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1.
Pan African Medical Journal ; JOUR, 42 (no pagination).
Article in English | EMBASE | ID: covidwho-2090890

ABSTRACT

Introduction: Rhino-orbito-cerebral-mucormycosis (ROCM) is the most common form of mucormycosis observed during the second wave of COVID-19 where a steep rise in the number of cases was seen. The orbital form is almost always associated with fungal sinusitis. Among the various treatment modalities available, the role of retrobulbar Amphotericin-B injections is under-reported. This study is conducted to determine the role of transcutaneous retrobulbar amphotericin-B (TRAMB) in the management of COVID-19 associated ROCM. Method(s): a retrospective analysis of 61 patients of COVID-19 associated ROCM was done, who met the inclusion criteria and presented to a tertiary care center, between May to August 2021. These patients were administered TRAMB (deoxycholate/emulsion form) along-with systemic amphotericin B. All the patients were evaluated for clinical improvement. Result(s): out of 61 patients, 58 (95.08%) showed overall improvement. 40 patients (65.57%) stabilized or improved clinically and 3 patients succumbed to the illness due to advanced systemic mucormycosis and acute kidney failure. Sixteen out of 58 patients underwent orbital exenteration. Out of remaining 43 patients, 35 showed complete recovery of orbital and ocular disease and the disease stabilized in eight patients. Seven patients demonstrated TRAMB associated ocular complications which however completely resolved in six patients. Conclusion(s): to the best of the author's knowledge, regression of orbital mucormycosis with improvement in ptosis, proptosis, ocular motility and stabilization of visual acuity are scarcely reported in literature. Further TRAMB as a globe non-deforming treatment modality is an option available for ROCM. Copyright © 2022, African Field Epidemiology Network. All rights reserved.

2.
European Journal of Molecular and Clinical Medicine ; JOUR:2032-2038, 9(6).
Article in English | EMBASE | ID: covidwho-2083673

ABSTRACT

Background: Healthcare workers (HCWs) are the frontline warriors in dealing with the COVID-19 pandemic and similar health crises. In developing countries, HCWs face high stress because they have to deal with the increased patient load and limited infrastructure. Long-term exposure to stress, anxiety, and depression may lead to impaired mental health in HCWs. It is, therefore, essential to assess the mental health of HCWs as a part of their annual health check-up. Objective(s): The present cross-sectional observational study was aimed to assess the mental health of HCWs by analysing the stress, anxiety and depression during their annual health check-up at a tertiary care hospital in North India. Method(s): Total 200 participants, including the consultants, and junior and senior resident doctors, were included in the study. The stress level was analyzed using PSS-10, and anxiety and depression were analyzed using GAD-7 and PHQ-9 respectively. Result(s): The mean PSS-10 score was 9.39 +/- 8.53, indicating low stress among HCWs;the mean GAD-7 score was 5.20 +/- 4.19, indicating mild anxiety in HCWs and the mean PHQ-9 score was 3.41 +/- 3.59, indicating minimal depression among HCWs. Conclusion(s): The present study revealed that the HCWs faced minimal to mild stress, anxiety, and depression. It is therefore recommended that the mental health check-up should be made a regular part of the annual health check-up in HCWs so that adequate, timely steps are taken to address the same. Copyright © 2022 Ubiquity Press. All rights reserved.

