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1.
Scientific reports ; 12(1):14752, 2022.
Article in English | MEDLINE | ID: covidwho-2008312

ABSTRACT

Peru was the country with the highest COVID-19 case fatality rate worldwide during second wave of infection, with dentists and pre-professional students being susceptible to infection due to clinical procedures they perform. This situation could have generated some kind of psychological disorder within this group. Therefore, the present study aimed to assess how COVID-19 pandemic affected this population group during second wave, in relation to depression, anxiety and stress. This observational and cross-sectional study in 368 Peruvian dentists (186 students and 182 professionals), was carried out during August to November 2021. The DASS-21 Scale was used to diagnose depression, anxiety and stress. For the statistical analysis, Pearson's chi-square test was used, in addition to a logit model using odds ratio (OR) to evaluate depression, anxiety and stress with the following factors: gender, age group, marital status, monthly family income, children, academic level, history of COVID-19, COVID-19 symptomatology, close relative with COVID-19, living with vulnerable people and work dedication. In addition, predictive models were constructed considering all possible significant causes. A significance level of p < 0.05 was considered. Dental students and professionals presented significant differences in levels of depression, anxiety and stress (p < 0.001, p = 0.022, p = 0.001;respectively). Male students were 56% less likely to develop stress (OR 0.44;CI 0.22-0.85) compared to females;while those unmarried were 81% less likely to develop stress (OR 0.19;CI 0.04-0.85). Likewise, those with children were 83% less likely to develop stress (OR 0.17;CI 0.06-0.52) and 65% less likely to develop depression (OR 0.35;CI 0.15-0.80). In addition, COVID-19 asymptomatics were 60% less likely to develop depression (OR 0.40;CI 0.17-0.92). However, having relatives with COVID-19 caused almost three times the probability of developing depression (OR 2.96;CI 1.29-6.79) and twice the probability of developing stress (OR 2.49;CI 1.07-5.78). As for dental professionals, it was noticed that those unmarried had almost three times the probability of developing stress (OR 2.93;CI 1.38-6.23);while those who only worked had twice the probability of developing stress (OR 2.37;CI 1.17-4.78). Dental students had a higher prevalence of depression, anxiety and stress. In addition, having children and being asymptomatic were protective predictors for depression, while being male, unmarried and having children were protective predictors for stress. However, having a relative with COVID-19 was a risk predictor for depression and stress. In professionals, only working and being unmarried were risk predictors for stress.

2.
Neurology ; 98(18 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1925439

ABSTRACT

Objective: To evaluate clinical, laboratory, and epidemiological features of acute neuroinflammatory disorders (ANIDs) that followed the 2016 Zika epidemic in Colombia. Background: The outbreak of Zika virus infection in Colombia in 2015-2016, produced an increased incidence of Guillain-Barré Syndrome (GBS) and other ANID cases. The Neuroviruses Emerging in the Americas Study (NEAS) network was established in 2016 as a multicenter-based observatory of ANIDs to investigate the role of emerging pathogens in neuroinflammatory diseases. Design/Methods: NEAS serves as a multi-center study based on 13 hospitals in 7 cities in Colombia which study all newly diagnosed patients who fulfill established criteria for GBS, encephalitis, myelitis, meningoencephalitis, or cranial nerve disorders as part of an observational cohort. We analyzed the clinical and epidemiological features of all cases evaluated between January 2016 and September 2021. Results: An observational cohort of 825 patients with ANIDs were recruited during the study period. 58.8% of cases were male with a median age of 43 (IQR 25-58) years. The most frequent ANIDs were GBS (46.1%) and facial nerve palsy (28.7%). The diagnosis of encephalitis (9.5%), myelitis (6.5%), and optic neuritis (5.9%) were less frequent. Patients with GBS were predominantly male (70.6%) and had a median age of 49 (IQR 32-60) years. Interestingly, there was an increase incidence of GBS in 2019. Conclusions: The outbreak of Zika in Colombia produced a marked increase in the incidence of GBS in 2016. Although cases of GBS and other ANIDs continued to emerge after the incidence of Zika infection decreased in July 2016, the recent SARS-CoV-2 pandemic has not produced any significant increase in the incidence of GBS in Colombia.

