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1.
Revista Cs En Ciencias Sociales ; : 117-138, 2022.
Article in Portuguese | Web of Science | ID: covidwho-1988702

ABSTRACT

Using data from the Encuesta Continua de Hogares (DANE) between 2001 and 2006, and from the Gran Encuesta Integrada de Hogares (DANE) between 2007 and 2021, for the cities of Cartagena, Barranquilla, Bucaramanga, and Pereira, quantile regressions were estimated to find and classify the determinants of labor income inequality, according to the effect of each one on the income distribution scale. The main result of the study is that education and the percentage of self-employed workers have regressive effects on the labor income distribution in the four cities, thus increasing the scale of the distribution. The covid-19 pandemic has a negative effect on mean and median income, as well as a regressive one on labor income distribution.

2.
Neurology Perspectives ; 1:S31-S36, 2021.
Article in English, Spanish | Scopus | ID: covidwho-1959888

ABSTRACT

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The acute infection is characterised not only by respiratory symptoms, but also by multiple systemic manifestations, including neurological symptoms. Among these, headache is a frequent complaint. As the pandemic progresses and the population of patients recovering from COVID-19 grows, it is becoming apparent that the headache present in the acute stage of the infection may persist for an indeterminate period, becoming a major problem for the patient and potentially leading to disability. In this review we describe the pathophysiological and clinical aspects of persistent headache after COVID-19 based on the information currently available in the literature and the authors’ clinical experience. © 2021 Sociedad Española de Neurología

3.
REVISTA DE LA UNIVERSIDAD DEL ZULIA ; 13(37):321-346, 2022.
Article in English | Web of Science | ID: covidwho-1912772

ABSTRACT

The objective of this article is to monitor the socio-economic impact of COVID-19 on the most vulnerable areas of Guayaquil one year after the start of the pandemic and to point out areas that remain vulnerable for future social linkage projects. The survey was used for the "EPICO-ECOTEC" Project, validated by expert judgment and the average score using Cronbach's alpha. Additionally, a description of the questions and contingency tables were made for better proactive decisions. In this way, this article recommends developing a System of Public Policies from the local level to face the consequences of inequity and the problems of sustainable human development due to COVID-19.

4.
Socialising Tourism: Rethinking Tourism for Social and Ecological Justice ; : 229-243, 2021.
Article in English | Scopus | ID: covidwho-1879579

ABSTRACT

This chapter explores the potential to “scale up” socialisation of the global tourism industry in the wake of the COVID-19 crisis. Tourism is one of the world’s largest industries, and hence a powerful global political and socio-economic force. Yet numerous problems associated with conventional tourism development are now greatly exacerbated by the impacts of the ongoing COVID-19 pandemic. Longstanding calls for sustainable tourism development to address such issues still tend to promote continued growth as the basis of the tourism industry’s development, while mounting demands for “degrowth” suggest that growth is itself the fundamental problem that needs to be addressed in discussion of sustainability in tourism and elsewhere. Given that incessant growth is intrinsic to capitalist development, pursuing touristic degrowth would necessarily entail post-capitalist practices aiming to socialise the tourism industry. Recent calls to foreground socialisation in tourism development largely focus on community-level initiatives. While this is important, the bulk of the tourism industry remains translocal in scale. We therefore apply a set of principles for conceptualising post-capitalist and degrowth-oriented tourism development to a series of case studies at different levels to conceptualise potential to scale up socialisation in a post-COVID-19 world within an overarching strategy of “eroding capitalism”. © 2022 selection and editorial matter, Freya Higgins-Desbiolles, Adam Doering and Bobbie Chew Bigby.

5.
Rev Esp Quimioter ; 35 Suppl 1: 21-24, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1836617

ABSTRACT

Classically the diagnosis of both bacterial and viral pneumonias was made with chest radiology, later the use of chest CT was implemented, however in recent years lung ultrasound has become very important in the diagnosis of pulmonary pathology and increased in pandemic by SARS-CoV-2, due to the practicality of being done at the patient's bedside, the ability to be reproducible, and the decrease in radiation exposure to patients.


