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1.
BMC Psychiatry ; 22(1):781, 2022.
Article in English | PubMed | ID: covidwho-2162326

ABSTRACT

BACKGROUND: The development of new aetiological premises, such as the microbiota-gut-brain axis theory, evidences the influence of dietary and nutritional patterns on mental health, affecting the patient's quality of life in terms of physical and cardiovascular health. The aim was to determine the impact of a nutritional programme focused on increasing the intake of prebiotic and probiotic food on cardio-metabolic status in individuals with schizophrenia spectrum disorders in the contextual setting of the SARS-CoV-2 era. METHODS: A randomised clinical trial (two-arm, double-blind, balanced-block, six-month intervention) was conducted in a group of 50 individuals diagnosed with schizophrenia spectrum disorder during the SARS-CoV-2 confinement period. The control group received conventional dietary counselling on an individual basis. In the intervention group, an individual nutritional education programme with a high content of prebiotics and probiotics (dairy and fermented foods, green leafy vegetables, high-fibre fruit, whole grains, etc.) was established. Data on cardiovascular status were collected at baseline, three and six months. In addition, anthropometric parameters were analysed monthly. RESULTS: Forty-four subjects completed follow-up and were analysed. Statistical differences (p < 0.05) were found in all anthropometric variables at baseline and six months of intervention. A 27.4% reduction in the prevalence of metabolic syndrome risk factors in all its components was evidenced, leading to a clinically significant improvement (decrease in cardiovascular risk) in the intervention group at six months. CONCLUSIONS: The development of a nutritional programme focused on increasing the dietary content of prebiotics and probiotics effectively improves the cardio-metabolic profile in schizophrenia spectrum disorders. Therefore, nursing assumes an essential role in the effectiveness of dietary interventions through nutritional education and the promotion of healthy lifestyles. Likewise, nursing acquires a relevant role in interdisciplinary coordination in confinement contexts. TRIAL REGISTRATION: The study protocol complied with the Declaration of Helsinki for medical studies;the study received ethical approval from referral Research Ethics Committee in November 2019 (reg. no. 468) and retrospectively registered in clinicaltrials.gov (NCT04366401. First Submitted: 28th April 2020;First Registration: 25th June 2020).

2.
Best Pract Res Clin Haematol ; 35(3):101386, 2022.
Article in English | PubMed | ID: covidwho-2158485

ABSTRACT

Reports of racial and ethnic disparities regarding both rates of infection of the SARS-CoV-2 virus and morbidity of the coronavirus disease-19 (COVID-19) contain profound differences depending on the population. Our previous study has shown that patients with COVID-19 who developed hypertriglyceridemia during hospitalization have a 2.3 times higher mortality rate. However, whether the correlation between hypertriglyceridemia and mortality has disparity among different racial and ethnic groups is unknown. In this study, we investigated the impact of race/ethnicity on the correlation between hypertriglyceridemia and mortality in hospitalized patients with COVID-19. De-identified information from 904 hospitalized patients diagnosed with COVID-19 between March 2020 and June 2021 were extracted from the Medical College of Wisconsin Clinical Data Warehouse. A multivariable regression analysis suggested that the Asians and non-White Hispanics had 4 or 3.9 times higher mortality rate, respectively, after adjusting for age, morbid obesity (BMI ≥40), and gender. The hypertriglyceridemia (≥150 mg/dL) was associated with higher mortality, after adjusting for age, gender, and morbid obesity. The baseline hypertriglyceridemia occurrence had relevantly more consistent percentages among all racial/ethnic groups. However, non-White Hispanic and Asian patients had the highest frequencies of peak hypertriglyceridemia occurrence during hospitalization. The peak hypertriglyceridemia developed during hospitalization correlates with the incidence of thrombosis after adjusting for morbid obesity, age, and sex. In summary, in this retrospective study of 904 hospitalized COVID-19 patients, Asians and non-White Hispanics had a greater likelihood of developing hypertriglyceridemia during hospitalization and mortality than White patients.

