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1.
Clinical Chemistry ; 68(11):1478-1478, 2022.
Article in English | Web of Science | ID: covidwho-2107394
2.
Thyroid ; 32(Supplement 1):A163, 2022.
Article in English | EMBASE | ID: covidwho-2097286

ABSTRACT

Aim: Post operative hypocalcaemia is the most frequent complication following thyroidectomy. It can be permanent or transient hypoparathyroidism of which the incidence of permanent hypoparathyroidism is less than 3 %. This study aimed to evaluate and identify the predictors of postoperative hypocalcaemia in patients undergoing thyroidectomy. Methodology: A prospective cohort study was conducted on 52 patients at an apex care institute. Preoperative testing for serum calcium, Parathormone (PTH) and Vitamin D were done on the day of surgery. These patients were subjected to surgery as per standard protocol. Postoperative testing for PTH was done 24 hours after surgery and serum calcium on day 0 and 1. All patients were assessed clinically for signs and symptoms of hypocalcemia till 48 hours post operatively and they were correlated with biochemical parameters and season in which surgery was performed. Result(s): A total of 52 patients were operated in our institute over a period of 18 months in the midst of COVID 19 outbreaks. Both hemi thyroidectomy (40) and total thyroidectomy (12) patients were included in the study. One significant finding was the low levels of preoperative Vitamin D values among 90% of the subjects. Out of the 52 patients, 12 underwent total thyroidectomy and 40 underwent hemi thyroidectomy as per standard protocols. 54% of the patients of total thyroidectomy and 52% of the patients of hemi thyroidectomy developed clinical as well as biochemical hypocalcemia over a period of 48 hours and were managed as per standard protocol. 38% of the patients were having low calcium values preoperatively and a statistically significant correlation was found between preoperative low calcium value and development of postoperative clinical hypocalcemia (P value 0.001). There was no statistically significant correlation between Pre operative Vitamin D level and season of surgery with postoperative clinical hypocalcemia. Conclusion(s): All patients being planned for surgery, whether it is total or hemi thyroidectomy should undergo preoperative serum calcium evaluation and necessary correction if required, since preoperative low calcium is a clear predictor of post thyroidectomy clinical hypocalcemia. Further studies are required to correlate relation between Vit. D level and postoperative hypocalcemia.

3.
Current Pediatric Research ; 26(5):1346-1350, 2022.
Article in English | EMBASE | ID: covidwho-2081556

ABSTRACT

Background: Multisystem Inflammatory Syndrome-Child (MIS-C) is a rare but life-threatening complication of COVID-19 in children. Objective(s): To study clinical profile of patients with MIS-C in pediatric ward in a tertiary care centre in Western Maharashtra Study design: Observational study Participants: Patients satisfying MIS-C criteria by WHO during the study period Results: 3.1 % (23 cases) of the total admissions during the study period in the pediatric ward were cases of MIS-C. The median age of MIS-C cases was 5 years (1.5 months to 12 years). Out of 23 cases, 10 cases were with shock, 7 cases without shock and 6 cases were of Kawasaki phenotype. They were treated with steroids alone, steroids plus IVIG or only symptomatic treatment. There was mortality in 1 patient (4.3%). Conclusion(s): Steroids and IVIG can be lifesaving in MIS-C cases if diagnosed early and given prompt treatment. Copyright © 2022 Scientific Publishers of India. All rights reserved.

4.
Journal of Mobile Multimedia ; 19(1), 2023.
Article in English | Scopus | ID: covidwho-2080998

ABSTRACT

Background: COVID-19 is a major public health emergency wreaking havoc on public health, happiness, and liberty of travel, as well as the worldwide economy. Scientists from all over the world are working to develop treatments and vaccines;the WHO has given emergency approval to eight vaccines from around the world. However, it is also seen that the efficiency of vaccines is not up to the mark in different age groups. COVID-19 symptoms come in many different shapes and sizes, so it s important to learn about them as soon as possible so that medical attention and management can be easier. Method: The GitHub Data Repository-made COVID-19 patient data is available on the internet, which is used in this investigation. We have used the association rule mining method to look for common patterns in a targeted class or segment and then look at the symptoms based on them. Result: The result is that this study involves individuals with a median age of 52 years old. Few frequent symptoms like respiratory failure (1%), septic shock (1.4%), respiratory distress syndrome (1.8%), diarhoea (1.8%), nausea (2%), sputum (3%), headache (5%), sore throat (8%), pneumonia (8%), weakness (7%), malaise/body pain (11%), cough (37%), fever (67%) and remaining diseases like myocardial infarction, cardiac failure, and renal illness (less than 1%) were present. If a patient had chronic disease, respiratory failure, and pneumonia, there was a higher risk of death;if a patient had a combination of chronic disease, respiratory failure, and pneumonia, respiratory failure in the age range of 45 to 84 years there was a higher risk of death. Patients having chronic conditions like pneumonia or renal disease symptoms that died as a result of the corona virus had more serious indication patterns than those without chronic diseases. © 2023 River Publishers. All rights reserved.