Subject(s)
COVID-19 , Pneumonia, Viral , COVID-19/diagnostic imaging , Follow-Up Studies , Humans , Pneumonia, Viral/diagnostic imaging , SARS-CoV-2 , Ultrasonography
6.
94th Annual Water Environment Federation Technical Exhibition and Conference, WEFTEC 2021 ; : 1600-1608, 2021.
Article in English | Scopus | ID: covidwho-1801427

ABSTRACT

The COVID-19 pandemic has highlighted the potential role that wastewater-based epidemiology can play in assessing aggregate community health. However, efforts to translate Sars-CoV-2 gene copy numbers obtained from wastewater samples into meaningful community health indicators are nascent. In this study, Sars-CoV-2 nucleocapsid (N) genes (N1 and N2) were quantified weekly using reverse transcriptase droplet digital PCR from two municipal wastewater treatment plants for approximately six months. Four biomarkers (ammonia, biological oxygen demand, creatinine, and human mitochondrial gene NADH dehydrogenase subunit 5) were quantified and used to normalize Sars-CoV-2 gene copy numbers. These were correlated to case data. Mitochondrial and creatinine normalization methods showed the strongest correlations throughout the studying indicating that human-specific biomarkers were better at normalizing wastewater data than ammonia or BOD. The human-specific biomarkers have different physical properties and corresponding behavior. As such, it may be important to use a suite of biomarkers to better align with the specific behavior of the epidemiological agent of interest. Copyright © 2021 Water Environment Federation

7.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333677

ABSTRACT

COVID-19 testing is not accessible for millions during this pandemic despite our best efforts. Without greatly expanded testing of asymptomatic individuals, contact tracing and subsequent isolation of spreaders remains as a means for control. In an effort to increase RT-PCR assay testing for the presence of the novel beta-coronavirus SARS-CoV-2 as well as improve sample collection safety, GenTegra LLC has introduced two products for saliva collection and viral RNA stabilization: GTR-STM TM (GenTegra Saliva Transport Medium) and GTR-STMdk TM (GenTegra Saliva Transport Medium Direct to PCR). Both products contain a proprietary formulation based on GenTegra's novel "Active Chemical Protection TM" (ACP) technology that gives non-dilutive, error-free saliva sample collection using RNA stabilization chemicals already dried in the collection tube. GTR-STM can be used for safer saliva-based sample collection at home (or at a test site). Following saliva collection, the sample-containing GTR-STM can be kept at ambient temperature during shipment to an authorized CLIA lab for analysis. SARS-CoV-2 viral RNA in GTR-STM is stable for over a month at ambient temperature, easily surviving the longest transit times from home to lab. GTR-STM enhances patient comfort, convenience, compliance and reduces infectious virus exposure to essential medical and lab professionals. Alternatively, the GTR-STMdk direct-into-PCR product can be used to improve lab throughput and reduce reagent costs for saliva sample collection and testing at any lab site with access to refrigeration. GTR-STMdk reduces lab process time by 25% and reagent costs by 30% compared to other approaches. Since GTR-STMdk retains SARS-CoV-2 viral RNA stability for three days at ambient temperature, it is optimized for lab test site rather than at home saliva collection. SARS-COV-2 viral RNA levels as low as 0.4 genome equivalents/uL are detected in saliva samples using GTR-STMdk. The increased sensitivity of SARS-CoV-2 detection can expand COVID-19 testing to include asymptomatic individuals using pooled saliva. ONE SENTENCE SUMMARY: GTR-STM and Direct-into-PCR GTR-STMdk offer substantive improvements in SARS-CoV-2 viral RNA stability, safety, and RT-PCR process efficiency for COVID-19 testing by using a non-dilutive saliva sample collection system for individuals at home or onsite respectively.

8.
International Journal of Sustainability in Higher Education ; 2022.
Article in English | Scopus | ID: covidwho-1784453

