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1.
J Affect Disord ; 2022.
Article in English | PubMed | ID: covidwho-2049368

ABSTRACT

BACKGROUND: Parents play a critical role in adolescents' psychological adjustment, especially in stress response. Few studies have investigated parental impact on adolescents' psychological adjustment in the pandemic. The longitudinal study examined how parental psychosocial factors at the surging period of the pandemic (T1) in China predicted adolescents' anxiety and depression concurrently and at the remission periods three (T2) and six months (T3) later. METHODS: Middle and high school students and their parents from three schools in Shanghai, China, completed online surveys on March 10, 2020 (T1), June 16, 2020 (T2), and Sep 25, 2020 (T3). Adolescents' anxiety/depression levels were assessed by matching self- and parent-reports at T1, T2, T3, and parents reported their psychological state (emotion and psychopathology), pandemic response (appraisal and coping), and perceived social support (PSS) at T1. RESULTS: Parental positive/negative emotions, anxiety, depression, control-appraisal, forward- and trauma-focus coping style and PSS were all significantly related to their children's anxiety/depression at T1. All factors, except coping style, predicted adolescents' anxiety/depression at T2 and T3, even after controlling for T1 adjustment levels. Parental positive emotion and depression had the strongest impact on adolescents' adjustment. LIMITATIONS: Some participants didn't complete the surveys at later time points, and the participants were only recruited in Shanghai. CONCLUSIONS: The study found that parents' psychosocial factors played a pivotal role on adolescents' psychological adjustment during COVID-19, highlighting the need to provide help to parents who were suffering from potential psychological distress.

2.
Chinese Medicine and Culture ; 4(1):25-30, 2021.
Article in English | Scopus | ID: covidwho-2024703

ABSTRACT

Since the outbreak of coronavirus disease-2019 (COVID-19), traditional Chinese medicine (TCM) has fully displayed its strength and specialty and has played an important role in the prevention and treatment of the pandemic. Faced with the unexpected development of the pandemic, the Chinese government has responded quickly and attached great importance to the effect of TCM. Comprehensive therapy integrating Chinese and Western medicine has achieved remarkable success. To summarize and introduce the prevention and treatment of COVID-19 with TCM, this article covers the perspectives of policy guideline issue, clinical diagnosis participation, and scientific research progress. © 2020 Chinese Medicine and Culture. All rights reserved.

3.
Chinese Journal of Evidence-Based Medicine ; 22(8):932-947, 2022.
Article in Chinese | EMBASE | ID: covidwho-2006473

ABSTRACT

Objective To evaluate the evidence of the experience with medical sewage treatment procedures in medical institutions in China. Methods Databases including CNKI, WanFang Data, PubMed, Web of Science, and EBSCO were electronically searched to collect studies on the medical sewage treatment process, flow, and specifications in medical institutions in China. We used the quality evaluation system to classify and grade the experiences based on the principles and methods of evidence-based science and performed a descriptive analysis. Results After the SARS pandemic in 2003, China systematically established and standardized the technical criteria of medical sewage treatment and discharge. Moreover, a prevention system for the epidemic using medical sewage was constructed, which guaranteed that the quality of medical sewage treatment and discharge would meet the criteria and protect the citizens, and the technical specifications of medical sewage treatment would progress and increase strictly. At present, medical sewage treatment in medical institutions in China was based on mechanical and biological methods, and disinfection was mainly performed using chlorine and its compounds, ozone, and ultraviolet light. Conclusion The COVID-19 pandemic requires a higher quality of medical sewage treatment and discharge criteria for medical institutions in China. To meet these criteria, all medical institutions in China should check, replace, and update their old facilities;strengthen personnel training and effectively ensure the quality of medical sewage treatment.

