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1.
Journal of Head Trauma Rehabilitation ; 37(6):E518, 2022.
Article in English | EMBASE | ID: covidwho-2161228

ABSTRACT

Background Mild traumatic brain injury (mTBI) is an acknowledged public health problem. Up to 25% of adult with mTBI present persistent symptoms. Headache, dizziness, nausea, and neck pain are the most commonly reported symptoms and are frequently associated with cervical spine and vestibular impairments. The most recent international consensus statement (2016 Berlin consensus) recommends the addition of an individualized rehabilitation approach for mTBI with persistent symptoms. The addition of an individualized rehabilitation approach including the evaluation and treatment of cervical and vestibular impairments leading to symptoms such as neck pain, headache and dizziness is then recommended and has been proven effective. Recently, the COVID-19 pandemic has led tele-consultations to seek healthcare professionals in primary care. The benefit of such a telerehabilitation approach compared with in-clinic rehabilitation program should therefore be further investigated. Objective The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program combined with a symptom-limited aerobic exercise (SLAE) program with the same program in a telerehabilitation format in adults with persistent symptoms following mTBI on severity of symptoms and other indicators of clinical recovery. Methods In this parallel-group nonrandomized clinical trial, 40 adults with persistent symptoms following mTBI were assigned to (1) an in-clinic 6-week cervicovestibular rehabilitation program combined with SLAE program (n =30) OR (2) the same program performed in a telerehabilitation format (n =10). All participants took part in 4 evaluation sessions (baseline, weeks 6, 12, and 26) performed by a blinded evaluator. The primary outcome was the Post-Concussion Symptoms Scale (PCSS). The secondary outcomes were Numerical Pain Rating Scale (NPRS), Neck Disability Index (NDI), Headache Disability Inventory (HDI), Dizziness Handicap Inventory (DHI), and time-to-return to function. Nonparametric analysis for longitudinal data was used to evaluate the effect of interventions on outcomes. Results For the PCSS total score, and PCSS number of symptoms, there were group-by-time interactions at 6-month follow-up (P < .05);clinically significant time effects were observed for both groups (P < .05). There were group-by-time interactions at all time point follow-up for the global rating of change (P < .05) and the NPRS neck pain (P < .01) in favor of the in-clinic rehabilitation program. There were no group-by-time interactions for other outcome measures. Conclusion The study indicates that an in-clinic cervicovestibular rehabilitation combined with SLAE program was superior to the same telerehabilitation program in terms of symptoms improvement and global rating of change inmTBI with persistent symptoms. However, other outcome measures were equally improved after either the in-clinic or the telerehabilitation program. These results must be interpreted with caution, given the limited number of participants in the telerehabilitation group and the nonrandomized group allocation.

2.
Jundishapur Journal of Microbiology ; 15(1):4845-4882, 2022.
Article in English | GIM | ID: covidwho-2124596

ABSTRACT

'Corona', this alarming word comes from the 'Latin' word 'Crown' that protects the virus. On Dec, 19, firstly, this virus was isolated from three patients having pneumonia connected to a cluster of acute illnesses. WHO declared it a 'pandemic' in Jan, 20 but later in Feb, WHO's general director Tedros Adhanom Ghebreyesus named the virus nCOVID-19. It was first identified in Wuhan, China, as a respiratory illness causing novel diseases (SARS and MERS). CDC informed corona primarily causes mild to moderate upper RTI and, in a few cases, lower RTI (pneumonia, bronchitis). Transmission occurs through direct contact or air droplets of sneezing, coughing, etc. The origin is not clear, but recent studies reported that ACE 2, a membrane exopeptidase receptor, was used to enter the human cell. The primary symptoms are fever above 104 degrees F, shortness of breath, pneumonia, throat soreness, diarrhea, etc. Available approved therapeutics include hydroxychloroquine. This current review updates about the viral transmission and main effect of this virus on children, pregnant women, diabetic, and cancer patients.