3.
Mausam ; 73(4):809-818, 2022.
Article in English | Scopus | ID: covidwho-2081639

ABSTRACT

The concentration of reactive trace gases in the atmosphere affects the human health differently. This study presents the changes of aerosol and reactive gases load in the atmosphere from the recent past with the help of Copernicus Atmosphere Monitoring Service (CAMS) data in Indian domain. The EAC4 (ECMWF Atmospheric Composition Reanalysis 4) data sets were used to examine spatially the load of ambient trace gases (NO2, O3, SO2 & CO) and aerosol present in the atmosphere as aerosol optical depth(AOD). The four weekly phases of the study are for April, 2020 (01-07, 08-14, 15-21 & 22-30). It has been observed during the above said phases that the concentration of aerosols, chemically reactive gases and greenhouse gases shows appreciable reduction up to ~60-70 % from CAMS Long Period Average (LPA) 17 years (2003-2019) data over the entire Indian sub-continent, except few pockets of Central (Durg, Indore, Bilaspuretc.) and South West (Kolhapur, Gujaratetc.) India. These slightly higher values in 2nd and 3rd week of April-2020 are due to pre-monsoon dust storm activity and well captured in vertical air flow Omega at 850/NCAR reanalysis. Concentrations of reactive gases from 12 different Central Pollution Control Board (CPCB) stations of India with CAMS, LPA data of April-2019 & 2020 has been compared and show that aerosol load in terms of PM-2.5 & PM-10 is appreciably drop down (60-70 %) over IGP and 25-30 % in other parts of India. The concentration of other reactive gases (NO2, SO2 & CO) with actual data from the month of April, 2019 &2020 also decreases ~ 32 %, 7 %, 17 % over IGP and 16 %, 8 %, 9 % in other parts of India respectively. The concentration of Ozone shows slightly positive behaviour over IGP and negative at other parts of India. This study is further brought out a message for future that we should use the natural resources judiciously as their long term exposure can cause severe health problems and a psychological burden or stress globally during this COVID-19 spread period. © 2022, India Meteorological Department. All rights reserved.

4.
Chest ; 162(4):A1286, 2022.
Article in English | EMBASE | ID: covidwho-2060794

ABSTRACT

SESSION TITLE: Critical Diffuse Lung Disease Cases 2 SESSION TYPE: Case Report Posters PRESENTED ON: 10/19/2022 12:45 pm - 01:45 pm INTRODUCTION: Acute eosinophilic pneumonia (AEP) is dramatic in presentation mimicking infectious pneumonia or acute respiratory distress syndrome in previously healthy individuals. Medications are a commonly recognized cause of AEP. Daptomycin, has been strongly linked to AEP. Herein, we present a case of a patient with a septic joint treated with Daptomycin who went on to develop AEP. CASE PRESENTATION: Patient is an 80 year old man with history of hypertension, hypothyroidism, atrial flutter, complete heart block status post pacemaker, who had a hx of a mucinous cyst on his left index finger, requiring hospitalization. Blood cultures were positive for MRSA s/p debridement of the joint. He was discharged on 4 weeks of intravenous daptomycin. Two weeks after being discharged he presented back to the hospital with fevers, fatigue and worsening shortness of breath. His temperature was 103.8 and O2 saturation of 90% on 2L NC. Laboratory findings included WBC count of 8.6 with no eosinophilia on differential, ESR 110, negative blood cultures, sputum cultures with commensal flora, negative urine legionella, PCR for SARS COV-2 was negative. Chest radiograph showed mild interstitial airspace disease in the left mid and lower thorax, along with small bilateral pleural effusions. CT chest showed scattered bilateral consolidations and ground glass opacities and trace bilateral effusions. Daptomycin was switched to Vancomycin. Patients oxygen requirements had increased to 6l NC. Patient underwent airway exam with bronchoscopy and broncheoalveolar lavage in superior segment of the lingula, which showed inflamed bronchial mucosa with copious secretions. Cell count of the BAL showed increased eosinophil count with negative gram stain and culture. Patient was started on methylprednisolone 60 mg four times per day and then tapered. Vancomycin was switched to oral linezolid. Patient's hypoxia improved and was discharged home on 3l NC. At four week follow up, he no longer required oxygen on ambulation and chest radiograph showed complete resolution of infiltrates. DISCUSSION: Over 140 drugs have been recognized as a cause of drug induced eosinophilic pneumonia (DIEP). The diagnosis of DIEP requires febrile illness <5 days, diffuse bilateral infiltrates, hypoxemia and BAL showing 25% eosinophils or eosinophilic pneumonitis on lung biopsy. Additionally, a diagnosis of DIEP requires exposure to a candidate drug in the appropriate time frame, exclusion of infectious causes of eosinophilic pulmonary opacities. It also requires clinical improvement after cessation of medication. Daptomycin has been strongly linked to DIEP. In 2010 US FDA issued a warning about the risk of developing eosinophilic pneumonia during treatment with Daptomycin. CONCLUSIONS: Daptomycin is strongly linked with DIEP. Clinicians should maintain a high index of suspicion for DIEP in patient treated with daptomycin who develop respiratory distress. Reference #1: Uppal, P., LaPlante, K.L., Gaitanis, M.M. et al. Daptomycin-induced eosinophilic pneumonia - a systematic review. Antimicrob Resist Infect Control 5, 55 (2016). https://doi.org/10.1186/s13756-016-0158-8 Reference #2: Cottin V. Eosinophilic Lung Diseases. Clin Chest Med. 2016 Sep;37(3):535-56. doi: 10.1016/j.ccm.2016.04.015. Epub 2016 Jun 25. PMID: 27514599. Reference #3: Rosenberg CE, Khoury P. Approach to Eosinophilia Presenting With Pulmonary Symptoms. Chest. 2021 Feb;159(2):507-516. doi: 10.1016/j.chest.2020.09.247. Epub 2020 Sep 28. PMID: 33002503;PMCID: PMC8039005. DISCLOSURES: No relevant relationships by Kamelia Albujoq No relevant relationships by Rajaninder Sharma

