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1.
Online Brazilian Journal of Nursing ; 21, 2022.
Article in English | Scopus | ID: covidwho-2025871

ABSTRACT

Objective: To know the perceptions of mothers of premature newborns hospitalized in the Neonatal Unit in the face of the COVID-19 pandemic. Method: Qualitative research carried out in June and July 2020, involving 12 mothers of premature newborns hospitalized in the neonatal units of a maternity hospital in the state of Ceará during the Coronavirus pandemic. Mothers were contacted via WhatsApp application. For the textual analysis, the descending hierarchical classification performed by the IRAMUTEQ software was used. Results: The mothers’ perception was centered on the difficulties faced in this pandemic period. The word “no” was strongly presented in the corpus of the text, evidencing the impact of the impediment of the visit, of the mothers’ permanence in the units and the fact of not being able to breastfeed. Conclusion: The provision of humanized care in neonatal units should not be limited to the newborn, and emotional support for mothers by the health team is essential © 2022. Online Brazilian Journal of Nursing. All Rights Reserved.

2.
Annals of the Rheumatic Diseases ; 81:978-979, 2022.
Article in English | EMBASE | ID: covidwho-2009189

ABSTRACT

Background: Across the globe, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 appears to affect paediatric population in a milder and non-threatening way, when compared to adults. However, since April 2020 case reports of previously healthy children presenting with unremitting fever, biologic infammatory syndrome and cardiac dysfunction have been emerging. This syndrome, which has been termed Pediatric Infammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 infection (PIMS-TS), represents a rare complication of COVID-19 in children1. Objectives: To describe the clinical, laboratory and imaging characteristics, course, management and outcomes of hospitalized children diagnosed with PIMS-TS in a Portuguese tertiary care hospital. Methods: A retrospective study including children (< 18 years) that attended our hospital from April 2020 to December 2021 was performed. All the children included fulflled the case defnition of PIMS-TS published by the Centre for Disease Control and Prevention. Sociodemographic and clinical data, laboratory markers and imaging fndings were collected. Results: A total of 19 children met the criteria for PIMS-TS, 68% male with a mean age at diagnosis of 8 years old (IQR 5.8-15). They were all caucasian, except for a mixed-race patient, and all previously healthy, except one patient who was obese. Twelve had recent infection by SARS-CoV-2 detected by reverse transcriptase (RT) PCR and 18 had positive IgG serology. All had fever at diagnosis, with a median duration of 6 days (IQR 5-6) and 89.5% had mucocutaneous, gastrointestinal and hematological attainment, respectively. Other affected systems were respiratory (73.7%), cardiovascular (63%), lymphoid organs (52.6%), musculoskeletal (47%), genito-urinary (31.6%) and neurological (26.3%). Laboratory fndings can be found in Table 1. Thirty-six percent were admitted in intensive care unit for a median duration of 8 days (IQR 4-9). 42.1% needed respiratory support, 87.5% with supplemental oxygen therapy, 62.5% with mechanical ventilation and 12.5% with non-invasive ventilation. All patients received intravenous (IV) immunoglobulin, 52.6% IV cor-ticosteroid (CS) pulses and 78.9% IV and oral CS. Other treatments included acetylsalicylic acid (n=18), heparin (n=8) and antibiotic therapy (n=19)-Table 3. Seventeen fully recovered and 2 had sequalae: one of them with coronary artery aneurysms and other exertional dyspnea. Conclusion: In this case series, there was a broad spectrum of clinical symptoms and disease severity, ranging from fever and systemic infammation to critical care admission with myocardial injury, shock, and development of coronary artery aneurysms. Despite short-term morbidity, there were no mortality cases, with most of them recovering without sequelae. All physicians providing clinical care to children should consider this rare but severe delayed syndrome in paediatric population.