3.
Revista Espanola de Salud Publica ; 94(e202011151):e1-e7, 2020.
Article in Portuguese | GIM | ID: covidwho-1898185

ABSTRACT

Background: Nursing homes are high-risk environments for the transmission of the SARS-CoV-2 coronavirus, as they are a closed environment, with patients who present atypical manifestations of the disease, high risk of unfavorable evolution, and staff who frequently present a high mobility in relation to their jobs. On the other hand, in a pandemic situation, numerous hospitals have suffered periods of great healthcare pressure. The objective of this work was to present an experience of medicalization of a residence where almost 50% of the residents contracted the disease.

4.
60th IEEE Conference on Decision and Control (CDC) ; : 4248-4253, 2021.
Article in English | Web of Science | ID: covidwho-1868536

ABSTRACT

Antimicrobial resistance is a major threat to global health, in particular, new SARS-CoV-2 variants during the COVID-19 pandemic. Scheduling cycling therapies by targeting phenotypic states associated with specific mutations can help us to eradicate pathogenic variants. In this paper, we introduce a logistic switching model to mutation networks of collateral resistance. We found conditions for which the unstable zero-equilibrium of the logistic maps can be stabilized through a switching signal. That is, persistent populations can be eradicated through tailored switching regimes. Starting from an optimal-control formulation, the switching policies show their potential in the stabilization of the zero-equilibrium for dynamics governed by logistic maps. Simulation results show the applicability of Parrondo's Paradox to design cycling therapies against drug resistance.

5.
Revista Cubana de Medicina General Integral ; 37(Special Issue), 2021.
Article in Spanish | Scopus | ID: covidwho-1843162
6.
Archivos Venezolanos de Farmacologia y Terapeutica ; 41(1):20-25, 2022.
Article in English | EMBASE | ID: covidwho-1818551

ABSTRACT

Introduction: Oral communication is the most important skill in learning a foreign language. The conventional English teaching method that is applied at different educational levels based on grammar and writing, does not allow the development of communication skills necessary for the Covid-19 pandemic. Communication is the process through which ideas are sent and received. In this sense, the communicative approach takes on a special importance that communication is the ba-sis of the teaching-learning process. Method: The research approach was quantitative with a descriptive scope. Results. The investigation found that the oral expression strategies met 58.2% of conditions at the beginning, 37.8% presented the process level and 4.1% presented the achieved level. The strategies carried out to improve pronunciation were found at 33.7% in initial conditions, 60.2% were present at the level in the process and 6.1% at the achieved level. In the strategies for improving fluidity, 42.9% presented at the beginning level, 44.9% presented at the process level and 12.2% presented at the achieved level and while the strategies for vocabulary improvement were found at 33.7% of conditions at the beginning, 50% present the level in process and the 16.3% present the level achieved.

8.
60th IEEE Conference on Decision and Control, CDC 2021 ; 2021-December:4248-4253, 2021.
Article in English | Scopus | ID: covidwho-1746100

ABSTRACT

Antimicrobial resistance is a major threat to global health, in particular, new SARS-CoV-2 variants during the COVID-19 pandemic. Scheduling cycling therapies by targeting phenotypic states associated with specific mutations can help us to eradicate pathogenic variants. In this paper, we introduce a logistic switching model to mutation networks of collateral resistance. We found conditions for which the unstable zero-equilibrium of the logistic maps can be stabilized through a switching signal. That is, persistent populations can be eradicated through tailored switching regimes.Starting from an optimal-control formulation, the switching policies show their potential in the stabilization of the zero-equilibrium for dynamics governed by logistic maps. Simulation results show the applicability of Parrondo's Paradox to design cycling therapies against drug resistance. © 2021 IEEE.

