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Kanzo/Acta Hepatologica Japonica ; 61(10):496-503, 2020.
Article in Japanese | EMBASE | ID: covidwho-20243418


COVID-19 due to severe acute respiratory syndrome coronavirus 2, which has become a global pandemic, produces elevated liver enzymes, especially in severe cases. The mechanism suggests involvement of an administrated drug, cytokine storm, or hypoxia, etc., as opposed to virus-induced direct damage. If liver enzymes are elevated in COVID-19, we should evaluate for the presence of other liver diseases, and strictly follow-up liver enzyme values. In patients with COVID-19 complicated by chronic liver disease, we will use telemedicine/visits by phone, so as not to interrupt the treatment of the underlying disease, avoid unnecessary outpatient visits, and strive to halt the spread of the infection. Metabolism-associated fatty liver disease, which is often related to obesity, diabetes, and hypertension, may be a risk factor for COVID-19 severity. International academic societies have recommended guidance outlining the evidence to date regarding the management of patients with COVID-19 and liver disorders, and chronic liver disease under the COVID-19 pandemic.Copyright 2020 The Japan Society of Hepatology.

Pediatric Blood & Cancer ; 69, 2022.
Article in English | Web of Science | ID: covidwho-2310749
Pediatric Blood & Cancer ; 70:S40-S41, 2023.
Article in English | Web of Science | ID: covidwho-2244814
Pediatric Blood and Cancer. Conference: 38th Annual Meeting of the Histiocyte. Virtual. ; 70(Supplement 1), 2023.
Article in English | EMBASE | ID: covidwho-2219813


Purpose: Various infectious diseases have dramatically decreased during the COVID-19 pandemic. In Japan, the most frequent cause of HLH in children and adolescents and young adults was infection. In this study, we assessed the incidence of six hematological diseases including HLH, before and during the COVID-19 pandemic Methods:We analyzed the public dataset from the Blood Disease Registration maintained by the Japanese Society of Hematology. From 2016 to 2019, the mean number of patients registered was 42,406 +/- 5,046. In 2020, this figure was 46,471. To analyze changes in annual incidence, we calculated the mean and standard deviation for the 2016-2019 data, and compared this to the annual incidence of each disease in 2020 Results: The total incidence of HLH decreased to 73.7%, compared with the 2016-2019 mean incidence of HLH (152.0 vs. 206.3+/-10.2) Furthermore, HLH incidence in 2020 decreased by 77.5% in those less than 20 years old, and 77.9% in those over 20 years old. Similarly the incidence of IM and aITP decreased by 91.5% and 78.4% in 2020, compared to the respective mean incidences of IMand aITP from 2016 to 2019. The decrease in the number of IM and aITP patients was larger among those less than 20 years of age, compared to those 20 years of age or older (IM: 84.8% vs. 96.6%, and aITP: 52.6% vs 106.5%). On the other hand, the incidences of LCH, ALL, and B-NHL did not decrease in 2020 (LCH, 109.9%;ALL, 102.9%;and B-NHL 111.9%). CONCLUSION(S): The incidence of HLH decreased during the COVID-19 pandemic. Lifestyle changes may be implemented during theCOVID-19 pandemic, specifically social distancing, wearing of facemasks alcohol disinfection, and school closure, effectively reduced contact and droplet transmission.

Meteoritics & Planetary Science ; 57:6111-6111, 2022.
Article in English | Academic Search Complete | ID: covidwho-2012665


Introduction: The JAXA's asteroid explorer Hayabusa2 investigated Cb-type near-Earth asteroid (162173) Ryugu from June 2018 to November 2019 [e.g., 1-3], during which the spacecraft made two touchdown operations onto the asteroid surface for sample collection with projectile shooting [4-8]. The spacecraft returned its reentry capsule to the Earth on December 6, 2020 [8, 9]. The mass of the returned samples was ~5 grams in total;~3 grams from the first touchdown site and ~2 grams from the second touchdown site [9]. At Institute of Space and Astronautical Science (ISAS), JAXA, particles larger than ~1 mm in size were individually photographed, weighed, and investigated spectroscopically inside the nitrogen-filled chamber system. Particles < 1mm were inspected in a sample dish as bulk aggregates. The initial characterization phase of the returned sample shows that it well represents the finding from spacecraft investigation of the asteroid surface [8-10]. Initial Analysis: After the first six-month of initial description at ISAS, ~300 mg of returned samples (~6 % of total mass) were allocated to the Hayabusa2 initial analysis team in June 2021 for one-year priority analysis led by the Hayabusa2 mission [11]. The number of allocated particles larger than 1 mm were 11 from the first touchdown site (Chamber A grains) and 11 from the second touchdown site (Chamber C grains). Ten sets of aggregate samples, consisting of particles smaller than 1 mm, were also allocated (5 from Chamber A and 5 from Chamber C). To characterize the Ryugu sample and to maximize the science output of the Hayabusa2 mission, the initial analysis team consisted of six sub-teams: Chemistry [12], Mineralogy and Petrology for coarse grains [13], Mineralogy and Petrology for fine grains [14], Volatiles [15], Macromolecular Organics [16], and Soluble Organic Matter [17]. The overall analysis activity went smoothly thanks to the dedication and hard work of the team in spite of challenges presented by a lack of in-person communication during the COVID-19 pandemic. What is Ryugu? All the results from the initial analysis are interpreted to support the hypothesis that Ryugu comes from a parent body of the most chemically primitive CI chondrites (least fractionated from the Sun's elemental abundance) [12-17]. Ryugu's volatile and organic contents are highest compared to the meteorites in our collections except for micrometeorites and interplanetary dust particles [15-17]. Because C-type asteroids are a major group of asteroids, the close relation of Ryugu to the rarest type of chondrites (CI) suggests that the Earth's atmosphere works an effective filter for the influx of fragile meteorites, resulting in a biased sampling of meteorites on the ground. A notable mineralogical difference of Ryugu samples from CI chondrites [12-14] indicates that all CI chondrites recovered on Earth experienced significant terrestrial weathering since their fall. The Hayabusa spacecraft retuned surface particles from S-type asteroid (25143) Itokawa in 2010, which was found to be a parent body of equilibrated LL ordinary chondrites [18, 19]. Therefore S-type asteroids and C-type asteroids are likely to be composed of the non-carbonaceous (NC) and carbonaceous chondrite (CC) group materials, representing isotopically dichotomous components in the early Solar System [20]. Coexistence of S- and C-type asteroids in the present main belt thus requires small body migration in the (early) Solar System, likely caused by migration of giant planets [21]. Comparison of Ryugu samples with the sample from B-type asteroid (101955) Bennu [22] will further constrain the dynamical and chemical evolution of small bodies and the (early) Solar System. [ FROM AUTHOR] Copyright of Meteoritics & Planetary Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)