3.
Universidad y Sociedad ; 14(S5):283-292, 2022.
Article in Spanish | Scopus | ID: covidwho-2124943

ABSTRACT

The aim of this work is to characterize the event organization service of the Amazonian city of Puyo in Ecuador, analyze its demand, considering the conditions that are currently required for the provision of this service, and draw alternatives in terms of public and health policies. that the needs of customers are adjusted in the new normality. A documentary descriptive cut methodology was used. The research methods of the study are mixed treatment which consists of the systematic integration of quantitative and qualitative methods in a single study in order to obtain a more complete “impression” of the phenomenon. It is concluded that the city of Puyo has establishments dedicated to the provision of the organization of formal and informal events and a significant percentage of citizens attend programs of all kinds annually. As a strategy, it is highlighted that from public policy the local server is valued, since for several important jobs providers from other provinces are used, and the local provider is ignored, as well as the regulation of the activities that these organizations offer. © 2022, University of Cienfuegos, Carlos Rafael Rodriguez. All rights reserved.

4.
Dermatology Online Journal ; 28(5) (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2144661
5.
Multiple Sclerosis Journal ; 28(3 Supplement):653-654, 2022.
Article in English | EMBASE | ID: covidwho-2138851

ABSTRACT

Background: Vaccination during immunosuppression can result in impaired vaccine responses. In highly active patients requiring a rapid treatment initiation, vaccination can delay treatment onset. Natalizumab (NTZ) is a high-efficacy agent with potential low interference in vaccination responses, and could be a bridge therapy to achieve an adequate immunisation before starting another treatment. Objective(s): To assess the safety and immunogenicity of inactivated vaccines administered during NTZ treatment. Method(s): Self-controlled study based on an ongoing prospective cohort that included adult MS patients with complete immunisation schedules for hepatitis B vaccine (HBV), hepatitis A vaccine (HAV) and/or COVID-19 vaccine during NTZ treatment, between September 2016 and February 2022. Seroprotection rates were calculated for each vaccine. Demographic, clinical and radiological characteristics were collected the year before (pre-exposure period) and after vaccination (post-exposure period). Differences in annual relapse rate (ARR), contrast-enhancing lesions (CELs), new T2 lesions (NewT2) and changes in Expanded Disability Status Scale (EDSS) during pre and post exposure period were evaluated. Patients were also categorised according to time on NTZ exposure before vaccination (long-term exposure >1 year and short-exposure <=1 year) and according to JCV status. Result(s): From 248 patients treated with NTZ, 60 were vaccinated during NTZ exposure: 44 (73%) women, mean age 45 years, mean disease duration 17 (SD 8.7) years. Thirty (50%) patients bridged to anti-CD20 after immunisation, because of high titers of JC virus. Between the pre and post-exposure period, we observed a decrease in both the AAR (0.28 vs 0.01;p=0.004) and newT2 (0.8 vs 0.02;p=0.1) and no changes in disability accumulation (EDSS 3.5 vs 3.5 p=0.6). The global seroprotection rate was 93% (91.6% (IC95% 73-99) for HAV (n=24), 92.6% (IC95% 76- 99) for HBV (n=27), 100% (IC95% 84-100) for Covid-19 (n=23)). No differences were seen between short and long term NTZ exposure or between JCV positive or negative patients, in terms of safety and immunogenicity. Conclusion(s): Immunisation with inactivated vaccines during NTZ treatment is safe and effective, both for short and long term NTZ exposure. In highly active PwMS who need immunisation, NTZ could be a valuable strategy to avoid delays in the onset of high-efficacy DMD, even in JC virus positive in which it could be used as a bridge therapy strategy.

