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1.
Ear Hear ; 2022 Jul 14.
Article in English | MEDLINE | ID: covidwho-1931919

ABSTRACT

OBJECTIVES: To report the direct and indirect impact of coronavirus disease 2019 pandemic on the Universal Newborn Hearing Screening program of our institution (Azienda Ospedaliero Universitaria di Sassari). DESIGN: Monocentric retrospective study whose target population included all the newborns born in or referred to our hospital in 2019 and 2020. RESULTS: There is no statistically significant difference in time to retest or loss to follow-up rate between the 2 years considered (2019 to 2020). Referral rate is not higher for newborns born to severe acute respiratory syndrome coronavirus 2 polymerase chain reaction positive mothers. CONCLUSIONS: In relation to the analyzed variables, coronavirus disease 2019 seems to have a limited impact on our screening program. Severe acute respiratory syndrome coronavirus 2 did not behave as an audiological risk factor in our series.

2.
J Infect Dev Ctries ; 15(11): 1640-1645, 2021 11 30.
Article in English | MEDLINE | ID: covidwho-1572709

ABSTRACT

INTRODUCTION: To analyze the virus spread among Sassari Hospital staff in the first Covid-19 wave and the impact of the Swab Team, a multidisciplinary task force entitled of nasopharyngeal swab collection and testing. METHODOLOGY: Nasopharyngeal swabs from HCWs between March 6 and May 28 2020 are evaluated. RESULTS: 4919 SARS-CoV-2 tests were performed on 3521 operators. Nurses and doctors are the categories at highest risk. After the Swab Team institution, the average number of swabs raised from 47/day to 86/day (p = 0.007). Positive samples decreased from 18.6% to 1.7% (p < 0.0001). CONCLUSIONS: The Swab Team is effective in increasing the cases tested and in reducing the reporting time. Procedure standardization reduces the risk for all the subjects involved (no transmission among swab team members, nor during the sample collection).


Subject(s)
COVID-19/prevention & control , Medical Staff, Hospital , Occupational Diseases/prevention & control , Patient Care Team , SARS-CoV-2 , Specimen Handling , Adult , COVID-19/diagnosis , COVID-19/epidemiology , Female , Humans , Italy/epidemiology , Male , Middle Aged , Pandemics , Retrospective Studies
3.
J Vestib Res ; 31(5): 381-387, 2021.
Article in English | MEDLINE | ID: covidwho-1081662

ABSTRACT

BACKGROUND: since the beginning of COVID-19 outbreak a growing number of symptoms and deficits associated with the new pathology have emerged, among them cochlear damage in otherwise asymptomatic COVID-19 patients has been described. OBJECTIVE: to investigate general and audiovestibular symptoms and sequelae in healed patients, and to seek for any sign of residual or permanent hearing or vestibular loss. METHODS: we reviewed the data coming from 48 Covid-19 patients whose nasopharyngeal swabs have turned negative, all employed at our facility, that opted in for a free screening of audiovestibular symptoms offered by our hospital after the aforementioned report was published. The screening included a tonal pure tone audiometry, a vHIT and SHIMP test, as well as a survey including known symptoms and audiovestibular symptoms. RESULTS: general symptoms as reported by our patients largely reflect what reported by others in the literature. 4 (8.3%) patients reported hearing loss, 2 (4.2%) tinnitus, 4 dizziness (8.3%), 1 spinning vertigo (2%), 1 dynamic imbalance (2%), 3 static imbalance (6.3%). Most audiovestibular symptoms have regressed. Thresholds at pure tone audiometry and vHIT gain were within normality range in all post-Covid-19 patients. CONCLUSIONS: even if some patients suffer from audiovestibular symptoms, these are mostly transitory and there is no clear evidence of clinically relevant persistent cochlear or vestibular damage after recovery.


Subject(s)
COVID-19 , Hearing Loss, Sensorineural , Audiometry, Pure-Tone , Humans , SARS-CoV-2 , Vertigo/diagnosis , Vertigo/etiology
4.
Infection ; 49(5): 1055-1060, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-983887

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 infection might induce a significant and sustained lymphopenia, increasing the risk of developing opportunistic infections. Mucormycosis is a rare but severe invasive fungal infection, mainly described in immunocompromised patients. The first case of a patient diagnosed with coronavirus disease (COVID-19) who developed a pulmonary mucormycosis with extensive cavitary lesions is here reported. This case highlights how this new coronavirus might impair the immune response, exposing patients to higher risk of developing opportunistic infections and leading to worse outcomes.