5.
Journal of Clinical and Diagnostic Research ; 16(9):DE01-DE05, 2022.
Article in English | EMBASE | ID: covidwho-2080893

ABSTRACT

Coronavirus associated with Severe Acute Respiratory Syndrome (SARS) has been identified as Coronavirus Disease-2019 (COVID-19) Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), first detected in Wuhan, Hubei province, China, the National Health Commission of China received reports of 27 cases of pneumonia, including seven severe cases of unknown origin, on 30th December 2019. In order to diagnose COVID-19, the virus responsible for the pandemic, SARS-CoV-2, was analysed for its Ribonucleic Acid (RNA). It is possible to detect specific sequences of genes encoding the RNA dependent RNA polymerase (RdRP), nucleocapsid (N), envelope (E), and spike (S) proteins of viruses using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). There are four major groups of drugs recommended by treatment guidelines worldwide: antiviral drugs (eight drugs), antimalarial drugs (two drugs), systemic corticosteroids (five drugs), and immune-based therapy (seven drugs). The recommendations for the treatment with these drugs in all of the guidelines differ depending on the severity of the case and the health conditions of the patient. A successful preventative vaccine is the most important and time-sensitive measure in combating the COVID-19 pandemic. There were 12 SARS-CoV-2 vaccines approved/authorised for full or emergency use in various parts of the world as of 25th February 2021, with more than 200 million doses administered worldwide. Because the disease is still relatively new and healthcare is under considerable pressure, many questions remain unanswered. There is a lack of publications regarding the effectiveness and safety of these drugs in COVID-19 patients. In addition, community members with limited financial resources must still consider the costs associated with some of the proposed treatment regimens. Copyright © 2022 Journal of Clinical and Diagnostic Research. All rights reserved.

6.
Environmental Science and Engineering ; : 1-20, 2022.
Article in English | Scopus | ID: covidwho-2075210

ABSTRACT

We are fond of varied colors and they are strongly bonded in our life. In most cases, even a child looks eagerly for colorful toys, bottles and with passage of time desire to have attractive textiles to psychological imprints for colorful life with individual perceptions. Thus, dyes and pigments are integral part of our civilization and documented since prehistoric days. They may be classified as natural and synthetic, application or solubility based with continual efforts to have best combinations. There is growing demand as well as concern over the adverse implication of synthetic colorants on both the consumer, environment, ecosystem and thus need for safe, nontoxic, sustainable coloring alternatives have increased multifold for varied applications in food additives, cosmetics, textiles, pharmaceuticals, packaging, automobiles, defense sectors, etc. They may be amine, nitro, Sulfur based azodyes, or others with established reports on usage at levels above than the permissible regulatory limits. The usage of bacterial and fungal biobased pigments is increasing gradually due to advantages over the synthetic pigments. They are preferred because of simple culturing, pigment extraction procedures, ease of scale-up, and economic viability in less time amidst few limitations. Liposome-dependent innovative pathways may be potential to meet the demand of next generations and developing cost-effective, environment-friendly biobased products with economical feasibility in a time bound manner. For effective decision-making in terms of market share, it is necessary to address market intelligence, consider Covid-19 or similar impacts for assessing the market trends, forecast, and human behavior for comprehensive scientific mapping. The strict implementations of updated holistic, industry-driven standards with compliances to international norms are vital from safety and quality perspective. We must strategically solve environmental issues faced by the current markets as a challenge and safeguard the environment for future generations. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
Chest ; 162(4):A911-A912, 2022.
Article in English | EMBASE | ID: covidwho-2060726