3.
Giovanetti, M.; Slavov, S. N.; Fonseca, V.; Wilkinson, E.; Tegally, H.; Patané, J. S. L.; Viala, V. L.; San, E. J.; Rodrigues, E. S.; Santos, E. V.; Aburjaile, F.; Xavier, J.; Fritsch, H.; Adelino, T. E. R.; Pereira, F.; Leal, A.; Iani, F. C. M.; de Carvalho Pereira, G.; Vazquez, C.; Sanabria, G. M. E.; Oliveira, E. C.; Demarchi, L.; Croda, J.; Dos Santos Bezerra, R.; Paola Oliveira de Lima, L.; Martins, A. J.; Renata Dos Santos Barros, C.; Marqueze, E. C.; de Souza Todao Bernardino, J.; Moretti, D. B.; Brassaloti, R. A.; de Lello Rocha Campos Cassano, R.; Mariani, Pdsc, Kitajima, J. P.; Santos, B.; Proto-Siqueira, R.; Cantarelli, V. V.; Tosta, S.; Nardy, V. B.; Reboredo de Oliveira da Silva, L.; Gómez, M. K. A.; Lima, J. G.; Ribeiro, A. A.; Guimarães, N. R.; Watanabe, L. T.; Barbosa Da Silva, L.; da Silva Ferreira, R.; da Penha, M. P. F.; Ortega, M. J.; de la Fuente, A. G.; Villalba, S.; Torales, J.; Gamarra, M. L.; Aquino, C.; Figueredo, G. P. M.; Fava, W. S.; Motta-Castro, A. R. C.; Venturini, J.; do Vale Leone de Oliveira, S. M.; Gonçalves, C. C. M.; do Carmo Debur Rossa, M.; Becker, G. N.; Giacomini, M. P.; Marques, N. Q.; Riediger, I. N.; Raboni, S.; Mattoso, G.; Cataneo, A. D.; Zanluca, C.; Duarte Dos Santos, C. N.; Assato, P. A.; Allan da Silva da Costa, F.; Poleti, M. D.; Lesbon, J. C. C.; Mattos, E. C.; Banho, C. A.; Sacchetto, L.; Moraes, M. M.; Grotto, R. M. T.; Souza-Neto, J. A.; Nogueira, M. L.; Fukumasu, H.; Coutinho, L. L.; Calado, R. T.; Neto, R. M.; Bispo de Filippis, A. M.; Venancio da Cunha, R.; Freitas, C.; Peterka, C. R. L.; de Fátima Rangel Fernandes, C.; Navegantes, W.; do Carmo Said, R. F.; Campelo de, A. E. Melo C. F.; Almiron, M.; Lourenço, J.; de Oliveira, T.; Holmes, E. C.; Haddad, R.; Sampaio, S. C.; Elias, M. C.; Kashima, S.; Junior de Alcantara, L. C.; Covas, D. T..
Nat Microbiol ; 2022.
Article in English | PubMed | ID: covidwho-1991610

ABSTRACT

The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, but important gaps remain in our understanding of virus transmission dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states and bordering country Paraguay. From March to November 2020, we detected co-circulation of multiple viral lineages that were linked to multiple importations (predominantly from Europe). After November 2020, we detected large, local transmission clusters within the country. In the absence of effective restriction measures, the epidemic progressed, and in January 2021 there was emergence and onward spread, both within and abroad, of variants of concern and variants under monitoring, including Gamma (P.1) and Zeta (P.2). We also characterized a genomic overview of the epidemic in Paraguay and detected evidence of importation of SARS-CoV-2 ancestor lineages and variants of concern from Brazil. Our findings show that genomic surveillance in Brazil enabled assessment of the real-time spread of emerging SARS-CoV-2 variants.

4.
Medicina (Brazil) ; 55(2), 2022.
Article in English | EMBASE | ID: covidwho-1979699

ABSTRACT

Objective: To assess the association between the degree of lung involvement (LI) on chest CT scans of COVID-19 patients, risk factors and outcomes. Methods: Observational and retrospective study of 284 COVID-19 patients. Age, sex, clinical presentation, oxygen saturation on admission, risk factors, time after symptom onset, percentage of LI, length of stay in ward and ICU, duration of ETI, and death were assessed. 3 groups were created according to the LI. Results: 167 patients had an involvement of <25%;80, 25-50%;and 37, >50%. The group with greater LI was older, had more males and a higher incidence of cough, dyspnea and some comorbidity. Moreover, the group with greater LI had lower saturation on admission, more ETI, more admissions to the ward or ICU, and higher mortality. LI, ETI and age were predictors of mortality. Conclusion: The degree of LI appears to be significantly associated with some clinical parameters, need for hospitalization, intubation, and death.

