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1.
Asia-Pacific Journal of Clinical Oncology ; 18(Supplement 3):91, 2022.
Article in English | EMBASE | ID: covidwho-2136590

ABSTRACT

Background: Adults and childrenwith cancer are susceptible to severe SARS-CoV-2 disease. Vaccination is protective;data beyond initial response and regarding effect of booster doses are lacking in cancer patients. Method(s): The SerOzNET study assesses SARS-CoV-2 vaccine response in haematological and solid cancer patients aged 5 and older. Patients are recruited pre dose 1 and receive standard BNT162b2 (Pfizer) or ChadOx1-S (AstraZeneca) vaccine. Blood is taken at baseline and after each dose. Neutralizing antibody (NAb) titre, absolute antibody titre (Abbott), T cell response (IFN-gamma) and epigenetics are analysed. Clinical data are collected. Patients are followed for up to 3 months beyond dose 5. Result(s): 105 children (64% haem, 36% solid cancers) and 399 adults (35% haem, 65% solid cancers) were enrolled. In adults, NAb response rate increased after dose 3 (Post 2: 40% haem, 87%solid;Post 3:70%haem,97%solid). Post dose 2, predictors of nonresponse were ChadOx1-S vaccine (OR 3 p = .02), haem cancer (OR 14 p < .001), ECOG >=1 (OR 2.6 p = .01) and steroids (OR 5 p = .01). Post dose 3, only haem cancer predicted non-response (OR 16). IFN-gamma response is available for a subset, detectable in 41/90 (46%) postdose 1, 78/96 (81%) post-dose 2 and 35/42 (83%) post-dose 3;without significant difference between haem and solid cancer. In children, NAb response post dose 2 is available for 50 patients. Response rate between haem (19/31, 61%) and solid patients (13/19, 68%) was similar. IFN-gamma response post dose 2 was also similar: (14/22, 63%) vs solid patients (12/14, 85%) (p = .25). Analysis is ongoing. Conclusion(s): Response to two doses of SARS-CoV-2 vaccine is suboptimal in patients with cancer. The third priming dose is integral, with significantly higher response rates observed. 36% of children did not develop neutralizing antibodies post dose 2;subsequent doses are likely to be important for young patients.

2.
J Endocr Soc ; 6(Suppl 1):A363-4, 2022.
Article in English | PubMed Central | ID: covidwho-2119737

ABSTRACT

Introduction: The outbreak of coronavirus disease 2019 (COVID-19) was initially detected in Wuhan, China in December 2019. It spread rapidly, and in March 2020, the World Health Organization (WHO) declared a worldwide pandemic. In May 2020, the 73rd World Health Assembly issued a resolution recognizing the role of extensive immunization as a global public-health goal for preventing and stopping transmission of COVID-19. Vaccine hesitancy is a great threat in fighting the COVID-19 pandemic, as it prevents populations from reaching target thresholds of coverage necessary for herd immunity. It is important to know the determinants of vaccine hesitancy so that we can develop tools to combat it. The goal of our study was to evaluate patient perspectives on vaccination in our outpatient Endocrinology clinics. Methods: We created a 7-question survey study which was offered to all patients waiting to be seen in our three Endocrinology clinic locations. We distributed and collected data from all clinics over a 3-week period (5/31/21-6/18/21). We used descriptive statistics to analyze this data. Results: We collected 446 responses between three clinic locations, one urban and two suburban. 361 patients (81%) reported planning to or already having received the COVID-19 vaccine. 29 patients (7%) reported being unsure and 56 patients (13%) reported they did not plan to get vaccinated. Among 85 patients with vaccine hesitancy, 51% are blacks, 35% are whites, 24% reported concerns related to side effects, 13% felt COVID was not as bad as the media portrays, 14% did not believe in vaccines and 29% wanted more data on side effects and efficacy before receiving it. Hesitancy is higher among blacks which is statistically significant (P = 0.035) and slightly higher at the urban compared to the suburban clinics (20% Vs. 15%;p=0.197). On chi square analysis, this had no significant difference. Discussion: In the United States, COVID-19 vaccine acceptance ranged from 60 to 79% in five surveys among the general population. The rate of vaccination acceptance is higher in our study compared to general population. We suspect this is related to our clinic patients having better vaccine counseling as most patients have multiple risk factors for severe infection. The results did show higher vaccine hesitancy among black patients and those seen in our urban clinics suggesting the need for improvement in health literacy in these populations.Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.