5.
Investigative Ophthalmology and Visual Science ; 63(7):3380-A0167, 2022.
Article in English | EMBASE | ID: covidwho-2058604

ABSTRACT

Purpose : The incidence of ocular herpetic pathologies, in particular Herpes Zoster Ophthalmicus (HZO), has seemingly been on a rise over the past years, especially among the elderly and immunocompromised. The nature of this rise is likely multifactorial ranging from access to Shingles vaccination programmes, potential increase in immunocompromised individuals, social factors and most recently, Covid-19 infection. The relationship between Covid-19 and ocular herpetic pathologies has anecdotal basis. Certain studies have hypothesized T-cell dysfunction as a mechanism of Varicella Zoster virus reactivation in patients affected by Covid-19. This retrospective, observational study analyses the pattern of incidence of ocular herpetic pathologies in a secondary care centre, United Kingdom (UK). Methods : This study was set in an eye casualty clinic in Queens Hospital, Burton-on-Trent (University Hospitals Derby & Burton NHS, UK). Diagnoses of each patient was recorded in the Eye Casualty Patient Register. Data was extracted from three time periods-i. Precovid pandemic (July -December 2019), ii. Pandemic (July-December 2021) and iii. Post coronavirus vaccine introduction, UK (April and May 2021). Extracted data was pooled into the following groups-Herpes Simplex Keratits (HSK)/ HZO/ Shingles/Herpetic Kertatouveitis/ Herpes Zoster/Herpes Simplex/Herpes simplex endothelitis. Results : The data between pre-pandemic and post-pandemic periods highlighted an increasing incidence of certain ocular herpetic conditions. Highest number of diagnoses were recorded as HSK and HZO. HSK accounted for the highest incidence across all time periods-41% (pandemic), 34% (pre-pandemic) and 37.5% (after vaccine introduction). On the other hand, similar incidence is noted with HZO diagnoses-32.9% (pandemic), 32.7% (pre-pandemic) and 37.5% (after vaccine introduction). Conclusions : Overall, a gradual increase in incidence of ocular herpetic pathologies was observed from 2019-2021 at this centre. Multiple factors could be responsible for this rise, with Covid-19 infection as a potential factor. However, there is insufficient data to draw up a definitive association between the increasing incidence of such conditions and Covid-19, especially as the immune response to the infection and vaccinations are poorly understood. Larger, multi-centre studies would be required to assess the burden of incidence in the UK.

