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1.
Multiple Sclerosis Journal ; 28(3 Supplement):653-654, 2022.
Article in English | EMBASE | ID: covidwho-2138851

ABSTRACT

Background: Vaccination during immunosuppression can result in impaired vaccine responses. In highly active patients requiring a rapid treatment initiation, vaccination can delay treatment onset. Natalizumab (NTZ) is a high-efficacy agent with potential low interference in vaccination responses, and could be a bridge therapy to achieve an adequate immunisation before starting another treatment. Objective(s): To assess the safety and immunogenicity of inactivated vaccines administered during NTZ treatment. Method(s): Self-controlled study based on an ongoing prospective cohort that included adult MS patients with complete immunisation schedules for hepatitis B vaccine (HBV), hepatitis A vaccine (HAV) and/or COVID-19 vaccine during NTZ treatment, between September 2016 and February 2022. Seroprotection rates were calculated for each vaccine. Demographic, clinical and radiological characteristics were collected the year before (pre-exposure period) and after vaccination (post-exposure period). Differences in annual relapse rate (ARR), contrast-enhancing lesions (CELs), new T2 lesions (NewT2) and changes in Expanded Disability Status Scale (EDSS) during pre and post exposure period were evaluated. Patients were also categorised according to time on NTZ exposure before vaccination (long-term exposure >1 year and short-exposure <=1 year) and according to JCV status. Result(s): From 248 patients treated with NTZ, 60 were vaccinated during NTZ exposure: 44 (73%) women, mean age 45 years, mean disease duration 17 (SD 8.7) years. Thirty (50%) patients bridged to anti-CD20 after immunisation, because of high titers of JC virus. Between the pre and post-exposure period, we observed a decrease in both the AAR (0.28 vs 0.01;p=0.004) and newT2 (0.8 vs 0.02;p=0.1) and no changes in disability accumulation (EDSS 3.5 vs 3.5 p=0.6). The global seroprotection rate was 93% (91.6% (IC95% 73-99) for HAV (n=24), 92.6% (IC95% 76- 99) for HBV (n=27), 100% (IC95% 84-100) for Covid-19 (n=23)). No differences were seen between short and long term NTZ exposure or between JCV positive or negative patients, in terms of safety and immunogenicity. Conclusion(s): Immunisation with inactivated vaccines during NTZ treatment is safe and effective, both for short and long term NTZ exposure. In highly active PwMS who need immunisation, NTZ could be a valuable strategy to avoid delays in the onset of high-efficacy DMD, even in JC virus positive in which it could be used as a bridge therapy strategy.

2.
Fertility and Sterility ; 118(4 Supplement):e26-e27, 2022.
Article in English | EMBASE | ID: covidwho-2086203

ABSTRACT

Objective: To evaluate evidence for any potential adverse effects of COVID-19 vaccination associated with oocyte donation for IVF. Material(s) and Method(s): Records of all non-directed oocyte donors undergoing multiple retrieval cycles for recipient IVF patients performed at a single fertility center from February 2017 through March 2022, including donation cycles both before and after COVID-19 vaccination, were reviewed retrospectively. For each oocyte donor, outcomes were averaged for all donations prior to any COVID-19 vaccination, and separately for all donations after receiving one or more COVID-19 vaccinations. Numbers of oocytes retrieved, mature (MII), fertilized (2pn) and blastocysts were compared before versus after COVID-19 vaccination by paired sample t-test. Result(s): Thirty-two subjects underwent multiple donation cycles, including oocyte aspirations both before and after receiving at least one Covid-19 vaccination. The duration of time between donors' most recent COVID-19 vaccination and subsequent oocyte aspiration ranged from 2 weeks to 11 months (mean=3.9 months, SD=2.8, median=3). There were no significant outcome differences between pre-COVAX and post-COVAX oocyte aspirations in any of the treatment outcomes evaluated. Numbers of oocytes retrieved, matured, fertilized, and developing to the blastocyst stage were all as high after COVID-19 vaccination as before. [Formula presented] Conclusion(s): The results of this study using individual oocyte donors as their own controls to evaluate any potential adverse effects of COVID-19 vaccination on ovarian hyperstimulation and oocyte retrieval for donation to recipient IVF patients suggest that COVID-19 vaccination does not interfere with treatment response or outcome. Impact Statement: Oocyte donation can be scheduled at any time in relation to COVID-19 vaccination without fear of adversely impacting treatment outcomes. Copyright © 2022