ABSTRACT

Purpose: The Sustainable Development Goal (SDG) 13 is at the core of many sustainability initiatives on Mexican higher education institutions (HEIs). Yet, progress to SDG 13 and the entire 2030 Agenda might today appear unlikely to meet. To change this situation, it is necessary to form professionals aware of the impacts of climate change and competent to respond efficiently to its adaptation and mitigation. In this context, the purpose of this study is to reveal the beliefs and concerns about global warming of Mexican students enrolled in engineering bachelor's degrees at higher education institutes that promote sustainability. Design/methodology/approach: In an exploratory study, engineering university students at six large public universities in Mexico answered questions regarding their beliefs and concerns regarding climate change. The study was carried out by using the Global Warming's Six Americas survey questionnaire. The questionnaire was developed by a research team from the Yale Program on Climate Change Communication at Yale University to identify different audiences within the American public regarding climate change. Participants were recruited via convenience/snowball techniques which provided access to a diverse sample. Those who agreed to partake in the study were directed to an online platform via Google forms. Data were collected from January to April 2021. Coding and data treatment was conducted according to the developers' codebook and SPSS scripts. After running the statistical program scripts to determine the respondents' segment, a univariate descriptive analysis was performed for each item in the questionnaire to describe general properties in each variable. Subsequently, a series of correspondence analyses was conducted to examine the existence of clusters or patterns that could indicate relationships among selected questions. Findings: The findings of this study revealed that the majority of the Mexican engineering higher education students participating in the survey fell in the segment of alarmed, 47.3%, or the segment of concerned, 46.%. Furthermore, 78.6% of higher education students in the alarmed segment were extremely sure that global warming is happening. In addition, 98% believed that it is caused mostly by human activities. Furthermore, 89% stated that global warming would harm them personally significantly and 96% thought that future generations would be harmed considerably. About 78% believed that people in Mexico and the USA are currently being harmed by global warming. On the other hand, about 45% of students in the concerned group noted they were extremely sure. In addition, 96% of them thought that global warming is being produced mostly by anthropogenic activities. Furthermore, 39% said global warming will harm them personally to a great deal. However, nearly 80% noted that global warming would also hurt future generations. Although those students in the alarmed and concerned group show similar beliefs and concerns about global warming, the magnitude of concern was more significant for those in the alarmed segment. Research limitations/implications: There are several limitations to the study. First, the online questionnaire did not allow for clarification or follow-up on behalf of the respondents. Therefore, it could be possible that respondents misunderstood some items. However, the research team took the following measures to limit confusion: (1) The questionnaire had been previously used in several studies. None of these studies reported problems related to confusion, so the research team took this fact as evidence of the acceptable reliability of the questionnaire. (2) A face-to-face pilot test was carried out with 30 university students where no problems of comprehension were reported. (3) The target population had adequate prior knowledge of climate change, so the possibility of misunderstandings was likely low. A second limitation relates to the nature of the study. Fighting to mitigate the global climate crisis is a positive social norm. Respondents may have provid d answers in line with this social norm and presented themselves as more pro-environmental than they actually are. Second, because of our selection criteria, our data may overestimate the general public's “worldviews” on climate change. Finally, this study was carried on during the COVID-19 pandemic, which could have impacted items' responses. These limitations constitute future opportunities for future research. Specifically, future research might ideally use a large-scale comprehensive study evaluating the broader Mexican public's beliefs and views about climate change. Furthermore, because our data showed that our respondents were very concerned about climate change, but did little in terms of behavioral mitigation, future research should continue to examine and explore differences in various measures of climate friendly behaviors among different segments of the population. Practical implications: This study's findings have at least twofold implications for university authorities and sustainability practitioners in their pursuit of meeting SDG 13. The first implication is related to academic life. Undoubtedly, having a high percentage of students believing in global warming and mainly that this phenomenon is by anthropogenic activities is a strong indication of their knowledge. But, indirectly, these results validate the sustainability teaching and research efforts in their HEIs, implying the commitment to sustaining and improving the quality of their sustainability-educational initiatives in all institutional areas. The second implication of our findings is related to HEIs' future commitments to address the target of SDG 13 during the present Decade of Actions. Results also lead us to reflect on the role of Mexican HEIs as agents of change, beyond offering good instruction on climate science as an agent of socialization to encourage positive mitigation and adaptation behaviors among the general population. Social implications: The social implication behind the environmental values of younger people found in this study is that a deeper understanding of these millennials' beliefs and concerns toward global warming will help Mexican policymakers implement policies in this regard and hopefully will be endorsed by a significant proportion of the Mexican population. Originality/value: The originality of this study is the application of the Global Warming's Six Americas survey questionnaire in higher education settings. Therefore, the knowledge generated determines the quality of the article. As findings in this study revealed, there is apparently little disagreement among the Mexican engineering higher education students about the belief of the existence of global warming and this phenomenon is being caused mainly by human-related activities. Nevertheless, a minority of students still believe that global warming is caused naturally or not occurring. However, it is not possible to claim victory, as these achievements should not be considered, in any way, a guarantee that students will carry out behaviors in their daily lives that impact a reduction in global warming. Nevertheless, the study provides insights to allow university authorities to ensure that the current beliefs and concerns will not fade in the post-pandemic times. Thus, the COVID-19 pandemic should be taken a pivotal era toward the goal of increasing the global average temperature to well below 2°C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5°C above pre-industrial levels. © 2022, Emerald Publishing Limited.