6.
Indian Veterinary Journal ; 99(7):7-15, 2022.
Article in English | EMBASE | ID: covidwho-2057431

ABSTRACT

The COVID-19 outbreak and the subsequent lockdown have had a negative impact on agriculture and other allied activity i.e. food, livestock, dairy etc. The most important and essential aspect of a unsustainable turn of events due to COVID-19 is dairy sector. When it comes to supplying products to clients, dairy suppliers are facing a difficult situation. These disruptions have a sudden impact on the dairy supply chain system and the process can collapse if necessary and immediate actions are not taken. The pandemic and its associated lockdown have not only made it difficult for a large number of poor and marginal dairy farmers but have also had an impact on the livestock feed industry, dairy industry, and related supply value chains of the dairy sector. This review article features different elements of the effects, specifically decreased popularity of various products, wastage of products, supply market chains, work absenteeism due to shortage of labor, and recovery strategy taken by the authorities to recover livestock and dairy sector. This review article provides a comprehensive view of the overall situation, a methodical report gathering critical data across the country and the impact on every sub-area of the dairy sector and associated value supply chains.

7.
Journal of Medical Pharmaceutical and Allied Sciences ; 11(4):5017-5025, 2022.
Article in English | Scopus | ID: covidwho-2030661

ABSTRACT

Indian population has potential threat of communicable and non-communicable diseases. The low preventive health measure is a cause of major loss to the economy. Integration of the cloud platform with remote wearable sensors not only helps the health stakeholders to capture the patient vitals but also perform predictive analysis during COVID-19. Raising timely alarms through Internet of Medical Things and Artificial Intelligence has wide application in preventive care through real time analytics. However, Health Merchandise Startups using artificial intelligence and machine learning for timely device delivery face delay in making themselves available and affordable for Remote patients of Tier II and III. This study takes a health service provider perspective and seeks to study problem situation systemically by using a casual loop model. Finally, analysis of the feedback loops is done to be able to come out with suitable strategies for COVID-19 patients of Remote locations. © MEDIC SCIENTIFIC, All rights reserved.

8.
2022 International Conference on Machine Learning, Big Data, Cloud and Parallel Computing, COM-IT-CON 2022 ; : 692-697, 2022.
Article in English | Scopus | ID: covidwho-2029197

ABSTRACT

A methodical approach to curb the spread of this menacing disease, COVID-19 must be taken. 'CO' answer for corona, 'VI' denote virus, and 'D' represent disease. The absence of highly effective medicines and scarcity of vaccination make this disease more lethal and vicious;this makes it important for us to find a provisional yet efficacious way to cushion ourselves and that one love. Wearing masks can act like that cushion, it's truly a camouflage, acting as a Non-Pharmaceutical Intervention (NPI) proceeding that could be easily implemented without much capital investment. This thesis evaluates an efficient way of face mask detection that can be used by private or government authorities as a tool against COVID-19. This research aims to build a light weighted and user-friendly model that can be easily used in static or real-time face mask detection. This study of face mask detection is made possible using Deep Learning, Convolutional neural network algorithm, and MobileNetV2, a python open-source image-processing and classification model. Steps involved in designing and implementing the model are collecting and accessing the dataset, data processing and encoding, testing, and training data, accuracy prediction, and model implementation in a real-time project that can instantly detect and provide the desired output. The model can make 98% accurate production in real-time, distinguishing between individuals with a mask or without ma masks. Our proposed face mask detection model outperforms existing models in terms of accuracy and easy usability. © 2022 IEEE.

10.
COVID-19's Impact on the Cryptocurrency Market and the Digital Economy ; : 118-140, 2022.
Article in English | Scopus | ID: covidwho-2024612

ABSTRACT

The COVID-19 pandemic has caused diverse sorts of disruption across the globe. The pandemic has drastically impacted the economies of almost every country of the world. The international economic scenario is full of despair as the entrepreneurs and business leaders find it hard to come to terms with the extent of damage caused by the pandemic. In view of largely prevalent gloom and despair, it is imperative that certain resilience strategies are worked out so that global economic crisis can be stemmed from further escalation. The gig economy has been viewed as a powerful resilience mechanism to tide over the economic crisis caused the world over by COVID-19. Entrepreneurial leadership can also make significant difference in providing a paddle-push to the pandemic-struck world by reactivating the engines of economic growth. The nature of this chapter is qualitative, and it seeks to theoretically work out certain strategies that can help various economies of the world to stand up and be resilient in the face of complex challenges that the pandemic has thrown before us. © 2021, IGI Global.

