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Journal of Drug Delivery and Therapeutics ; 12(4-s):101-111, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056786


In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, indepth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

Journal of Drug Delivery and Therapeutics ; 12(2):87-99, 2022.
Article in English | CAB Abstracts | ID: covidwho-1841785


Plant Based Natural Products (PBNPs) have been subject of interest since ancient time due to their use in food, industrial and biomedical applications. Research attention has further augmented to explore their phytochemical composition, properties, and potential application in the post-COVID era. In the present study phytochemical screening has been carried out with Methanolic Leaf Extracts of Moringa oleifera (MLEMO) followed by Gas Chromatography-Mass Spectrometry (GCMS) analysis. Phytochemical analysis of MLEMO revealed the presence of Alkaloids, Carbohydrates, Coumarins, Flavonoids, Glycosides, Phenol, Proteins, Quinones, Saponins, Steroids, Tannins and Terpenoids. Further, GCMS analysis revealed the presence of 41 compounds of which Dihydroxyacetone;Monomethyl malonate;4H-Pyran-4-one,2,3-dihydro- 3,5-dihydroxy-6-methyl;1,3-Propanediol, 2-ethyl-2-(hydroxymethyl);Propanoic acid, 2- methyl-, octyl ester;3-Deoxy-d-mannoic lactone;Sorbitol;Inositol;Cyclohexanemethanol, alpha-methyl-4-(1-methylethyl), Hexadecanoic acid, Methyl palmitate;n-Hexadecanoic acid (Palmitic acid);9-Octadecenoic acid, methyl ester;Phytol;9,12,15-Octadecatrienoic acid;Octadecanoic acid;9-Octadecenamide were prominent. Most of the compounds in the list are bioactive and possess medicinal properties that are expected to serve as a baseline lead for the development of therapeutic agents.

Annals of Phytomedicine-an International Journal ; 10(1):S195-S208, 2021.
Article in English | Web of Science | ID: covidwho-1389939


The COVID-19 pandemic is due to the spread of SARS-CoV-2, a virulent infectious coronavirus which created severe threats to the public health systems and global socioeconomic impact. It spreads over 221 countries and territories around the world and has reported a total of 130,954,934 confirmed cases with a death toll of 2,853,007. An indepth understanding of SARS-CoV-2 virus in terms of structure, variants, mechanism of infection, spread and impacts is needed to develop strategies to eradicate it. It is the condition that, India is facing second wave of SARS-CoV-2 spread in major cities like Mumbai, Delhi and Chennai. Since historic epidemics, most of the antiviral medicines are mainly developed based on medicinal plants with the aid of ethnobotanical records. Conventional medicine along with dietary therapy could be a complementary therapeutic measure to prevent and manage SARS-CoV-2 infections. Herbal drugs from medicinal and aromatic plants are major source for the development of novel antiviral drugs. Exploration of plants with numerous bioactive compounds of therapeutic importance remains mostly scanty. Identifying potential natural plant sources constitute an alternate to contain and prevent SARS-CoV-2 infection either by being a viricidal or by boosting the immune system is need of the hour. In order to prevent and contain the severe respiratory infections associated with the COVID 19 pandemic in the absence of potential medicines against the SARS-CoV-2 virus, search for antiviral compounds from natural resources gains importance. This article aimed to provide comprehensive list of plants and their active compounds of antiviral properties which would pave a way to develop herbal drug to prevent and contain SARS-CoV-2 infection.