5.
Hematology, Transfusion and Cell Therapy ; 43:S513-S514, 2021.
Article in English | EMBASE | ID: covidwho-1859711

ABSTRACT

Introdução: Desde de dezembro de 2019, temos enfrentado a infecção pelo novo coronavírus (SARS-COV-2), causando repercussões diversas, que vão de síndrome respiratória aguda grave até formas assintomáticas. Uma hiperativação inflamatória parece estar associada a fenômenos autoimunes associada ao SARS-COV2. Se tratando de uma afecção emergente pouco se sabe dos fenômenos autoimunes induzidos pela infecção, sobretudo, patologias autoimunes hematológicas. Com esse intuito, o presente estudo vem relatar uma aplasia medular transitória em paciente internado pela infecção. Relato: Trata-se de paciente adulto, sexo masculino,52 anos, apresentando sintomas gripais e teste positivo para COVID-19, vinha em seguimento ambulatorial em uso de moxifloxacino, quando no 12°dia de sintomas foi internado em leito de terapia intensiva, após evolução com síndrome respiratória aguda grave (SRAG) e intubação orotraqueal. Iniciada terapia com dexametasona 10mg/dia, enoxaparina 40 mg de 12/12h SC, Ceftriaxona 1 g 12/12h. Intercorrendo após 10 dias de internação com disfunção renal, necessitando suporte dialítico. No 18°dia evoluindo com pancitopenia, sem sangramentos e sendo suspenso a profilaxia para tromboembolismo venoso (nesse momento era feita com heparina não fracionada devido a disfunção renal) e acionado o serviço de hematologia. Realizando seguimento diário com exames de sangue, e evoluindo para pancitopenia grave, com agranulocitose (neutrófilos: < 200). Exames Hb:7,90 Htc:22% VCM: 84,3 HCM: 30,30 GB:487 (Seg:194 — Lin:243 — Mon:49) Plaquetas: 50000. Havendo troca de esquema de antimicrobianos para Meropenem, Vancomicina e após 3 dias sem melhora clínica, introduzido Anfotericina B, e ampliado esquema antimicrobiano com associação de Polimixina B. Realizada biopsia de medula óssea com achados corroborando para hipótese de Aplasia de medula óssea. Afastados critérios para linfohistiocitose hemofagocítica e com sorologias negativas para outras infecções virais que sabidamente poderiam apresentar esse quadro. Após o 26°dia paciente iniciou melhora clínica e resolução espontânea da neutropenia, persistindo até o 30°dia com anemia e necessidade transfusional em raras ocasiões. Evolui com desmame ventilatório e recuperação da função renal, tendo alta após 45 dias de internação. Discussão: Acreditamos que a aplasia medular nesse caso foi associada a infecção pelo SARS-COV2, paciente que intercorreu com doença grave, necessidade de suporte ventilatório e acometimento sistêmico pela infecção. Dados da literatura trazem descrição de fenômenos imunes associados a infecção, como trombocitopenia imune, sem associação com linfohistiocitose ou coagulação intravascular disseminada. O mecanismo pelo qual os fenômenos imunes hematológicos ocorrem não estão claros.