6.
Journal of Gastroenterology and Hepatology ; 37(Supplement 1):163, 2022.
Article in English | EMBASE | ID: covidwho-2088258

ABSTRACT

Background and Aim: Inflammatory bowel disease (IBD) commonly affects men and women during their reproductive years. Misconceptions surrounding the impact of IBD and associated therapies on the peripartum period contributes to increased rates of voluntary childlessness. Navigating IBD and obstetric-related decisions during pregnancy can be challenging. We established a monthly multidisciplinary clinic comprising a gastroenterologist, IBD nurse, and obstetric fellow, in addition to dietetic and psychological referral pathways, to optimize care for women with IBD in the peripartum period.We aim to describe the patient cohort and associated pregnancy-related outcomes. Method(s): Between January 2021 and May 2022, 43 women were referred to the multidisciplinary pregnancy in IBD clinic for the indications of preconception counseling or IBD care during pregnancy and postpartum. The consultations were conducted face-to-face or via telehealth due to the impact of the COVID-19 pandemic. Nutritional and psychological screening occurred before clinic review, while intestinal ultrasound (IUS) was done as needed;however, the latter was limited due to COVID-19-related clinical restrictions. A review of prospectively collected patient records, including the use of Crohn's Colitis Care (CCCare), was performed to obtain demographic data, medical and surgical history, and obstetric outcomes. Patients referred for preconception counseling were prospectively assessed using the decisional conflict scale (DCS) and Crohn's and Colitis Pregnancy Knowledge Score (CCPKnow). Result(s): Of the 43 women (mean age, 30.9 years) who received care in our clinic, 14 were at preconception stage, and 29 were pregnant. Twenty-one patients had a diagnosis of ulcerative colitis, 19 had Crohn's disease, and one had IBD-unclassified. Two additional patients with pregnancy-onset IBD did not yet have a confirmed diagnosis, as their endoscopic assessment was deferred until after delivery. The mean DCS score for women referred for preconception counseling was 39.1 (>37.5 being associated with decision delay and difficulty with implementation). The median CCPKnow score at baseline was 7/18 (range, 3-11), suggesting poor IBD and pregnancy-related knowledge. The median score improved to 9/18 (range, 4-11) at 1 month follow-up and to 11/18 (range, 4-13) at 3 months. Nineteen patients (44.2%) were prescribed 5-aminosalicylates alone, eight (18.6%) thiopurines, and 21 (48.8%) biologic therapy (antitumor necrosis factor agents, 12;ustekinumab, 6;vedolizumab, 3). Eleven of 29 patients (37.9%) had active disease at conception, as assessed through symptomatic, biochemical, and radiological assessment. Two patients (4.7%) were prescribed oral budesonide during pregnancy. Five of 29 patients (17.2%) were assessed using IUS, while none required endoscopic assessment during pregnancy. Fifteen of 29 patients (51.7%) have given birth to date, with 12 (80%) having an uncomplicated vaginal delivery and three (20%) having a caesarean section, temporally compared with a caesarean section rate of 32.5% in the general South West Sydney Local Health district population. None were indicated for known perianal Crohn's disease. There have been no cases of preterm birth or pregnancy. The mean birth weight was 3.53 kg (range, 2.67-4.29). Two of 15 women (13.3%) experienced a postpartum flare. Nine of 15 women (60%) breastfed, while three (20%) formula-fed, and the remaining three (20%) mixed-fed their infants. Conclusion(s): Establishment of a multidisciplinary clinic has enabled provision of IBD care in the reproductive stage of life, with the ongoing aim to minimize the impact of voluntary childlessness through the delivery of dedicated clinic sessions for preconception counseling and the negative impact of active disease on obstetric and maternal outcomes.

7.
Healthcare and Knowledge Management for Society 5.0: Trends, Issues, and Innovations ; : 89-100, 2022.
Article in English | Scopus | ID: covidwho-2079587