6.
Urban Stud ; 2022.
Article in English | PubMed Central | ID: covidwho-2138514

ABSTRACT

This paper examines the Self-Managed Housing Program (Law 341), in Buenos Aires, Argentina. This programme created 45 cooperative housing units between 2001 and 2020 in consolidated urban areas currently undergoing renewal processes. It investigates the conditions that the programme has generated for the realisation of the ‘right to the city’ in the context of ‘actually existing neoliberalism’ and challenges posed by the COVID-19 pandemic. This paper analyses the origins of the process and mode of cooperative housing production, including tangible and intangible aspects and capacities acquired by the inhabitants. This study used a mixed quantitative and qualitative methodology. The analytical strategy focused on defining a set of dimensions that characterised the self-managed mode of production, conditions of social and urban insertion in the case studied and participants’ perceptions of the influence of material characteristics and organisational arrangements during the pandemic. This paper contributes to our understanding of the socio-economic dynamics in the production of urban space by elucidating the role of the state and specific tensions arising due to bottom-up policies, specific forms adopted by urban experiences of resistance and their contribution in the promotion of concrete conditions of urban life. Finally, this paper characterises an emergent self-managed urbanism and reflects on its possibilities of dialogue with the construction of alternative local policies that challenge growing territorial inequality caused by the subordination of policies to real estate financialisation and its deepening tendencies in the pandemic context.

8.
Pharmaceuticals ; 15(12):1448, 2022.
Article in English | MDPI | ID: covidwho-2123786

ABSTRACT

Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other coronavirus outbreaks that may occur in the future. Here we report the identification and characterization of RNA-binding compounds that inhibit SARS-CoV-2 replication. The compounds were detected by screening a small library of antiviral compounds previously shown to bind HIV-1 or HCV RNA elements with a live-virus cellular assay detecting inhibition of SARS-CoV-2 replication. These experiments allowed detection of eight compounds with promising anti-SARS-CoV-2 activity in the sub-micromolar to micromolar range and wide selectivity indexes. Examination of the mechanism of action of three selected hit compounds excluded action on the entry or egress stages of the virus replication cycle and confirmed recognition by two of the molecules of conserved RNA elements of the SARS-CoV-2 genome, including the highly conserved S2m hairpin located in the 3'-untranslated region of the virus. While further studies are needed to clarify the mechanism of action responsible for antiviral activity, these results facilitate the discovery of RNA-targeted antivirals and provide new chemical scaffolds for developing therapeutic agents against coronaviruses.

9.
Geographia-Uff ; 24(53), 2022.
Article in Spanish | Web of Science | ID: covidwho-2121698

ABSTRACT

This article recovers as an object of analysis one of the constitutive devices of the SELVIHP (Latin American Secretariat of Housing and Popular Habitat): the Latin American School of Habitat Self-Management (ELAH). Specifically, it seeks to analyze ELAH in terms of a strategy promoted by the Secretariat for the meeting and production of knowledge and knowledge, and as a regional integration tactic between popular organizations and resistance built from a self-managed perspective of habitat production. Based on a qualitative approach methodology, we seek to reflect on the characteristics that the School imprints on the mobility of ideas and practices that are articulated between the socio-territorial movements that are members of the SELVIHP on a regional scale, the role that this device plays in the production of situated knowledge-within the SELVIHP strategy and as an articulation of its movements- and, in particular, the strategies used to sustain the space during the context of the COVID19 pandemic in terms of appropriation of the territory of virtuality.