3.
[ECO]systems of Resilience Practices: Contributions for Sustainability and Climate Change Adaptation ; : xvii-xxii, 2022.
Article in English | Scopus | ID: covidwho-2060198
4.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i412-i414, 2022.
Article in English | EMBASE | ID: covidwho-1915608

ABSTRACT

Introduction: Although the effects of SARS-CoV-2 infection on the cardiovascular system are well known in the acute phase, the cardiovascular impact in the elderly population surviving respiratory COVID-19 infection after 1-year follow-up has not been sufficiently studied. Methods: Observational registry of 240 elderly patients (75 years or older) consecutively admitted for and surviving COVID-19 respiratory infection between March 1 and April 30, 2020. The incidence of major cardiovascular events [MACE] (cardiovascular death [CD], acute coronary syndrome [ACS], cerebrovascular disease [CVD], venous thromboembolic disease [VTE], and heart failure [HF]) was prospectively analyzed. Results: The mean age was 83.8 ± 5.6 years (range 75-103 years). A total of 54.2% were women. Most patients had a personal history of cardiovascular risk factors: hypertension (83.3%), diabetes mellitus (27.9%), dyslipidemia (43.8%). Among the main cardiological comorbidities, a history of atrial fibrillation was the most frequent (18.8%). Of note was the high percentage of institutionalized patients (37.1%) and those with moderate-severe dementia (16.7%). After a mean follow-up of 352.2±70.4 days, 13.8% of patients died and 9.6% had MACE, the most frequent being heart failure (7.5%), with no differences in the severity or overall evolution of the acute disease. Of the 33 patients who developed HF, only 3 died of cardiovascular causes. Only 2 patients suffered a stroke, in both cases without a history of AF or anticoagulants. Only 2 patients had a thromboembolic event (0.8%). The low incidence of thrombotic events may be due in part to the high rate of anticoagulation and chronic antiplatelet therapy and the high percentage of prophylactic heparin prescription at discharge, as well as the fact that only cases with clinical repercussions. COPD, CKD, institutionalization and moderate-severe dementia are associated with an increased risk of MACE, although only COPD and prescription of loop diuretics were identified as independent risk markers in the multivariate analysis. Conclusions: In elderly COVID-19 survivors, the incidence of MACE after one year of follow-up is high, the main manifestation being heart failure. COPD and the prescription of loop diuretics were identified as independent risk markers for the development of MACE in the multivariate analysis. Baseline clinical characteristics Cox survival analysis.Predictors of MACE.

5.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i117-i118, 2022.
Article in English | EMBASE | ID: covidwho-1915578

ABSTRACT

Introduction: The management of antihypertensive drugs and especially ACEI/ARA2 during the first wave of the SARS-CoV-2 pandemic was a matter of debate. The change in antihypertensive treatment during the pandemic and its repercussions have not been sufficiently studied. Methods: Observational and prospective study that analyzed consecutive patients admitted for respiratory infection and positive polymerase chain reaction (PCR) between March 1 and April 30, 2020. During the period analyzed, 921 patients were registered, of whom 673 patients were discharged;among them 359 were patients with a diagnosis of arterial hypertension and pharmacological treatment. These patients were followed up in days, from the time of discharge to data analysis, with a mean of 352±70.4 days. Results: The mean age was 74.4±12.9 years, and 50.7% were male. A total of 28.7% were diabetic patients, 49% were dyslipidemic, 17.8% were smokers, and 19.8% were obese. Of the patients analyzed, 13.4% had a previous diagnosis of ischemic heart disease, a similar percentage, 13.1% had heart failure, and 13.6% had atrial fibrillation. The antihypertensive drugs analyzed were ACE inhibitors (angiotensin-converting enzyme inhibitors), ARA-2 (angiotensin II receptor antagonists), calcium antagonists, thiazide diuretics, loop diuretics, aldosterone antagonists, beta-blockers and alpha-blockers. At discharge, 75.8% of the patients maintained their antihypertensive treatment, and the remaining 24.2% were modified. Prior to admission, 77.2% were taking ACE inhibitors or ARA-2;however, in 16.4% of the patients they were discontinued after admission. In contrast, treatment with calcium antagonists increased from 27.6% to 34.1% after hospitalization. In both cases there were statistically significant differences in the bivariate analysis in the McNemar test (p < 0.05 in both cases), with no differences in the other antihypertensive drugs analyzed. After follow-up, the combined event occurred in 28 patients, with the most frequent event being the development of HF;in contrast, only 0.8% presented ACS. Overall mortality was 8.9%. Picture 1 shows the events recorded according to the change in antihypertensive treatment and the maintenance or discontinuation of ACEI/ARA-2 in those patients who were already taking it on admission. Similarly, a survival analysis was performed in which no differences were observed in terms of all-cause mortality or major cardiovascular events between patients who maintained their antihypertensive treatment and those who modified it. Conclusions: In the population surviving SARS-CoV-2 respiratory infection, maintaining or discontinuing treatment with ACEI/ARA-2 did not influence mortality or the appearance of major cardiovascular events after the first year of follow-up. (Table Presented).