ABSTRACT

SESSION TITLE: Critical Care Management of COVID-19 SESSION TYPE: Original Investigations PRESENTED ON: 10/17/2022 01:30 pm - 02:30 pm PURPOSE: Superimposed bacterial co-infection is common among patients with Coronavirus disease-19 (COVID-19) pneumonia. Incidence of any superimposed infection ranges from 0% to 40%. Up to 50% of COVID-19 patients who died, had concomitant bacterial or fungal infection. Steroids are recommended for the treatment of acute hypoxemic respiratory failure (AHRF) due to COVID-19 and are thought to mitigate inflammatory organ injury. This retrospective study explores a subset of COVID-19 patients receiving Epoprostenol (iEPO) for AHRF and compared two different steroid treatment strategies and the impact on patient outcomes. METHODS: This is a retrospective study of 101 COVID-19 patients with AHRF receiving iEPO and systemic steroids. Patients in the high dose steroid group (n=59) received a minimum of dexamethasone 20mg daily or solumedrol 100mg daily while the standard dose steroid group (n=52) were those who received any lower dose. Patients that were DNR/I were excluded from the study. The primary outcome of the study was the rate of bacterial co-infection defined by positive cultures. Secondary outcome was mortality. RESULTS: Results showed that patients treated with high dose steroids were older (66.77±11.17 vs 60.33±14.49, p0.006) and received a longer treatment course (18 days (12-25) vs 12.5 days (10-17), p 0.004). Univariate and Multivariate analysis showed that higher dose steroids were not associated with increased risk of superimposed bacterial infection (OR 0.96, CI (0.34-2.66), p0.93). The duration of steroids, regardless of the dose, was associated with increased risk of superimposed bacterial infection (OR 1.06, CI (1.01-1.13), p0.033). When adjusted for comorbidities and inflammatory state, there was no significant difference in mortality between patients treated with high dose compared to standard dose steroids (OR 3.60, CI (0.65-19.93), p0.14). A longer duration of steroids was associated with a trend towards improved mortality (OR 0.93, CI (0.87-1.00), p0.072). CONCLUSIONS: Our study suggests that the duration of steroids, rather than dosage, had an effect on patient outcomes. There was no difference in bacterial co-infection rates between the two groups, but infection rates were increased among those who received a longer course of steroid treatment. There was a trend towards lower mortality with increased steroid duration, however, this did not reach statistical significance. Given this trend towards lower mortality, future prospective studies should investigate steroid duration to determine if a longer course of treatment leads to better outcomes in patients with COVID-19 pneumonia and refractory AHRF. CLINICAL IMPLICATIONS: Based on our study, patients should not receive a higher dose or longer duration of steroid treatment given the increased risk of bacterial infection with no definitive improvement in mortality. DISCLOSURES: No relevant relationships by Natasha Garg No relevant relationships by Abhinav Hoskote No relevant relationships by Raymonde Jean No relevant relationships by Arpanjeet Kaur No relevant relationships by Sara Luby No relevant relationships by Omar Mahmoud No relevant relationships by Maria Athena Riego No relevant relationships by Edith Robin No relevant relationships by James Salonia No relevant relationships by DISHANT SHAH No relevant relationships by Venus Sharma No relevant relationships by Elizabeth Zipf

8.
3rd International Conference on Machine Learning, Advances in Computing, Renewable Energy and Communication, MARC 2021 ; 915:701-706, 2022.
Article in English | Scopus | ID: covidwho-2059754

ABSTRACT

In medical domain, the accuracy of the data supplied is critical. Missing values, on the other hand, are a typical occurrence in this sector for a variety of reasons. Most current science concentrates on establishing novel data imputation procedures, but more research on conducting a comprehensive review of existing algorithms is highly desired. Authors have evaluated the performance of four mostly adopted data imputation techniques, i.e., MICE, EM, mean, and KNN on a real-world dataset of COVID-19. KNN is an imputation approach that, according to the findings of the studies, is expected to be a good fit for dealing with missing data in the healthcare industry. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