6.
Hematology, Transfusion and Cell Therapy ; 43:S349, 2021.
Article in English | EMBASE | ID: covidwho-1859652

ABSTRACT

Objetivos: Em vigência da pandemia COVID-19, foi implementada uma rotina de captação intra-hospitalar de doadores de sangue no Hospital Universitário Pedro Ernesto (HUPE), tendo o corpo clínico do hospital como ponto focal através do engajamento de equipes das diversos setores clínicos e cirúrgicos, em campanhas mensais de doação de sangue, visando a manutenção do estoque de sangue no núcleo de hemoterapia do hospital. Material e métodos: Entre março e julho de 2021, identificadas as clínicas de maior demanda por hemocomponentes no hospital, foram realizadas reuniões de sensibilização para a doação de sangue entre as equipes, com atividades lúdicas e educacionais. O recurso de mídias sociais, principalmente Instagram® e FaceBook® foi utilizado para divulgação das ações visando a captação de doador. Foram contabilizados o número de setores e pessoas atingidas em cada ação, assim como número de doações de sangue nos respectivos meses de atividades de captação intra-hospitalar. Foi feita avaliação qualitativa sobre o conhecimento, sentimento e curiosidade das equipes sobre doação de sangue. Resultados: Os setores envolvidos foram 7, sendo eles, neurocirurgia, cirurgia cardíaca, pediatria, reumatologia, urologia, cirurgia vascular e hematologia. Foram realizadas 20 reuniões, atingindo 169 pessoas do corpo clínico dos diversos setores envolvidos. Cada equipe criou e desenvolveu atividades lúdicas educacionais nos respectivos setores, visando motivar a equipe para a doação de sangue. As principais dúvidas foram quanto aos critérios de inaptidão à doação, apesar de haverem doadores de sangue entre eles. Requisitos básicos para a doação, presença de tatuagem e mais recentemente, a doação de sangue por homem que tem sexo com homem, foram as dúvidas mais frequentes. As equipes não realizavam atividades de captação intra-hospitalar e não estavam diretamente envolvidas neste tipo de ação até as intervenções em questão. O número de candidatos aptos à doação entre março a julho de 2021, foi 17,6% maior, quando comparado com o mesmo período em 2020. Discussão: Apesar da captação intra-hospitalar não ser o modelo ideal para sensibilização à doação, diante de um recurso escasso e em vigência da pandemia COVID-19, considerou-se necessário incluir este tema de discussão, dentro de um hospital de elevado potencial transfusional. O não conhecimento sobre critérios básicos para doação de sangue entre a equipe de saúde, revela a necessidade de disseminar o conhecimento sobre esta atitude na sociedade como um todo, com ênfase neste grupo de pessoas. Mesmo durante atividades diárias extenuantes, os profissionais de saúde mostraram-se dispostos a participar do processo transfusional, seja como captador, ou como doador. Conclusão: Em vigência de situações que tragam risco para a manutenção do estoque de hemocomponentes, a captação intra-hospitalar parece viável e pode ser encorajada entre a equipe de saúde. Estas atividades são oportunidades educativas e devem ser estimuladas, incluindo o corpo clínico no processo transfusional.

7.
Cochrane Database of Systematic Reviews ; 2022(4), 2022.
Article in English | EMBASE | ID: covidwho-1798050

ABSTRACT

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and occurrence of deep venous thrombosis and pulmonary embolism in non-hospitalised people with COVID-19.

8.
Giovanetti, M.; Slavov, S. N.; Fonseca, V.; Wilkinson, E.; Tegally, H.; Patané, J. S. L.; Viala, V. L.; San, J. E.; Rodrigues, E. S.; Vieira Santos, E.; Aburjaile, F.; Xavier, J.; Fritsch, H.; Ribeiro Adelino, T. E.; Pereira, F.; Leal, A.; Campos de Melo Iani, F.; de Carvalho Pereira, G.; Vazquez, C.; Mercedes Estigarribia Sanabria, G.; de Oliveira, E. C.; Demarchi, L.; Croda, J.; Dos Santos Bezerra, R.; Oliveira de Lima, L. P.; Martins, A. J.; Dos Santos Barros, C. R.; Marqueze, E. C.; de Souza Todao Bernardino, J.; Moretti, D. B.; Brassaloti, R. A.; de Lello Rocha Campos Cassano, R.; Drummond Sampaio Corrêa Mariani, P.; Kitajima, J. P.; Santos, B.; Proto-Siqueira, R.; Cantarelli, V. V.; Tosta, S.; Brandão Nardy, V.; Reboredo de Oliveira da Silva, L.; Astete Gómez, M. K.; Lima, J. G.; Ribeiro, A. A.; Guimarães, N. R.; Watanabe, L. T.; Barbosa Da Silva, L.; da Silva Ferreira, R.; MP, F. da Penha, Ortega, M. J.; Gómez de la Fuente, A.; Villalba, S.; Torales, J.; Gamarra, M. L.; Aquino, C.; Martínez Figueredo, G. P.; Fava, W. S.; Motta-Castro, A. R. C.; Venturini, J.; do Vale Leone de Oliveira, S. M.; Cavalheiro Maymone Gonçalves, C.; Debur Rossa, M. D. C.; Becker, G. N.; Presibella, M. M.; Marques, N. Q.; Riediger, I. N.; Raboni, S.; Coelho, G. M.; Cataneo, A. H. D.; Zanluca, C.; Dos Santos, C. N. D.; Assato, P. A.; Allan da Silva da Costa, F.; Poleti, M. D.; Chagas Lesbon, J. C.; Mattos, E. C.; Banho, C. A.; Sacchetto, L.; Moraes, M. M.; Tommasini Grotto, R. M.; Souza-Neto, J. A.; Nogueira, M. L.; Fukumasu, H.; Coutinho, L. L.; Calado, R. T.; Neto, R. M.; Bispo de Filippis, A. M.; Venancio da Cunha, R.; Freitas, C.; Leonel Peterka, C. R.; Rangel Fernandes, C. F.; de Araújo, W. N.; do Carmo Said, R. F.; Almiron, M.; Campelo de Albuquerque, E. Melo C. F.; Lourenço, J.; de Oliveira, T.; Holmes, E. C.; Haddad, R.; Sampaio, S. C.; Elias, M. C.; Kashima, S.; de Alcantara, L. C. J.; Covas, D. T..
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-332259