9.
2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021 ; : 1251-1256, 2021.
Article in English | Scopus | ID: covidwho-1722887

ABSTRACT

Since COVID-19 appeared in December 2019, scientists are researching new ways to improve the management of the disease. Considering machine learning approaches have proven to be very useful tools to discover hidden patterns in data, we propose in this paper to apply a Self Organizing Map (SOM) to characterize the health-status evolution of COVID-19 patients. The SOM is a neural network whose neurons can be represented as cells in a bi-dimensional grid preserving the mapping from the original space to the map units. We consider real-world data of hospitalized COVID-19 patients in a Spanish hospital during the first wave of the pandemic. Patients are represented by six blood tests (leukocytes and D-dimer, among others) in a daily basis. Besides, each patient is associated with one of two different health-status: favorable evolution (discharged home) and unfavorable evolution (exitus or admission to the intensive care unit). We show the potential of our approach by detailing the mapping of the health trajectory associated with different particular cases and drawing their trajectory on the bi-dimensional map of the SOM. © 2021 IEEE.

10.
Nexo Revista Cientifica ; 34(5):64-74, 2021.
Article in Spanish | Web of Science | ID: covidwho-1698948

ABSTRACT

Marketing can provide a region with various strategies through urban and territorial planning that enhances the market for its resources, the vocation of the land and human capital in the face of development for the social well-being of the inhabitants. This is a term that has taken hold on the planet. It acts as a process that brings benefits and advantages between organizations or regions that are not yet known. Examples of its practice are being demonstrated in government decisions and economic unions in Latin America and the Caribbean, who, after the COVID -19 pandemic, have resorted to different marketing strategies to reactivate economies, territories and the different necessary activities for the population. This work aims to show how the marketing strategy provides benefits to urban and territorial development with the positioning of the city brand in the markets and consumers of goods and services. As a strategic tool, it can be taken advantage of from the organizational planning of the regions, as well as from business ventures that have not yet been exploited.

11.
Rehabilitacion (Madr) ; 2022 Jan 14.
Article in Spanish | MEDLINE | ID: covidwho-1649223

ABSTRACT

OBJECTIVE: Assess clinical evolution and health-related quality of life at three months after discharge in patients who were admitted and diagnosed with COVID-19 pneumonia, evaluated by the Rehabilitation Service and received physiotherapy in Fuenlabrada Hospital. METHODS: Data were collected from 59 patients, separating those who were assessed in ICU (41 patients) from those assessed in the hospital ward (18). Data were obtained from their Electronic Medical Record, and a telephone interview was performed three months after their discharge. Data about their clinical progress during their hospitalization, after discharge, over the next months and their condition at the time of the interview is analyzed. Patients were asked to assess the quality of the physiotherapy received and to answer the SF-36 health-related quality of life questionnaire. RESULTS: These patients had the worst progress of the COVID pneumonia among all patients hospitalized in our hospital, but they had a good functional recovery with the inpatient physiotherapy received, which was positively rated. After three months, 84% have persistent symptoms, with the most common being dyspnoea, fatigue and anxiety/depression, and score worse in the SF-36 questionnaire than the reference population. CONCLUSIONS: Most patients who require rehabilitation during their COVID pneumonia admission have persistent symptoms and perceive a deterioration in their health-related quality of life after three months of discharge.