6.
Revista Espanola de Salud Publica ; 94(e202011146), 2020.
Article in Spanish | GIM | ID: covidwho-1870699

ABSTRACT

Background: The health crisis caused by COVID-19 required the prompt launch of research in order to generate scientific evidence pertaining to the new disease oriented to control its devastating effects and continuous spread. Therefore, it was essential to adapt the work flow of Research Ethics Committees, to prioritize and to accelerate the evaluation of projects related to this disease.

7.
Revista Complutense De Educacion ; 33(2):351-360, 2022.
Article in Spanish | Web of Science | ID: covidwho-1820476

ABSTRACT

INTRODUCTION. The population confinement caused by coronavirus pandemic forced teachers and families to make an almost instant transition from traditional teaching to on-line teaching. But how did it work regarding the digital gap? The aim of the study was to assess the impact of the schools' lockdown on the three existing digital gaps, access, cognitive and school, from the teachers and the families' perspectives. METHOD. 9567 Spanish citizens, 3700 teachers and 5867 parents, agreed to participate. The study followed an ex post facto research design within a questionnaire quantitative methodology. A "snowball" non-probabilistic sampling was used to recruit participants. Data collection was performed virtually from April 15th to May 8th, 2020. RESULTS. They uncovered an "access gap" that teachers blame on a deficient internet connection and not enough resources at home, but families do not share it and point to telecommuting as the main limitation. DISCUSSION. There is a clear "cognitive gap" acknowledged by teachers and families and a "school gap" that teachers blame on insufficient resources provided by the administration and the schools, and an insufficient experience on on-line education. In conclusion, the confinement caused by the COVID-19 pandemic has brought to light a "digital gap" that many believe overcame or at least minimized. However, the cognitive and the school gaps need actions.

8.
30th Annual Conference of the European-Association-for-Education-in-Electrical-and-Information-Enginee ring (EAEEIE) ; : 201-208, 2021.
Article in English | Web of Science | ID: covidwho-1559469

ABSTRACT

Due to the unusual pandemic situation caused by the SARS-CoV-2 virus, the Universitat Politecnica de Valencia (UPV) needed to adapt its teaching strategies consequently and schemed a mix of on-site lectures combined with online lectures during the first and second waves, that affected classes programmed for the second semester of the scholar term 2019-2020 and first semester 2020-2021, and implemented 100% online teaching during the third wave, that affected classes programed for the second semester 2020-2021. Despite all the efforts to adapt tuition, UPV professors faced serious problems not only to teach but also to guarantee students assessment. In this paper it is shown how teaching was adapted for one subject of the Computer Engineering Degree carried out during the 1st semester, one of the Data Science Degree taught throughout the 3rd semester, and one of the Master's Degree of Graphic Arts. The syllabus remarking how was adapted, the assessment and the classes is presented for each case in this document.