ABSTRACT

Brazil has experienced some of the highest numbers of COVID-19 cases and deaths globally and from May 2021 made Latin America a pandemic epicenter. Although SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, important gaps remain in our understanding of virus transmission dynamics at the national scale. Here, we describe the genomic epidemiology of SARS-CoV-2 using near-full genomes sampled from 27 Brazilian states and a bordering country - Paraguay. We show that the early stage of the pandemic in Brazil was characterised by the co-circulation of multiple viral lineages, linked to multiple importations predominantly from Europe, and subsequently characterized by large local transmission clusters. As the epidemic progressed under an absence of effective restriction measures, there was a local emergence and onward international spread of Variants of Concern (VOC) and Variants Under Monitoring (VUM), including Gamma (P.1) and Zeta (P.2). In addition, we provide a preliminary genomic overview of the epidemic in Paraguay, showing evidence of importation from Brazil. These data reinforce the usefulness and need for the implementation of widespread genomic surveillance in South America as a toolkit for pandemic monitoring that provides a means to follow the real-time spread of emerging SARS-CoV-2 variants with possible implications for public health and immunization strategies.

9.
Izquierdas ; 51:11, 2022.
Article in Spanish | Web of Science | ID: covidwho-1766803

ABSTRACT

The cultural domination of capitalism and its influence on the construction of modern democracies could not have been possible without educational institutions becoming one of the main territories for discursive, material and power disputes. This fact has conditioned the existence of a model that educates "from fear" and that, based on this, has ensured the non-expansion of emancipatory and supportive subjectivities. To explore this idea further, and as an epilogue to this dossier "Social movements, activism and resistance from the school", we spoke with Professor Boaventura de Sousa Santos to reflect on the role of education in the context of the COVID-19 pandemic and what the main challenges are for building more democracy and educational justice through resistance and emancipation.

10.
Open Forum Infectious Diseases ; 8(SUPPL 1):S584, 2021.
Article in English | EMBASE | ID: covidwho-1746336

ABSTRACT

Background. Invasive pulmonary aspergillosis (IPA) is increasingly recognized as a complication of severe respiratory viral infections (RVIs), including influenza and COVID-19. However, the incidence and outcomes of IPA following other RVIs is not well-described. We hypothesized that IPA may be an underreported complication of non-influenza RVIs. The objective of this study was to quantify the incidence and associated outcomes of IPA following RVI in hospitalized patients. Methods. We conducted a single-center retrospective cohort study of adult hospitalized patients with RVI diagnosed by multiplex PCR-based assay at the University of Kansas Hospital (Kansas City, Kansas) from September 2018-October 2019. Patients with a diagnosis of proven or probable IPA prior to RVI and those with hospital admission < 24 h were excluded from analysis. Proven or probable IPA was defined according to EORTC/MSGERC consensus definitions. The primary outcome was 1-year all-cause mortality. Results. A total of 195 patients met study criteria and were included in the analysis. The most common types of RVI observed were rhinovirus/enterovirus (57.9%, n=113), parainfluenza (13.3%, n=26), influenza (8.2%, n=16), and respiratory syncytial virus (7.7%, n=15). The cumulative incidence of IPA infection within 6 weeks of RVI was 5.6% (n=11). Excluding patients co-infected with multiple respiratory viruses (n=5), IPA was numerically more likely to occur following influenza compared to non-influenza RVI (12.5% [ n=2/16] vs. 4.6% [n=8/174];odds ratio, 2.96;95% confidence interval [CI], 0.57-15.3;P=0.176). Overall, one-year all-cause mortality was 20% (n=39/195) in this cohort. Development of IPA as a complication of RVI was associated with a significant decrease in 1-year survival (hazard ratio [HR], 3.04;95% CI, 1.19-7.78;P=0.021), and this relationship persisted after adjustment for age (HR, 2.77;95% CI, 1.08-7.10;P=0.034). Conclusion. In a cohort of hospitalized patients with RVI, 5.6% of patients developed proven or probable IPA. Although IPA was more likely to occur in patients with influenza, this complication was also observed with other types of RVI. Invasive pulmonary aspergillosis may be an underappreciated complication of non-influenza RVI in hospitalized patients and warrants continued study.