ABSTRACT

Coronavirus 2 (SARS-CoV-2), which is a severe acute respiratory syndrome, is spreading rapidly all over the world. This disease has been declared a pandemic by the World Health Organization (WHO). The death toll has been increasing due to COVID-19. Global effort is needed to stop the spread of the virus and decrease the death rate. Technically, the death toll is because of improper data management and information sharing. The traditional database system has limitations on tampering with data and collective control systems, especially when data is shared with others. To overcome this problem, “blockchain” technology can be used. It is a distributed ledger technology that acts as a shared database by keeping all the copies verified and synced. This article focuses on blockchain technology and how future pandemics can be prevented using this concept. Blockchain technology can help in preventing pandemics and tracking drug trials, early detection of epidemics, and management of outbreaks and treatment. The containment of outbreaks becomes manageable with easy access to data. It will also be helpful to health authorities. In this chapter, a model is proposed that uses blockchain where each block contains information regarding Covid patients so it becomes easier to track and get the count of infected patients, and data will be secure and can be used for future analysis. © 2022 selection and editorial matter, Vineet Kansal, Raju Ranjan, Sapna Sinha, Rajdev Tiwari, and Nilmini Wickramasinghe;individual chapters, the contributors.

8.
Sexually Transmitted Diseases ; 49(10S):S129-S130, 2022.
Article in English | Web of Science | ID: covidwho-2067819
9.
Chest ; 162(4):A1459, 2022.
Article in English | EMBASE | ID: covidwho-2060820

ABSTRACT

SESSION TITLE: Actionable Improvements in Safety and Quality SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/17/2022 12:15 pm - 1:15 pm PURPOSE: Hypoxemia is common amongst hospitalized patients with Chronic Obstructive Pulmonary disease (COPD), Pulmonary Hypertension (PH), Interstitial Lung disease (ILD) and Congestive heart failure (CHF). At discharge, these patients are evaluated for home oxygen using an oxygen prescription test. This test entails evaluating the patient for hypoxemia at rest or while walking for a maximum duration of 6 minutes. This project aims to evaluate the ordering practices of oxygen prescription test at Allegheny General Hospital and adherence to guidelines set by Center for Medicaid Services. We hope to identify a threshold resting oxygen saturation that is not associated with desaturation requiring oxygen supplementation, and identify patient characteristics that are associated with these desaturations. METHODS: We performed a retrospective review of patients who underwent an oxygen prescription test from January-March 2021. The variables studied included demographic details, co-morbidities as well as results of the test. Desaturation was defined as a drop in oxygen saturation to ≤ 88%. We analyzed if any of these variables affected the outcome of the test. RESULTS: One hundred and ninety-eight oxygen prescription tests were performed of which 168 tests were valid and utilized for analysis. Fifty three percent of these patients were female and the median BMI was 31. About 32% of these patients had COPD, 2% had ILD, 35% had PH, 50% had CHF and 15% had Covid-19. The median age was significantly higher in patients with an oxygen requirement at hospital discharge (median = 68.5 yrs., IQR = 15) than in patients without an oxygen requirement (median = 64 yrs., IQR = 20) (p =.036). Resting saturation was significantly lower in patients with an oxygen requirement at hospital discharge (median = 91, IQR = 6) than in patients without an oxygen requirement (median = 94.5, IQR = 4) (p <.001). An ROC showed resting saturation was significant in predicting patients who would be discharged on home oxygen with an AUC of 0.832. More patients with PH had an oxygen requirement at discharge (42%) than did patients without PH (23%), odds ratio = 2.436, 95 CI, 1.24 - 4.77. CONCLUSIONS: About 15% of the tests performed had to be terminated prior to completion of the test - insurance companies could deny claims for costs arising as a consequence of these tests. We identified that resting saturation and pulmonary hypertension were most likely to predict the need for oxygen requirement on discharge. A resting saturation of about 91% was identified as the median for patients requiring oxygen on discharge. CLINICAL IMPLICATIONS: Each study cost about 364$ and entails a significant amount of time to be invested by the care teams involved. By identifying patients who are likely to desaturate, we may be able to decrease the number of time consuming and resource intensive tests, improving patient satisfaction and overall quality of care. DISCLOSURES: No relevant relationships by Marvin Balaan No relevant relationships by Deeksha Ramanujam No relevant relationships by Sheldon Rao no disclosure on file for Diane Thompson;