9.
Carbon Management ; 13(1):1-16, 2022.
Article in English | Scopus | ID: covidwho-1740675

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has strongly affected economies and human lifestyles globally. The changes observed in domestic energy consumption patterns have had an impact on household greenhouse gas (GHG) emissions. Since GHG emissions inventories are only available at the country level and at annual intervals, most studies have calculated the local emission variations by extrapolating annual emissions with smaller time and territorial scale consumption data. This research presents a bottom-up method, based on the exploitation of a survey addressed to 1200 households, that provides the information to calculate directly the variation in their energy-related GHG emissions, without the need for extrapolations. This method has been applied to four medium-sized Chilean cities with serious air quality problems. Given the high correlation between atmospheric pollutants such as NOx and CO2 emissions, we estimate that before the appearance of COVID-19, per capita CO2 emissions were already high. The results show that space heating-related GHG emissions have increased moderately (between 1 and 6%), while emissions from electricity and gas consumption for non-heating uses have increased significantly (between 8 and 23%). This has harmed the household economy, highlighting the importance of considering socioeconomic aspects when assessing the impact of COVID-19 in its entirety. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

11.
Revista De La Universidad Del Zulia ; 12(35):573-584, 2021.
Article in Spanish | Web of Science | ID: covidwho-1677844

ABSTRACT

Objective: To determine the relationship of Computer Visual Syndrome with academic stress in nursing students during confinement by COVID-19. Methods: descriptive, relational, cross-sectional study;whose non-probabilistic sample was 119 nursing students from Amazonas, Peru;The survey technique was used and two instruments were applied through the Google form, the 16-item Computer Vision Syndrome Questionnaire (CVS-Q), (sensitivity and specificity is greater than 70%) and the SISCO SV academic stress questionnaire of 47 items (Aiken V concordance coefficient greater than 0.75), during the months of November to December 2020. The data were processed in the Statistical Package for the Social Sciences program version 25, from which the descriptive statistics were obtained and the nonparametric Chi Square statistical test. Conclusions: Visual Computer Syndrome is not significantly related to academic stress in nursing students during confinement by COVID-19. However, it is necessary to implement improvement measures in the teaching-learning process by increasing asynchronous hours.

12.
Revista Cubana de Educacion Medica Superior ; 35, 2021.
Article in Spanish | Scopus | ID: covidwho-1589916

ABSTRACT

Introduction: The rapid spread of the COVID-19 pandemic has become a source of concern for dental students in recent years, as long as they are exposed to an increased risk of infection due to close contact with patients. Objective: To determine the level of epidemiological, preventive and healthcare-related knowledge about COVID-19 in dental students during their last academic year from three Peruvian universities. Methods: Descriptive, analytical and cross-sectional study, whose sample consisted of 219 dental students in their last academic year from Federico Villarreal National University, Peruvian Wings University and Inca Garcilaso de la Vega University in Lima, Peru. The instrument was a questionnaire of twenty closed questions on epidemiological, preventive and healthcare knowledge about COVID-19. The results were classified in three levels: low, medium and high. Central tendency measures and the ANOVA test with Tukey's adjustment test were performed for independent pairwise comparisons. In addition, the Spearman correlation test was applied to control the confounding variables (gender and age). Results: The students, in general, presented epidemiological (high), preventive (low) and healthcare (medium) knowledge, accounting for 86.3%, 53.4% and 63.5%, respectively. The global average score was 14.80±1.98. The students from Federico Villarreal National University presented significantly lower scores than the students from Inca Garcilaso de la Vega University (P≤0.001) and Peruvian Wings University (P=0.002). Conclusion: Knowledge deficiencies were found regarding preventive and care measures for COVID-19 control;therefore, it is important to train dental students with constant educational sessions and training programs on infection control practices regarding COVID-19. © 2021, Editorial Ciencias Medicas. All rights reserved.