10.
Tecnologia En Marcha ; 35:205-213, 2022.
Article in Spanish | Web of Science | ID: covidwho-2121178

ABSTRACT

The constant increase in the number of tourists traveling around the world, has led governments in each country to work permanently and more specifically on tourism, guaranteeing better management in the influx of visitors at places, in order to control the use of natural resources, and attend the needs of inhabitants, as the imminent shortage of vital elements for survival is a subject even more delicate and urgency to deal with. As a part of the projects to eradicate this problem and in the middle of a pandemic several international organizations had provided lots of alternatives that must be taken into count in the development plans for a better public policy. In the points to deal with, we have tourism carrying overcapacity at interest places since derivate the quick increase of population in the world and the increase of travel, the limit of people that must be in the same space has been exceeded and with that the increase of problems at a local level un touristic destinations. Because of the current situation of COVID-19, tourism was one of the most affected. To guarantee the development and resurgence of post-pandemic tourism, it needs to lead to good planning based on the new passengers' and locals' requirements on the subject of biosecurity and trust in each touristic destination, in addition to bet for sustainable tourism.

12.
Jimenez, S.; Miro, O.; Alquezar-Arbe, A.; Pinera, P.; Jacob, J.; Llorens, P.; Garcia-Lamberechts, E. J.; Martin-Sanchez, F. J.; Del Castillo, J. G.; Burillo-Putze, G.; Martin, A.; Grima, M. L. L.; Gomez, M. A. J.; Millan, J.; Lazaro, L. S.; Espinosa, B.; Paya, A. B.; Noceda, J.; Cano, M. J. C.; Serra, R. S.; Bayarri, M. J. F.; Suarez, F. J. S.; Tejera, M. G.; Porrino, J. M. M.; Maestre, M. R.; Melendez, N.; Albero, P. B.; Escolano, E. R.; Manrique, K. J. A.; Del Rio, R.; Mestre, A. M.; Garcia, C. P.; Amador, P. S.; Aznar, J. V. B.; Lopez, J. L. R.; Ponce, M. C.; Belda, M. B. R.; Fernandez, E. D.; Valero, C. C.; Gimenez, L. M.; Gomez, A. P.; Bellver, E. G.; Rizzi, M.; Suarez, C. C.; Cardozo, C.; Llopis-Roca, F.; Roset-Rigat, A.; Boter, N. R.; Rovira, M. A.; Tost, J.; Tejedo, A. A.; Lorenzo, I. C.; Palau-Vendrell, A.; Tur, R. G.; Munoz, M. A.; Ferrer, E. S.; Garcia, L. L.; Mojarro, E. M.; Jimenez, B. S. A.; Huerta, A.; Fragiel, M.; Quiros, A. M.; Del Val, E. M.; Del Arco Galan, C.; Jimenez, G. F.; Garate, R. T.; Borrego, B. V.; Arias, A. S.; Cabezas, V. P.; Aviles, R. M.; Gonzalez, S. R.; Ramos, M. E. B.; Alonso, M. A.; Martin-Borregon Bendito, P.; Aguado, A. C.; Martin, S. G.; Somohano, F. V.; Lopez-Laguna, N.; Panadero, R. P.; De Frutos, M. F.; Robledo, F. D.; Madrigal, A. A.; Castaneda, A. B.; Diez, M. P. L.; Izquierdo, R. L.; Ruperez, I. G.; Chaib, F. B.; Abdelkader, I. S. M.; Rafael, I. R.; Tornero, A. P.; Soriano, J. J. C.; Perez, E. M.; Urbano, C. A.; Soto, A. B. G.; Garcia, J. P.; De Simon Almela, A. F.; Lopez, R. C.; Diaz, J. J. L.; Vera, M. T. M.; Calveiro, R. R.; Lucas-Imbernon, F. J.; Moreno, M. R.; Martinez, F. G.; Olmeda, D. M.; Juarez, R.; Hernandez, P. E.; Rodriguez, M. E.; Monzo, J. P.; Gonzalez, N. C.; Herrera, D. M. V.; Bautista, B. M. M.; Alvarez, L. A.; Hevia, M. D. R. C.; Motto, E. Q.; Garcia, N. T.; Diaz, N. M.; Mercader, M. P. O.; De Lobera, N. R.; Amez, J. M. F.; Entrala, B. A..
Emergencias ; 34(5):369-376, 2022.
Article in Spanish | EMBASE | ID: covidwho-2111934