10.
Cyber-Physical Systems: AI and COVID-19 ; : 37-54, 2022.
Article in English | Scopus | ID: covidwho-2048750

ABSTRACT

Mobile health (mHealth), an abbreviated term used for portable healthcare, is characterized by the World Health Organization (WHO) as an utilization of portable healthcare monitoring equipments by the health care delivery system. The review article is based on the utilization of the mobile phones in the form of text information, image sharing, video call, doctor appointment, and auto-generated schedule during the global pandemics situations. Initially the motivation behind the technology was the availability of physical and psychological care for unreached communities. But, in the situation of pandemics, there is a high momentum to the mHealth application in the healthcare delivery system. The differential utilization of cell phone has led to the multiplication of health-related personalized applications day by day for the human race;there are numerous expected roads for mHealth to be fill in as an aide instrument to general health care when most of the developed and developing nations are in a cyclic process of lockdown of the century. In the present times, people are advised by the WHO to make a physical distance from everyone;hence the mHealth promptly came into existence with its importance. However, there are both pros and cons of every technology;here mHealth helps to provide improved treatment availability due to its promptness, ease, accessibility but on the another hand, there is the limitation of mHealth applications as personal data sharing with the network providers is easier. There are concerns like moral, legitimate, and clinical issues identified with mHealth usage, incorporating issues with information security, protection issues with limits, and interjurisdictional practice concerns. The technology-centric model launching incorporates the traditional medical approaches and training through the emerging technology-centric model into medical and educational systems to support medical practitioners and the patients. The review article presents the proof for the focal points and impediments of rebuilding a medicinal service framework on essential considerations. It depends on a fast, however, orderly audit of critical sources of strewn writing. The results are unpredictable for various reasons, including varying meanings of administrations, staff and the limits among essential and auxiliary consideration, changing hierarchical structures, and expanding dependence on essential consideration groups for mHealth. © 2022 Elsevier Inc. All rights reserved.

12.
Hum Cell ; 35(6): 1633-1639, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2014580

ABSTRACT

Endothelial dysfunction is one of the key cornerstone complications of emerging and re-emerging viruses which lead to vascular leakage and a high mortality rate. The mechanism that regulates the origin of endothelial dysregulation is not completely elucidated. Currently, there are no potential pharmacological treatments and curable management for such diseases. In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. Thus, we have discussed the therapeutic role of MSCs in restoring vascular integrity by (i) inhibiting the metalloprotease activity thereby preventing the cleavage of tight junction proteins, which are essential for maintaining membrane integrity (ii) possessing antioxidant properties which neutralize the excessive ROS production due to virus infection and its associated hyper host immune response (iii) modulating micro RNAs that regulate the endothelial activation and its integrity by downregulating the inflammatory response during ssRNA infection.


Subject(s)
Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells , Virus Diseases , Antioxidants/metabolism , Endothelial Cells/metabolism , Humans , Mesenchymal Stem Cells/physiology , Metalloproteases/metabolism , RNA , Reactive Oxygen Species/metabolism , Tight Junction Proteins/metabolism , Virus Diseases/metabolism
14.
The Journal of Applied Business and Economics ; 24(4):1-9, 2022.
Article in English | ProQuest Central | ID: covidwho-1989382

ABSTRACT

The COVID-19 pandemic of the year 2020 resulted in high unemployment, business closings, property loss and decimation of individual wealth, disruption of global supply chains, and illness and deaths everywhere, but most intensely in countries classified as emerging markets. However, during this year, cash flow from investors in established markets to emerging markets has been of immense magnitude. While many companies, in emerging markets, reported very high risk-adjusted rates of return, many others reported so low rates during this period. This study aims to establish a unique profile of risk-return characteristics of the companies in emerging markets that have constantly reported the highest risk-adjusted returns to total capital during the pandemic. The statistical results of our study suggest that such unique profile can be used as a tool to forecast which companies, in such markets and during such disturbances in the future, will maintain high returns to capital providing an invaluable tool for investors, investment counselors and financial researchers tasked to determine firm's intrinsic value in such an environment.

