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The FASEB Journal ; 35(S1), 2021.
Article in English | Wiley | ID: covidwho-1233886


The Protein Data Bank (PDB) was established in 1971 as the first open-access digital data resource in biology. Beginning with only seven protein structures, the PDB archive has ballooned to >170,000 structures of proteins, DNA, and RNA (totaling >1 billion atoms). Today, the PDB is universally regarded as a core data science resource of fundamental importance to the wider life-science community and long-term preservation of machine-readable biological data. PDB structures are the molecules of life. Knowledge of 3D structures (shapes) of biomolecules, how they evolve with time, and how they function in nature is essential for understanding critical areas of science. PDB data impacts basic and applied research on health and disease of humans, animals, and plants;production of food and energy;and other research pertaining to global prosperity and environmental sustainability. Structure data are also important to biopharmaceutical and biotechnology companies, accelerating data-driven discovery of new drugs, materials, and devices. Today, powerful pulsed X-ray facilities, cryogenic electron microscopes, and new integrative/hybrid (I/H) methods for structure determination are accelerating biomedical research with functional insights into ever more complex biological systems at the atomic level. Cryo-electron tomography even allows study of molecular machines ?caught in the act? inside frozen cells. The PDB is managed by the Worldwide Protein Data Bank partnership (wwPDB; RCSB PDB ( operates the US wwPDB data center, and makes PDB data available at no charge and without limitations. The 50th anniversary of the PDB archive is being celebrated with special symposia and related resources, including a May 4-5 virtual meeting hosted by the ASBMB. These celebrations will include first hand accounts traversing five decades from the beginnings of structural biology all the way to ongoing efforts aimed at combatting the COVID-19 pandemic.

Nucleic Acids Res ; 49(D1): D437-D451, 2021 01 08.
Article in English | MEDLINE | ID: covidwho-936421


The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center for the global PDB archive and a founding member of the Worldwide Protein Data Bank partnership, serves tens of thousands of data depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without restrictions to millions of users around the world, including >660 000 educators, students and members of the curious public using PDB data depositors include structural biologists using macromolecular crystallography, nuclear magnetic resonance spectroscopy, 3D electron microscopy and micro-electron diffraction. PDB data consumers accessing our web portals include researchers, educators and students studying fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. During the past 2 years, the research-focused RCSB PDB web portal ( has undergone a complete redesign, enabling improved searching with full Boolean operator logic and more facile access to PDB data integrated with >40 external biodata resources. New features and resources are described in detail using examples that showcase recently released structures of SARS-CoV-2 proteins and host cell proteins relevant to understanding and addressing the COVID-19 global pandemic.

Computational Biology/methods , Databases, Protein , Macromolecular Substances/chemistry , Protein Conformation , Proteins/chemistry , Bioengineering/methods , Biomedical Research/methods , Biotechnology/methods , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19/virology , Humans , Macromolecular Substances/metabolism , Pandemics , Proteins/genetics , Proteins/metabolism , SARS-CoV-2/genetics , SARS-CoV-2/metabolism , SARS-CoV-2/physiology , Software , Viral Proteins/chemistry , Viral Proteins/genetics , Viral Proteins/metabolism