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1.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324758

ABSTRACT

Background: In December 2019, Coronavirus Disease 2019(COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection appeared in Wuhan, Hubei Province, China. The disease is highly infectious. Wuhan, Hubei Province decided restrict personnel movement on January 23.We analyze relevant data to show the situation of the COVID-19 epidemic in China. Methods: The data was classified according to Hubei group, non-Hubei group, Hong Kong, Macao and Taiwan group, and Chinese Mainland group, and analyze the current situation and trend of the epidemic. Results: There was an explosive growth in the early stage of the epidemic. The epidemic situation began to improve in about two weeks after Wuhan was restricted,and the situation in non-Hubei was significantly better than that in Hubei. Conclusion: The blockade of Wuhan was a correct decision, cut off the outflow of tinfection sources, and the epidemic situation in all places turned around after the incubation period.

2.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-319975

ABSTRACT

This study has formulated an evaluation framework for the interpretation and presentation performance of Online virtual reality 360°world cultural heritage tourism (OVRWCHT) approach during the covid-2019 break. The research framework is based on seven main principles of the Charter of the World Cultural Heritage Interpretation and Presentation theory, and establishes evaluation criteria for each principle. The World Cultural Heritage Site Hailongtun Tusi was selected as the case study, the Online virtual reality 360° system was for this site was established and evaluated accordingly. A collection of 1062 effective online questionnaires were support the evaluation. The results show that the OVRWCHT made by the research team which has received relatively wide recognition from stakeholders during the COVID-2019 outbreak period. However, it still needs more data support to improve technology and theory, especially transferability of OVRWCHT in other countries besides China. Finally, this study suggests that the ICOMOS should continue to issue relevant charters (documents) on how emerging technologies which may activate cultural heritage interpretation and presentation.

3.
BMC Public Health ; 21(1): 2257, 2021 12 11.
Article in English | MEDLINE | ID: covidwho-1571754

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) quickly developed into a global pandemic and affected patients' mental health. However, little is known about psychological experience of patients with COVID-19. The aim was to elucidate the psychological experience of patients with confirmed COVID-19 in Wuhan, at the initial stage of the pandemic. METHODS: This study was conducted using a phenomenological approach in a qualitative study. Thirteen patients with confirmed COVID-19 from a COVID-19-designated hospital in Wuhan, were recruited between March 15th and April 20th, 2020 via purposive sampling. Semi-structured in-depth interviews were conducted face-to-face. The interview data were analyzed using inductive thematic analysis. RESULTS: The psychological experience of patients was summarized into three themes: mental distress related to COVID-19, expectations of life scenarios after discharge, and making sense of the experience. These themes were classified into 10 sub-themes. Patients experienced confusion, uncertainty, worry, guilt and concern. Both positive and negative expectations of life scenarios after discharge were reported, manifested as expectations about making up for lost time with family, anxiety about social discrimination and feelings of helplessness about poor financial security. Moreover, patients perceived strength of abundant social support and awareness of social responsibility from their unique experience to cope with their condition. CONCLUSIONS: This study demonstrated that patients with confirmed COVID-19 in Wuhan underwent complex psychological experience, both positive and negative at the initial stage of the pandemic. These findings will contribute to the delivery of effective mental health care to safeguard patients' wellbeing.


Subject(s)
COVID-19 , China/epidemiology , Humans , Pandemics , Qualitative Research , SARS-CoV-2
4.
IEEE Transactions on Network Science and Engineering ; 8(2):1502-1516, 2021.
Article in English | ProQuest Central | ID: covidwho-1301433

ABSTRACT

Electronic healthcare (e-health) networks are increasingly popular, particular during pandemics such as COVID-19. This reinforces the importance of ensuring security and privacy for data-in-transit. One such solution is steganography-based schemes that utilize biological signals (e.g., ECG) as cover signals to preserve the privacy of patient personal information without affecting the diagnostic features. There are various limitations in existing steganography-based schemes, and in this study we present an effective privacy protection scheme leveraging both multidimensional steganography and shared keys. To enhance security and accelerate signal processing in our design, the Fast Walsh-Hadamard transform (FWHT) is employed to decompose ECG signals into a set of coefficients, of which the less-significant coefficients are used to construct the multidimensional space. The negotiated shared keys facilitate the embedding of encrypted data in the constructed space. We then evaluate the proposed scheme using different categories of ECG signals in the MIT-BIH database. It is observed that the signal distortion is minimal (i.e., less than 1%), even if the embedded data reaches the maximum embedding capacity. The security analysis also demonstrates that unauthorized retrieval of hidden information is not practical, within a short period of time.