4.
IEEE Transactions on Affective Computing ; : 1-15, 2022.
Article in English | Scopus | ID: covidwho-1922769

ABSTRACT

The long-lasting global pandemic of Coronavirus disease 2019 (COVID-19) has changed our daily life in many ways and put heavy burden on our mental health. Having a predictive model of negative emotions during COVID-19 is of great importance for identifying potential risky population. To establish a neural predictive model achieving both good interpretability and predictivity, we have utilized a large-scale (n =542) longitudinal dataset, alongside two independent samples for external validation. We built a predictive model based on psychologically meaningful resting state neural activities. The whole-brain resting-state neural activity and social-psychological profile of the subjects were obtained from Sept. to Dec. 2019 (Time 1). Their negative emotions were tracked and re-assessed twice, on Feb 22 (Time 2) and Apr 24 (Time 3), 2020, respectively. We first applied canonical correlation analysis on both the neural profiles and psychological profiles collected on Time 1, this step selects only the psychological meaningful neural patterns for later model construction. We then trained the neural predictive model using those identified features on data obtained on Time 2. It achieved a good prediction performance (r =0.44, p =8.13 ×10-27). The two most important neural predictors are associated with self-control and social interaction. This study established an effective neural prediction model of negative emotions, achieving good interpretability and predictivity. It will be useful for identifying potential risky population of emotional disorders related to COVID-19. IEEE

5.
Food Science and Technology ; 42:8, 2022.
Article in English | Web of Science | ID: covidwho-1917069

ABSTRACT

Alcoholic beverages play an important role in social gatherings and the consumption of alcohol drinks keep increasing worldwide in recent years, especially during the COVID-19 pandemic months. The authentication of alcoholic beverage is usually evaluated by trained panels or chromatography analysis. Over the last few decades, intelligent sensory technology (IST) that imitate the human sensory organs have been developed for quality control and authentication of alcoholic beverages. The artificial sensing system consist of arrays of sensors with cross-sensitivity and various pattern recognition methods, which can be used to discriminate or classify the samples based on the detection requirements. Application of IST on wine authenticity have been extensively studied, however, application of IST in authentication of other alcoholic beverages lacks of systemic study. This paper firstly describes the basic mechanism of current IST instruments and then summarizes the applications of IST in alcoholic beverages authenticity assessments, including discrimination of varietal and geographical origins, detection of frauds and adulterations, discrimination of years of aging, distinction of brands and types, aroma analysis, detection of spoilage and off-flavors, and monitoring of the production process. The potential applications and future development of IST in the brewing industry are also discussed.

6.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 34(2): 149-157, 2022 Apr 07.
Article in Chinese | MEDLINE | ID: covidwho-1893448