9.
Multiple Sclerosis Journal ; 27(2 SUPPL):758-759, 2021.
Article in English | EMBASE | ID: covidwho-1496076

ABSTRACT

Introduction: Information about how SARS-CoV-2 specific humoral and cellular response is modified by disease-modifying therapies (DMTs) is scarce. Objective: To investigate humoral and cellular responses to SARS-CoV-2 and factors for presenting them in a Barcelona cohort of pwMS. Methods: Retrospective cohort study of adult unvaccinated PwMS with confirmed COVID-19 with at least one SARS-CoV-2 antibody (Ab) determination included from February 2020 to May 2021 and followed until May 2021. Demographic, clinical and laboratory data were obtained. Humoral SARS-CoV-2 response was measured with commercial chemiluminescence immunoassays targeting specific Ab against spike (IgG-S) and nucleocapsid proteins (Ig-N), as per clinical practice. SARS-CoV-2 specific T-cell response was studied in 42 selected pwMS according to DMT by a whole blood Interferon-Gamma (IFN-y) Release Immunoassay. Humoral and cellular response was assesed using a logistic regression model corrected for age, sex, comorbidities, MS form, expanded disability status scale, DMT, COVID-19 severity and PCR result. Results: 145 pwMS were enrolled (mean age 46.8 years;64.1% female;18.6% progressive forms, 20.7% untreated, 22.8% on anti-CD20s therapies and 56.6% on other DMTs). Humoral and cellular tests were performed from 0.3 to 13.1 months after COVID-19. 121(83.5%) presented positive Ab (57.6% anti-CD20 therapy, 90.2% other DMTs, 93.3% untreated). Untreated patients presented higher Ig-N titres (34.3[128.8]) compared to those with anti-CD20s (0.08[0.13], p<0.01), and other DMTs (19.55[42.92], p<0.01). Humoral response persisted over 6 months in 12/12 untreated, 9/22 with anti-CD20s and 22/28 with other DMTs (p=0.068). 31/42(73.8%) presented cellular response (81.0% anti- CD20, 62.5% other DMTs, 80.0% untreated), with similar levels of IFN-y levels among DMTs. 5/12(41.7%) anti-CD20-treated PwMS with negative Ab presented cellular response. In the multivariate analysis, humoral response decreased in anti-CD20 therapy (OR 0.08[95% CI,0.01-0.55]) and was associated with male sex (OR 3.59[1.02-12.68]). Cellular response was associated with seropositivity (OR13.0[1.29-130.4]), but can be present even in the absence of Ab. Conclusions: Humoral response is altered by DMTs, specially in anti-CD20-treated PwMS. Cellular response is associated with seropositivity but can be present in anti-CD20-treated PwMS even in the absence of Ab. Both can be detected up to 13.1 months after COVID-19.

10.
Multiple Sclerosis Journal ; 27(2 SUPPL):769-770, 2021.
Article in English | EMBASE | ID: covidwho-1496075

ABSTRACT

Background: Information about humoral and cellular responses to SARS-CoV-2 vaccination in patients with Multiple Sclerosis (PwMS) and other autoimmune diseases (AID) is scarce. Objective: To determine humoral and cellular responses after SARS-CoV-2 vaccination in PwMS and anti-CD20-treated patients with other AID. Methods: Ongoing prospective study performed in two Catalan MS centres from February 2021. Unvaccinated adult pwMS and other anti-CD20-treated AID were recruited. Demographic, clinical and laboratory data were obtained. Whole blood samples were obtained before and 30-90 days after vaccination. The humoral response to SARS-CoV-2 was qualitatively and quantitatively measured before and after vaccination with commercial chemiluminescence immunoassays targeting SARS-CoV-2 antibodies against spike (TrimericS, IgG anti-S) and nucleocasid proteins (Elecsys, Ig anti-N). In 150 selected patients according to diseasemodifying therapy (DMT), the SARS-CoV-2 specific T-cell response was assessed after vaccination by a whole blood Interferon-Gamma Release immuno Assay (IGRA) that uses two Qiagen proprietary mixes of SARS-CoV-2 S protein (Ag.1 and Ag.2) selected to activate both CD4 and CD8 T cells. Results: 457 patients have been enrolled in the study (anti-CD20 therapy n=164, S1P DMTs n=37, natalizumab n=32, cladribine n=29, alemtuzumab n=31, other DMTs n=129, no DMT n=35). Participants characteristics are: mean age 48.1 years (SD 12.0), 69% female, 422 pwMS (29.4% progressive forms) and 35 with other AID, disease duration 13.9 years (IQR 14.1), median EDSS 3.0 (IQR 3.0). 450 have been fully vaccinated (94.2% mRNA vaccine). Pre-vaccination samples were collected 0.33 days (SD 0.5) before the first vaccine dose of which 12 (3.35%) had positive anti S/N immunoglobulin (Ig). As of June 30th, 42 post-vaccination samples have been obtained (1.3 months [SD 0.42] after the 2nd vaccination dose). Positive IgG rates were 44.8% (n=13/29) for CD20s, 100% (8/8) for other DMTs and 100% (4/4) for no DMT. No anti-N Ig were detected. Media titres of anti-S IgG were lower in anti-CD20-treated patients (7.8 [IQR 50.1]) compared to untreated patients (800 [0], p<0.01) or other DMTs (755 [228], p<0.01). Conclusions: Initial results of the study suggest blunted anti-S/N Ig response under anti-CD20 therapy. Knowledge of the cellular response in these patients will be crucial. Data from the cellular study and the completed humoral study will be presented at the meeting.