3.
Anti-Infective Agents ; 20(4) (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2065291

ABSTRACT

Mucormycosis is the most emerging angioinvasive fungal infection of filamentous fungi of the Zygomycetes class, which, when neglected, causes severe disseminated infection along with significant chances of morbidity and mortality. The diagnosis and treatment remain challenging for the doctors. It has been observed that people who have been suffering from different diseases, such as hematological malignancies and uncontrolled diabetes, or who have gone through different surgeries, such as hemato-poietic stem cell transplant, and solid transplantation, are the most affected ones. On the other hand, people who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) typically show the symptoms of mucormycosis after 1-2 weeks of successful recovery. Standard treatment of mu-cormycosis is traditionally considered an amphotericin B intravenous (IV) drug as initial therapy, alt-hough posaconazole and isavuconazole are also used. The core objective of the review is to typically focus on the area of the sudden cause of mucormycosis in the patients who have already recovered from SARS-CoV-2. Copyright © 2022 Bentham Science Publishers.

4.
Journal of Rheumatology ; 49(7):827-827, 2022.
Article in English | Web of Science | ID: covidwho-1976302
5.
A Research Agenda for Multilevel Governance ; : 95-113, 2021.
Article in English | Scopus | ID: covidwho-1871650

ABSTRACT

As the scope of digitalisation widens across society at large, multilevel governance arrangements have become more complex and more consequential to the coherence, performance, and accountability of public sector institutions. While this assertion has arguably been true for quite some time, the emergence of Covid-19 has magnified its importance. This chapter therefore seeks to examine the evolution of multilevel governance within the evolving context of digitization, generally as well as more specifically through the contemporary and disruptive lens of the Covid-19 health pandemic. Drawing upon a literature review, as well as current empirical observation from several OECD countries, notably Canada and Australia, the chapter sketches out prospective research directions aimed at deepening our understanding of multilevel governance systems within a rapidly evolving digitization context. © Arthur Benz, Jörg Broschek and Markus Lederer 2021.

6.
Neurologia (Barcelona, Spain) ; 36(7):531-536, 2021.
Article in Spanish | EuropePMC | ID: covidwho-1864136

ABSTRACT

Introducción La pandemia por COVID-19 ha tenido un impacto en el manejo del ictus isquémico;se ha descrito una disminución de los ingresos hospitalarios e incluso una interrupción en la cadena de atención y un aumento de la mortalidad intrahospitalaria. Sin embargo, falta evidencia sobre su impacto en el pronóstico funcional. El objetivo de este estudio es analizar el efecto de la pandemia por COVID-19 en el pronóstico funcional a 3 meses de los pacientes con ictus isquémico agudo hospitalizados en Aragón. Material y métodos Revisamos los datos de todos los pacientes ingresados por ictus isquémico en todos los hospitales de nuestro sistema sanitario entre el 30 de diciembre del 2019 y el 3 de mayo del 2020. Comparamos su mRS y la mortalidad a 3 meses de los hospitalizados antes y después de haberse establecido el estado de emergencia secundario a la pandemia por COVID-19. Resultados En total, 318 pacientes con ictus isquémico agudo cumplieron nuestros criterios de inclusión. No hubo diferencias en las características globales y específicas de cada periodo, excepto por una mayor proporción de pacientes mayores de 80 años de edad durante el periodo pre-CoV (42,2% vs. 29,0%, p = 0,028). En el análisis comparativo, no encontramos una diferencia significativa en la mortalidad (12,3 vs. 7,9, p = 0,465) o la proporción de pacientes con mRS ≤ 2 (57,7% vs. 57,1%, p = 0,425) a los 3 meses. Conclusión Hasta donde sabemos, este es el primer estudio que analiza el impacto de la pandemia por COVID-19 en el pronóstico funcional a 3 meses de pacientes con ictus isquémico. En nuestra comunidad autónoma, no ha habido un incremento en la mortalidad o discapacidad a 3 meses de pacientes hospitalizados por ictus isquémico durante el periodo de COVID-19.