ABSTRACT

OBJECTIVE: To examine the effects of Toxoplasma gondii infection on the proportion, quantity, differentiation and function of mouse and human uterine natural killer cells (uNK cells), so as to explore the role of uNK cells in abortion of early pregnancy caused by T. gondii infection. METHODS: Pregnant mice were injected intraperitoneally with T. gondii tachyzoites on day 6.5 of pregnancy, and the abortion mouse model caused by T. gondii infections was constructed. Mouse uterine lymphocytes were isolated on day 9.5 of pregnancy. Human uterine lymphocytes were isolated from fresh human decidual specimens after abortion in normal early pregnancy and co-cultured with tachyzoites of the T. gondii RH strain for 48 h at T. gondii/uterine lymphocytes ratios of 0.5:1, 1:1 and 2:1. The phenotypes of mouse uNK cells (CD122, NK1.1, DX5) and human uNK cells (CD3, CD56, CD11b, CD27) and the expression of intracellular cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were detected by flow cytometry. Mouse and human uNK cells were sorted by magnetic beads, and the cytotoxicity of uNK cells was tested using the lactate dehydrogenase (LDH) release assay at effector/target cell ratios of 1:1, 5:1, 10:1 and 20:1 with mouse or human uNK cells as effector cells and mouse YAC-1 cells or human K562 cells as target cells. RESULTS: On day 9.5 of pregnancy, the mouse abortion rate was significantly higher in the infected group than that in the control group (83.02% vs. 3.51%; χ2 = 71.359, P < 0.001). Significantly lower absolute number of uNK cells [(4 547 ± 1 610) cells/mouse vs. (8 978 ± 3 339) cells/mouse; U = 2.000, P < 0.05], lower NK1.1 expression on uNK cell surface [(74.53 ± 8.37)% vs. (93.00 ± 1.11)%; U = 0.000, P < 0.05], higher proportion of NK1.1-DX5-cells [(20.10 ± 8.03)% vs. (5.04 ± 0.68)%; U = 0.000, P < 0.05], lower proportion of NK1.1+ DX5+ cells [(21.70 ± 12.48)% vs. (45.75 ± 2.26)%; U = 0.000, P < 0.05] and higher IFN-γ expression [(16.74 ± 1.36)% vs. (8.13 ± 1.90)%; U = 0.000, P < 0.05] were detected in the infected group than in the control group, while no significant difference was seen in TNF-α expression between the two groups [(67.98 ± 9.20)% vs. (52.93 ± 10.42)%; U = 2.000, P > 0.05]. The mouse uNK cells showed a strong cytotoxicity in the infected group, and the cytotoxicity gradually increased with the effector/target cell ratio. The cytotoxicity of uNK cells against YAC-1 cells was 2.30%, 4.32%, 8.12% and 12.65% in the infected group and 1.21%, 1.63%, 2.51% and 3.22% in the control group at effector/target cell ratios of 1:1, 5:1, 10:1 and 20:1, respectively. Following co-culture of human uterine lymphocytes and tachyzoites of the T. gondii RH strain for 48 h, the proportion [TOX 2:1 group vs. control group: (6.61 ± 1.75)% vs. (17.48 ± 4.81)%; F = 7.307, P < 0.01], and absolute number of human uNK cells in uterine lymphocytes of human uNK cells in uterine lymphocytes [TOX 2:1 group vs. control group: (12 104 ± 5 726) cells/well vs. (65 285 ± 21 810) cells/well; H = 11.540, P < 0.01] were significantly lower in the infected group than in the control group. A lower proportion of CD56brightCD16- NK cells [TOX 2:1 group vs. control group: (25.25 ± 5.90)% vs. (36.03 ± 4.51)%; F = 3.213, P > 0.05] and higher proportion of CD56dimCD16+ NK cells [TOX 2:1 group vs. control group: (11.15 ± 2.15)% vs. (7.09 ± 2.24)%; F = 2.992, P > 0.05] were detected in uNK cells in the infected group than in the control group, and the ratio of CD56brightCD16- cells/CD56dimCD16+ cells was significantly lower in the infected group than in the control group [TOX2:1 group vs. control group: (2.37 ± 0.92) vs. (5.58 ± 2.39); H = 8.228, P < 0.05]. In addition, the proportion of CD11b+CD27- cells in human uNK cells was significantly higher in the infected group than in the control group [TOX 2:1 group vs. control group: (30.28 ± 6.91)% vs. (17.48 ± 4.67)%; H = 6.556, P < 0.05], while no significant differences were found between the two groups in terms of IFN-γ [TOX 2:1 group vs. control group: (14.13 ± 1.28)% vs. (15.19 ± 1.64)%; F = 1.639, P > 0.05] or TNF-α expression [TOX 2:1 group vs. control group: (54.76 ± 10.02)% vs. (50.33 ± 3.67)%; F = 0.415, P > 0.05]. Human uNK cells presented a strong cytotoxicity in the infected group, and the cytotoxicity gradually increased with the effector/target cell ratio. The cytotoxicity of human uNK cells against K562 cells was 11.90%, 28.11%, 49.91% and 73.35% in the infected group and 12.21%, 21.63%, 33.51% and 48.22% in the control group at effector/target cell ratios of 1:1, 5:1, 10:1 and 20:1, respectively. CONCLUSIONS: T. gondii infection presents diverse effects on the differentiation and secretion ability of mouse and human uNK cells. However, T. gondii infection causes a reduction in the absolute number and enhances the cytotoxicity of both mouse and human uNK cells.