13.
Blood ; 138:2520, 2021.
Article in English | EMBASE | ID: covidwho-1582169

ABSTRACT

Updated analysis confirms sustained poor prognosis of COVID-19 in patients with lymphoma in Latin America: A cohort of 160 patients from GELL. Introduction: Ongoing SARS-COV-2 pandemic has impacted the management of cancer patients worldwide. Several reports have demonstrated inferior outcomes of patients with hematological malignancies, including higher rates of intensive care unit admission, need for mechanical ventilation and death. The impact of COVID-19 is profound in resource-restricted countries, including Latin America. Most cohorts reported have not included patients from Latin America, and there is paucity of data of the outcome of cancer patients with COVID-19 in low- and middle-income countries. Grupo de Estudio De Linfoproliferativos En Latino-America (GELL )is a collaborative network of hematological centers in 13 countries in Latin America. We report updated outcomes of lymphoma patients diagnosed with COVID-19 in Latin America. Methods: We conducted a retrospective study including patients with a diagnosis of lymphoma and COVID-19 infection. Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma were excluded from the analysis We defined active disease as follow: (1) patients with detectable disease either prior to initiating therapy or upon relapse, and/or (2) patients undergoing active cancer treatment. The primary outcome was overall survival at 100 days. Survival curves were estimated using the Kaplan Meier method. Uni and multivariable analysis were carried out with Cox model. Results: A total of 160 patients were available for analysis. Median age was 60 years old. Hypertension was the most common comorbidity (33%). Most patients had aggressive lymphomas (62%), including 43% of patients with diffuse large B-Cell lymphoma (DLBCL). Follicular lymphomas were observed in 13% of patients and Hodgkin lymphoma in 12.5% of patients. With a median follow-up of 37 days, the 100-day OS was 64% (95CI 56-74%, fig. 1). In univariate analysis, age (HR 1.03, p=0.0025), hypertension (HR 2.01, p=0.017), >1 number of prior lines (HR 2.78, p=0.011), patients currently on treatment (HR 1.83, p=0.043), ferritin >2000 ng/mL (HR 4.74 p=0.00047) were associated with inferior OS. In multivariate analysis, age (HR 1.03, p=0.0026) and patients currently on treatment (HR 1.82, p=0.04) had inferior OS. There was a trend towards inferior outcomes in patients receiving monoclonal antibodies in univariate analysis (HR 1.82, p=0.081) but not in multivariable analysis (HR=1.29, p=0.48). Use of steroids was not statistically related to mortality (HR 1.79, p=0.074). Finally, contrary to other cohorts, no improvement in OS was observed in patients diagnosed later on the pandemic (fig. 2). Conclusion: In this large cohort of Latin American patients with lymphoma malignancies, our updated analysis showed a maintained dismal prognosis with COVID-19 infection. With a median follow up of 37 days, the 100-day OS was 64%. Older age and ongoing active cancer treatment were significantly associated with mortality. The use of monoclonal antibodies and systemic corticosteroids were not statistically associated to poor survival. Current efforts are focused on improving immunization in the Latin American population. There is an unmet need for improving survival in patients with hematologic malignancies and COVID-19 infection. [Formula presented] Disclosures: Perini: Janssen: Honoraria, Speakers Bureau;Takeda: Honoraria, Speakers Bureau;Astra Zeneca: Honoraria, Speakers Bureau;MSD: Honoraria, Speakers Bureau. Otero: ASTRA ZENECA: Current Employment. Abello: Dr Reddy's: Research Funding;Amgen: Honoraria;Janssen: Honoraria. Castillo: Abbvie: Consultancy, Research Funding;BeiGene: Consultancy, Research Funding;Pharmacyclics: Consultancy, Research Funding;Janssen: Consultancy;Roche: Consultancy;TG Therapeutics: Research Funding.

14.
International Journal of Engineering Education ; 37(6):1518-1532, 2021.
Article in English | Web of Science | ID: covidwho-1576644

ABSTRACT

Quality technical education on healthcare technologies is still inaccessible to young adults in low-resource settings due to high costs, low-tech environments, and gaps in learning materials. The online and open-source collaborative Project-Based Learning (PBL) methodology intends to introduce early-career engineers into the development of healthcare technologies by allowing students from all around the world, regardless of background or place of origin, to engage in collaborative design methods, the use of open-source resources and learning experiences from experts in the field. This paper discusses a case study in which the aforementioned methodology was implemented, the "COVID-19 Innovation Competition and Design Bootcamp 2020", which brought together 105 participants from 22 countries, mostly in Africa, to conceptualize the design of 10 medical devices in two weeks for an integral management of the COVID-19 pandemic that is applicable to other infectious disease outbreaks. The presented experience demonstrates that highly formative virtual PBL experiences can be carried out, in a cost-effective way and in connection with real societal needs, for which remarkable solutions can be found, by virtue of multidisciplinary and international cooperation. Our findings demonstrate that even if it is difficult to reach the degree of project completion achievable with longer-term and on-site design-build experiences, on-line PBL has been shown to promote students' professional skills in an effective way.