ABSTRACT

Objectives. To define quality of care indicators and care process standards for treating patients with COVID-19 in hospital emergency departments (EDs), to determine the level of adherence to standards during the first wave in 2020, and to detect factors associated with different levels of adherence. Methods. We selected care indicators and standards by applying the Delphi method. We then analyzed the level of adherence in the SIESTA cohort (registered by the Spanish Investigators in Emergency Situations Team). This cohort was comprised of patients with COVID-19 treated in 62 Spanish hospitals in March and April 2020. Adherence was compared according to pandemic-related ED caseload pressure, time periods during the wave (earlier and later), and age groups. Results. Fourteen quality indicators were identified. Three were adhered to in less than 50% of the patients. Polymerase chain reaction testing for SARS-CoV-2 infection was the indicator most often disregarded, in 29% of patients when the caseload was high vs 40% at other times (P <.001) and in 30% of patients in the later period vs 37% in the earlier period (P =.04). Adherence to the following indicators was better in the later part of the wave: Monitoring of oxygen saturation (100% vs 99%, P =.035), electrocardiogram monitoring in patients treated with hydroxychloroquine (87% vs 65%, P <.001), and avoiding of lopinavir/ritonavir treatment in patients with diarrhea (79% vs 53%, P <.001). No differences related to age groups were found. Conclusions. Adherence to certain quality indicators deteriorated during ED treatment of patients with COVID-19 during the first wave of the pandemic. Pressure from high caseloads may have exacerbated this deterioration. A learning effect led to improvement. No differences related to patient age were detected. Copyright © 2022, Saned. All rights reserved.

13.
Tour Manag Perspect ; 44: 101037, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2106060

ABSTRACT

This paper explores global differences in travel risk perception based on i) attitudes towards travel abroad, and ii) the time required to plan travel. Baseline data from 2019 is compared with data from 2020, the first year of the COVID-19 pandemic. A methodology based on Big Data is developed through the Skyscanner metasearch engine, working with 20,756 million flight searches and 1979 million flight picks worldwide. We conduct an exploratory analysis by region, followed by a cluster analysis of 45 countries. We argue that the findings respond to uncertainty avoidance, with clear differences between Europe, America and Asia-Pacific. This knowledge has marketing implications for tourist destinations in terms of what marketing messages to convey and the best time to introduce marketing campaigns for each country or group of countries, so that the opportunity for reactivation of tourism is maximised.

14.
European journal of public health ; 32(Suppl 3), 2022.
Article in English | EuropePMC | ID: covidwho-2102723

ABSTRACT

Background A better understanding of possible future developments is essential for policy makers to anticipate and influence these trends. Public health foresight studies (PHFS) are tools to support this. The current health crisis makes clear that PHFS are necessary more than ever to target possible future impacts resulting from SARS-COV-2 induced changes in e.g. regular health care services, lifestyle and socio-economic developments. To support European countries in doing their own foresight studies, PHIRI aims to strengthen foresight capacity. Methods PHIRI follows a 4-step approach: 1. Making an inventory of current PHFS capacities and capacity needs across European countries using desk research and an online survey;2. Providing PHFS capacity building via a training course and workshops;3. Supporting the development of public health scenarios for the short term (0-5 years) and longer-term (5-20 years);4. Supporting the identification of promising policy strategies, using policy dialogues. Results The online survey was completed by participants of 21 countries and shed light on existing national PHFS and needs for capacity building. It also provided a basis for the development of a professional network on PHFS within the project. A PHFS capacity building course was developed, including videos posted on the PHIRI website and a template structuring the different foresight elements. Around 15 researchers undertook their own PHFS, covering a wide range of public health topics, using the material provided during the course. In addition, a compact guide was developed and provided, explaining the different foresight elements. Based on these studies, common challenges and promising policies are identified. Conclusions Foresight in public health is gaining more and more interest, especially now in these times of crisis. PHIRI provides more insight in the wider public health impacts of the SARS-CoV-2 pandemic and in translating this into policy options.

