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1.
J Obstet Gynaecol ; 42(5): 1054-1057, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1617050

ABSTRACT

There are limited studies on predisposing factors for COVID-19 positivity in asymptomatic pregnant women. The literature published to date on asymptomatic COVID-19 pregnant carriers does not focus on pregnancy or pre-pregnancy comorbidities. We wanted to identify risk factors for COVID-19 in asymptomatic pregnant women. We performed a retrospective chart review of 263 asymptomatic pregnant women admitted to labour and delivery at New York City Health + Hospitals/Lincoln.We analysed the association between race, body mass index (BMI), smoking, indication for admission, gravidity, parity, pre-pregnancy comorbidity, pregnancy comorbidity via uni- and multivariate statistical tests. Only Hispanic race was significant in the univariate analysis (p = .049). At the post-hoc analysis, Hispanics had a higher proportion of COVID-19 cases compared to non-Hispanic Blacks (p = .019). No variables were significantly associated with COVID-19 positivity in the multivariate analysis.Hispanic race appears to be a risk factor for asymptomatic COVID-19 infection during pregnancy. We speculate that the cultural and socioeconomic reality of Hispanic women living in our community leads to more exposure opportunities and therefore, a higher infection rate.Impact statementWhat is already known on this subject? Little is known on the role of comorbidities and risk factors that can favour COVID-19 infection during pregnancy.What do the results of this study add? We found that Hispanic pregnant asymptomatic women had a higher rate of COVID-19 in comparison to non-Hispanic Black women. Pre-pregnancy comorbidities such as pregestational diabetes, hypertension and asthma were not associated with COVID-19 positivity.What are the implications of these findings for clinical practice and/or further research? The reasons why the Hispanic race is more affected by COVID-19 during pregnancy is unclear. The social environment of Hispanic women living in our community, such as their tendency to live in multigenerational and multi-family households, might contribute to a higher infection rate. More resources might be dedicated in the future to Hispanic-dense neighbourhoods.


Subject(s)
COVID-19 , Pregnancy Complications, Infectious , COVID-19/epidemiology , Female , Hospitals, Urban , Humans , New York City/epidemiology , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Retrospective Studies , Risk Factors , SARS-CoV-2
2.
Acta Biomed ; 91(4): e2020123, 2020 07 16.
Article in English | MEDLINE | ID: covidwho-1055390

ABSTRACT

The combination of hydroxychloroquine (HCQ) and azithromycin could represent a suitable treatment for SarS-CoV-2 positive pregnancies. The authors report one of the first cases of COVID-19 positive pregnant woman successfully treated with HCQ in April 2020.


Subject(s)
Azithromycin/therapeutic use , COVID-19/drug therapy , Enzyme Inhibitors/therapeutic use , Hydroxychloroquine/therapeutic use , Pregnancy Complications, Infectious/drug therapy , Anti-Bacterial Agents/therapeutic use , COVID-19/diagnosis , Female , Humans , Middle Aged , Pregnancy , Pregnancy Complications, Infectious/diagnosis
3.
Int J Mol Sci ; 22(3)2021 Jan 26.
Article in English | MEDLINE | ID: covidwho-1050618

ABSTRACT

The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.


Subject(s)
COVID-19/blood , Diabetes, Gestational/prevention & control , Diet, Mediterranean , Interleukin-6/blood , Animals , COVID-19/epidemiology , Diabetes, Gestational/blood , Diabetes, Gestational/epidemiology , Female , Gestational Weight Gain , Humans , Life Style , Obesity/blood , Obesity/epidemiology , Obesity/prevention & control , Pregnancy
4.
Acta Biomed ; 91(3): e2020002, 2020 09 07.
Article in English | MEDLINE | ID: covidwho-761223

ABSTRACT

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome 2 virus (SARS-CoV-2) and it is spreading worldwide with an alarming high transmission rate. SARS-CoV-2 usually attacks the lungs causing a wide range of symptoms ranging from mild dyspnea to severe shortness of breath requiring intubation. Elevation of liver transaminases in the patients' sera has been described in up to 53% of the COVID-19 positive patients. The underlying pathogenic mechanisms of the virus on the liver cells are unclear and only few hypotheses are currently available. Data on COVID-19 in pregnant women are lacking and the management of COVID-19 pregnant women is challenging. An elevation of the transaminases during pregnancies infected by SARS-CoV-2 has never been described before. METHODS: Here we presented the case of a 29 years-old patient at 38 weeks of gestation COVID-19 positive with elevated transaminases. RESULTS: The patient showed a progressive decrease of transaminases after the delivery of the fetus. We provided details about the daily transaminases trend, the therapy used and the maternal/neonatal outcomes. CONCLUSIONS: We speculate that in our case the delivery of the fetus contributed to the normalization of the liver enzymes. In patients affected by COVID-19, at term of gestation, with elevated transaminases, delivery of the fetus is an appealing option. If confirmed by larger studies, our proposed management might be incorporated in the obstetrical management guidelines for COVID-19 positive patients.


Subject(s)
Betacoronavirus , Coronavirus Infections/enzymology , Lung/diagnostic imaging , Pneumonia, Viral/enzymology , Pregnancy Complications, Infectious/enzymology , Transaminases/blood , Adult , Biomarkers/blood , COVID-19 , Cesarean Section , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Female , Gestational Age , Humans , Infant, Newborn , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Outcome , Radiography, Thoracic , SARS-CoV-2
5.
Acta Biomed ; 91(3): e2020041, 2020 09 07.
Article in English | MEDLINE | ID: covidwho-761222

ABSTRACT

We report the first case of SARS-CoV-2 pregnancy in the U.S. Our literature review highlights the rarity of COVID-19 intrauterine transmission and the need for clinicians to promptly test neonates born to SARS-CoV-2 positive mothers at delivery for COVID-19. It is imperative to establish the real risk of intrauterine transmission and to develop appropriate preventive and treatment strategies.


Subject(s)
Betacoronavirus , Coronavirus Infections/transmission , Disease Transmission, Infectious , Pneumonia, Viral/transmission , Pregnancy Complications, Infectious/epidemiology , Uterus/virology , Adult , COVID-19 , Coronavirus Infections/epidemiology , Female , Humans , Pandemics , Pneumonia, Viral/epidemiology , Pregnancy , SARS-CoV-2
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