5.
Mindfulness (N Y) ; 12(9): 2184-2195, 2021.
Article in English | MEDLINE | ID: covidwho-1285944

ABSTRACT

OBJECTIVES: The outbreak of contagious diseases and their associated non-pharmaceutical interventions can lead to negative mental health consequences. This study aimed to investigate online self-compassion exercises' effectiveness in alleviating people's negative affect (anxiety and negative emotions) during the COVID-19 pandemic lockdown. METHODS: Study 1 examined the associations between self-compassion and negative affect using an anonymous online survey. In study 2, two pilot experiments were conducted to examine online self-compassion exercises' (i.e., instructor-guided meditation and self-guided writing) effectiveness to mitigate individuals' negative affect. In study 3, a randomized controlled study was conducted to further examine online self-compassion writing's effectiveness in reducing people's negative affect. RESULTS: The results of study 1 indicated a significant negative association between self-compassion and participants' negative affect. Participants in study 2a reported significant decreases in negative affect after completing the self-compassion meditation. Study 2b showed that participants who completed the self-compassion writing reported significantly more self-compassion and less anxiety when compared to participants who did not. Study 3 showed substantial pre/post-test changes in participants who completed self-compassion writing. Importantly, there were significant increases in participants' self-compassion and decreases in negative affect when compared to participants in the control condition. CONCLUSIONS: Self-compassion exercises were effective to alleviate individuals' anxiety and reduce negative emotions (even within a brief session) during the pandemic lockdown. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12671-021-01674-w.

7.
J Health Psychol ; 27(8): 1861-1874, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1206119

ABSTRACT

The study explored how traditional and social media use produced various cognitive responses toward COVID-19, including perceived severity, susceptibility, and efficacy, and direct and indirect facilitation of COVID-19 preventive behaviors. We tested the hypotheses on data collected from 433 university students in Wuhan, China, using structural equation modeling. We found that traditional media enhanced engagement for preventive behaviors both directly and indirectly by enhancing perceived severity and efficacy, whereas social media showed no impact on preventive behaviors, either directly or indirectly. Furthermore, the direct effect of traditional media on preventive behaviors was markedly stronger than the indirect effect through perceptions.


Subject(s)
COVID-19 , Social Media , COVID-19/prevention & control , China , Health Behavior , Humans , SARS-CoV-2
8.
Front Pharmacol ; 11: 589714, 2020.
Article in English | MEDLINE | ID: covidwho-1083588

ABSTRACT

Since the sudden epidemic of coronavirus disease 2019 (COVID-19), the State Administration of Traditional Chinese Medicine immediately organized experts to formulate and screen the effective prescriptions of traditional Chinese medicine according to the characteristics of the novel coronavirus infection. Qingfei Paidu decoction (QFPDD) has been proven to be effective in multi-provincial clinical trials, and has been selected as a general prescription for the treatment of COVID-19 in different stages that was later promoted to be used nationwide. This review highlights the latest advances of QFPDD, focusing on the TCM theory, mechanism analysis, clinical application of QFPDD and its future perspectives. Moreover, an in-depth discussion of some valuable issues and possible development for future research on QFPDD is also discussed, aiming to provide a novel guide to combat the global epidemic COVID-19.

9.
Biomed Pharmacother ; 137: 111310, 2021 May.
Article in English | MEDLINE | ID: covidwho-1062247

ABSTRACT

BACKGROUND: Currently, the number of confirmed cases and deaths of COVID-19 worldwide continues to rise, receiving great concern from the international community. However, there is no specific and widely accepted effective vaccines. The experience in controlling the outbreak in China has proven the effectiveness of traditional Chinese medicine (TCM). OBJECTIVES: This review aims to evaluate the role of TCM in COVID-19 treatment, hoping to provide references for prevention and control of global pandemic. DATA SOURCES: China National Knowledge Infrastructure, Web of Science, Baidu Scholar, ScienceDirect, Elsevier and PubMed were used to search literatures published from December 2019 to December 2020 by entering the keywords "Traditional Chinese medicine", "COVID-19″, "Severe acute respiratory syndrome coronavirus 2″, "Pathogenesis", "Syndrome differentiation", "Prescriptions" and their combinations. Hence, we have performed an extensive review of research articles, reviews and primary scientific studies to identify TCM against COVID-19. RESULTS: Among clinical treatments of COVID-19, several TCM prescriptions and characteristic therapies have been effectively suggested, the underlying mechanisms of which are mainly involved in antiviral, anti-inflammatory, immunomodulatory and organ-protective effects of multi-components acting on multi-targets at multi-pathways. CONCLUSIONS: This review may provide meaningful and feasible information that can be considered for the treatment of COVID-19 pandemic globally.


