ABSTRACT
India is a country where majority of the population resides in rural areas. For the development of India, it is necessary to focus on the core of India, i.e., the villages. Now, for developing villages, demand needs to be generated and supply chains to be put in place for ensuring fast-paced development. There are a plethora of employment opportunities and a million plus one can be created but villagers generally tend to relocate to metro cities for better facilities, resulting in overburdening of cities as well as slow development of villages. During the pandemic, India witnessed a large-scale migrant crisis. To bridge the gap between employers and employees, primarily focused on villages, we have developed an application—Atamnirbhar Gaon. Using this application, the workers can get equitable employment prospects like entrepreneurship, businesses, and skill set enhancement in their respective hometown. This venture can boost the development of villages and hence the development of the nation. This is a bilingual application—supports both Hindi and English;any illiterate person can also avail the functionality of this application through voice, know about the places near him where a person can learn new technologies or update his skills, weather updates for sowing the crops, latest updates in farming, and lastly can also get the importance of vaccination against Covid-19 and the available slots for vaccination. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
ABSTRACT
To stop the spread of COVID-19 in this outbreak, diagnostic testing is essential. Quick diagnostic tests must be employed in this pandemic, which is brought on by the severe acute respiratory syndrome (SARS)-CoV-2 virus, to successfully treat and manage COVID-19. There are several problems with the present RT-PCR system that the lateral flow assay (LFA), a kind of clinically sensitive diagnostic test, may be able to fix, especially in low-and middle-income nations. Gold nanoparticle-(AuNP-LFA) is a practical method for detecting COVID-19 in basic hospitals and laboratories, particularly in emergency situations where many samples must be quickly examined. Safe, accurate, and non-toxic diagnostic tests must be employed during the pandemic, to successfully treat and manage COVID-19. Recombinant SARS-CoV-2 nucleocapsid monoclonal antibody was employed to detect COVID-19 antigens in the presence of patients to establish a fast LFA for COVID-19. Synthesis of colloidal gold particles and antibody colloidal gold conjugates was evaluated by using UV/Vis spectroscopy. A capture line made of anti-SARS-CoV-2 antibody was coated on nitrocellulose membrane. To create the control line, goat anti-mouse IgG monoclonal antibody was coated. On a polystyrene backing board, the immunochromatographic strip was constructed in the ideal order. Using ELISA as the standard procedure, the strips' sensitivity and specificity were assessed. The results' stability and repeatability were evaluated over a 9-month period. Colloidal gold nanoparticle-based LFAs created in this study can be employed for quicker and more accurate detection of SARS-CoV-2. © 2023 Singh, et al.
ABSTRACT
The corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome corona virus type 2 (SARS-CoV-2), belongs to emerging and reemerging diseases, which was first identified and reported in Wuhan, China, during December 2019. The genetic sequence of SARS-CoV-2 was similar to SARS virus, a ß-corona virus. The epidemiologicalstudies suggest that the transmission of SARS-CoV-2 mainly occurs from an infected person to others through close contact with the respiratory droplets or by having contact with SARS-CoV-2adhering toobjects and surfaces. The incubation period ranges from 5 to14 days. During COVID-19, the occurrence of fever, dry cough, tiredness, aches, chest pain, conjunctivitis, diarrhea, headache, difficulty in breathing or short breath, loss of taste, smell, rashes on the skin,andsore throat.Some reports indicated that males exhibited lower scores than females, the younger populations displayed increased symptoms, Chinese/Taiwanese people registered only scarce symptoms and Canadians experienced more symptoms. The results of some studiesindictaed that COVID-19 significantly impacted on depression whereas job insecurity impacted on anxiety and depression. The risk factors of COVID-19 pandemic include steep rise in the degree of fear, worry, mainly the health care providers, infants, pregnant ladies, older adults, patients receiving treatment in hospitals, development of psychosomatic disorders including depression with serious immunological consequences in infectedindividuals. The diagnostics to detect the presence of corona virus involves ELISA and RT-PCR. There is no specific treatment available to eradicate COVID-19. The therapeutics used to treat COVID 19 exhibited severe side effects. Recently, some Indian traditional medicinal plants have shown promises to reduce the risk of viral infection and also boost immunity of an invidual.This paper presents an overview of the current status of depression in the SARS CoV2 infected people and the measures required to overcome COVID-19 induced depression in patients even after recovery.
ABSTRACT
The corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome corona virus type 2 (SARS-CoV-2), belongs to emerging and reemerging diseases, which was first identified and reported in Wuhan, China, during December 2019. The genetic sequence of SARS-CoV-2 was similar to SARS virus, a ß-corona virus. The epidemiologicalstudies suggest that the transmission of SARS-CoV-2 mainly occurs from an infected person to others through close contact with the respiratory droplets or by having contact with SARS-CoV-2adhering toobjects and surfaces. The incubation period ranges from 5 to14 days. During COVID-19, the occurrence of fever, dry cough, tiredness, aches, chest pain, conjunctivitis, diarrhea, headache, difficulty in breathing or short breath, loss of taste, smell, rashes on the skin,andsore throat.Some reports indicated that males exhibited lower scores than females, the younger populations displayed increased symptoms, Chinese/Taiwanese people registered only scarce symptoms and Canadians experienced more symptoms. The results of some studiesindictaed that COVID-19 significantly impacted on depression whereas job insecurity impacted on anxiety and depression. The risk factors of COVID-19 pandemic include steep rise in the degree of fear, worry, mainly the health care providers, infants, pregnant ladies, older adults, patients receiving treatment in hospitals, development of psychosomatic disorders including depression with serious immunological consequences in infectedindividuals. The diagnostics to detect the presence of corona virus involves ELISA and RT-PCR. There is no specific treatment available to eradicate COVID-19. The therapeutics used to treat COVID 19 exhibited severe side effects. Recently, some Indian traditional medicinal plants have shown promises to reduce the risk of viral infection and also boost immunity of an invidual.This paper presents an overview of the current status of depression in the SARS CoV2 infected people and the measures required to overcome COVID-19 induced depression in patients even after recovery.