11.
Carbon Management ; 13(1):1-16, 2022.
Article in English | Scopus | ID: covidwho-1740675

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has strongly affected economies and human lifestyles globally. The changes observed in domestic energy consumption patterns have had an impact on household greenhouse gas (GHG) emissions. Since GHG emissions inventories are only available at the country level and at annual intervals, most studies have calculated the local emission variations by extrapolating annual emissions with smaller time and territorial scale consumption data. This research presents a bottom-up method, based on the exploitation of a survey addressed to 1200 households, that provides the information to calculate directly the variation in their energy-related GHG emissions, without the need for extrapolations. This method has been applied to four medium-sized Chilean cities with serious air quality problems. Given the high correlation between atmospheric pollutants such as NOx and CO2 emissions, we estimate that before the appearance of COVID-19, per capita CO2 emissions were already high. The results show that space heating-related GHG emissions have increased moderately (between 1 and 6%), while emissions from electricity and gas consumption for non-heating uses have increased significantly (between 8 and 23%). This has harmed the household economy, highlighting the importance of considering socioeconomic aspects when assessing the impact of COVID-19 in its entirety. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

13.
Safety and Health at Work ; 13:S73, 2022.
Article in English | EMBASE | ID: covidwho-1676979

ABSTRACT

Introduction: AquaSafe is a mobile learning application that can be used as one of the modalities for teaching, training and risk assessment in aquaculture occupational health and safety (AOHS). The app has checklists, risk assessment tools and other relevant information on AOHS. Materials and Methods: Content information was based on global scientific literature, ILO, FAO, WHO and OHSAS 18001. An online survey is also available to identify which application tools are used and to assess the application’s effectiveness in promoting prevention of injury and illness in aquaculture workers. Results: Available for Android, its interfaces promote learning through a questionnaire;risk assessment checklists;and tools to identify the root cause of the AOHS problem. Users can find information on risks, personal protective equipment and educational videos on AOHS as well as COVID-19. Findings from the online survey revealed that most responders indicated that AquaSafe increased their knowledge of AOHS. Participants reported that risk tools, checklists and what-if are used more frequently than quizzes, videos and the “5-whys”. Conclusions: While AquaSafe is designed to support knowledge awareness, risk assessment and decision making in AOHS, it is not used widely enough. The low response rate to the survey and downloads suggest that AOHS is not a priority in low-middle income countries, such Brazil. AOHS awareness remains a challenge and requires differentiated approaches.