15.
Economics Bulletin ; 41(3):1553-1565, 2021.
Article in English | Scopus | ID: covidwho-1515903

ABSTRACT

We evaluate the impact of the COVID-19 pandemic on the volume and quality of firms' daily usage of remote (video) meeting technologies. While per-firm daily meeting volume (minutes, number of meetings, and total participants) increase significantly (between 15\% and 48\%), the average meeting is more crowded (+15\%), shorter (-30\%, or 10 minutes) and of significantly poorer (video/audio) quality (-59\%). Firms in the service sector experience the most notable increases in volume usage, while effects on the duration, size and quality of meetings is experienced by firms in all industries. © 2021. All Rights Reserved.

16.
Revista Cubana de Medicina General Integral ; 37(Special Issue), 2021.
Article in Spanish | Scopus | ID: covidwho-1371131
17.
9th International Workshop on Learning Technology for Education Challenges, LTEC 2021 ; 1428:138-150, 2021.
Article in English | Scopus | ID: covidwho-1366326

ABSTRACT

Learning methodologies and experiences have changed over the recent years thanks to the incorporation of digital technology in education, among many of this technologies are Serious Games, however the process of designing and incorporating this technologies is not easy and there are very few available tools, this paper focus is to give some guidelines from real experiences and its results in order to improve the incorporation of this new tools. With modern gadgets and interfaces, now one can initiate learning experiences based on students needs, preferences, and increase the engagement among students, this last period with COVID 19 impacting our institutions and the abrupt incorporation of full online programs and hybrid mode has made us search for new ways to improve the learning experience, young students and millennials are use to playing with games and the results indicates that they are more likely to enjoy learning experiences with them. There has been use of digital simulation environments since many years ago and gamification is more recently, but new technology has made available new ways of developing experiential learning trough games and Edutainment, gamification and more serious games have been recently developed. The empirical results lead to the conclusion that games have a very positive impact in the students learning process in higher education and adds a very good component of experiential teaching to students that can simulate complex environments and decision making through these tools and platforms. © 2021, Springer Nature Switzerland AG.

18.
Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies ; 5(1), 2021.
Article in English | Scopus | ID: covidwho-1173598
19.
Journal of Entrepreneurship in Emerging Economies ; ahead-of-print(ahead-of-print):22, 2021.
Article in English | Web of Science | ID: covidwho-1276354

ABSTRACT

Purpose Canada has lagged in access to capital for high-potential, growth-oriented new ventures, but has made considerable strides in the past decade. This study aims to examine the evolving state of the market for risk capital in Canada during the COVID-19 pandemic, providing a critical assessment of government policy from the perspective of angel investors and diverse communities of entrepreneurs. Design/methodology/approach A thematic analysis was conducted of seven COVID-19 roundtable discussions hosted by the National Angel Capital Organization that included 51 global and national-level business and political leaders. The analysis extracted the most salient details from the discussions, distilling them into timely and actionable insights for policymakers. Findings The analysis suggests that the government's economic policy response to the COVID-19 crisis fails to address the sudden liquidity problems faced by new ventures. Entrepreneurs and angel investors have remained resilient, rallied as a community and demonstrated an extraordinary level of trust. Traditionally under-represented communities of entrepreneurs are more affected by the crisis than others. Practical implications The findings and recommendations are of relevance to policymakers interested in post-COVID-19 economic policies to address the unique challenges faced by start-ups and ensure their full contribution to economic recovery. Originality/value The paper presents several policy recommendations and proposes a novel framework to describe the impacts of the pandemic on different categories of start-ups.

20.
Microbiol Resour Announc ; 10(12)2021 Mar 25.
Article in English | MEDLINE | ID: covidwho-1153646

ABSTRACT

A near-complete genome sequence was obtained for a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) 202012/01 strain obtained from an oropharyngeal swab sample from a Peruvian patient with coronavirus syndrome who had contact with an individual who had recently returned from England.

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