11.
30th Annual Conference of the European Association for Education in Electrical and Information Engineering, EAEEIE 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1447816

ABSTRACT

Due to the unusual pandemic situation caused by the SARS-CoV-2 virus, the Universitat Politècnica de València (UPV) needed to adapt its teaching strategies consequently and schemed a mix of on-site lectures combined with online lectures during the first and second waves, that affected classes programmed for the second semester of the scholar term 20192020 and first semester 2020-2021, and implemented 100% online teaching during the third wave, that affected classes programed for the second semester 2020-2021. Despite all the efforts to adapt tuition, UPV professors faced serious problems not only to teach but also to guarantee students assessment. In this paper it is shown how teaching was adapted for one subject of the Computer Engineering Degree carried out during the 1st semester, one of the Data Science Degree taught throughout the 3rd semester, and one of the Master's Degree of Graphic Arts. The syllabus remarking how was adapted, the assessment and the classes is presented for each case in this document. © 2021 IEEE.

12.
Buletin Ekonomi Moneter dan Perbankan ; 38(1):36-40, 2021.
Article in English | Scopus | ID: covidwho-1225983

ABSTRACT

In March 14th 2020, the Spanish Government declared the“State of Emergency”due to the pandemic caused by the COVID-19 and all the population was forced to “shelter-at-home” for two weeks. Citizens had less than 24 hours to prepare for the self-quarantine. The goal of the present was to assess Spanish citizens’ physical activity practice at the end of the first week of the home quarantine. A total of 1858 Spanish citizens, 674 males and 1184 females (M = 40.18, SD = 15.84 years) agreed to participate. The study is descriptive in nature, based on an on-line questionnaire conducted seven days after the mandatory shelter-at-home health order issued by the Spanish Government. It included The International Physical Activity Questionnaire, Anthropometric parameters, Sociometric and COVID-19 information. Global results showed that the vast majority of the confined population was below the World Health Organization recommendations on Vigorous Physical Activity, Moderate Physical Activity or a combination. Physical activity practice was dependent on personal factors such as gender, age or weight, but also on contextual factors such as living with a dependent person or the type of house (square meters, having a balcony or a backyard). Insufficient physical activity has been considered a prominent risk factor for non-communicable diseases, mental health and, consequently, quality of life. Mandatory shelter-at home orders like the ones issued due to COVID-19 could be repeated in the future. National authorities should consider the findings from the present study to prevent citizens from putting their health at jeopardy while in confinement. © The Author(s), 2021.

13.
European Journal of Hospital Pharmacy ; 28(SUPPL 1):A71, 2021.
Article in English | EMBASE | ID: covidwho-1186315

ABSTRACT

Background and importance Baricitinib is an immunosuppressive agent included as one of the therapeutic options for COVID-19 in the Spanish protocol Agencia Española del Medicamento y Productos Sanitarios. Aim and objectives The objective was to assess the effectiveness of this drug in hospitalised but non-critically ill patients. Material and methods An observational retrospective study was conducted in a third level hospital from 26 March to 5 May. Inclusion criteria were: hospitalised patients diagnosed with COVID-19 pneumonia and treated with baricitinib. Data collected were: age, gender, comorbidities, severe pneumonia diagnosis, ferritin and interleukin 6 (IL-6) prior to the beginning of treatment with baricitinib, standard of care according to the hospital's protocol, concomitant treatment with anakinra, duration of treatment with baricitinib, average hospital stay (AHS), deaths and hospital discharges. The data were collected from the electronic medical records and the hospital's management department. Results 171 patients treated with baricitinib were included, with an average age of 69.5 (34-96) years. 71.3% (122) were men. 87.1% (149) had comorbidities and 73.1% (125) were diagnosed with a severe pneumonia, with 25% of them dying (31). Median duration of treatment with baricitinib was 5 days (1- 12). AHS for the baricitinib group was 14.60 (3-47) days, and AHS for the whole sample of patients diagnosed with COVID- 19 pneumonia was 17.2 days. 23.4% (40) of patients had high levels of ferritin (>2500 UI/L). Among them, 87.5% (35) were discharged and 12.5% (5) died. IL-6 levels were high (>40 U/ L) in 29.8% (51) of patients, <40 U/L in 37.4% (64) and not measured in 32.7% (56). In the group with high IL-6 levels, 70.6% (36) were discharged and 29.4% (15) died. Among those with normal levels of IL-6, 93.8% (60) were discharged and 6.3% (4) died. 84.2% (144) of baricitinib patients were also treated with the SoC. During the hospital stay, 31.0% (53) of patients were treated with anakinra and baricitinib, 83.0% (44) were discharged and 17.0% (9) died. Global mortality of the whole sample of patients diagnosed with COVID-19 pneumonia was 18.1% (31). Conclusion and relevance AHS for baricitinib patients was shorter than for the whole sample of COVID-19 patients. The percentage of patients with high levels of IL-6 was superior to that of patients with high ferritin, with mortality greater in patients with IL-6 >40 UI/L. Hence IL-6 level appears to be a better prognostic factor of mortality than ferritin. This could also be related to a greater patient's immune response. Regarding treatment effectiveness, mortality of patients who were treated with SoC plus baricitinib was similar to that of patients treated with anakinra plus baricitinib.

