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Adult Covid-19 Comorbidity Incidence Risk Spain ; 2020(Rev Esp Salud Publica): es,
Article in 2173-9110 vila-Córcoles Ángel Ozhoa-Gondar Olga Torrente-fraga Cristina vila-Rovira Ángel Satué-Gracia Eva Hospitl-Guardiola Immaculada de Diego-cabanes Cinta Gómez-Bertomeu frderic Basora-Gallisà Josep en Abstract Journal Article esin Rev esp Salud Publica. 2020 Jun 26 | Jun 26 | ID: covidwho-617006


OBJECTIVE: Population-based data on the current Covid-19 pandemic is scarce. This study investigated incidence and risk to suffer Covid-19 by baseline underlying conditions in people ≥50 years in Tarragona region across march-april 2020. METHODS: Population-based retrospective cohort study involving 79,071 adults ≥50 years-old in Tarragona region (Southern Catalonia, Spain). Cohort characteristics (age, sex, residence, vaccinations history and comorbidities) were established at baseline, and Covid-19 cases occurring between 01/03/2020-30/04/2020 were registered. Cox regression analysis calculating Hazard ratios (HRs) adjusted by age, sex and comorbidities was used to estimate risk for Covid-19. RESULTS: Across study period, 1,547 cohort members were PCR tested (22.6% positive) and 367 were presumptive cases without PCR tested. Considering PCR-confirmed Covid-19, incidence (per 100,000 persons-period) was 441 overall (248, 141, 424, 1,303 and 3,135 in 50-59, 60-69, 70-79, 80-89 and ≥90 years-old, respectively;380 in men and 497 in women;259 in community-dwelling and 10,571 in nursing-home). By comorbidities, maximum incidence emerged among persons with neurological disease (2,723), atrial fibrillation (1,348), chronic renal failure (1,050), cardiac disease (856), respiratory disease (798) and diabetes (706). Lower incidence appeared in rheumatic diseases (230) and smokers (180). In multivariable analysis focused on community-dwelling individuals (N=77,671), only cardiac disease (HR: 1.47;95% CI: 1.01-2.15;p=0.045) and respiratory disease (HR: 1.75;95% CI: 1.00-3.02;p=0.051) were associated with an increased risk, whereas smoking (HR:0.43;95% CI: 0.25-0.74;p=0.002) and influenza vaccinated (HR: 0.63;95% CI: 0.43-0.92;p=0.015) appeared associated with a decreased risk. CONCLUSIONS: Apart of increasing age and nursing-home residence, chronic respiratory and cardiac disease appear at increased risk for suffering covid19. This study investigated population-based incidence of Covid-19 infection by underlying conditions among adults ≥50 years in Tarragona (Southern Catalonia, Spain) across two first months pandemic period.