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International Journal of Academic Medicine and Pharmacy ; 4(3):70-73, 2022.
Article in English | EMBASE | ID: covidwho-1998208


Background: In India, laboratory diagnosis of SARS - CoV-2 infection has been mostly based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Studies have shown that IgG antibodies may be detected usually 10-18 days after the onset of covid-19 infection, persist after 4 weeks till few months but may decline later. In the neutralization of SARS-CoV-2, B-cell response and the production of IgG antibodies play an important role. The aim of the present study is to describe the antibody kinetics in relation to treatment in health care workers with RT-qPCR-confirmed COVID-19, and analyse antibody response by using IgG antibody Merilisa kit. Materials and Methods: The present study enrolled 120 health care workers who were working in COVID wards (aged between 20-60 years) with laboratory confirmed COVID-19, from whom sera were analyzed on 10th day and 3 months after COVID-19 diagnosis. Result: Out of the study population which included 120 health care workers, only 46.6% remained positive for IgG antibodies after 3 months post infection of COVID-19. This study showed that presence of IgG antibodies against SARS-CoV-2 was higher among HCWs who were only on Antibiotics (60%) followed by those only on Antivirals (53.3%) as treatment modality. Conclusion: Compared to the IgG detected during treatment or hospitalization, the difference in IgG positivity after 3months was significant. It also shows that administration of steroids results in early weaning of antibodies suggesting re-infection could be more in such cases. Our findings may be of significance in interpreting anti-SARS-CoV-2 antibody test results and in understanding humoral immune response patterns for SARS-CoV-2 infection with respect to treatment strategies in current and potential future COVID-19 outbreak scenarios.

Indian Journal of Medical Microbiology ; 39:S66-S67, 2021.
Article in English | EMBASE | ID: covidwho-1734495


Background:COVID-19 caused by SARS CoV 2 has emerged into a global pandemic. Paediatric COVID-19 infection is rela- tively mild when compared to adults, and children are reported to have a better prognosis. Mortality in children appears rare. Many infected children are often asymptomatic and remain undiagnosed without population screening. Due to these reasons children can be potential source of infection and may lead to higher transmission. Therefore knowledge on prevalence of asymptomatic and symptomatic cases among children is essential for effective control of COVID Methods:Nasopharyngeal Samples received at VRDL which were collected from children from 1st June to 30th Novem- ber of 2020 were subjected to RT-PCR for detection of SARS CoV-2 RNA and the Positive cases were correlated with the clinical information submitted along with the samples Results:Among the samples of children received and analysed at VRDL in three months, 343 tested positive for COVID - 19, of which 129 (37.60%) cases were symptomatic and 214(62.3%) were asymptomatic. Among the symptomatic cases, 25(19.3%) cases were diagnosed with SARI. Fever was the most common non respiratory symptom seen. The results of the remaining three months will be produced at the time of the presentation Conclusions:Knowing the prevalence of asymptomatic and symptomatic cases of COVID-19 among children helps in making strategies for effective control of COVID-19

Indian Journal of Medical Microbiology ; 39:S56, 2021.
Article in English | EMBASE | ID: covidwho-1734459


Background: COVID-19 caused by a novel coronavirus (SARS- COV-2) has emerged as a global pandemic. There is a con- tinuous debate whether to consider allergic respiratory disorders as protective factor or as a risk factor for COVID -19. At the same time severity of COVID 19 is found to be more if patient’s level of disease control is poor according to some studies. Hence there is a need to find the prevalence of allergic respiratory diseases among COVID 19 positive cases. HCW are taken as the study population as they have equal COVID exposer risk and also good level of disease control. AIM: To find the prevalence of allergic respiratory diseases among COVID positive HCW. Methods: Nasopharyngeal samples of HCW collected from May 15 to November 15 2020 were subjected to RT PCR for detection of SARS COV -2 RNA and the positive cases were noted for history of allergic respiratory disorders like chronic rhinosinusitis, asthma from the clinical information provided while sample collection. Results: Out of total 912 Health Care Workers tested for COVID 19 in first 5 months by RT PCR 121 were COVID positive, among them 24(19.8%) have known history of allergic respiratory diseases of which 4(3.3%) were known for Chronic Rhinosinusitis, 15(12.3%) were asthmatic, 5(4.13%) have both CRS and asthma, further results will be provided at the time of presentation. Conclusions:Prevalence of allergic respiratory diseases helps in finding out if it’s a risk factor or not and also if any pro- tective role against COVID 19 to help in further studies