9.
RNA Technologies ; 13:41-71, 2022.
Article in English | Scopus | ID: covidwho-2059695

ABSTRACT

Last decade has witnessed tremendous growth in the new promising treatment options based on mRNA, RNAi, antisense RNA, and RNA aptamers, the four classes of RNA-based therapeutics. Among these, mRNA-based therapy is centered on producing proteins within the cells to supplant deficient or abnormal proteins and in vaccination to a target pathogen. The potential of mRNA therapeutics is evident from the two major mRNA vaccines approved for COVID-19: developed by Moderna and by Pfizer. Nonetheless, mRNA therapeutic potential extends far beyond this, such as in treating genetic diseases, cancers, and other infectious diseases. Given the potential of mRNA therapeutics, this chapter is written to provide the reader an insight into the features of several synthetic mRNA platforms, production, purification;strategies to increase the stability and reduce the immunogenicity of therapeutic mRNA molecules;delivery methods of these mRNAs in vivo;and their applications, safety, and efficacy. Graphical : A detailed diagram of the chemically modified mRNA, with the in vitro delivery modes on the left, and the myriad of applications, namely the treatment of major genetic diseases on the right. The IVT mRNA is represented with more details above the diagram. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

10.
Cyber-Physical Systems: AI and COVID-19 ; : 117-138, 2022.
Article in English | Scopus | ID: covidwho-2048758

ABSTRACT

Coronavirus pandemic has driven the entire world to crush. It has influenced every single segment of society straightforwardly and in a roundabout way. There is an unexpected break in everything. A monetary downturn, psychological maladjustment, and joblessness are spreading its underlying foundations alongside the spread of COVID-19. To forestall the spread of COVID-19, the Indian government has made different strides. One such measure was the whole country lockdown, which was put in place on March 22, 2020. Despite the fact that the countrywide lockdown was implemented to curtail the spread of infection, numerous issues have risen alongside the lockdown. In this chapter, we compare the impact of COVID-19 on the five worst-hit countries in the world. Further, temporal sentiment analysis of Twitter data to understand the effect of lockdown on public perception in these five countries is presented. Results reveal that sentiments in the United States vary from neutral to negative, whereas, in India and Italy, people have mixed attitudes toward the 2019-nCOV-2 virus crises. Further, the impact of government control policies through various stages of lockdown in India is analyzed, which provides interesting aspects of public emotions. Some of the most trending hashtags such as #WorkFromHome and #MigrantLabour are also analyzed using sentiment analysis techniques. It was observed that most people had positive sentiments about working from home during the lockdown. At the same time, migrant workers’ stories dominated on Twitter. © 2022 Elsevier Inc. All rights reserved.

11.
Journal of Clinical and Diagnostic Research ; 16(8):BC19-BC23, 2022.
Article in English | EMBASE | ID: covidwho-2033410

ABSTRACT

Introduction: Lipids are fundamental biomolecules of the body. Infections like COVID-19 with intricate immune response in some patient’s leads to acute complications by affecting metabolic pathways at multiple levels. Metabolism of cholesterol, triglyceride and High Density Lipoprotein (HDL)-Cholesterol is deranged by cytokines and multiple inflammatory mediators. The sex differences in lipid metabolism may contribute in susceptibility, severity and outcome of Coronavirus Disease 2019 (COVID-19). Performing lipid profile in COVID-19 patient may help in assessing severity and prognosis of disease. Aim: To assess the relationship between lipid profile and inflammatory markers in COVID-19 patients and also to evaluate the gender wise differences in lipid parameters and their correlations with inflammatory markers. Materials and Methods: This retrospective study was conducted in Department of Biochemistry at SHKM, GMC, Mewat, Haryana, India (tertiary care health centre) on COVID-19 positive patients attending Outpatient Department (OPD) and Inpatient Department (IPD), from October 2020 to December 2020. The data of 85 patients with COVID-19 positive, confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and who were prescribed for lipid profile along with C-Reactive Protein (CRP) and serum ferritin were included in the study. Serum total cholesterol, triglyceride, HDL-Cholesterol, CRP and ferritin were measured in the subjects. Data was statistically analysed using Student’s t test and Pearson correlation coefficient. results: Total 85 (46 males and 39 females) COVID-19 patients were included in the study. Mean age in male and female patients were 43.02±15.52 years and 42.02±15.25 years, respectively with a range of 5-82 years. Mean value of Serum triglycerides, HDL-C and total cholesterol was 204.94±141.27 mg/dL, 42.97±13.38 mg/ dL and 187.058±45.75 mg/dL, respectively. Serum triglycerides were statistically significantly higher in males than females (p-value=0.0413). The HDL-C however was significantly higher in females than males (p-value=0.0006). In male patients, r-value between cholesterol and CRP was -0.3538, and p-value was 0.016. Ferritin had a significant negative correlation with HDL-C (r-value=-0.3578, p-value=0.00079). Weak Positive correlation was noted between triglyceride and ferritin (r-value= 0.2285, p-value=0.035). conclusion: High levels of serum triglycerides, low total cholesterol, and low HDL-cholesterol correlates with inflammatory markers like CRP and ferritin in COVID-19 patients. Lipid profile may be used as a potential marker in all COVID-19 patients in assessing prognosis of disease.