Subject(s)
COVID-19 , Invasive Fungal Infections , Mucormycosis , Opportunistic Infections , Humans , Mucormycosis/diagnosis , SARS-CoV-2
5.
J Otolaryngol Head Neck Surg ; 49(1): 56, 2020 Aug 06.
Article in English | MEDLINE | ID: covidwho-696850

ABSTRACT

BACKGROUND: The lack of objective data makes it difficult to establish the prognostic value of chemosensitive disorders in coronavirus disease 2019 (COVID-19) patients. We aimed to prospectively monitor patients diagnosed with COVID-19 to see if the severity of olfactory and gustatory dysfunction associates with subsequent disease severity. METHODS: Multicentre prospective study that recruited 106 COVID-19 subjects at diagnosis. Chemosensitive functions were assessed with psychophysical tests within 4 days of clinical onset, at 10 and 20 days. Daily body temperature and oxygen saturation were recorded as markers of disease severity alongside need for hospitalisation. The correlation between olfactory and gustatory scores and disease severity was assessed with linear regression analysis. RESULTS: At T0, 71 patients (67%) presented with olfactory dysfunction while gustatory impairment was detected in 76 cases (65.6%). Chemosensitive disorders gradually improved over the observation period. No significant correlations were found between T0 chemosensitive scores and final disease severity. The correlation between olfactory scores and fever proved significant at T2 (p = 0.05), while the relationship with gustatory scores was significant at T1 (p = 0.01) and T2 (p <  0.001), however neither was clinically relevant. The correlation between chemosensitive scores and oxygen saturation was significant only for taste at T2 (p <  0.001). Logistic regression analysis found significant correlations between olfactory impairment severity and need for hospitalization at T2 (OR 3.750, p = 0.005). CONCLUSIONS: Initial objective olfactory and gustatory scores do not seem to have a significant prognostic value in predicting the severity of the COVID-19 course; however, persistence of olfactory dysfunction at 20 days, associated with a more severe course. Unfortunately, olfactory and gustatory dysfunction do not seem to hold prognostic value at the time of initial diagnosis.


Subject(s)
Betacoronavirus , Coronavirus Infections/complications , Coronavirus Infections/diagnosis , Olfaction Disorders/diagnosis , Pneumonia, Viral/complications , Pneumonia, Viral/diagnosis , Taste Disorders/diagnosis , Adult , COVID-19 , Coronavirus Infections/psychology , Disease Progression , Female , Hospitalization , Humans , Male , Middle Aged , Olfaction Disorders/virology , Pandemics , Pneumonia, Viral/psychology , Predictive Value of Tests , Prognosis , Prospective Studies , SARS-CoV-2 , Severity of Illness Index , Taste Disorders/virology
6.
Am J Otolaryngol ; 41(5): 102551, 2020.
Article in English | MEDLINE | ID: covidwho-525813

ABSTRACT

RT-PCR detection of SARS-CoV-2 mRNA on nasopharyngeal swab is the standard for diagnosing active Covid-19 disease in asymptomatic subjects and in symptomatic patients without the typical radiological findings. Nasopharyngeal swabbing appears a trivial procedure, still an inappropriate nasopharyngeal sampling, performed by untrained operators, can be a relevant cause of false negative findings with a clear negative impact on the effort to control the epidemic and, when PPE is not properly used, this can expose healthcare workers and patients to risks of contagion.


Subject(s)
Betacoronavirus/isolation & purification , Clinical Laboratory Techniques/methods , Coronavirus Infections/diagnosis , Nasopharynx/virology , Pneumonia, Viral/diagnosis , Specimen Handling/methods , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/instrumentation , Humans , Pandemics , SARS-CoV-2 , Specimen Handling/instrumentation
7.
Otolaryngol Head Neck Surg ; 163(3): 459-461, 2020 09.
Article in English | MEDLINE | ID: covidwho-378045

ABSTRACT

Reverse transcriptase polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 mRNA on nasopharyngeal swab is the standard for diagnosing active COVID-19 disease in asymptomatic cases and in symptomatic patients without the typical radiologic findings. For the present COVID-19 outbreak in Italy, we describe 4 symptomatic patients with negative RT-PCR results at the first nasopharyngeal swab, which became positive when collected a few hours later by an otolaryngologist. All the patients showed nasal obstruction. The present report suggests that inadequate nasopharyngeal sampling performed by untrained operators in the presence of nasal obstruction can be a relevant case of false-negative findings at RT-PCR, with a clear negative impact on the efforts to contain the current outbreak.


Subject(s)
Clinical Competence , Coronavirus Infections/diagnosis , Nasopharynx/virology , Pneumonia, Viral/diagnosis , Specimen Handling/methods , Aged , Betacoronavirus , COVID-19 , False Negative Reactions , Female , Humans , Italy , Male , Middle Aged , Nasal Obstruction/complications , Pandemics , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2
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