12.
Rehabilitacion ; 2022.
Article in Spanish | EuropePMC | ID: covidwho-1624236

ABSTRACT

Objetivo Conocer la evolución y calidad de vida relacionada con la salud a los tres meses del alta, en pacientes que fueron hospitalizados en el hospital de Fuenlabrada con diagnóstico de neumonía por COVID-19, valorados por el Servicio de Rehabilitación y que realizaron fisioterapia. Métodos Se recogen datos de 59 pacientes, diferenciando los que fueron valorados en UCI (41 pacientes), de los valorados en planta de hospitalización (18). Los datos se toman de su historia clínica electrónica, y se realiza una entrevista telefónica tres meses después del alta hospitalaria. Se analizan datos de su evolución durante hospitalización, tras el alta y durante los meses siguientes, y de su situación en el momento de la entrevista. Se pide a los pacientes una valoración de la fisioterapia recibida y que contesten el cuestionario de calidad de vida relacionado con la salud SF-36. Resultados Estos pacientes han tenido la peor evolución de su neumonía COVID de entre los ingresados en nuestro hospital, pero tuvieron una buena recuperación funcional con la fisioterapia intrahospitalaria recibida, la cual fue valorada muy positivamente por los pacientes. Después de tres meses, el 84% tienen síntomas persistentes, siendo los más frecuentes disnea, cansancio y depresión/ansiedad, y tienen peores puntuaciones en SF-36 que la población de referencia. Conclusiones La mayoría de los pacientes que requieren rehabilitación durante su hospitalización por neumonía COVID-19, tienen síntomas persistentes y perciben un deterioro de su calidad de vida relacionada con la salud, tras tres meses del alta hospitalaria.

13.
Neurology Perspectives ; 1:S31-S36, 2021.
Article in English | EuropePMC | ID: covidwho-1602272

ABSTRACT

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The acute infection is characterised not only by respiratory symptoms, but also by multiple systemic manifestations, including neurological symptoms. Among these, headache is a frequent complaint. As the pandemic progresses and the population of patients recovering from COVID-19 grows, it is becoming apparent that the headache present in the acute stage of the infection may persist for an indeterminate period, becoming a major problem for the patient and potentially leading to disability. In this review we describe the pathophysiological and clinical aspects of persistent headache after COVID-19 based on the information currently available in the literature and the authors’ clinical experience.

14.
Gastroenterology ; 160(6):S-320-S-321, 2021.
Article in English | EMBASE | ID: covidwho-1597391

ABSTRACT

Background: A minimum of physical activity and low liquid intake are factors that havebeen associated with constipation. The health emergency brought on by the COVID-19pandemic has resulted in adopting behavior, such as sheltering-in-place (less mobility) anddietary changes, creating a scenario we believe to be an adequate model for examining theappearance of symptoms of constipation and its associated factors. At present, there are no reports in the literature that establish a relation between a change in bowel movement habitand being under the current lockdown. Thus, the aim of our study was to evaluate theincidence of symptoms of constipation and associated factors during the lockdown implementedto contain the spread of COVID-19 in Mexico.Methods: A cross-sectional and descriptive study was conducted on an open population,applying an electronic survey (4 weeks after lockdown due to COVID-19 in Mexico) toevaluate: demographic characteristics, physical activity, water and fiber intake, appearanceof constipation symptoms (including stool consistency), and quality of life. Incidence (newcases) of constipation after the lockdown (“new-onset” constipation) was calculated and the95% CI was reported. A comparative analysis of the categorical variables and continuousvariables was carried out between the participants with “new-onset” constipation and thosewith no constipation during the lockdown, utilizing the Student’s t test, the Mann-WhitneyU test, the chi-square test, or the Wilcoxon test, as appropriate. Statistical significance wasset a p < 0.05.Results: Out of 678 subjects evaluated, 170 (25%, 95% CI 21.7-28.4) developed symptomsof “new-onset” constipation, with a significant decrease in the number of daily bowelmovements (p<0.05) and stool consistency (p<0.05) during lockdown (Figure 1). Furthermore,in the “new-onset” constipation population, there was a higher proportion of subjects(48%) who stopped exercising during the pandemic compared to the subjects who did notdevelop constipation symptoms (29%, p=0.0005, OR 2.23, CI 95% 1.4-3.48, Figure 2).The multivariate analysis (logistic regression) showed that female sex (p=0.001), water intake(p=0.039), and physical activity (p=0.012) were associated with “new-onset” constipation.Conclusions: In conclusion, in our study we found that one-fourth of the population thatreduced their physical activity and drank less water due to mobility restrictions imposedfor epidemiologic reasons, in the face of the COVID-19 pandemic, developed “new-onset”constipation symptoms. Given those results, appropriate physical activity and adequateliquid intake during prolonged periods of lockdown should be recommended to preventsaid symptoms.(Image Presented)Number of bowel movements, days of physical activity and stool consistency before and after the lockdown(Image Presented)Percentage of subjects who stop physical activity during the pandemic among groups.