Subject(s)
Abortion, Spontaneous , Toxoplasma , Toxoplasmosis , Female , Humans , Interferon-gamma/genetics , Killer Cells, Natural/pathology , Pregnancy , Tumor Necrosis Factor-alpha/genetics
7.
New England Journal of Medicine ; 386(4):402-403, 2022.
Article in English | Web of Science | ID: covidwho-1710916
8.
2021 International Conference on Artificial Intelligence and Big Data Applications, ICAIBD 2021 ; 2138, 2021.
Article in English | Scopus | ID: covidwho-1672071

ABSTRACT

The sudden outbreak of COVID-19 has caused great losses to the economy and the life of the masses. Long short-term memory (LSTM) network is a time recursive neural network, which is suitable for processing and predicting important events with relatively long interval and delay in time series. Using LSTM network to predict and analyze the development trend of epidemic situation, it is imperative to prevent epidemic situation from causing secondary harm to China's development. In this paper, we first obtained the COVID-19 data published by China Health Net using crawler technology, which is the accurate value of infection trend after the outbreak of COVID-19 in China. Then, based on these data, the LSTM model is used to predict the development trend of the epidemic in one year, and the mean square error is used to calculate the error between the prediction and the real data. The experimental model is used to predict and analyze the development trend of COVID-19. The results show that the error between predicted data and real data is small and the effect is very good, which provides a reasonable basis and forecast for scientific prevention and control of epidemic situation. © Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Published under licence by IOP Publishing Ltd

9.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(12): 1377-1382, 2021 Dec 06.
Article in Chinese | MEDLINE | ID: covidwho-1600026

ABSTRACT

Since the Global Polio Eradication Initiative was launched by the World Health Assembly in 1988, significant progress has been made in global polio prevention and control. But the occurrence of vaccine-associated paralytic poliomyelitis cases and vaccine-derived poliovirus related cases have become a major challenge during the post-polio era. While coronavirus disease 2019(COVID-19) has brought serious disease burden and economic burden to all countries in the world, prevention and control of vaccine-preventable infectious diseases such as polio should not be neglected under the background of the global common fight against COVID-19. Taking the type Ⅲ VDPV cycle event in Shanghai as an example, the paper discussed how to do a good job of routine inoculation under the prevention and control of COVID-19 to strictly prevent the outbreak of vaccine-preventable infectious diseases.


Subject(s)
COVID-19 , Poliovirus , China , Humans , Poliovirus Vaccine, Oral , SARS-CoV-2 , Vaccination
10.
Medical Journal of Peking Union Medical College Hospital ; 12(1):9-12, 2021.
Article in Chinese | Scopus | ID: covidwho-1513194

ABSTRACT

Coronavirus disease 2019 (COVID-19), as a public health emergency, is a serious threat to human health. Cancer patients have a high risk of being infected with COVID-19. As one of important means of cancer treatment, radiotherapy has become an important alternative to surgery during the epidemic of COVID-19. The radiotherapy department of Peking Union Medical College Hospital ensured the smooth development of radiotherapy work on the setup of prevention and control systems for COVID-19 by establishing admission strategies for cancer patients, disinfection, isolation, daily management measures, scientific exploration, and clinical practice. In this paper, the associated strategies are summarized and analyzed, which can provide experience and reference for radiotherapy treatment under public health emergencies. © 2021, Peking Union Medical College Hospital. All rights reserved.

11.
Journal of Shanghai Jiaotong University (Medical Science) ; 41(10):1359-1365, 2021.
Article in Chinese | EMBASE | ID: covidwho-1497436