11.
Australian Journal of Adult Learning ; 62(2):236-256, 2022.
Article in English | Scopus | ID: covidwho-2010881

ABSTRACT

This paper examines the response by a Vocational Education and Training (VET) provider in the Northern Territory (NT) of Australia to the travel and social distancing restrictions brought about by COVID-19. The paper commences with a description of the impact of COVID-19 on the VET sector. The paper then describes the VET regulatory environment prior to February 2020 and the responsibility of VET providers to comply with the requirements of the Australian Skills Quality Authority (ASQA), in the delivery of VET programs to domestic and international students. A discussion of the lack of a specific vocational education pedagogy, the complexity of delivering VET programs online as well as current research findings in this area follows. A description of the College provides the context to examine the impact of COVID-19 on the delivery of programs in the Northern Territory VET sector. The paper describes how the College, which had a high international student cohort, migrated their courses online in order to remain viable in the highly volatile and unforeseen circumstances brought about by COVID-19. In order to ascertain the effectiveness of the online delivery of course offerings, a questionnaire and a series of face to face and telephone interviews were conducted with key stakeholders. The mixed method approach employed in this research was consistent with contemporary social and educational research. The paper concludes with the call for a new paradigm and policy shift in Vocational Education and Training post COVID-19. © 2022, Adult Learning Australia. All rights reserved.

12.
International Journal of Pharmaceutical Sciences Review and Research ; 75(2):196-199, 2022.
Article in English | EMBASE | ID: covidwho-2010619

ABSTRACT

Tomato flu is an infectious disease caused by an unexplained virus. The main symptoms of the infection are tomato-shaped blisters all over the body which enlarges to resemble the shape of a tomato, therefore being named as ‘Tomato flu’. Most commonly affects children below the age of 5 years. Tomato flu is considered a “Hand, Foot and Mouth disease”. The clinical manifestation of most cases is mild. It is a self-limiting infection;which gets resolved on its own in 7-10 days. The diagnosis is based on the clinical history and physical examination, especially in regions where there are outbreaks. This infectious disease etiological agent, its treatment regimen, and vaccination stills remain unknown and is a crucial area of research at present. COVID-19 has taught us lessons for outbreak preparedness and management of cases in emergency conditions by repurposing drugs and vaccines which is also synonymously being tried to curb the condition at present situation.

13.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2005702

ABSTRACT

Background: Trans-arterial chemoembolization (TACE) is the gold-standard for intermediate stage HCC. We hypothesised the ischemic and cytotoxic effect of TACE to boost anti-cancer immunity and to synergise with the anti PD-1 pembrolizumab (pembro). We designed a phase Ib study to test the safety and preliminary efficacy of pembro after TACE in intermediate HCC. Methods: PETAL study will enroll up to 32 patients with intermediate HCC to receive pembro 200 mg every 3 weeks for up to 1 year or until disease progression or unacceptable toxicity. The first safety-run-in phase includes 6 patients: if no dose limiting toxicities (DLTs) emerge over a 21-day window after first pembro, the others are enrolled in the expansion phase. Pembro is given within 30 days after 1 or 2 TACEs. The first phase includes 1 patient scoring Child-Pugh (CP)-B7 and the remaining have to be CP-A. Safety is the primary endpoint and is measured as the incidence of treatment-related adverse events (TRAEs), graded according to NCI CTCAEv4. Efficacy is the secondary endpoint and is evaluated as progression free survival (PFS) from first TACE, according to mRECIST criteria. Survival is estimated using Kaplan-Meier method. All the patients who have received at least one dose of pembro are evaluable for safety. Results: At the time of data cut-off, on the 14th of January 2022, 14 patients had received at least one dose of pembro. The median age was 72 (IQR: 63.3-74.6), 79% were male, 71% were cirrhotic, 29% had viral hepatis and 43% ECOG PS 1. One patient had Child-Pugh (CP) class B7 and 13 had A. The median number of nodules was 1.5 (IQR:1-2.8), and 4.1 cm (IQR: 3.7-4.5) the median diameter. Overall, 5 patients received 2 TACEs and 9 had 1. Patients received a median of 4.5 cycles (IQR: 2.3-6.5) of pembro. No DLTs emerged in the first phase. Treatment-related adverse events (TRAE) of any grade (G) were reported in 86% of participants, 21% of participants experienced G3 TRAEs, and there were no G4 or G5 TRAEs. Specific skin-related toxicity was the most frequently reported (35%) TRAE. No patients had treatment-related liver toxicity. Causes of treatment discontinuation were PD (n=7), TRAEs (n=1), clinical deterioration in the CP B patient (n=1), COVID pandemic (n=2) and withdrawal of consent (n=1);at the time of data cut-off, mPFS from first TACE was 10.8 months (95%CI: 6.63-14.97). Conclusions: Adjuvant pembro following TACE is manageable and tolerable with signs of activity. These results prompt the investigation in larger trials.