7.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii ; 98(4):397-415, 2021.
Article in English | Scopus | ID: covidwho-1471361

ABSTRACT

Introduction. COVID-19 has become a global impediment by bringing everything to a halt starting from January 2020. India underwent the lockdown starting from 22nd March 2020 with the sudden spike in the number of COVID-19 patients in major cities and states. This study focused on how metabolites play a crucial role in SARSCoV- 2 prognosis. Materials and methods. Metabolome profiling of 106 plasma samples and 24 swab samples from symptomatic patients in the Indian population of the Mumbai region was done. COVID-19 positive samples were further segregated under the non-severe COVID-19 and severe COVID-19 patient cohort for both plasma and swab. Results. After analyzing the raw files, total 7,949 and 12,871 metabolites in plasma and swab were found. 11 and 35 significantly altered metabolites were found in COVID-19 positive compared to COVID-19 negative plasma and swab samples, respectively. Also, 9 and 23 significantly altered metabolites were found in severe COVID-19 positive to non-severe COVID-19 positive plasma and swab samples, respectively. The majorly affected pathways in COVID-19 patients were found to be the amino acid metabolism pathway, sphingosine metabolism pathway, and bile salt metabolism pathway. Conclusion. This study facilitates identification of potential metabolite-based biomarker candidates for rapid diagnosis and prognosis for clinical applications. © 2021, Central Research Institute for Epidemiology. All rights reserved.

8.
American Journal of Respiratory and Critical Care Medicine ; 203(9):1, 2021.
Article in English | Web of Science | ID: covidwho-1407454
9.
American Journal of Respiratory and Critical Care Medicine ; 203(9), 2021.
Article in English | EMBASE | ID: covidwho-1277716

ABSTRACT

Introduction Spontaneous pneumomediastinum, a rare condition in viral pneumonias, has been increasingly reported during the ongoing COVID-19 pandemic. Emerging literature suggests a higher incidence and mortality in COVID-19 patients with both a pneumothorax and pneumomediastinum. Early recognition and understanding of these complications are necessary to improve outcomes. We present a case of an older man initially diagnosed with mild COVID-19 symptoms who quickly progressed with increasing oxygen levels found to have a small pneumothorax and pneumomediastinum. Description A 77-year-old man with hypertension, obstructive sleep apnea on home continuous positive airway pressure (CPAP) therapy, and diagnosis of mild COVID-19 via reverse transcriptase polymerase chain reaction 1-week prior, presented to the emergency department for worsening shortness of breath. He was found to have a temperature of 101.5°F, heart rate of 103bpm, stable blood pressure, respiratory rate of 25 breaths/minute, and oxygen saturation of 70% on ambient air. He was placed on 15lpm mid-flow. Labs were significant for a white blood cell count of 14k/uL, hemoglobin 11.7g/dL, c-reactive protein 185 mg/L, pro- BNP of 637pg/mL, ferritin 802 ng/mL, lactic acid 2 mmol/L, procalcitonin of 0.84 ng/mL. He had a chest x-ray with bilateral perihilar and lower lobe infiltrates. He was started on dexamethasone, remdesivir, antibiotics, tocilizumab, and enoxaparin. His CPAP was held and continued on oxygen therapy. Discussion Pneumomediastinum, or air in the mediastinum, occurs through various etiologies categorized into secondary and spontaneous. Common secondary causes include blunt injuries by trauma, iatrogenic causes such as intubation, central lines, and chest operations, and finally, medical conditions such as interstitial lung disease, asthma, connective tissue disorders, and respiratory infections may be other causes (1). Several cases have been reported with spontaneous pneumomediastinum in patients with COVID-19, however, the exact etiology is unknown as none were placed on mechanical ventilation (2-5). One mechanism is likely due to the repetitive episodes of cough causing increased airway pressure leading to alveolar rupture in already extensively damaged alveoli and proximal gas leakage (2). Based on one autopsy report, there were findings of desquamation of pneumocytes and hyaline membrane formation indicating early acute respiratory distress syndrome (6). In another case series, barotrauma from higher PEEP (positive end-expiratory pressure) with the use of CPAP is potentially another mechanism (7). Careful consideration for these complications should occur in patients with progressive forms of COVID-19, ensuring cough suppression, use of anti-emetics, diuretics and low PEEP strategy to help mitigate this previously rare phenomenon.