ABSTRACT

Objective: ·To explore the reliability and validity of Corona Virus Disease 2019 (COVID-19) Peritraumatic Distress Index (CPDI) in evaluating pandemic-related acute stress reaction. Methods: ·From 31 January 2020 to 29 February 2020, CPDI, Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7) and Self-reporting Questionnaire-20 (SRQ-20) were measured in 253 outpatients, their family members and medical staff of our hospital. At the same time, leveraging the Siuvo Intelligent Psychological Assessment Platform, we presented QR codes of the CPDI questionnaire online openly, accessible to the participants nationwide, and received a total of 75 867 valid responses. Cronbach's α coefficient was used to evaluate the internal consistency. The correlation between CPDI and PHQ-9, GAD-7 and SRQ-20 was used to test the criterion validity. Exploratory factor analysis was used to detect the structural validity and the cut-off score of the questionnaire to screen the psychological symptoms associated with COVID-19 was also detected. Results: ·The Cronbach's α of the 15-item questionnaire was 0.932. The correlation coefficients between the 15-item CPDI and PHQ-9, GAD-7 and SRQ-20 were 0. 670, 0.699 and 0.711 respectively (all P=0.000). The exploratory factor analysis results contained 15 items and 4 factors, the factor load was 0.491-0.681, and the cumulative variance interpretation rate was 72.006%. In terms of cut-off score, it was identified as suspicious symptom by cut-off score of 10/11 points. The sensitivity and specificity were 0.822 and 0.811, respectively. The cut-off score to confirm the presence of symptoms was 14/15 points. The sensitivity and specificity were 0.815 and 0.824, respectively. Conclusion: ·The study indicates that CPDI is with good internal consistency reliability, criterion validity and structural validity.

12.
Medicine and Science in Sports and Exercise ; 53(8):187-187, 2021.
Article in English | Web of Science | ID: covidwho-1436868
13.
Scientific American ; 322(6):26-32, 2020.
Article in English | Web of Science | ID: covidwho-1390050
14.
Southeast Asian Journal of Tropical Medicine and Public Health ; 51(6):919-927, 2020.
Article in English | Scopus | ID: covidwho-1303123

ABSTRACT

Epidemiological characteristics of COVID-19 in non-core infected regions were identified to provide evidences for prevention and management of COVID-19 epidemic in China. Data collected through an online reporting system were age, gender, source of infection, date of disease occurrence, date and type of primary medical examination and treatment, and classification of COVID-19, mode of infection and clinical symptoms. Confirmed COVID-19 patients (n = 518) constituted male:female ratio of 1.19:1, 30-75 years of age (82.74%), and with clustered cases significantly higher than sporadic cases, percent close contact transmission during dining being highest (39.30%), 88.89% of the patients having a latent period of 2-14 days, duration from primary medical examination to diagnosis ranging from 1 to 16 days, and 43.83% of the patients having fever or cough. In order to prevent further spread of COVID-19 epidemic, measures should be taken to increase detection and isolation of infection sources, reduce unsafe contact behavior, and impose 14-day quarantine of suspected contact individuals together with periodic tests of SARS-Cov-2 infection. © 2020, SEAMEO TROPMED Network. All rights reserved.

15.
Chinese Journal of New Drugs ; 29(21):2511-2514, 2020.
Article in Chinese | EMBASE | ID: covidwho-984334

ABSTRACT

Objective: To establish a detection method for the methylene blue residues in inactivated plasma against SARS-CoV-2, and to apply the method to inactivated plasma of different dosages. Methods: Methylene blue in plasma was absorbed using solid phase extraction cartridge, and the absorbance at 654 nm was measured by UV-2550 spectrophotometer. The absorbance of the eluate extract from standard control plasma and virus inactivated plasma by solid phase was measured, and the methylene blue residue in the test plasma was calculated based on the ratio of the absorbance. Then, linearity-range, precision, accuracy and quantitative limit of the method are validated based on 11 batches of inactivated plasma in specifications of 50, 75 and 100 mL. Results: The detection method of methylene blue residue, was established within the linear range of 0.01~0.05 μmol•L-1. The verification standards are as follows: R value is 0.994 4;precision is 7% and accuracy is between 102%~110%;and the quantitative limit is 0.013 μmol•L-1;the quantitative detection CV is less than 5%, all of which are in conformity with requirements of Pharmacopoeia of PRC (Edition 2015). The levels of methylene blue residue in inactivated plasma of each specification were within the detection range of the developed method, and the residue levels were much lower than that in standard(≤0.30 μmol•L-1). Conclusion: The method can be successfully applied for the detection of methylene blue residues in the inactivated plasma against SARS-COV-2 of different specifications.

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