14.
National Journal of Physiology, Pharmacy and Pharmacology ; 12(8):1197-1201, 2022.
Article in English | EMBASE | ID: covidwho-1988323

ABSTRACT

Background: Coronavirus-19 (COVID-19) was identified as a cause of a disease outbreak in 2019 that originated in China. An infection without a cure makes the people, especially health care workers more vulnerable to get affected because of insufficient knowledge and unhealthy practices. Aim and Objective: This study aims to assess the knowledge and perceptions among medical students. Materials and Methods: A questionnaire-based cross-sectional study was conducted from December 2020 to February 2021 among the undergraduates and interns. The study was adapted from the current interim guidelines and information provided by Ministry Health and Family Welfare, Government of India (MOHFW, GOI) and Indian Council of Medical Research. Results: There were a total 355 participants. The majority (90.4%) of students had adequate knowledge. Only 9.5% had partial or no knowledge, the majority >90% of them showed a positive perception of COVID-19 prevention and control. In fact, majority 98.30% of students also got vaccinated against COVID-19. Conclusion: As there is no specific cure against COVID-19, it is essential to improve knowledge and belief among general public to prevent the spread. Medical students can, therefore, play a significant role by making community people aware about the seriousness of this pandemic.

15.
Indian Journal of Biochemistry and Biophysics ; 59(6):667-674, 2022.
Article in English | Scopus | ID: covidwho-1981127

ABSTRACT

It has been two years since the global outbreak of the highly contagious and deadly corona virus disease (COVID-19) caused by SARS-CoV-2 first emerged in China. Since then, various diagnostic, prognostic and treatment strategies undertaken to address the pandemic have been dynamically evolving. Predictive and prognostic role of various biomarkers in COVID-19 has been a subject of intense exploration. We aimed to determine the association of Carcinoembryonic antigen (CEA) and various surrogate inflammatory biomarkers with the severity of COVID-19 disease. This retrospective cohort study was carried out on 98 patients admitted in Jaypee Hospital, Noida with COVID-19 disease. Information regarding demographics, laboratory parameters and clinical history was collected from Hospital Information System. Serum levels of CEA and other biomarkers such as Neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), Interleukin-6 (IL-6), Ferritin, and Procalcitonin (PCT) were assessed. Correlation analyses were performed between the parameters and acute respiratory distress syndrome (ARDS) stages. Logistic regression and ROC curve analysis were performed to assess the various parameters for distinguishing COVID-19 patients requiring ICU admission. Mean hospital stay, NLR, CEA, IL-6, CRP, Ferritin (P <0.0001) and PCT (P = 0.01) were significantly higher in ICU patients when compared to general ward patients. NLR, median serum CEA, IL-6, and CRP levels were significantly higher in non-survivor compared to the survivors (P <0.0001, 0.0341 and 0.0092). CEA correlated well with disease severity based upon ARDS classification and was a better marker to differentiate patient according to ARDS stages (ARDS 0 vs 2 P = 0.0006;0 vs 3 P <0.0001;ARDS 1 vs 2 P = 0.0183;1 vs 3 P = 0.0006). The area under the Receiver operating characteristic (ROC) curve for CEA was 0.7467 (95% CI-0.64885-0.84459) which revealed the potential of CEA as a biomarker to distinguish COVID-19 patients requiring ICU admission. CEA can be used to predict the severity of COVID-19 associated ARDS as well as patients requiring ICU admission. Along with routine inflammatory biomarkers (NLR, CRP, IL-6, PCT, and ferritin), CEA should be used for early identification of critical COVID-19 positive patients and for assessing prognosis. © 2022, National Institute of Science Communication and Information Resources. All rights reserved.