10.
Neurologia (Engl Ed) ; 36(7): 531-536, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1253425

ABSTRACT

INTRODUCTION: The COVID-19 pandemic has had an impact on ischaemic stroke management, with a reported decrease in hospital admissions, and even disruptions in healthcare and increased in-hospital mortality. However, there is a lack of evidence on the impact of the pandemic on functional prognosis. The aim of this study is to analyse the effect of the COVID-19 pandemic on the 3-month functional outcomes of patients hospitalised due to acute ischaemic stroke in Aragon (Spain). METHODS: We reviewed the data of all patients admitted due to ischaemic stroke to any hospital in our regional healthcare system between 30 December 2019 and 3 May 2020. We compared modified Rankin Scale scores and mortality at 3 months in patients hospitalised before and after the declaration of a state of emergency due to the COVID-19 pandemic. RESULTS: In total, 318 patients with acute ischaemic stroke met our inclusion criteria. No differences were observed between periods in global or specific characteristics, with the exception of a higher proportion of patients older than 80 years during the first period (42.2% vs 29.0%, P = .028). In the comparative analysis, we found no significant differences in mortality (12.3 vs 7.9, P = .465) or in the proportion of patients with modified Rankin Scale scores ≤ 2 (57.7% vs 57.1%, P = .425) at 3 months. CONCLUSION: To our knowledge, this is the first study to analyse the impact of COVID-19 pandemic on the 3-month functional outcomes of patients with ischaemic stroke. In our region, there has been no increase in rates of mortality or disability at 3 months in patients admitted due to ischaemic stroke during the pandemic.


Subject(s)
Brain Ischemia , COVID-19 , Ischemic Stroke , Stroke , Brain Ischemia/epidemiology , Humans , Pandemics , Prognosis , SARS-CoV-2 , Stroke/epidemiology , Treatment Outcome
11.
International Energy Journal ; 21:1-8, 2021.
Article in English | Scopus | ID: covidwho-1181971

ABSTRACT

COVID 19 recovery path, economic growth path and climate resilient path have much in common to help in building back better for Bangladesh which experienced multiple hazards due to hydro-meteorological disasters during the pandemic year. Changing the framework around this intersection of sustainable developmental actions can strengthen the productive base of the economy which can create momentum for the attainment of equitable human wellbeing for people of Bangladesh. For successful implementation of actions updated methods, community involvement and data are the most important elements. © 2021 Regional Energy Resources Information Center (RERIC), Asian Institute of Technology. All rights reserved.

12.
J. Phys. Conf. Ser. ; 1797, 2021.
Article in English | Scopus | ID: covidwho-1139947

ABSTRACT

Technology has played an integral role in the field of education. Its prominence and efficacy have proved to be a great boon for the people in this New Normal after the severe outbreak of COVID-19. Although the entire world is confined among the four walls, it is the technology that contributed a lot by enabling the conduction of online classes through different Learning Management Systems and multidimensional efforts of student-teacher fraternity. Earlier the Distance Learning was prevalent but was not given much importance owing to own limitations. This period of emergency has identified and highlighted the need and immense contribution of technology in digital pedagogy through online mode. In this paper we have surveyed various ways, where technology has played a gigantic role in the field of education. Various techniques for monitoring the attendance of the learners are also explored. Identifying several problems and related drawbacks of the digital transformation in the pedagogical approach, we have proposed some dynamic systems that can resolve certain issues efficiently and effectively. Solutions to mitigate the problems of attendance and to prevent the lack of attention/concentration of the students during the conduction of the online classes are presented. © 2021 Institute of Physics Publishing. All rights reserved.

13.
J. Phys. Conf. Ser. ; 1797, 2021.
Article in English | Scopus | ID: covidwho-1139918

ABSTRACT

In this crisis of deadly worldwide pandemic of COVID – 19, thousands of people are getting admitted in the hospitals, with the hope of getting cured. In this point of time, doctors, nurses, and the other medical staff have a lot to pressure and stress to deal with such a large number of patients. Once admitted, family members of the patients don’t get regular updates about the patient. After considering all these problems, we have proposed an idea entitled, “WeCare”, which can suitably be a solution to mitigate such problems. This will be basically, a tracker worn by a patient once admitted in the hospital. This tracker has sensors to sense various vital body parameters such as body temperature, heart rate, pulse rate and most importantly, the oxygen level in the body of the patient. The entire information is stored in the database of the hospital. Trained machines will be there to give an alert when the condition of the patient deteriorates, and immediately help will be arranged. Adequate provisions and arrangements are also made which will help the family members of the patients to keep a track of the health of the patient through a mobile app. © 2021 Institute of Physics Publishing. All rights reserved.