Subject(s)
Antiviral Agents/administration & dosage , COVID-19/drug therapy , Drugs, Chinese Herbal/administration & dosage , COVID-19/epidemiology , China/epidemiology , Humans , Medicine, Chinese Traditional , Prescription Drugs , SARS-CoV-2/isolation & purification
10.
Front Psychiatry ; 11: 551812, 2020.
Article in English | MEDLINE | ID: covidwho-1006207

ABSTRACT

Objective: This study aims to investigate perinatal depression in women who gave birth during the COVID-19 pandemic in Wuhan, and to evaluate the effect of the pandemic on perinatal depression prevalence. Methods: A cross-sectional investigation was conducted into women hospitalized for delivery in Hubei Maternity and Child Healthcare Hospital from December 31, 2019 to March 22, 2020, a period which encompasses the entire time frame of the COVID-19 pandemic in Wuhan. The Edinburgh Postnatal Depression Scale (EPDS) was adopted to evaluate perinatal depression status. A Chi-square test and logistic regression model were utilized for data analysis. Results: A total of 2,883 participants were included, 33.71% of whom were found to suffer from depressive symptoms. In detail, 27.02%, 5.24%, and 1.46% were designated as having mild, moderate, and severe depressive symptoms, respectively. The perinatal depression prevalence increased as the COVID-19 pandemic worsened. Compared to the period from December 31, 2019 to January 12, 2020, perinatal depression risk significantly decreased within the 3 weeks of March 2-22, 2020 (1st week: OR = 0.39, 95% CI: 0.20, 0.78; 2nd week: OR = 0.35, 95% CI: 0.17, 0.73; and 3rd week: OR = 0.48, 95% CI: 0.25, 0.94); and the postnatal depression risk significantly rose within the four weeks of January 27-February 23, 2020 (1st week: OR = 1.78, 95% CI: 1.18, 2.68; 2nd week: OR = 2.03, 95% CI: 1.35, 3.04; 3rd week: OR = 1.48, 95% CI: 1.02, 2.14; and 4th week: OR = 1.73, 95% CI: 1.20, 2.48). Conclusion: The dynamic change of perinatal depression was associated with the progression of the COVID-19 pandemic among new mothers who were exposed to the pandemic. An elevated risk of postnatal depression was also observed during the COVID-19 pandemic.

11.
Chinese Journal of Nosocomiology ; 30(10):1446-1451, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-827874

ABSTRACT

OBJECTIVE: To analyze the strategies for prevention and control of Corona Virus Disease 2019 (COVID-19) based on the practical experience of prevention and control of nosocomial infection so as to provide reference for the formulation and improvement of programs for prevention and control of COVID-19 in hospitals. METHODS: Close attention was paid to the dynamic condition of the epidemic, the programs for prevention and control of COVID-19 were formulated based on the related national laws and regulations for prevention and treatment of infectious diseases and normative documents released by health administrative departments in combination with the practice of prevention and control of nosocomial infection in Inner Mongolia People's Hospital, and the practical experience was summarized. RESULTS: The prevention and control programs involving the organizational guarantee, training of all staff, implementation of related prevention and control measures and social responsibility were formulated. In the practical work, there were problems in pre-inspection and triage, mastery of key points of process of putting on and taking off protective equipment, layout process and disposal of medical waste, and they needed to be rectified. CONCLUSION: In response to COVID-19 epidemic, it is the primary step for prevention and control of nosocomial infection to strengthen the pre-examination and triage work, the key step to properly select personal protective equipment and rigidly follow the procedure of putting on and taking off, and the quality control and supervision are effective for prevention and control of nosocomial infection.

12.
SSRN; 2020.
Preprint | SSRN | ID: ppcovidwho-597

ABSTRACT

Background: Even since the end of 2019, a small virus termed as SARS-CoV-2 has been making big impact on global people’s health. Despite the clinical features o

14.
Chin. Trad. Herbal Drugs ; 6(51): 1443-1449, 20200328.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-380428

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a serious threat to the lives and health of our people, but there is currently no clear target for therapeutic drugs. Therefore, prevention is of great significance for the prevention and control of COVID-19. The Health Management Administration of the different provinces and cities have successively released the “Traditional Chinese Medicine Diagnosis and Treatment Programs for New Coronavirus Pneumonia” in response to the epidemic situation, among them including preventive prescriptions, which showed the theoretical characteristics of “treating disease before its onset” of traditional Chinese medicine (TCM), and also showed the characteristics of medication in different provinces. Therefore, we collected 66 formulas for treating COVID-19 in China and studied the rules of TCM prevention in various provinces and autonomous regions, and unified the thinking of medication, which could provide a reference for the prevention of COVID-19a.

