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1.
2022 Winter Simulation Conference, WSC 2022 ; 2022-December:593-604, 2022.
Article in English | Scopus | ID: covidwho-2275595

ABSTRACT

We present a case study on modeling and predicting the course of Covid-19 in the Indian city of Pune. The results presented in this paper are concerned primarily with the wave of infections triggered by the Delta variant during the period between February and June 2021. Our work demonstrates the necessity for bringing together compartmental stock-and-flow and agent-based models and the limitations of each approach when used individually. Some of the work presented here was carried out in the process of advising the local city administration and reflects the challenges associated with employing these models in a real-world environment with its uncertainties and time pressures. Our experience, described in the paper, also highlights the risks associated with forecasting the course of an epidemic with evolving variants. © 2022 IEEE.

2.
Journal of Pharmaceutical Negative Results ; 13:5041-5045, 2022.
Article in English | EMBASE | ID: covidwho-2254193

ABSTRACT

The impact of COVID-19 pandemic on nurses has been significant on their mental & physical health. To minimize their psychological impact Emotional Freedom Technique (EFT) is cost effective, self-administrative successful treatment in very minimum time and highly effective on stress and anxiety. Aim(s): To assess the effect of Emotional Freedom Technique (EFT) on stress & anxiety among nurses working in covid ward. The focus of the study was analysis of data related to the effect of Emotional Freedom Technique (EFT) on stress & anxiety among nurses in covid ward at Dr. D.Y. Patil Hospital in Pune city. Methodology: An evaluative with One- group pre-test post-test research design was adopted to this study.A Non-probability purposive sampling technique was used for selecting 60 samples of covid ward nurses who met the designated set of criteria in the period of data collection in Dr. D.Y. Patil Hospital. In this study there was one experimental group, 60 covid ward nurses were taught EFT method by the researcher and advised to apply this technique continue for 10days twice a day, early morning & night time before sleep. Telephonic follow up was taken with record. Result(s): In pre-test, 20% of the nurses working in covid ward had mild stress levels, 75% of them had moderate stress and 5% of them had severe stress. In post-test, 90% of them had mild stress levels and 10% of them had moderate stress and in pre-test, 73.3% of the nurses working in covid ward had mild anxiety levels, 25% of them had moderate anxiety and 1.7% of them had severe anxiety. In post-test, all of them had mild anxiety. The findings related to association of stress and anxiety levels with demographic variables said that p-value corresponding to number of children is small (<= 0.05), the demographic variable number of children and family type was found to have significant association with the stress among nurses working in COVID ward, and the association of stress with demographic variables said that p-values are large (greater than 0.05) So, there is no significant association with the anxiety among the nurses working in covid ward. Conclusion(s): The research found that in pre-test nurses working in covid ward had mild stress levels and in post-test, all of them had mild anxiety.Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

3.
Journal of Pharmaceutical Negative Results ; 13:4717-4721, 2022.
Article in English | EMBASE | ID: covidwho-2250541

ABSTRACT

Prevention is better than cure This covid-19 pandemic has made many changes in everyone's life, in this pandemic WHO focuses on the safety of healthcare workers and Safety ofpatients, WHO set COVID-19 protocols. Aim(s): Assessment of educational intervention on knowledge regarding World Health Organization covid-19 protocols during delivery among staff nurses. Methodology: The present study is evaluative study with methodological research design. A total of 60 samples were selected for the study by using the non -probability purposive sampling technique based on the selection criteria. The reliability was done by using the test re-test method for structured questionnaire. Data were analysed by using descriptive and inferential statistics. Result(s): In pre-test, 43.3% of the staff nurses had average knowledge (Score 4 to 6), 55% of them had good knowledge (Score 7 to 9) and 1.7% of them had excellent knowledge (Score 10) regarding WHO covid 19 protocols.In post-test, 18.3% of them had good knowledge (Score 7 to 9) and 81.7% of them had excellent knowledge (Score 10) regarding WHO covid 19 protocols. This indicates that the knowledge among the staff nurses regarding WHO covid 19 protocols had improved remarkably after the health teaching. Researcher had applied paired t-test for the effect of health teaching on knowledge regarding WHO covid 19 protocols. Average knowledge scorein pre-test was 6.8;which increased to 9.8 in post-test. T-value for this test was 14.08 with 59degrees of freedom. Corresponding p-value was small (less than 0.05), the null hypothesis is rejected. It is evident that the knowledge among the staff nurses regarding WHO covid 19protocols had improved significantly after health teaching. Conclusion(s): there is a significant gap in the knowledge score WHO COVID-19 Protocol among labour room nurses, and hence there is need for a WHO COVID-19 Protocol for the improvement of knowledge.Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