15.
International Conference on Production and Operations Management, POMS 2021 ; 391:541-549, 2022.
Article in English | Scopus | ID: covidwho-2094336

ABSTRACT

The demand for transport without agglomerations in many cities has increased lately to avoid infections of COVID19. Therefore, this research is focused on a mathematical model for a cycling network minimizing the distances of cycle paths and maximizing the factors that are more important for citizens of Lima using linear programming and analytics. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

16.
International Conference on Production and Operations Management, POMS 2021 ; 391:463-473, 2022.
Article in English | Scopus | ID: covidwho-2094333

ABSTRACT

Research demonstrates that the large-scale access and analysis to data can help cities plan for more inclusive and efficient growth. However, policy makers and researchers around the world still lack sufficient access to granular and dynamic sources of data – a challenge that has come to prominence as cities attempt to respond to the local impacts of the COVID-19 pandemic. To address this challenge, this paper presents UrbanPy, a new open-source library that makes the automated collection, processing, and visualization of spatial urban data simple and consistent for cities. UrbanPy, first developed as a tool to help Latin American cities design rapid responses to COVID-19, presents six innovative capabilities for researchers and practitioners focused on data collection, processing and visualization. To illustrate the potential applications of UrbanPy, this paper presents a case study from Lima, Peru, where the library helped municipal leaders with their COVID-19 response by identifying vulnerable populations, creating food accessibility metrics, and optimizing the location of food supply facilities. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

19.
Universidad y Sociedad ; 14(5):412-426, 2022.
Article in Spanish | Scopus | ID: covidwho-2092281

ABSTRACT

As an imperative and strategic response to the health emergency caused by COVID-19, the vast majority of universities implemented various alternatives for the virtualization of academic processes. It is based on a comparative methodological approach of an exploratory nature between students of the Education Area of the Indo-American Technological University (Ecuador) and the Autonomous University of the State of Hidalgo (Mexico), between the months of May and June of 2021. With the intention to analyze the socio-educational factors and their influence on the teaching and learning processes, based on knowing the conditions of use of the technology, the didactic organization for the support of the teaching and learning process and the personal factors that affected their learning during the lockdown. Among the most relevant results in both contexts, situations related to access and limited speed of the internet, the non-availability of suitable technological resources, the increase in the time dedicated to academic activities, the interference caused by the conditions of the home and family life, changes in sleep schedule, health-related effects. These findings show how the abrupt transition from the face-to-face to the virtual modality has altered the academic life of the students, criteria that must be considered for decision-making in the context of the institutions involved in the study, since the effects of the virus still persist and viable alternatives aligned with the immediate social sphere must be foreseen. © 2022, University of Cienfuegos, Carlos Rafael Rodriguez. All rights reserved.

20.
Etic Net-Revista Cientifica Electronica De Educacion Y Comunicacion En La Sociedad Del Conocimiento ; 22(1):131-154, 2022.
Article in Spanish | Web of Science | ID: covidwho-2091571

ABSTRACT

With the emergence of COVID-19, the educational community has needed to incorporate new methodological approaches to face the new forms of teaching required by the pandemic scenario. One of these approaches is gamification, which implies introducing educational content in a playful way. In Higher Education, gamification must have a level of complexity that the most popular programs can't provide. Mentimeter is a program that is based on an online audience software and allows a wide range of questions and questionnaires significantly suitable for the educational level analysed. It facilitates the active learning of students, increasing their attention, commitment and motivation, thus allowing the student to be the centre of the teaching-learning process. This article analyses the use of Mentimeter in a wide range of classes of various university disciplines and reviews its theoretical and practical potential for the improvement of teaching-learning processes, the acquisition of knowledge by students and the use of new teaching methodologies.

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