12.
Annals of the Rheumatic Diseases ; 81:1327-1328, 2022.
Article in English | EMBASE | ID: covidwho-2008917

ABSTRACT

Background: Current pharmacological treatments remain inadequate for a signifcant proportion of patients with rheumatoid arthritis (RA), and thus alternative treatment approaches are needed. Prior results from the frst 12 weeks of a proof-of-concept (POC) study showed that ATHENS, a non-invasive high-frequency vagus nerve therapy, was well-tolerated with meaningful reductions in RA disease severity as measured by the American College of Rheumatology response criteria (ACR) and the Disease Activity Score using 28 joints (DAS28)[1]. Objectives: The current analysis assessed long-term changes (52 weeks total follow-up) in disease activity as measured by ACR, DAS28, and the following MRI-assessed changes: synovitis, osteitis, bone erosion, and cartilage loss. Methods: Following the completion of the 12-week POC study, patients achieving a reduction in DAS28-CRP of ≥1.2 were given the option to enroll in the 9-month open-label extension (OLE) study. During the extension phase, patients were to use the wearable device for 15 minutes per day. Adjustment of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or biologic disease-modifying antirheumatic drugs (bDMARDs) were allowed during the OLE. Changes from baseline were assessed at 12 weeks (end of initial POC) and 52 weeks (end of the OLE). Structural damage and disease progression were evaluated by standardized MRI of the wrist and hand, with and without intravenous gadolinium-based contrast. MRIs were evaluated by two independent, central readers, blinded to clinical information and visit-order of the images, and were scored for synovitis, osteitis and bone erosion using the OMERACT-RAM-RIS method. Cartilage loss was also determined using the 9-point cartilage loss scale (CARLOS). Results: Twenty-seven of 30 patients completed the initial 12-week study, of whom 19 consented and entered the OLE. Of those 19 patients, 4 (21%) discontinued due to lack of efficacy, while the remaining 15 completed the 9-month extension. Due to the COVID-19 pandemic, 7 patients were unable to complete a 52-week MRI scan;MRI evaluations at baseline, 12 weeks, and 52 weeks were available for 8 patients. DAS28-CRP mean (standard deviation [SD]) change from baseline was-1.78 (1.01) at 12 weeks (n=19;p<0.0001) and-2.30 (1.22) at 52 weeks (n=15;p<0.0001). ACR20, ACR50, and ACR70 response rates were 68%, 42%, and 21% at 52 weeks (n=19;discontinued participants were deemed non-responders). MRI analysis of synovitis, osteitis, bone erosion, and cartilage loss showed no evidence of disease progression through 52 weeks compared with baseline (Table 1). During the 9-month extension study, two new adverse events were reported (cornea transplant and right hand dysesthesia) in 2 (11%) patients;neither was treatment-related and both resolved without intervention. No serious adverse events were reported. Conclusion: In patients with an initial treatment response to the Nēsos ATHENS therapy in the 12-week POC study, reductions in DAS28-CRP were sustained through 52 weeks. Although results should be interpreted cautiously given the small sample size and lack of control arm, MRI evaluation of synovitis, osteitis, bone erosion, and cartilage loss suggested no disease progression.

13.
Specialusis Ugdymas ; 1(43):3124-3134, 2022.
Article in English | Scopus | ID: covidwho-1970292

ABSTRACT

The main objective of this research paper is to highlight the challenges faced by the staffs of the hospitality industry in India during and after the COVID pandemic. It is of utmost importance that the frontline staffs who are working in the hotels & restaurants need to take the optimum safety measures to keep themselves safe while in the operations. After a lockdown of more than 60 days, on 1st June 2020 India started its first unlock. The hospitality industry had to start following new standard operating procedures to prevent the spreading of the disease further. However, the hospitality industry didn’t start then. The orthodox practices need to get re-designed according to the situations. The resumption commenced after another one month of the unlocking phase. Hence, with the instantaneous catastrophe there were also serious concerns regards to the continual progression in such times of distress. Many employees were asked to stay back at home as the industry decided to resume with half or less than half of the staffs so that it can combat the revenue crunch. The essayists have collected plenty of information from reputed International & National chain category of hotels’ staffs based on which this paper has been presented. © 2022. Specialusis Ugdymas. All Rights Reserved.