15.
Journal of Thoracic Oncology ; 16(10):S883-S884, 2021.
Article in English | EMBASE | ID: covidwho-1474794

ABSTRACT

Introduction: There are currently no predictive biomarkers for long-term survival after neoadjuvant chemoimmunotherapy. However, the identification of non-small lung cancer (NSCLC) patients who obtain long-term benefit from chemoimmunotherapy is essential to optimize therapies. Methods: Using samples from NADIM clinical trial (NCT03081689), in which resectable stage IIIA NSCLC patients were treated with neoadjuvant chemo-immunotherapy with nivolumab, we have evaluated the capacity of ctDNA levels before treatment initiation to predict overall survival (OS) and progression-free survival (PFS) by calculating Harrell’s C-statistic and we compare its predictive value with classical survival surrogates as the pathological response and clinical response assessed according to RECIST criteria v.1.1. The ctDNA was analyzed by NGS, using the Oncomine Pan-Cancer Cell-Free Assay™ (Thermo Fisher Scientific®). To explore the prognostic value of the amount of ctDNA at baseline, for each positive plasma sample, we calculated the sum of the mutant allele frequency (MAF) for all detected mutations. Patients who died from COVID19 were excluded from this analysis. Results: In our study, clinical responses based on RECIST criteria were not predictive for OS or PFS. On the contrary, in the multivariate analysis, patients with low ctDNA levels (<1% MAF), in the baseline sample, had significantly improved PFS and OS than patients in whom the opposite situation occurred (adjusted HR: 0.22;95%CI: 0.06-0.75;P=0.016 and adjusted HR: 0.04;95%CI: 0.00-0.45;P=0.008 for PFS and OS, respectively). The adjusted C-statistic (c) to predict PFS for ctDNA was 0.68 (95%CI: 0.51-0.84), which was superior to that of RECIST criteria (c=0.61;95%CI: 0.45-0.78) and similar to that of pathological response (c=0.68;95%CI: 0.52-0.84). Similarly, baseline ctDNA levels predicted OS (c=0.85;95%CI: 0.72-0.99) better than RECIST criteria (c=0.68;95%CI: 0.44-0.93). Conclusion: Pre-treatment ctDNA levels predicted more accurately long-term survival than radiological assessments in NADIM study and might be useful for the design of new clinical trials.

16.
Journal of Thoracic Oncology ; 16(10):S883, 2021.
Article in English | EMBASE | ID: covidwho-1474793

ABSTRACT

Introduction: Neoadjuvant chemoimmunotherapy been shown to be highly effective in resectable stage IIIA NSCLC. Now we provide long term survival data Methods: This was an open-label, multicentre, single-arm phase 2 trial in which patients with histologically or cytologically documented stage IIIA NSCLC and Eastern Cooperative Oncology Group performance status of 0 or 1 and who were deemed locally to be surgically resectable by a multidisciplinary clinical team were treated with neoadjuvant intravenous paclitaxel (200 mg/m2) and carboplatin (area under curve 6;6 mg/mL per min) plus nivolumab (360 mg) on day 1 of each 21-day cycle, for three cycles before surgical resection, followed by adjuvant intravenous nivolumab monotherapy for 1 year (240 mg every 2 weeks for 4 months, followed by 480 mg every 4 weeks for 8 months). Here we report progression-free survival (PFS) and Overall survival (OS) at 36 and 42 months, assessed in the modified intention-to-treat population (ITT), which included all patients who received neoadjuvant treatment, and in the per-protocol population (PP), which included all patients who had tumour resection and received at least one cycle of adjuvant treatment. Results: Median follow-up time was 37.9 months (95%CI: 36.7-40.7), with a 94% maturity at 36 months. Among the ITT population (N=46), 37 patients, constituting the PP population, received subsequent adjuvant therapy. Of them, 27 (58.7%) patients completed the adjuvant treatment (16 cycles), 10 (21.7%) patients received between 3 and 15 cycles of adjuvant therapy, and 9 (19.6%) patients did not receive adjuvant therapy. At the time of data cutoff (March 2021), progression disease was diagnosed in 14 patients and 9 deaths were recorded in the ITT population. Of these, three deaths corresponded to patients who did not undergo surgery and had disease progression, four deaths corresponded to patients who underwent surgery and had disease progression, and the two remaining deaths corresponded to patients who were diagnosed as being disease free but died from COVID19 infection. Notably, among patients who could not undergo surgery (N=5), one of them is still alive and with no evidence of disease. PFS at 36 and 42 months in the ITT population were 69.6% (95%CI: 54.1-80.7), in both cases. Similarly, PFS at 36 and 42 in the PP population were 81.1% (95%CI: 64.4-90.5) in both cases. The percentage of patients who were alive at 36 and 42 months in the modified ITT population were 81.86% (95% CI: 66.8-90.6) and 78.94% (95%CI: 63.1-88.6), respectively. Likewise, OS at 36 and 42 months in the PP population was 91.0% (95%CI: 74.2-97.0) and 87.3% (95%CI: 69.3-95.1), respectively. Conclusion: The efficacy of nivolumab in combination with platinum-based chemotherapy in patients with resectable stage IIIA NSCLC is clearly supported by long term survival data. Keywords: NADIM trial, neoadjuvant chemo-therapy, long term survival

