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Jac-Antimicrobial Resistance ; 4:1, 2022.
Article in English | Web of Science | ID: covidwho-1769302
Hiv Medicine ; 22:215-215, 2021.
Article in English | Web of Science | ID: covidwho-1519269
European Journal of Neurology ; 28(SUPPL 1):829, 2021.
Article in English | EMBASE | ID: covidwho-1307814


Background and aims: Neurologic manifestations (myalgia, headache, anosmia and ageusia) or acute cerebrovascular diseases, skeletal muscle injury, encephalopathy, prominent agitation and confusion have also been reported in the spectrum of coronavirus disease 2019. Myoclonus is the term used to describe the sudden, involuntary jerking of a muscle or group of muscles caused by muscle contractions or muscle relaxation. In severe cases it can interfere with movement control and balance, eating or talking. Recently, a new cause of myoclonic jerks is COVID-19 infection. In these cases myoclonus may be multifactorial and represent a combination of hypoxia, medication toxicity and direct or para- infectious complications of the virus itself. Methods: We report a case of a COVID-19 infection, a male patient by the age of 46. Results: He was presented in our clinic on 3 December 2021 with generalized myoclonus associated with dysarthria. Myoclonus onset started on the 11th day of patient treatment for a bilateral interstitial pneumonia. No previous disease were reported and other causes of myoclonus were ruled out. Generalized myoclonus occurred spontaneously and were extremely sensitive to multisensory stimuli, predominantly involving the upper and lower muscles of the extremities and facial muscles resulting in movement disorders and dysarthria. Cerebral MRI was normal. We treated this patient with piracetam, rivotril and a reduction in myoclonic movements was observed five days after. Conclusion: The occurrence of myoclonus during COVID- 19 is a rare event that requires further investigation to clarify the full clinical spectrum of neurologic involvement and optimal treatment.