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Indian Journal of Medical Microbiology ; 39:S55-S56, 2021.
Article in English | EMBASE | ID: covidwho-1734457

ABSTRACT

Background:COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). Serologic assays for SARS- CoV-2, play an important role in understanding the immune status of post covid health care workers who are at highest risk of infection. In this infection, IgM and IgG antibodies can arise nearly simultaneously in serum within 2 to 3 weeks after illness onset. Around day 14 after symptom onset, IgG will rise above detection levels and will generally continue to rise for 28 - 35 days after symptom onset, peaking around or after clinical recovery. IgG typically has a long half-life and will remain above detectable thresholds for months after the resolution of infection. Most widely used treatment strategies include steroids, antivirals and antibiotics. Aim of the study is to assess the effect of treatment strategies on IgG antibodies against SARS-CoV-2 among covid infected Health care workers Methods:All the post covid HCWs (60-75 days after detection) were categorized into 4 groups on the basis of treatment strategies. 1st group (30) – combination of antiviral and steroid therapy, 2nd group (30) – only steroids, 3rd group (15) – only antivirals, 4th group (15)– only antibiotics (asymptomatic). All the groups were treated with multivitamins and VitC along with above mentioned therapy. Qualitative IgG ELISA using Merilisa kits was adopted to assess the prevalence of IgG antibodies against SARS-CoV-2 to know the pattern of IgG antibody titres. Results:90 samples were collected for this study, which were subjected to qualitative ELISA. Out of these highest IgG titres were found in patients only on antibiotics followed by only on antivirals, followed by steroid and antiviral combi- nation and least was found in patients only on steroids. Conclusions:This study showed that administration of steroids results in early weaning of antibodies. Re -infection could be more in these cases

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