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Preprint | SSRN | ID: ppcovidwho-983


Background: COVID-19 is a global pandemic and with current knowledge about the virus rapidly evolving, systematic reviews are needed to assess those most at ris

Diabetes Obes Metab ; 22(10): 1915-1924, 2020 10.
Article in English | MEDLINE | ID: covidwho-657128


AIM: To estimate the prevalence of both cardiometabolic and other co-morbidities in patients with COVID-19, and to estimate the increased risk of severity of disease and mortality in people with co-morbidities. MATERIALS AND METHODS: Medline, Scopus and the World Health Organization website were searched for global research on COVID-19 conducted from January 2019 up to 23 April 2020. Study inclusion was restricted to English language publications, original articles that reported the prevalence of co-morbidities in individuals with COVID-19, and case series including more than 10 patients. Eighteen studies were selected for inclusion. Data were analysed using random effects meta-analysis models. RESULTS: Eighteen studies with a total of 14 558 individuals were identified. The pooled prevalence for co-morbidities in patients with COVID-19 disease was 22.9% (95% CI: 15.8 to 29.9) for hypertension, 11.5% (9.7 to 13.4) for diabetes, and 9.7% (6.8 to 12.6) for cardiovascular disease (CVD). For chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), cerebrovascular disease and cancer, the pooled prevalences were all less than 4%. With the exception of cerebrovascular disease, all the other co-morbidities presented a significantly increased risk for having severe COVID-19. In addition, the risk of mortality was significantly increased in individuals with CVD, COPD, CKD, cerebrovascular disease and cancer. CONCLUSIONS: In individuals with COVID-19, the presence of co-morbidities (both cardiometabolic and other) is associated with a higher risk of severe COVID-19 and mortality. These findings have important implications for public health with regard to risk stratification and future planning.

COVID-19/epidemiology , COVID-19/pathology , COVID-19/complications , COVID-19/mortality , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/mortality , Cardiovascular Diseases/pathology , Comorbidity , Diabetes Complications/mortality , Diabetes Mellitus/epidemiology , Diabetes Mellitus/mortality , Diabetes Mellitus/pathology , Humans , Hypertension/complications , Hypertension/epidemiology , Hypertension/mortality , Mortality , Neoplasms/complications , Neoplasms/epidemiology , Neoplasms/mortality , Pandemics , Prevalence , Pulmonary Disease, Chronic Obstructive/epidemiology , Pulmonary Disease, Chronic Obstructive/mortality , Pulmonary Disease, Chronic Obstructive/pathology , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/epidemiology , Renal Insufficiency, Chronic/mortality , Risk Factors , SARS-CoV-2/physiology , Severity of Illness Index