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1.
Annals of Phytomedicine-an International Journal ; 10:S77-S85, 2021.
Article in English | Web of Science | ID: covidwho-2026890

ABSTRACT

Viral mutations can become more common as a result of natural selection, random genetic drift or recent epidemiological trends. Even more difficult is to determine whether a single mutation will affect the fate of an illness or a pandemic. World Health Organization designated the latest strain of SARS-CoV-2, the Omicron, as a "variant of concern" as more countries are reporting cases, and it contains a unique mix of mutations that might help it spread faster. Mutations in the SARS-CoV-2 strains at the high rates lead to the in effectiveness of vaccines and developed drugs. As the mutations occur only on the spike proteins of the viral particles, targeting other vital enzymes, i.e., proteases for drug discovery paves way for potential drug candidate irrespective of the mutations. So, the present study focuses on identifying the phytocompounds from Datura metal L. inhibiting the SARS-CoV-2 proteases. The druglikeness, PASS predictions and ADMET properties of the selected compounds were performed. 31 compounds were identified from the KNApSAck database and subjected to molecular docking studies. From the analysis, 7 compounds. Withametelin I, Withametelin J, Withametelin K, Withametelin L, Withametelin M, Withametelin N and Withametelin O showed significant binding energies and ADMET values. Therefore, these compounds can be further utilized for development of novel drugs for treatment of SARS-CoV-2 infections.

2.
Journal of Natural Remedies ; 22(2):121-122, 2022.
Article in English | Scopus | ID: covidwho-1847912
3.
Journal of Nanomaterials ; 2022, 2022.
Article in English | ProQuest Central | ID: covidwho-1794361

ABSTRACT

Historically, silver has been recognized as a powerful antibacterial agent with a broad spectrum of functions, and it has been employed safely in healthcare for several years. It seems that the incorporation of silver into embedded medical devices may be advantageous when particular genetic features, including such antibacterial behavior, are needed for the device to function. According to current and prior bacterial studies, it appears that the toxicity against bacteria was significantly more significant than the toxicity against human cells. Silver nanoparticles are nanoparticles with sizes ranging between one and one hundred nanometers (nm) in size. When it comes to molecular diagnostics, therapies, and equipment that are employed in a wide range of medical procedures, silver nanoparticles have a number of unique qualities that make them very useful. The physical and chemical approaches are the two majority ways for the creation of silver nanoparticles. The challenge with chemical and physical approaches is that the synthesis is complicated and can result in harmful compounds being absorbed onto the surfaces of the materials. In order to address this, the biological technique offers a viable alternative solution. Bacteria, fungus, and plant extracts are the three principal biological systems concerned in this process. A complete overview of the mechanism of action, manufacture, and uses in the medical area, as well as the healthcare and ecological concerns that are believed to be produced by these nanoparticles, is provided in this paper. The emphasis is on the proper and effective synthesis of silver nanoparticles even while exploring their numerous promising utility and attempting to assess the current status in the debates over the toxicity concerns that these nanoparticles pose, as well as attempting to reflect the needs in the debates over the toxicity concerns that these nanoparticles pose.

4.
Physiotherapy (United Kingdom) ; 114:e90-e91, 2022.
Article in English | EMBASE | ID: covidwho-1705339

ABSTRACT

Keywords: Simulation;On-call;Respiratory Purpose: Some newly qualified physiotherapists had reported feeling anxious about at being the respiratory physiotherapist on call. While this is a common theme with each year's new starters, this is likely exacerbated by the changes to some of their placements in their final year due to Covid-19. Alongside this, we were aware that there was a great demand on the on-call respiratory physiotherapy team due to Covid-19, and there was also a need to make them familiar with the PPE required for the treatment they may wish to perform;particularly for those physiotherapists working in MSK out-pts for whom this was unfamiliar. We wanted to put something in place to support these new graduates. Methods: A teaching package was designed with teaching in simulation for newly qualified physiotherapists about to go on the respiratory physiotherapy on-call rota focusing on common on-call scenarios. It was delivered by physiotherapists, an ACP and a consultant anaesthetist (who attended virtually). Scenarios were broken down into 3 competents: (1) do I have to go in? How to get the right information over the phone to decide. (2) what do I want done while I am travelling in? What advice to give to stabilise the pt while on route, what equipment to get ready, what PPE to get ready, etc., (3) What do I do when I get there – A–E assessment of the pt, treatment and ongoing management plan. Feedback on the sessions was collected from participants by anonymous questionnaire. In the simulation room attendees scan a QR code which generates a MS teams electronic feedback form. Results: Positive feedback -informative, interesting session, met their learning outcomes, reduced anxiety. ‘We were allowed time to practice in a safe environment and ask anything that may concern us’, increased confidence. Conclusion(s): Provision of simulation for newly qualified physiotherapists is helpful at preparing them for being the on-call respiratory physiotherapist. Impact: Funding is now being sort to make this part of standard induction each year at the Trust for newly qualified physiotherapists. We have liaised with the West Midlands sim lead to see if they will recommend this across the West Midlands. Funding acknowledgements: Not funded.

5.
International Journal of Ecological Economics & Statistics ; 41(4):45-56, 2020.
Article in English | Web of Science | ID: covidwho-1097633

ABSTRACT

In this article, we propose, fit, and promote an incidence rate restricted Poisson distribution for the gathered number of coronavirus (1) confirmed, (2) cured, and (3) deaths across thirty two India's states/territories as of May 1, 2020. The restriction on the incidence rate in each of the three categories is quantitatively estimated and interpreted in terms of the attained administrative efficiency of preventive/treatment procedures by the government, using the public domain data in htto://mohfw.clovin webpage. The statistical conclusions based on the data analytic results demonstrate a valuable lesson to be procured to deal with any future pandemic episode.

6.
Journal of Experimental Biology and Agricultural Sciences ; 8(Special Issue 1):S219-S245, 2020.
Article in English | Scopus | ID: covidwho-1000711

ABSTRACT

The coronavirus disease – 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus virus – 2 (SARS-CoV-2), set it foots in China during December 2019 as a high-alert public health emergency. This malady had thereafter spread rapidly across the globe in more than 215 countries, affecting more than 50 million people and causing the death of nearly 1.3 million as of 9th November, 2020 and resulted in a massive panic, fear, and economic crashes in most of the world. A better understanding of the disease, the virus, structural biology, clinical manifestations, risk factors, transmission, diagnosis, treatment, and management can be extrapolated from the literature review of the research up to date. In addition, deliberations on animal linkages, spillover and zoonotic implications for exploring the actual origin of the disease and all possible animal-human interfaces, intermediate host;diagnosis for devising specific and sensitive tests of ease, accessibility and affordability;advances in the development of safe and effective vaccines and therapeutics for prevention and treatment;management of COVID-19 practicable in all countries;application of traditional or regularly used modalities including plant-based products and medicinal herbs against SARS-COV-2;nutritious dietary foods against this disease;and socio-economic impacts of COVID-19 can provide valuable information on these various aspects. Most of the research currently focuses on disease, development of a vaccine or therapeutic modalities. But the future mortality rate and virulence of virus not only depends on the evolution of the virus, but also on how we develop preventive measures and effective treatment as well as in advance preparedness. The present review highlights salient aspects of SARS-CoV-2 / COVID-19, pathology, risk factors, transmission, diagnosis, potential treatment, and alternative / supportive therapeutic options. © 2020, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

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