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Cocuk Enfeksiyon Dergisi ; 15(4):236-239, 2021.
Article in Turkish | EMBASE | ID: covidwho-1650975


Objective: With the rapid spread of SARS-CoV-2, a new coronavirus, around the world, a pandemic was declared by World Health Organization on March 2020. The first cases were reported in March 2020 from Turkey. In our hospital, the first pediatric case was detected on April 2, 2020. However, there is no data on whether this virus had been present in our region or not before this date. The aim of our study was to de-termine the first entry of SARS-CoV-2 virus to our region for pediatric patients. Material and Methods: SARS-CoV-2 positivity was investigated retro-spectively with the RT-qPCR method in the pediatric respiratory tract specimens taken between the October 1, 2019 and March 31, 2020. In the specimens, SARS-CoV-2 RNA was studied using real-time PCR based “COVID-19 RT-qPCR Detection Kit”. Results: 886 samples were included in the study. Of the respiratory tract specimens, 97.1% were nasopharyngeal swabs, 2.8% were bronchoal-veolar lavage. Most frequently, rhinovirus (28.6%), influenza A subtype H1N1 (pandemic H1N1) (18.5%) and influenza B (16%) were detected. Rhinovirus and enterovirus were the most frequent double agents seen together. No SARS-CoV-2 positivity was detected in the respiratory tract specimens studied. Conclusion: SARS-CoV-2 PCR test was conducted in a limited number of centers at the beginning of the pandemics may have affected the detection of the first case in Turkey. Multicenter studies of archived samples would enable more realistic results in tracking SARS-CoV-2 in our country.

Respir Med Res ; 79: 100826, 2021 May.
Article in English | MEDLINE | ID: covidwho-1221020


BACKGROUND: Early recognition of the severe illness is critical in coronavirus disease-19 (COVID-19) to provide best care and optimize the use of limited resources. OBJECTIVES: We aimed to determine the predictive properties of common community-acquired pneumonia (CAP) severity scores and COVID-19 specific indices. METHODS: In this retrospective cohort, COVID-19 patients hospitalized in a teaching hospital between 18 March-20 May 2020 were included. Demographic, clinical, and laboratory characteristics related to severity and mortality were measured and CURB-65, PSI, A-DROP, CALL, and COVID-GRAM scores were calculated as defined previously in the literature. Progression to severe disease and in-hospital/overall mortality during the follow-up of the patients were determined from electronic records. Kaplan-Meier, log-rank test, and Cox proportional hazard regression model was used. The discrimination capability of pneumonia severity indices was evaluated by receiver-operating-characteristic (ROC) analysis. RESULTS: Two hundred ninety-eight patients were included in the study. Sixty-two patients (20.8%) presented with severe COVID-19 while thirty-one (10.4%) developed severe COVID-19 at any time from the admission. In-hospital mortality was 39 (13.1%) while the overall mortality was 44 (14.8%). The mortality in low-risk groups that were identified to manage outside the hospital was 0 in CALL Class A, 1.67% in PSI low risk, and 2.68% in CURB-65 low-risk. However, the AUCs for the mortality prediction in COVID-19 were 0.875, 0.873, 0.859, 0.855, and 0.828 for A-DROP, PSI, CURB-65, COVID-GRAM, and CALL scores respectively. The AUCs for the prediction of progression to severe disease was 0.739, 0.711, 0,697, 0.673, and 0.668 for CURB-65, CALL, PSI, COVID-GRAM, A-DROP respectively. The hazard ratios (HR) for the tested pneumonia severity indices demonstrated that A-DROP and CURB-65 scores had the strongest association with mortality, and PSI, and COVID-GRAM scores predicted mortality independent from age and comorbidity. CONCLUSION: Community-acquired pneumonia (CAP) scores can predict in COVID-19. The indices proposed specifically to COVID-19 work less than nonspecific scoring systems surprisingly. The CALL score may be used to decide outpatient management in COVID-19.

COVID-19/mortality , Severity of Illness Index , Aged , Aged, 80 and over , Cohort Studies , Disease Progression , Female , Hospital Mortality , Hospitalization , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Turkey/epidemiology