14.
Journal of Pharmacology and Pharmacotherapeutics ; 13(1):95-96, 2022.
Article in English | EMBASE | ID: covidwho-1916510
15.
Mushroom Research ; 30(2):99-108, 2021.
Article in English | CAB Abstracts | ID: covidwho-1904210

ABSTRACT

There has been rapid growth in mushroom production worldwide reaching 43 million tonne in 2018- 19. The subsequent two years have been a difficult period for all economies of the world as COVID- 19 has impacted all the sectors including mushroom output. Despite the rapid increase in mushroom production in this century, the production is highly localized. In all major mushroom producing countries, there are specific regions of concentrated production. In countries producing different types of mushrooms such as China, Japan and India, there are localized regions of production for different species. Species and region-wise production in major mushroom producing countries has been presented here for 2018-19. These data may serve as a bench mark to analyse the changes in mushroom production in the post-COVID era.

16.
Indian Journal of Agricultural Sciences ; 91(9):1274-1279, 2021.
Article in English | Scopus | ID: covidwho-1897938

ABSTRACT

The discovery of the CRISPR/Cas microbial adaptive immune system and its ongoing development as a genome editing tool represents the work of many scientists around the world.The time line of CRISPR/Cas system shows that this technology is improving continuously to remove the demerits of preceding one with the aim of development of highly efficient, specific with low off target effect and ultimately transgene free technology in light of ethical and environmental issues related with transgenic technology.Initially, CRISPR/Cas9 was developed as method of choice as it provides targeted mutagenesis under in vivo condition and all the homeoalleles of a gene can be targeted in same plant, especially in case of polyploid species efficiently which is difficult through other existing technology.No residual or foreign gene insertion is required and modification is permanent.Now, CRISPR/Cpfl has been developed as more potent, efficient and simpler than CRISPR/Cas9.Different forms of Cas enzymes provide new avenues for regulation of genomic component.In view of the present devastating COVID-19 disaster the scientists used this novel technology for detection of virus in humans at an early stage of infection thus saving human lives.The evolution of CRlSPR'Cas technology, their advantages, apprehensions and solution, experimental design and updates of this technology is discussed in the present review. © 2021 Indian Council of Agricultural Research. All rights reserved.

17.
Acs Photonics ; 9(5):1513-1521, 2022.
Article in English | Web of Science | ID: covidwho-1895566

ABSTRACT

The COVID-19 pandemic has generated great interest in ultraviolet (UV) disinfection, particularly for air disinfection. Although UV disinfection was discovered close to 90 years ago, only very recently has it reached the consumer market and achieved much acceptance from the public, starting in the 2000s. The current UV light source of choice has been almost exclusively a low-pressure mercury vapor discharge lamp. Today, however, with emerging deep-UV (DUV) chip-scale technologies, there has been a significant advancement, along with ever-increasing interest, in the development and deployment of disinfection systems that employ compact devices that emit in the deep-UV spectral band (200- 280 nm), including UV light-emitting diodes (LEDs) and cathodoluminescent (CL) chips. This perspective looks into competing UV technologies (including mercury lamps and excimer lamps as benchmarks) on their optical merits and demerits and discusses the emerging chip-scale technologies of DUV electroluminescent and cathodoluminescent devices, comparing them against the benchmarks and providing an overview of the challenges and prospects. The accelerating progress in chip-scale solutions for deep-UV light sources promises a bright future in UV disinfection.

18.
Journal of Punjab Academy of Forensic Medicine and Toxicology ; 21(2):127-131, 2021.
Article in English | Scopus | ID: covidwho-1876082