4.
Drug Safety ; 45(10):1183-1184, 2022.
Article in English | EMBASE | ID: covidwho-2085679

ABSTRACT

Introduction: Equine hyperimmune serum (F(ab')2 fragments) has been widely used in Argentina in the last 100 years with satisfactory results and an acceptable safety profile in the treatment of accidents with poisonous animals such as snakes (bothrops, chrotalus, elapids) and arthropods (Loxosceles, Latrodectus, Phoneutria and Tityus). These antisera were developed by the National Institute for the production of Biologicals (ANLIS-Malbran) and distributed free of charge in public hospitals in the country. Objective(s): The aims of this study (NCT04913779) is to analyze the efficacy and safety of a passive immunotherapy strategy using hyperimmune equine serum known as Anti-SARS-CoV-2 elaborated by the National Institute for the Production of Biologicals (ANLISMalbran) as an addition to the standard therapeutic approach for hospitalized patients with COVID-19, in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Method(s): A randomized, double-blind controlled clinical study is carried out in 200 patients with COVID-19 requiring oxygen therapy in which the safety and efficacy of early use (72 hours from the onset of symptoms) of the research product is evaluated. The present work corresponds to a preliminary result of the safety and pharmacokinetic analysis in the first 20 patients included. Result(s): 20 initial patients (1:1 treatment: control ratio) were studied. The post-administration follow-up time was 28 days. The pharmacokinetic analysis shows that the research product presents an extracellular volume of distribution, with a median half-life of distribution was 6.3h (10-90% percentiles: 3.4-8.1 h) and half-life of elimination, 121h (10th-90th percentiles: 83-171 h). Neutralizing activity in plasma was correlated with drug concentration. Daily controls were carried out including physical examination, questioning in relation to symptoms presented, and blood extraction for routine laboratory control. No patient reported symptoms consistent with adverse reactions. Although some patients presented mild laboratory alterations (hepatogram, urea, creatinine), in all cases they were alterations that existed prior to the administration of the research product and that improved after treatment. Conclusion(s): Despite the small number of patients studied initially, and the possible masking of an adverse event due to the underlying disease (COVID-19), no significant adverse reactions were evidenced during treatment with the research product. There were no serious reactions and the pharmacokinetic characteristics appear to show a long-acting profile correlated with neutralizing activity in vitro.

5.
Drug Safety ; 45(10):1183-1184, 2022.
Article in English | ProQuest Central | ID: covidwho-2045859

ABSTRACT

Introduction: Equine hyperimmune serum (F(ab')2 fragments) has been widely used in Argentina in the last 100 years with satisfactory results and an acceptable safety profile in the treatment of accidents with poisonous animals such as snakes (bothrops, chrotalus, elapids) and arthropods (Loxosceles, Latrodectus, Phoneutria and Tityus). These antisera were developed by the National Institute for the production of Biologicals (ANLIS-Malbraín) and distributed free of charge in public hospitals in the country. Objective: The aims of this study (NCT04913779) is to analyze the efficacy and safety of a passive immunotherapy strategy using hyperimmune equine serum known as Anti-SARS-CoV-2 elaborated by the National Institute for the Production of Biologicals (ANLIS-Malbraín) as an addition to the standard therapeutic approach for hospitalized patients with COVID-19, in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: A randomized, double-blind controlled clinical study is carried out in 200 patients with COVID-19 requiring oxygen therapy in which the safety and efficacy of early use (72 hours from the onset of symptoms) of the research product is evaluated. The present work corresponds to a preliminary result of the safety and pharmacokinetic analysis in the first 20 patients included. Results: 20 initial patients (1:1 treatment: control ratio) were studied. The post-administration follow-up time was 28 days. The pharmacokinetic analysis shows that the research product presents an extracellular volume of distribution, with a median half-life of distribution was 6.3h (10-90% percentiles: 3.4-8.1 h) and half-life of elimination, 121h (10th-90th percentiles: 83-171 h). Neutralizing activity in plasma was correlated with drug concentration. Daily controls were carried out including physical examination, questioning in relation to symptoms presented, and blood extraction for routine laboratory control. No patient reported symptoms consistent with adverse reactions. Although some patients presented mild laboratory alterations (hepatogram, urea, creatinine), in all cases they were alterations that existed prior to the administration of the research product and that improved after treatment. Conclusion: Despite the small number of patients studied initially, and the possible masking of an adverse event due to the underlying disease (COVID-19), no significant adverse reactions were evidenced during treatment with the research product. There were no serious reactions and the pharmacokinetic characteristics appear to show a long-acting profile correlated with neutralizing activity in vitro.

6.
European Journal of Molecular and Clinical Medicine ; 8(3):2363-2373, 2021.
Article in English | EMBASE | ID: covidwho-1197913

ABSTRACT

Background:The incidence and prevalence of Corona virus among the population are increasing day by day. It has spread globally. It affects different people in different way. Most of the people will have mild to moderate symptom and recover without hospitalization. Coronavirus disease (COVID-19) is acontagious disease caused by a newly discovered coronavirus. Senior citizen and those with underlying health problems like cardiac disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.People with diabetes develop a viral infection;it can be difficult to treat because of variations in blood glucose levels and probably, the presence of diabetes complications.1The best you to prevent and control transmission Corona Virus are of educating people regarding causative factor and spread of this infection. The primary prevention of this disease is washing hands or use of alcohol based sanizer and mask. The other preventive measures to keep safe from Covid 19 infection such as social distancing, avoid crowd and keeps rooms well ventilated. Objective: To evaluate the effectiveness of educational interventions regarding knowledge of Self-care management of Diabetes Mellitus during Pandemic COVID 19 among senior citizens. To find out the association between study findings and demographic variables. Method: One group pre-testpost was adopted as study design and involved 60Senior Citizens. The pretest was conducted followed by educational intervention and after 7 days post test was conducted. Outcomes were stated that knowledge among the senior citizens residing in old age homes improved remarkably after educational interventions. Result: Educational interventions were found to be significantly effective in improving the knowledge of the senior citizens.Conclusion: The overall study findings concluded that educational intervention is an effective strategy in improving knowledge of Self-care management of Diabetes Mellitus during Pandemic COVID among the senior citizens.

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