14.
Hipertens Riesgo Vasc ; 38(3): 148-150, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1131314

ABSTRACT

Although SARS-CoV-2 mainly affects the respiratory system, its impact on other systems is becoming increasingly evident. Cardiovascular involvement is highly significant in the form of acute myocardial damage (AMD) and thromboembolic complications due to the hypercoagulable state produced by this infection. This clinical case presents the coexistence of several cardiovascular complications in a young patient, with no previous disease and recent COVID-19 infection. It also highlights the need for screening for cardiovascular complications by imaging techniques due to the increase in their incidence.


Subject(s)
COVID-19/complications , Heart Diseases/etiology , Heart Ventricles , Myocarditis/etiology , Thrombosis/etiology , Adult , Humans , Male
15.
International Journal of Sport and Exercise Psychology ; : 1-15, 2021.
Article in English | Taylor & Francis | ID: covidwho-1059055
17.
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao ; 2020(E36):295-308, 2020.
Article in Spanish | ProQuest Central | ID: covidwho-907641

ABSTRACT

This work focuses on the situation of the tourism sector in Colombia and presents a cross-sectional qualitative approach and a propositional nature. Its objective is that through the situations or problems that tourism goes through, companies can monitor opportunities to develop strategies and skills that allow tourism to recover its income as soon as its operations are reactivated, answering many questions that arise due to that companies were not prepared for this situation. For this reason, it is very important to implement digital media that facilitate adaptation in order to remain competitive in the market. © 2020, Associacao Iberica de Sistemas e Tecnologias de Informacao. All rights reserved.

18.
Rev Esp Salud Publica ; 94, 2020.
Article in English | PubMed | ID: covidwho-896228

ABSTRACT

OBJECTIVE: The health crisis caused by COVID-19 required the prompt launch of research in order to generate scientific evidence pertaining to the new disease oriented to control its devastating effects and continuous spread. Therefore, it was essential to adapt the work flow of Research Ethics Committees, to prioritize and to accelerate the evaluation of projects related to this disease. METHODS: This work analyses the evaluation conducted by our Regional Ethics Committees during the initial period of the health emergency (between 13th March and 28th May 2020). RESULTS: 81 research projects were evaluated, 73 of them of regional scope (62 single-centre), 4 national and 4 international. 57 projects obtained a favourable opinion, 4 were withdrawn by the sponsors, 6 did not require ethics approval and 14 did not respond to the clarifications requested up to the date of the study's closure. CONCLUSIONS: The most important research procedures to be analysed in this context are those related to the methodology and informed consent process. It is also essential to address aspects related to the privacy of personal data, and to take into account the workload of the researchers. As an improvement proposal, we think that greater collaboration between the different research teams should be encourage to obtain more robust results.

19.
Actualidad Juridica Iberoamericana ; - (12):108-117, 2020.
Article in Spanish | Scopus | ID: covidwho-824297

ABSTRACT

The pandemic caused by the 2019-nCoV coronavirus has determined the publication of a Royal Decree establishing the state of alarm that has altered the management of health activity and the application of health legislation in its normal parameters, establishing said management under the designated authority, and as an extreme measure the isolation of affected people in hospitals or in their own homes, together with the confinement of the rest of the population in order to stop the spread of said pandemic in our country. © 2020 Ibero-American Law Institute. All rights reserved.

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