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1.
Salud i Ciencia ; 24(6):316-317, 2021.
Article in Portuguese | GIM | ID: covidwho-2012860

ABSTRACT

In patients with acute ischemic stroke and COVID-19, the highest ratio between neutrophils and lymphocytes and increased serum levels of C-reactive protein, ferritin, D-dimer and fibrinogen are associated with poor neurological prognosis;75% of these patients die or survive with significant disability. At the moment, however, they cannot be established firm conclusions about the long-term evolution of these patients. Thus, the objective of this systematic review was to identify and correlate clinical and biochemical findings in patients with infection confirmed by SARS-CoV-2 and acute ischemic stroke.

2.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-336192

ABSTRACT

Accurate short-term prediction of Covid19 cases with empirical models allow Health Officials to prepare for hospital contingencies in a two-three week window given the delay between case reporting and the admission of patients in a hospital. We investigate the ability of Gompertz-type empiric models to provide accurate prediction up to two and three weeks to give a large window of preparation in case of a surge in virus transmission. We investigate the stability of the prediction and its accuracy using bi-weekly predictions during the last trimester of 2020 and 2021. Using data from 2020, we show that understanding and correcting for the daily reporting structure of cases in the different countries is key to accomplish accurate predictions. Furthermore, we found that filtering out predictions that are highly unstable to changes in the parameters of the model, which are roughly 20%, reduces strongly the number of predictions that are way-off. The method is then tested for robustness with data from 2021. We found that, for this data, only 1-2% of the one-week predictions were off by more than 50%. This increased to 3% for two-week predictions, and only for three-week predictions it reached 10%.

3.
Neuroepidemiology ; 56(SUPPL 1):94, 2022.
Article in English | EMBASE | ID: covidwho-1813111

ABSTRACT

There are currently 449,368,894 confirmed cases and 6,033,022 deaths from the coronavirus COVID- 19 outbreak as of March 08, 2022, leaving 443,335,872 survivors. The actual number of global COVID- 19 cases is likely to be two to three times higher than reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, resulting in unprecedented global health and economic crises with massive social impacts and massively strained health resources globally. COVID-19 is well recognized as a multi-organ disease with a broad spectrum of manifestations. During the early phases of the pandemic, patient advocacy groups, many members of which identify themselves as long COVID, have helped contribute to the recognition of post-acute COVID-19 Neurological Syndrome (PCNS), a syndrome characterized by persistent symptoms and delayed or long-term complications beyond four weeks from the onset of symptoms. This paper provides a comprehensive review of the current literature on post-acute COVID- 19 Neurological Syndrome, its pathophysiology, and its organ-specific sequelae. We explore the shared pathobiological profiles of stroke and COVID-19 involvement in the brain with a significant impact on the long-term care of both groups of survivors. The paper will discuss the role of universal biomarker, serial systemic immune-inflammatory indices (SSIIi) in the context of PCNS and potential implications in post-stroke neurological complications to introduce a systems biology approach to promote brain health for all globally.

4.
Philippine Journal of Science ; 151(1):35-58, 2022.
Article in English | Scopus | ID: covidwho-1668363

ABSTRACT

The global pandemic disease COVID-19 commands a number of host immunological responses to deadly cytokine-storm manifestations. Mitigation of incoming infectious comorbidities ushered by immunosuppression such as tuberculosis (TB) is warranted including the requirement of new drugs. Employment of computational screening methods and intricate selection of putative viral protein targets allows identification of lead mitigating compounds against COVID-19. Antitubercular natural products may offer privileged starting points as potential antagonistic prospects for SARS-CoV-2 non-structural proteins implicated in viral replication and infection mechanisms. In this study, antitubercular natural products from Philippine medicinal plants are repurposed as inhibitors of vital SARS-CoV-2 nsps such as 3CLpro (3-chymotrypsin-like protease), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase) using in silico methods. A total of 67 antitubercular compounds were computationally screened using molecular docking in 3CLpro, PLpro, and RdRp followed by subsequent ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis of top-binding compounds to assess their drug-likeness and pharmacokinetic properties. Based on the results of our molecular docking analysis, 10 antitubercular natural product cocktails exhibited strong binding propensities against 3CLpro, PLpro, and RdRp. Several compounds demonstrated multi-targeting inhibition to at least two vital non-structural proteins (nsps). Vobtusine lactone (1), deoxyvobtusine lactone (6), and deoxyvobtusine (7) exhibited superior target-specific binding while globospiramine (3) was found to be a potential multi-targeting alkaloid with amenable drug-like properties. The study elaborated for the first time, the computational screening of antitubercular compounds against three vital targets of SARS-CoV-2 yielding potential drug-like compounds against COVID-19 infection. A combination of excellent binding scores, dynamic stability, drug-likeness, and pharmacokinetic properties identified vobtusine lactone (1), deoxyvobtusine lactone (6), deoxyvobtusine (7), and the triple targeting globospiramine (3) as promising leads representing new anti-SARS-CoV-2 scaffolds. © 2022, Department of Science and Technology. All rights reserved.

5.
Laplage Em Revista ; 7(3C):210-217, 2021.
Article in English | Web of Science | ID: covidwho-1444645

ABSTRACT

The pandemic generated by COVID-19 has brought major challenges to higher education in a globalized manner, causing an abrupt break from face-to-face activities to virtual/remote processes, ordering changes in both the pedagogical and structural aspects. The courses in the health area needed an extra reorganization, as it involves practical activities, developed in health environments, which were not feasible in this new moment. A concern that moved professors was, how to advance the training process in the face of the new scenario, aiming at the completion of the course in a viable time, with quality and in a safe way? This article describes the trajectory of the construction and implementation of a proposal that the nursing course at the State University of Mato Grosso do Sul has been delineating/running in a dialogic perspective with the course's professors and students.

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