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IEEE Int. Conf. E-Health Netw., Appl. Serv., HEALTHCOM ; 2021.
Article in English | Scopus | ID: covidwho-1214727


Right after the Chinese example in conducting COVID-19 epidemic originated in Wuhan, the readiness to detect and respond by health authorities to local (sometimes global) epidemics has become central lately. Within the idea of health 4.0, information about the individual is essential in supporting public community health policies. This paper presents a proposal for an epidemiological surveillance system applied to arboviruses. Data mining techniques and Machine Learning (ML) are used to design mathematical models for detecting epidemics enhanced by Aedes Aegypti (vector for dengue, chikungunaya, yellow fever and zica). Based on data, it is proposed an adaptive manner to reach better stability on results. A Prove of Concept (PoC) is presented for dengue epidemics detection, a common endemic disease in the semiarid region of Brazil. © 2021 IEEE.

Cytotherapy (Elsevier Inc.) ; 23:38-39, 2021.
Article in English | Academic Search Complete | ID: covidwho-1193379


Currently, there is no specific treatment for coronavirus disease, and some drugs and cell-based therapy have been tested as alternatives. This work aims to evaluate the effects of the combined use of humanized recombinant monoclonal antibody capable of binding the IL-6 receptor (Tocilizumab), and umbilical cord tissue-derived mesenchymal stromal cells (UCT-MSC) in the treatment of a patient with severe COVID-19 admitted to the intensive care unit (IUC) and submitted to mechanical ventilation. This study is part of a project approved by the National Research Ethics Commission (CONEP);CAAE: 30833820.8.0000.0020. The patient had a diagnostic criterion for the severe acute respiratory syndrome resulting from infection with SARS-CoV-2 and received two 400 mg doses of tocilizumab, three infusions of 500,000 CTM / kg plus full anticoagulation. TCU-MSC were obtained from healthy donors. The following parameters were evaluated in the pre-infusion of cells (D1), on the day following each infusion (D2, D4, and D6), on the 14th and 60th day after the first infusion (D14 and D60): viral load, immune response (Regulatory T lymphocytes), C-reactive protein level in plasma, oxygen saturation, respiratory rate, total lymphocyte count and subpopulations (platelets, inflammatory cells, and reticulocytes), TGO / TGP, increased prothrombin time, D-dimer, creatinine, troponin. The relative viral quantification decreased gradually from 1 (D1) to 0.06 (D6) RdRP / RNApol, undetectable in D14. An increase in the absolute number of total lymphocytes / µL has also been seen to have progressively increased from 281 (D1) to 954.9 (D6) and since then decreased to 641.6 in D60 in the same way as T lymphocytes 148.6 (D1) 642.6 (D6) 607.4 (D14) 485.7 (D60), CD4 T lymphocytes, 102 (D1) 481.2 (D6) 459.5 (D14) 358 (D60) and Treg lymphocytes 10.8 (D1) 34 (D6) 29.8 (D14), 25.9 (D60). Plasmablasts, in contrast, decreased from 52 (D1) to 4.5 (D6) to almost undetectable in D60 (0.2). Laboratory tests outside the reference values decreased during the follow-up from D1 to D14 were within the normal parameters at D60. The patient was extubated uneventfully on D6, discharged from the ICU on D10, and the hospital on D14. the combined use of tocilizumab and MSC is safe, without adverse effects, and the results of this case report prove to be a promising alternative in the treatment of patients with severe acute respiratory syndrome due to SARS-CoV-2. [ABSTRACT FROM AUTHOR] Copyright of Cytotherapy (Elsevier Inc.) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)