14.
Circulation ; 144(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1632168

ABSTRACT

Introduction: Coronavirus disease 2019 (COVID-19) has become one of the more dramatic health problems in the century. This disease has enormous consequence for the health care worldwide. In addition to high mortality rate, patients recovered from COVID-19 present short and long-term cardiovascular sequelae including chest pain, myocardial dysfunction, arrhythmia, dyspnea, breathlessness, postural tachycardia syndrome, and thrombotic complications. The explanations for these clinical manifestations are still uncertain but can involve a constellation of physiological alterations. Hypothesis: To test if COVID-19 survivors have augmented sympathetic outflow, diminished endothelial function, elevated aortic stiffness, and reduced physical capacity compared to healthy individuals. Methods: Nineteen COVID-19 survivors [age: 47.0±2.3 years, BMI: 30.1±1.2 Kg/m2] and eighteen well-matched healthy controls (age: 44.0±2.0 years, BMI: 28.4 ±1.2 Kg.m2] were included in study. COVID-19 survivors were evaluated within 6 months of original diagnosis by RT-PCR. Muscle sympathetic nerve activity (MSNA) from fibular nerve (Microneurography), brachial artery flowmediated dilation (BAFMD;Doppler-Ultrasound), carotid-femoral pulse wave velocity (cf-PWV;Complior), beat-to-beat blood pressure (Peripheral BP;Finometer), heart rate (HR;Electrocardiography) and peak oxygen uptake (VO2peak, Cardiopulmonary exercise testing) were measured in both groups. Results: MSNA was higher in COVID-19 survivors compared to controls (33.0±1.0 vs. 22.0±1.0 bursts/min, p=0.001). Both BAFMD and VO2peakwere lower in COVID-19 survivors compared to controls (4.6±0.7 vs. 8.2 ±0.8%, p=0.005 and 22.2±1.5 vs. 29.7±1.6 mL/Kg/min p=0.001, respectively). Although COVID-19 survivors had greater cf-PWV than controls (8.6±0.5 m/s vs. 7.4±0.4 m/s, p=0.03), BP and HR were not different between groups. Conclusions: Our study revealed that patients recently recovered from COVID-19 have abnormal neurovascular control, vascular alterations and reduced physical capacity. These findings strongly indicate the need of further long-term investigations to uncover cardiovascular sequelae provoked by COVID-19.

15.
Hematology, Transfusion and Cell Therapy ; 42:536-536, 2020.
Article in Spanish | PMC | ID: covidwho-1385640

ABSTRACT

Objetivo: O presente estudo buscou analisar a suscetibilidade pela infecção por SARS-CoV-2 entre a tipagem sanguínea com base em estudos publicados. Introdução: O SARS-CoV-2 é um vírus pertencente à família dos Coronaviridae, tendo o RNA como seu material genético, que leva ao desenvolvimento da doença COVID-19. O novo coronavírus foi detectado pela primeira vez em dezembro de 2019 na cidade de Wuhan, China, tornando-se uma pandemia acometendo até agosto de 2020, 215 países. Neste sentido, a busca por entender os mecanismos e/ou suscetibilidade frente a infecção por este vírus, se tornou prioridade entre os pesquisadores do mundo, sugerindo então uma correlação entre o sistema ABO frente a infecção por SARS-CoV-2. Metodologia: Foi realizada uma revisão da literatura com base em artigos indexados nas plataformas: Pubmed e medRxiv, no ano de 2020. Ao final da aplicação dos critérios de exclusão para seleção dos artigos, foram selecionados 17 estudos. Resultados e discussões: Mesmo com a escassez de estudos, o que é justificável por se tratar de um novo vírus, as pesquisas apontam que o tipo A é o mais susceptível e o grupo O menos susceptível, todavia, a gravidade quanto ao risco de óbito está associado ao tipo AB. Até o presente momento não se sabe ao certo o porquê o SARS-CoV-2 é menos susceptível ao grupo O. Hipotetiza-se que o anti-A desse grupo é capaz de interferir na ligação entre a proteína Spike com o receptor da enzima conversora angiotensina 2 (ACE2), mecanismo este visto na infecção por SARS-CoV-1. Outro fato que pode ser considerado é em relação a neutralização que os anticorpos anti-A e/ou anti-B podem exercer em infecções virais semelhantemente visto nas infecções por HIV, que poderia neutralizar também o SARS-CoV-2. Conclusão: Em suma, nota-se que o tipo sanguíneo O apresenta uma menor suscetibilidade diante a infecção pelo novo coronavírus, porém, não há nenhum estudo que elucide de qual forma o SARS-CoV-2 se porta diante o grupo ABO, fazendo então a necessidade de pesquisas para esclarecer este processo.

16.
Encontros Bibli ; 26, 2021.
Article in Portuguese | Scopus | ID: covidwho-1134360

ABSTRACT

Objective:The study aims to verify, based on the guidelines of the Brazilian Ministry of Health for the prevention of Covid-19, how the application drivers use this information during their work routine. Methods: This isan applied research, with qualitative and quantitative character, which uses the Netnography Method for the collection and analysis of data immersed in groups of communication applications, especially the WhatsApp. Results: The results showed a tendency for Brazilian application drivers to comply with the World Health Organization and the Brazilian Ministry of Health guidelines for the prevention of Covid-19, in view of the self-care revealed in the questionnaire responses. Conclusions: It is concluded that, in the complex ecosystem of this research, which involves public health, discussions must be faced with academic research, and science of quality. © 2020, Universidade Federal de Santa Catarina. All rights reserved.