16.
Annals of Phytomedicine-an International Journal ; 11(1):543-548, 2022.
Article in English | Web of Science | ID: covidwho-1980049

ABSTRACT

The SARS-COV-2 pandemic is causing mayhem on people all over the world. Although, immunization is progressing quickly, its effectiveness against new variants is unknown. The virus has proven to be exceedingly resistant to treatments, and no drugs have been demonstrated to be totally effective against SARS-COV-2 antiviral. However, a few vaccines have been produced, but best option for now is to adopt preventive steps for now and future as well. In general, the use of herbs is emerging as the best ploy among all preventive measures to enhance the immunity as they have great antiviral potential and antioxidant properties. Bryophytes especially (liverworts) are well known to contain a variety of potentially beneficial compounds such as terpenoids, quinones, phenylpropanoids, flavonoids, etc. In recent past, different liverwort extracts and isolated chemicals have demonstrated antibacterial, antiviral, and cytotoxic effects;highlighting the potential of liverworts as herbal treatments and chemical manufacture for application in a variety of goods. However, due to their small size, difficulties in collection, and identification, the bulk of liverworts remain unknown, particularly in India. In this light, an attempt has been made to screen a commonly growing liverwort, Plagiochasma rupestre (J.R. Forst. and G. Forst.) Steph. has been evaluated for its phytochemical profile and bioactivity.

17.
Ieee Access ; 10:78268-78289, 2022.
Article in English | Web of Science | ID: covidwho-1978322

ABSTRACT

The fake news "infodemic", facilitated by social media and mobile message sharing platforms, has progressed from causing a nuisance to seriously impacting law and order through deliberate and large-scale manipulation of public sentiments. There are social, religious, political, and economic dimensions to the fake news phenomenon, providing enough motivation for interested parties to push biased opinions, claims, conspiracies and fraud to many naive information consumers. The ease with which fake news can be created and propagated makes it extremely challenging to detect and mitigate. To combat the fake news, the researchers have utilized mechanisms which are largely based on Artificial Intelligence (AI) algorithms and social network analysis. However, no viable solution has yet been deployed at a scale. This paper present a comprehensive survey on combating fake news and evaluates the challenges involved in its detection with the help of existing detection mechanisms and techniques to control its spread. The challenges associated with combating fake news have been addressed based on the various aspects such as psychological, economic, and technical. Furthermore, we consider the fake news combat spectrum to analyze the stakeholder interventions due to the spread of fake news. Finally, various technology-based solutions have been presented for combating fake news and the associated future challenges and opportunities.

18.
International Journal of Toxicological and Pharmacological Research ; 12(7):56-66, 2022.
Article in English | EMBASE | ID: covidwho-1976278

ABSTRACT

Introduction: While managing COVID-19 patients, the healthcare professionals are at higher risk for contracting the infection and also could be a potential source of transmitting the disease in the community unknowingly. Therefore awareness [knowledge, attitude, and practice (KAP)] among healthcare professionals becomes of utmost importance. Methods: We conducted this observational cross sectional study to evaluate the knowledge, attitude and perceived practices toward COVID-19 among HCWs using a self-administered questionnaire at tertiary level healthcare facility in western Rajasthan. The questionnaire was shared with all the healthcare professionals of the pre identified tertiary care facilities through electronic mail (e-mail) and the responses received were recorded and analyzed. Results: A total of 59 responses were recorded. Out of the total participants, 61% were aware of national COVID-19 helpline numbers, 54.2% answered correctly about Hydroxychloroquine prophylaxis, 13.6% answered appropriately on COVID-19 testing. Almost 96.6% acknowledged to wear a medical mask however only 55.9% participants answered correctly regarding using a face mask. 52.5% responded that ash collection as a ritual may be allowed after funeral (cremation) of the body of a COVID-19 patient. More than 90% of participants acknowledged to clean their hands > 6-10 times in a day. 72.9% of participants admitted to open the MoHFW website to keep themselves updated on COVID-19 in India and 66.1% have 'Aarogya Setu' application in their mobile phone. However only 23.7% have ever used central helpline number or email-ID to get information on COVID-19. Conlcusion: We concluded that healthcare professionals were aware of the management strategies and treatment protocol however there is significant differences in the KAP of HCW sub groups. It also becomes important to study the KAP in various other populations (general populations, close contacts of COVID-19 etc.) for planning effective intervention strategies for them.

