blood
10.
Med. J. Chin. Peoples Liberation Army ; 5(45): 481-485, 20200528.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-701008

ABSTRACT

Objective To investigate the clinical features of 13 fatal cases of corona virus disease 2019 (COVID-19). Methods The clinical data of 13 patients who died of COVID-19 in Central Theater General Hospital, China, between January 4, 2020, and February 24, 2020, were analyzed retrospectively. The data reviewed included clinical manifestations, laboratory test results, radiographic features and dinical treatment plan. The cellular immune function, the expression of inflammatory factors, and lactate level in deceased patients at different stages of the disease were analyzed. Results Of those who died, the patients consisted of 10 men and 3 women. The age of those who died was (74±19) years, and 10(76.9%) patients were over 70 years old. For the patients who died, 9 presented with underlying diseases, 6(46.2%) of whom had more than 2 diseases. On admission, the chest computed tomography (CT) for 8 patients (61.5%) mainly showed multiple patchy ground-glass opacities. When the disease progressed, the ground-glass opacities rapidly developed into diffuse lesions in both lungs. The lymphocyte and CD3+, CD4+, and CD8+ T lymphocyte counts in the peripheral blood of 13 patients were significantly lower than normal levels and decreased more substantially during the disease course based on the levels when admitted (P<0.01). Additionally, the interleukin (IL)-6, D-dimer, C-reactive protein (CRP), lactic acid levels gradually increased, and most peaked before death. The cause of death for most patients was acute respiratory distress syndrome (ARDS) with type I respiratory failure. Three patients eventually developed multiorgan deficiency syndrome (MODS). Conclusions The risk factors of death for COVID-19 patients included older men, more underlying diseases, poor cellular immune function and over-expression of inflammatory factors. The main cause of death in patients with COVID-19 was ARDS, which led to respiratory failure and MODS.

11.
Med. J. Chin. Peoples Liberation Army ; 3(45): 236-240, 2020.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-378388

ABSTRACT

Corona virus disease 2019 (COVID-19) progresses very rapidly and a part of patients' condition quickly deteriorate to a severe type or critical severe type, even died of multiple organ failure. Therapeutic principle of these patients is centered on improving oxygenation and lung protection and multiple organ function support. Respiration support includes high-flow nasal cannula oxygen therapy (HFNC), non-invasive positive pressure ventilation (NIPPV), tracheal cannula with mechanical ventilation and extracorporeal membrane oxygenation (ECMO) and assistance methods including lung recruitment and prone position ventilation. Considering COVID-19 progresses rapidly and is very difficult in respiratory therapy, we should pay close attention to above mentioned methods. In particular, identifying risk factors of treatment failure of HFNC and NIPPV in early phase, applying lung recruitment prudently and active application of turning around and beat back and prone position ventilation to help postural drainage and early tracheal cannula with mechanical ventilation and ECMO would be beneficial to the patients.

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