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Science ; 370(6517): 691-697, 2020 11 06.
Article in English | MEDLINE | ID: covidwho-913667

ABSTRACT

Although most cases of coronavirus disease 2019 (COVID-19) have occurred in low-resource countries, little is known about the epidemiology of the disease in such contexts. Data from the Indian states of Tamil Nadu and Andhra Pradesh provide a detailed view into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission pathways and mortality in a high-incidence setting. Reported cases and deaths have been concentrated in younger cohorts than would be expected from observations in higher-income countries, even after accounting for demographic differences across settings. Among 575,071 individuals exposed to 84,965 confirmed cases, infection probabilities ranged from 4.7 to 10.7% for low-risk and high-risk contact types, respectively. Same-age contacts were associated with the greatest infection risk. Case fatality ratios spanned 0.05% at ages of 5 to 17 years to 16.6% at ages of 85 years or more. Primary data from low-resource countries are urgently needed to guide control measures.


Subject(s)
Coronavirus Infections/mortality , Coronavirus Infections/transmission , Pneumonia, Viral/mortality , Pneumonia, Viral/transmission , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Betacoronavirus , COVID-19 , Child , Child, Preschool , Contact Tracing , Female , Humans , Incidence , India/epidemiology , Infant , Infant, Newborn , Male , Middle Aged , Pandemics , SARS-CoV-2 , Young Adult
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