17.
Advances in Medicine and Biology ; 179:91-128, 2021.
Article in English | Scopus | ID: covidwho-1469206

ABSTRACT

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by an uncontrolled inflammation, and hypercytokinemia as a result of uncontrolled activation of cytotoxic T cells and macrophages, resulting in the HLH classical symptoms such as: Persistent fever, hepatosplenomegaly, rash, cytopenias, hemophagocytosis, hyperferritine-mia, hypertriglyceridemia and central nervous system infiltration. Patients can develop coagulopathy, liver failure and progress to multi-organ failure with high mortality rates. HLH is classified as primary when it is associated with a familial, inherited factor whereas it is secondary when associated with a non-inherited factor. Evidence supports that infections can trigger the physiopathology of HLH. The most common viral infections are;cytomegalovirus and Epstein Barr however, other viruses such as dengue, HIV and more recently, the acute respiratory distress syndrome induced by SARS-CoV2 have been identified as infections associated with HLH (iHLH). The link between viral infection and immunoreactivity is well recognized, however, the mechanism in which the viruses are involved in the development of HLH remains unclear. In this chapter we discuss the role of the viral infection and some features from the host which takes part in the development of HLH. © 2021 by Nova Science Publishers, Inc. All rights reserved.

20.
Revista Rol De Enfermeria ; 43(9):60-68, 2020.
Article in Spanish | Web of Science | ID: covidwho-1283100

ABSTRACT

BACKGROUND. The COVID-19 pandemic has reached more than five million Infections and three hundred thousand deaths worldwide, all of which require the assessment of prognostic factors;In addition to advanced age, comorbidities or the Inflammatory response, IS also evident the need to assess body temperature to determine contagion, exposure, especially In people with different risk factors, and different evolutionary patterns to know Its Influence on clinical outcomes. METHODS. A cross-sectional study of temperature measurements was performed on 42 volunteer subjects, to assess the reliability in terms of agreement between two thermometers used in body temperature measurements;the measurements of 2 thermometers in the frontal and ear areas were compared in 2 rooms (higher and lower lighting). Confidence intervals were compared and the Intraclass Correlation Coefficient (ICC) was calculated to obtain the statistical differences, providing limits of agreement from the calculation of the confidence interval for the difference of two measurements. RESULTS. With a 95 % confidence Interval, ap <0.5 and under the measured conditions, and on our sample of subjects, we observe that the correlation of the measurements does not have significant statistical difference, but Indeed In different environments with greater lighting. CONCLUSIONS. The average body temperature (front) measured with the laser thermometer IS greater than the temperature (front) measured With the Testo thermometer. There IS a Significant difference In the measurements made In the 2rooms, being greater In the room With less lighting. There IS correlation In the temperature measurements of the same instrument in the frontal zone and In the ear. Laser thermometers are more effective in detecting variations In body temperature, and more assertive in identifying one of the symptoms most associated with SARS-CoV-2 infection.

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