15.
Journal of Clinical Oncology ; 40(17), 2022.
Article in English | EMBASE | ID: covidwho-1987091

ABSTRACT

Background: COVID-19 infection has poor outcomes for patients (pts) with cancer. Understanding vaccine response as a correlate of protection from severe infection is essential to advise pts regarding protective behaviours and optimal vaccine schedule. This Australian cohort is unique due to low rates of COVID-19 exposure at study entry (July-November 2021). and use of a 3 dose schedule. Pts initially received 2 doses of either BNT162b2 (Pf) at a 3 week interval, or ChadOx1-S (AZ) at a 6 week interval, all then received a 3rd dose, either mRNA-1273 (Mod) or Pf after 2-4 months, and finally a 4th dose at an interval of a further 3 months, for a subset. Methods: SerOzNET (ACTRN12621001004853) has enrolled pts with solid and haematological (haem) cancers prior to initial vaccination. Serial blood samples were processed for serum, PBMC and PMN at timepoints: 0, then 3-4 weeks post dose 1 then 2 then 3 then 4 (where administered). We report here neutralizing antibodies (nAb) against wild type (wt) and delta and omicron variants of concern (VOC);quantitative S-protein IgG antibody (Abbott);Tcell correlates measured by levels of interferon-g (IFN g), tumour necrosis factor-a, interleukins (IL-) 2/ 4/5/13;and epigenetic profiling of T cells. Results: The cohort consists of 401 pts with median age 58 (range 18-85);59% female;128 (32%) haem cancers. 377 (94%) are on current or recent (< 12 months) systemic therapy: 162 (43%) chemotherapy, 62 (16%) immunotherapy, 40 (10%) combined chemo/immunotherapy, 113 (29%) hormonal or targeted therapy. 42 (10%) received anti-CD20 therapy < 12 months, 6 (1.4%) had allogeneic stem cell transplant. NAb levels against wt are available for 256 pts post dose 1, 245 pts post dose 2 and 159 pts post dose 3 (will be updated). Response rates post dose were respectively 27%, 77% and 88%. Pts with haem cancer were less likely to respond to vaccination at any time compared to pts with solid cancer (p < 0.001, chi-squared test). After 3 doses, 3.8% of pts with solid cancer and 27.8% with haem cancer lacked NAb. NAb results to VOC delta are available for 92 pts post dose 2: 25/92 (27%) were negative, compared with a non-response rate to wt of 15% at same time in same pts. IFN-γ-Spike response was detectable in 18/31 (58%) and 24/30 (80%) pts post dose 1 and 2 respectively. 101 pts to date have received a 4th dose;data will be available at the meeting, as will epigenetic profiles and detailed clinicopathological correlations. Conclusions: This interim analysis shows that a significant proportion of pts with haem cancers (27.8%) lack protective Sars-CoV-2 antibodies following 3 vaccinations, whereas only 3.8% of solid cancer pts lack detectable response. Results from other B and T cell parameters may also be important in identifying pts less well protected by vaccination. Follow up is ongoing, response rate post 4th dose will be presented at the meeting.

16.
Cancer Research ; 82(12), 2022.
Article in English | EMBASE | ID: covidwho-1986506

ABSTRACT

Background: Defining cancer and treatment-related factors which influence protection against COVID-19 following vaccination are important given the worse outcomes following infection in this group. Sophisticated and detailed studies which go beyond a single measure are required particularly with correlation to multiple disease and treatment factors. This study cohort is unique due to (a) very low prior COVID-19 infection at time of sampling (July-Nov 2021), (b) vaccines studied were BNT162b2 (Pf) given 3 weeks apart or ChAdOx1 (AZ) spaced 12 weeks (dose 1, 2) (c) most participants then received a third dose 2 months later (heterologous for AZ). Methods: SerOzNET (ACTRN12621001004853) enrols Australian blood and solid cancer patients prior to vaccination, with serial blood analyses and qualitative measures. We measured neutralizing antibodies (nAb) against SARS-CoV-2 wild type (wt) and variants of concern delta and omicron, quantitative S-protein IgG antibody level (Abbott), and T-cell correlates (interferon-g, tumour necrosis factor-a, interleukins 2/4/5/13) and epigenetic profiling at baseline and 3-4 weeks post dose 1, 2 +/- 3.Results: 379 participants were included, median age 58 years (IQR 47-66) and 60% female. 30% participants had hematological malignancies with the remainder solid organ cancers. 90% patients were on current systemic cancer treatment (most commonly chemotherapy in 41%, chemoimmunotherapy or immunotherapy in 20%). In 331 patients where treatment intent was recorded, 47% was palliative. Only one patient had known prior COVID-19 infection. Of the initial 94 participants who received Pf vaccination, median (IQR) neutralizing antibody titre 4 weeks following dose 2 was 80 (40-160) for SARS-CoV-2 wt and 40 (0-80) for delta variant. Conclusion: Neutralizing antibody titres in this Australian cancer population following Pf vaccination appear lower than those reported elsewhere such as CAPTURE study (Fendler et al, 2021), possibly related to shorter interdose interval. Preliminary data highlights low nAb titres as expected in haematology patients but also in some cases with treatment not traditionally associated with immunosuppression such as hormonal therapy. These results will be updated in February 2022 with third dose, AZ and omicron variant data.