14.
Global Sustainability ; 2020.
Article in English | Scopus | ID: covidwho-1132007

ABSTRACT

Non-technical summary We summarize some of the past year's most important findings within climate change-related research. New research has improved our understanding of Earth's sensitivity to carbon dioxide, finds that permafrost thaw could release more carbon emissions than expected and that the uptake of carbon in tropical ecosystems is weakening. Adverse impacts on human society include increasing water shortages and impacts on mental health. Options for solutions emerge from rethinking economic models, rights-based litigation, strengthened governance systems and a new social contract. The disruption caused by COVID-19 could be seized as an opportunity for positive change, directing economic stimulus towards sustainable investments. Technical summary A synthesis is made of ten fields within climate science where there have been significant advances since mid-2019, through an expert elicitation process with broad disciplinary scope. Findings include: (1) a better understanding of equilibrium climate sensitivity;(2) abrupt thaw as an accelerator of carbon release from permafrost;(3) changes to global and regional land carbon sinks;(4) impacts of climate change on water crises, including equity perspectives;(5) adverse effects on mental health from climate change;(6) immediate effects on climate of the COVID-19 pandemic and requirements for recovery packages to deliver on the Paris Agreement;(7) suggested long-term changes to governance and a social contract to address climate change, learning from the current pandemic, (8) updated positive cost-benefit ratio and new perspectives on the potential for green growth in the short- A nd long-term perspective;(9) urban electrification as a strategy to move towards low-carbon energy systems and (10) rights-based litigation as an increasingly important method to address climate change, with recent clarifications on the legal standing and representation of future generations. Social media summary Stronger permafrost thaw, COVID-19 effects and growing mental health impacts among highlights of latest climate science. Copyright © The Author(s), 2021. Published by Cambridge University Press.

15.
Neurologia ; 36(7): 531-536, 2021 Sep.
Article in Spanish | MEDLINE | ID: covidwho-1096184

ABSTRACT

INTRODUCTION: The COVID-19 pandemic has had an impact on ischaemic stroke management, with a reported decrease in hospital admissions, and even disruptions in healthcare and increased in-hospital mortality. However, there is a lack of evidence on the impact of the pandemic on functional prognosis. The aim of this study is to analyse the effect of the COVID-19 pandemic on the 3-month functional outcomes of patients hospitalised due to acute ischaemic stroke in Aragon (Spain). MATERIL AND METHODS: We reviewed the data of all patients admitted due to ischaemic stroke to any hospital in our regional healthcare system between 30 December 2019 and 3 May 2020. We compared modified Rankin Scale scores and mortality at 3 months in patients hospitalised before and after the declaration of a state of emergency due to the COVID-19 pandemic. RESULTS: In total, 318 patients with acute ischaemic stroke met our inclusion criteria. No differences were observed between periods in global or specific characteristics, with the exception of a higher proportion of patients older than 80 years during the first period (42.2% vs. 29.0%, P=.028). In the comparative analysis, we found no significant differences in mortality (12.3 vs. 7.9, P=.465) or in the proportion of patients with modified Rankin Scale scores ≤ 2 (57.7% vs. 57.1%, P=.425) at 3 months. CONCLUSION: To our knowledge, this is the first study to analyse the impact of COVID-19 pandemic on the 3-month functional outcomes of patients with ischaemic stroke. In our region, there has been no increase in rates of mortality or disability at 3 months in patients admitted due to ischaemic stroke during the pandemic.

17.
Negotiation Journal ; 2020.
Article in English | Web of Science | ID: covidwho-857956

ABSTRACT

Bartering is a common form of negotiation, and COVID-19 may have heightened its occurrence at least temporarily. Yet, bartering has received little attention in the negotiation literature. After defining bartering and describing its relevance and prevalence in the COVID-19 era, this article suggests that an understanding of bartering would significantly enhance our understanding of negotiation in general. Two broad research questions illustrate the importance of better understanding bartering, with important theoretical, pedagogical, and practical implications.

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