17.
Atoz-Novas Praticas Em Informacao E Conhecimento ; 9(2):183-195, 2020.
Article in Portuguese | Web of Science | ID: covidwho-1089108

ABSTRACT

Introduction: this paper assesses the home page of the digital informational environment of the Brazilian federal government website on COVID-19 from the perspective of information architecture. It aims to contribute to effective information retrieval for the informational subjects that browse this environment. Method: a qualitative, exploratory, and applied study uses the netnography as a method for the investigation and description of the object of study. Results: we found five positive points and five negative points in the studied digital information environment. As an example of the positive points, the website presents a panel with updated news on the topic and as an example of the negative points the omission of data and a search box on the home page. Conclusions: Based on the results, a wireframe for the home page of the COVID-19 website in Brazil is proposed.

18.
Physica Scripta ; 96(3), 2021.
Article in English | Scopus | ID: covidwho-1035694

ABSTRACT

In this paper, we presented an overview diagnosis consider the time series of daily deaths by COVID-19 in the Brazilian States using Bandt &Pompe method (BPM) to estimate the Information Theory quantifiers, more specifically the Permutation entropy (Hs) and the Fisher information measure (Fs). Based on the Information Theory quantifiers, we build up the Shannon-Fisher causality plane (SFCP) to promote insights into the COVID-19 temporal evolution inherent in the phenomenology associated with the number of daily deaths well as their respective locations along the SFCP. Moreover, we apply Hs and Fs to elaborate on the rank of the Brazilian States’ real situation, considering the number of daily death due to COVID-19 based on the complexity hierarchy. The Brazilian States that are located in the middle region of the two-dimensional plane (Hs x Fs), such as Amapá (AP), Roraima (RO), Acre (AC), and Tocantins (TO) are characterized by a less entropic and low disorder, which implies in high predictability of the COVID-19 lethality. While, the Brazilian States that are located in the lower-right region, such as Ceará (CE), Bahia (BA), Pernambuco (PE), and Rio de Janeiro (RJ), are characterized by high entropy and high disorder, which leads to low predictability of the COVID-19 lethality. Given this, our results provide empirical evidence that the permutation entropy is a powerful approach to predicting infectious diseases. Dynamic monitoring of permutation entropy can help policymakers to take more or less restrictive measures to combat COVID-19. © 2021 IOP Publishing Ltd.

19.
Social Sciences ; 10(1):1-20, 2021.
Article in English | Scopus | ID: covidwho-1029971

ABSTRACT

Brazil has made international headlines for the government’s inept and irresponsible response to the COVID-19 pandemic. In this context, sex worker activists have once again taken on an essential role in responding to the pandemic amidst State absences and abuses. Drawing on the theoretical framework of necropolitics, we trace the gendered, sexualized, and racialized dimensions of how prostitution and work have been (un)governed in Brazil and how this has framed sex worker activists’ responses to COVID-19. As a group of scholars and sex worker activists based in Rio de Janeiro and São Paulo, we specifically explore the idea of sex workers as “essential workers”, but also of sex work as, essentially, work, demonstrating complicities, differences, and congruencies in how sex workers see what they do and who their allies in the context of the 21st century’s greatest health crisis to date. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

20.
Revista de Economia Institucional ; 23(44):81-101, 2020.
Article in Spanish | Scopus | ID: covidwho-1000723

ABSTRACT

This writing is part of a more detailed study on the pandemic and the current context. The COVID-19 pandemic has aggravated the situation to which the population has been subjected since the time when capitalism, in its neoliberal version, dismantled the social and welfare state policies that made it possible to maintain a level of income to increase mass consumption, as well as facing serious emergencies. Although human life only represents 0.01% of life on Earth, the protection of all life forms is essential for human life to continue. If our species continues to destroy other forms of life and fails to overcome the political, cultural and ideological quarantine of capitalism closed in on itself for some four decades, the effects caused are increasingly lethal.The author concludes that we can only overcome the quarantine of capitalism when we understand that the planet is our common home and nature is our original mother, to whom we owe love and respect. When we overcome that quarantine, we will be freer from the quarantines caused by pandemics. © 2020, Universidad Externado de Colombia. All rights reserved.

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