15.
J Heart Lung Transplant ; 39(5): 412-417, 2020 05.
Article in English | MEDLINE | ID: covidwho-180903

ABSTRACT

BACKGROUND: The epidemiologic and clinical characteristics of heart transplant (HTx) recipients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic remains unclear. We studied the characteristics of HTx recipients from December 20, 2019, to February 25, 2020, in an effort to understand their risk and outcomes. METHODS: All accessible HTx recipients were included in this single-center retrospective study. We collected information on the recipients using a web-based questionnaire as well as the hospital database. RESULTS: We followed 87 HTx recipients (72.4% were men, and the average age was 51 years). A total of 79 recipients resided in Hubei, and 57 recipients had a Wuhan-related history of travel or contact. Most took precautionary measures while in contact with suspicious crowds, and 96.6% of the families and communities undertook prevention and quarantine procedures. Four upper airway infections were reported, and 3 of them tested negative for SARS-CoV-2 (the fourth recovered and was not tested). All cases were mild and successfully recovered after proper treatment. Laboratory results of 47 HTx cases within the last 2 months were extracted. Of these, 21.3% of recipients had pre-existing lymphopenia, and 87.2% of recipients had a therapeutic concentration of tacrolimus (5-12 ng/ml). Liver and kidney insufficiency was seen in 5 and 6 recipients, respectively. CONCLUSION: HTx recipients who practiced appropriate prevention measures had a low rate of infection with SARS-CoV-2 and transition to the associated disease COVID-19. These early data will require confirmation as the pandemic establishes around the world.


Subject(s)
Coronavirus Infections/epidemiology , Coronavirus , Disease Outbreaks/prevention & control , Heart Transplantation , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Adult , Angiotensin-Converting Enzyme 2 , Betacoronavirus , COVID-19 , China/epidemiology , Coronavirus/genetics , Coronavirus/isolation & purification , Coronavirus Infections/diagnosis , Coronavirus Infections/drug therapy , Coronavirus Infections/prevention & control , Female , Humans , Immunosuppressive Agents/therapeutic use , Male , Middle Aged , Peptidyl-Dipeptidase A/therapeutic use , Pneumonia, Viral/diagnosis , Pneumonia, Viral/drug therapy , Pneumonia, Viral/prevention & control , Quarantine , Retrospective Studies , SARS-CoV-2 , Surveys and Questionnaires
16.
Virol Sin ; 35(3): 305-310, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-88643

ABSTRACT

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic has become a major challenge to public health in China and other countries, considering its pathogenicity across all age groups. Pregnancy is a unique physiological condition, and is characterized by altered immunity and elevated hormone levels to actively tolerate the semi-allogeneic fetus, which undergoes a sudden and substantial fluctuation during the immediate postpartum period. Changes in clinical features, laboratory characteristics, and imaging features of pregnant women during the pre-partum and post-partum periods require further elucidation. Here, we retrospectively analyzed the clinical features, laboratory characteristics, and imaging features of eight pregnant cases of SARS-CoV-2 infection during the pre-partum and post-partum periods. Our results showed that four of the eight pregnant women were asymptomatic before delivery but became symptomatic post-partum. Correspondingly, white blood cell (WBC) counts increased and lymphocyte (LYMPH) counts decreased. C-reactive protein (CRP) levels in the serum also increased to a higher level than those in general pregnancy. Therefore, it is imperative to closely monitor laboratory parameters including the WBC count, LYMPH count, and CRP, along with other imaging features in chest CT scans, to promptly prevent, diagnose, and treat a SARS-CoV-2 infection during pregnancy.


Subject(s)
Betacoronavirus/immunology , Coronavirus Infections/immunology , Coronavirus Infections/physiopathology , Pneumonia, Viral/immunology , Pneumonia, Viral/physiopathology , Adult , Betacoronavirus/pathogenicity , Blood Cell Count , C-Reactive Protein , COVID-19 , China , Coronavirus Infections/blood , Coronavirus Infections/diagnostic imaging , Female , Humans , Immunity , Leukocyte Count , Lymphocytes , Pandemics , Pneumonia, Viral/blood , Pneumonia, Viral/diagnostic imaging , Pregnancy , Retrospective Studies , SARS-CoV-2
17.
Chin. Trad. Herbal Drugs ; 5(51): 1139-1146, 20200312.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-52364

ABSTRACT

Since December 2019, a novel coronavirus-infected pneumonia was first detected in Wuhan, such cases had been subsequently discovered in other cities. The disease caused by the novel coronavirus was officially named COVID -19 (coronavirus disease 2019) by the world health organization. National Health Commission of China and other provinces and cities have successively performed syndrome differentiation of COVID-19 and provided corresponding Chinese medicine treatment programs. In this epidemic, the disease is a “dampness toxin”. The best principle for treatment is early detection and early treatment. Both Chinese and Western medicine have their own advantages. The advantages could be complementary and could not be replaced each other. Therefore, we collected the Chinese medicine treatment programs for the treatment of COVID-19 comprehensively, conducted a systematic analysis, and especially analyzed the pharmacological basis of traditional Chinese medicine for the treatment of COVID-19, which provided a basis for the rationality of Chinese medicine prescription for the treatment of COVID-19, and provided a reference of updating the diagnosis and treatment plan for provinces and cities.

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