19.
Indonesian Journal of Electrical Engineering and Computer Science ; 27(2):911-921, 2022.
Article in English | Scopus | ID: covidwho-1975360

ABSTRACT

Coronavirus has become one of the most deadly pandemics in 2021. Starting in 2019, this virus is now a significant medical issue all over the world. It is spreading extensively because of its modes of transmission. The virus spreads directly, indirectly, or through close contact with infected people. It is proclaimed that people should wear a mask in public areas as a counteraction measure, as it helps in suppressing transmission. A portion of the spaces, where the virus has broadly fanned out, is because of inappropriate wearing of facial cover. In crowded areas, keeping a check on facial masks manually is difficult. To automate this process, an effective and robust face mask detector is required. This paper discusses a hybrid approach using a machine learning technique called eigenfaces, along with vanilla neural networks. The accuracy was compared for three different values of principal components. The test accuracy achieved was 0.87 for 64 components, 0.987 for 512 components, and 0.989 for 1,000 components. Hence, this approach proved to be more promising and efficient than its counters. © 2022 Institute of Advanced Engineering and Science. All rights reserved.

20.
INTERNATIONAL JOURNAL OF EARLY CHILDHOOD SPECIAL EDUCATION ; 14(1):3336-3345, 2022.
Article in English | Web of Science | ID: covidwho-1969765

ABSTRACT

The present study was taken toanalyse the coping strategies during the COVID 19 pandemic among school childreninthe national capital region of India.A sample of three hundred school children was randomly selected for the present study with agesranging between 14 to 18 years.Out of 300 subjects, 150 were boys, and 150 were girls.Further, all the subjects were divided into three groups, i.e. less than 15 years (50 boys and 50 girls), between 15 to 17 years (50 boys and 50 girls), above 17 years (50 boys and 50 girls), and each group had 100 subjects. All the subjects voluntarily participated in the study, and a detailed procedure was informed.Brief-COPE (Carver, 1997) 28 item self-report questionnaire was used to assess Coping strategies, i.e.self-distraction, active coping, denial, substance use, emotional support, behavioural disagreement, venting, instrumental support, positive reframing, self-blame, Planning, humour, acceptance and religion. The 2 X 2 Factorial MANOVA was used as a statistical technique, and the result of the study showed the value of Wilk's lambda=0.862, p=0.000 for gender, Wilk's lambda=0.804, p=0.000 for age group & Wilk's lambda=0.824, p=0.000 interaction gender*age group in a multivariate test which means gender and age had a significant impact on coping strategies.Further significant difference was found in gender in behavioral disagreement (F = 5.32;p <.022) venting (F = 19.69;p <.000), positive reframing (F = 7.21;p <.008) and self blame (F = 4.35;p <.038). Also age group has a statistically significant effect on active coping (F = 6.63;p <.002) planning (F = 8.44;p <.000) and religion (F = 4.19;p <.016).This table also shows interaction effect has a statistically significant effect on behavioural disagreement (F = 3.06;p <.048),positive reframing (F = 3.22;p <.041) and humour (F = 6.5;p <.002), hence null hypothesis may be rejected at 0.05 level. From the above results, it may be concluded that girls use more emotion-focused coping styles in response to stressors. Older age groups are better at using coping strategies like active coping, Planning and religion than younger age groups.The combined effect of age group and gender were seen on behavioural disagreement, positive reframing and humour.

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