ABSTRACT

Introduction: During global Covid-19 pandemic, India fought against the situation by implementing strict lockdown in whole country starting from 25th March 2020. Looking at severity of situation government decided to extend it in 4 phases till 31st May, 2020 which has been applied strictly in all district belonging to "Red Zone". Agra is the worst hit district in Uttar-Pradesh and it remained in the condition of strict Lockdown. Materials and Methods: Record-based comparative cross-sectional study looking for the impact of lockdown on change in pattern and number of medico-legal cases in Agra was done. Data related to name, age, sex, place of residence, type of medico-legal case was collected from records of medicolegal cases admitted in Emergency department of S.N. Medical College, Agra for the period of 25th March to 31 May 2020 (lockdown period) and compared it with data collected from 25th March to 31st May 2019 i.e. data of same corresponding period in last year. Results: On comparison we found out that during lockdown there was a decrease in no. of total admissions by 37.7%, while no. of medico legal cases is decreased by 54.2%. On further analysis of the data maximum decrease is seen in cases of road traffic accident, burns and firearm injuries while there was an increase in number of MLC cases of hanging. On gender wise comparison it was found that during lockdown period male MLC patients are decreased by 62.9% while female MLC patients decreased by 23.5%, which is lesser than decrease in total no. of admission. Interestingly we found out that there is increase in no. of MLC cases of female poisoning and hanging also increased significantly which might be due to increased domestic unrest or financial crisis emerged due to lockdown. Although on comparison of age groups no significant difference is seen during lockdown period. On area-wise comparison there was a decrease from 33% to 18% in total no. of MLC cases coming from districts other than Agra. This may be due to affected referral service or restrictions in inter-district transport. Conclusions: There is overall decrease in medico-legal cases with increased cases of hanging. Cases of female poisoning is also increased probably due to undue raised burden caused due to lockdown. © 2021, Punjab Academy of Forensic Medicine and Toxicology. All rights reserved.

19.
Journal of Experimental Biology and Agricultural Sciences ; 10(2):396-404, 2022.
Article in English | Scopus | ID: covidwho-1863450

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (S ARS-CoV-2) emerging variants particularly those of concern contain numerous mutations that influence the behavior and transmissibility of the virus and could adversely affect the efficacies of existing coronavirus disease 2019 (COVID-19) vaccines and immunotherapies. The emerging SARS-CoV-2 variants have resulted in different waves of the pandemic within the ongoing COVID-19 pandemic. On 26 November 2021 World Health Organization designated omicron (B.1.1.529) as the fifth variant of concern which was first reported from South Africa on November 24, 2021, and thereafter rapidly spread across the globe owing to its very high transmission rates along with impeding efficacies of existing vaccines and immunotherapies. Omicron contains more than 50 mutations with many mutations (26-32) in spike protein that might be associated with high transmissibility. Natural compounds particularly phytochemicals have been used since ancient times for the treatment of different diseases, and owing to their potent anti-viral properties have also been explored recently against COVID-19. In the present study, molecular docking of nine phytochemicals (Oleocanthal, Tangeritin, Coumarin, Malvidin, Glycitein, Piceatannol, Pinosylnin, Daidzein, and Naringenin) with omicron spike protein (7QNW (electron microscopy, resolution 2.40 Å) was done. The docking study revealed that selected ligands interact with the receptor with binding energy in the range of-6.2 to-7.0 kcal/mol. Pinosylnin showed the highest binding energy of-7.0 kcal/mol which may be used as potential ligands against omicron spike protein. Based on the docking studies, it was suggested that these phytochemicals are potential molecules to be tested against omicron SARS-CoV-2 and can be used to develop effective antiviral drugs. © 2022, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

20.
12th National Conference on Recent Advancements in Biomedical Engineering, NCRABE 2020 ; 2405, 2022.
Article in English | Scopus | ID: covidwho-1805761

ABSTRACT

Educational Data Mining (EDM) refers to the field that focuses on using various statistical methods and data mining techniques to draw inferences from large amount of educational data set. Over the years it has been used for student performance prediction by applying various machine learning processes and more recently deep learning. As a result of the lockdown announced after the spread of Covid-19, many colleges were forced to adapt to online learning tools. In this paper, we identify and evaluate the impact of the Covid-19 pandemic and its subsequent fallout in predicting student's academic performance. For this, a data set of various undergraduate students was compiled from March 2021. A Likert-type questionnaire was administered and large number of responses were gathered from various primary and secondary resources. This was subsequently used to validate the proposed methodology. Furthermore, different classification algorithms were used to predict the performance of the student and subsequently compared with one another based on their accuracy. The results show that the excessive use of e- learning tools including smartphones, laptops and tablets have a significant impact on student's academic performance as well as on their psychological health. The work will help us to better understand the impact of the lockdown on student's scholastic performance and point out areas where online-learning methods can be improved. © 2022 Author(s).

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