17.
IEEE Frontiers in Education Conference (FIE) ; 2021.
Article in English | Web of Science | ID: covidwho-1978380

ABSTRACT

This work in progress paper describes our efforts and challenges in delivering undergraduate and graduate courses during COVID-19 conditions. More specifically, we focus on the adaptation and delivery of digital signal analysis laboratories for all the remote learners during the pandemic conditions. Methods for online labs and workforce training have been developed and deployed on a virtual basis. These labs and simulation environments have been deployed in signals and systems and DSP classes as well as in workforce development programs such as the REU and RET. The assessment of these efforts included evaluation forms and interviews. Challenges and opportunities from virtual delivery of content and labs were also part of the assessment.

18.
IEEE Frontiers in Education Conference (FIE) ; 2021.
Article in English | Web of Science | ID: covidwho-1978332

ABSTRACT

Machine learning and Artificial Intelligence (AI) are national priority areas for research, education and workforce development. This work in progress paper describes a Research Experiences for Teachers program in sensors and machine learning launched in the summer of 2020. Motivated by national AI workforce needs, we designed a program that engaged high school teachers from STEM fields in machine learning research. In 2020, the program focused on AI algorithms for solar energy systems. Because of the COVID-19 conditions, the research experience was virtual and ran with a smaller teacher group than originally planned. The program included development of training content, algorithm and software training, research in solar energy monitoring, development of research reports and lesson plans, research presentations, and assessment. The assessment of the program included surveys, interviews, presentation observations, and follow-up in high school content delivery.

19.
European Journal of Molecular and Clinical Medicine ; 9(4):387-392, 2022.
Article in English | EMBASE | ID: covidwho-1965471

ABSTRACT

Aim:ToknowtheincidenceofnosocomialinfectionsintheCOVID19patientsadmitted in the hospital that may help in the selection of the suitable antibiotics followsthebetter managementof theCOVID 19patients.Materials and methods: A total of 1534 COVID 19 patients were includedin thestudy.Therespiratory,blood,urinaryandpusformsurgicalsitessampleswerecollected to find the incidence of the bacterial infection in hospitalized COVID 19patients. The samples were collected 48 hours after the admission of the patient in to thehospital.Results: The incidence of the nosocomial infections in the COVID 19 patients was30.24%. The Staphylococcus aureus, Klebsiellapneumoniae, and Coagulase negativestaphylococci were more prevalent bacteria causing secondary infection in COVID 19patients.E.coliwas predominantly seeninUrinesamples.Conclusion: The rate of bacterial infections in the COVID 19 patients was observed ashighandneedtobeconsideredtotakeprecautionstominimisethespreadofnosocomial infections. The incidence of the bacteria reported in this study may be ofgreat value in the management of the COVID 19 patients and may also help to reducethemortality and morbidity.

20.
Australian and New Zealand Journal of Psychiatry ; 56(SUPPL 1):232, 2022.
Article in English | EMBASE | ID: covidwho-1916621

ABSTRACT

Background: Social distancing restrictions during the COVID-19 pandemic led to the adoption of telehealth in place of services previously provided in-person. Specialised psychotherapy is the primary evidence-based treatment for people diagnosed with personality disorder. Objective: To investigate the perceptions of clients of a specialist personality disorder clinic receiving psychotherapy via telehealth (video-conference and/or phone). Methods: An online survey was conducted during the first round of social restrictions (March-May 2020). Clients receiving psychotherapy treatment prior to the restrictions were invited to participate (n = 77). Findings: Thirty-seven clients completed the survey (48% response rate). Most participants were female (86.5%) and aged younger than 38 years (64.8%). When asked about their transition from in-person to telehealth during the pandemic, about half (n = 18 of 35, 51.4%) had few or no technical issues. Most participants preferred not having the stress of travelling (57.1%) and some felt more relaxed and able to talk more freely during telehealth sessions (28.6%). However, some (34.3%) found it more challenging to stay engaged in treatment when their main communication was via telehealth, with telehealth not working as well as in-person treatment. Almost half of the participants (48.6%) wanted to retain the option of receiving psychological treatment via telehealth when restrictions were lifted. While positive aspects of telehealth services were highlighted, there were some significant shortcomings. Conclusion: The overall perception of clients diagnosed with personality disorder was that delivery of psychotherapy via telehealth was generally therapeutic, was valued by participants and did not lead to harmful outcomes.

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