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1.
Chinese Journal of Biologicals ; 35(3):293-298 and 303, 2022.
Article in Chinese | EMBASE | ID: covidwho-2102632

ABSTRACT

Objective To establish a sample panel for detection of severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) antigen and apply to the development and quality evaluation of SARS-CoV-2 antigen colloidal gold test cassettes. Methods A sample panel for detection of SARS-CoV-2 antigen was established using 12 kinds of bulks of inactivated non-SARS-CoV-2 vaccine as negative controls, while two batches (Bl and B2) of bulks of inactivated SARS-CoV-2 vaccine (Bl, B2) and one batch (SI) of inactivated SARS-CoV-2 culture as positive controls. Bl was used as a positive control to evaluate the colloidal gold test cassettes from four manufacturers (A, B, C and D), and to monitor the development process of cassette from manufacturer A to improve its sensitivity. The negative sample panel was used to evaluate the specificity of colloidal gold test cassettes from five manufacturers (A, C, E, F and G), while positive sample panel (B2, SI and recombinant N protein) to evaluate the sensitivity. Inactivated SARS-CoV-2 culture SI was deter-mined with the commercial SARS-CoV-2 nucleic acid detection kit, and the result was compared with that by the colloidal gold test cassette from manufacturer A. Results N protein was determined as the main epitope of SARS-CoV-2 antigen by evaluation with positive control. The colloidal gold test cassettes from manufacturer A showed a sensitivity of 1 : 2 x 103to B1. The colloidal gold test cassettes from five manufacturers showed no cross reactions with inactivated non-SARS-CoV-2 vaccines, indicating a high specificity. The sensitivity of colloidal gold test cassette from manufacturer A was 106to B2 and 1 : 2 x 107to S1. However, the sensitivities of colloidal gold test cassettes from manufacturers E, F and were more than 1 : 103to B2 and 1 : 104- 1 : 105to SI, and that from manufacturer C was 1 : 104to B2 and 1 : 106to SI. The sensitivity of colloidal gold test cassette from manufacturer A was 100 pg/mL, while those from the other four manufacturers were 10 pg/mL, to recombinant N protein. The sensitivity of commercial nucleic acid detection kit to SI was 1 : 107, which was equal to that of colloidal gold test cassette from manufacturer A (1 : 2 x 107). Conclusion A sample panel for detection of SARS-CoV-2 antigen was successfully established, which showed high specificity and sensitivity, and might be used for the development and quality evaluation of SARS-CoV-2 antigen colloidal gold test cassettes. Copyright © 2022 Changchun Institute of Biological Products. All rights reserved.

2.
Chinese Journal of Disease Control and Prevention ; 26(10):1217-1223, 2022.
Article in Chinese | EMBASE | ID: covidwho-2100542

ABSTRACT

Objective To investigate the correlation between Global Health Security Index (GHSI) and the epidemic situation of COVID-19 and to explore the value of GHSI. Methods A crosssectional study of 159 countries from an open database was conducted. Analyze the correlation of GHSI with the COVID-19 pandemic with Spearman and plot the correlation matrix. Fitted multiple linear regression models controlled for variables such as socioeconomic and health conditions in countries, and further studied the association of GHSI with COVID-19 pandemic outcome indicators. Results The mean total GHSI score of the 159 countries in 2021 was (41. 19+/-13. 41), with a minimum of 16. 10 (Yemen) and a maximum of 75.90 (The United States). As of 31 December 2021, the crude case fatality rate of COVID-19 in 159 countries was 0. 02 (0. 01, 0. 03), with a minimum <0. 01 (Bhutan) and a maximum of 0. 20 (Yemen). The total number of confirmed cases per million population was 50 844.42 (5 807. 88, 101 572.70), with a minimum of 22.26 (Republic of Vanuatu) and a maximum of 251 608. 38 (Slovakia). The total number of deaths per million population was 590. 71 (105. 66,1533. 20), with a minimum of 3. 10 (Burundi) and a maximum of 6 075. 95 (Peru). Multiple linear regression analysis results showed that the Detect score of GHS1 was negatively correlated with the total confirmed cases per million population (fi =-0. 34, P =0. 038) and the total deaths per million population (fi = -0.42, P = 0. 025);the Norms score of GHS1 was negatively correlated with the total confirmed cases per million population (fi = -0. 49, P = 0. 041), and the Health score of GHS1 was positively correlated with the total deaths per million population (fi =0.65, P = 0.003). Risk score of GHS1 was inversely correlated with case fatality rate(fi = -0. 91, P = 0. 044). Conclusion The GHS 1ndex has limited value in assessing a country's capacity to respond to the COV1D-19 pandemic. Nevertheless, it has potential value in others. Copyright © 2022, Publication Centre of Anhui Medical University. All rights reserved.

3.
Journal of Environmental Management ; Part B. 325 (no pagination), 2023.
Article in English | EMBASE | ID: covidwho-2086407

ABSTRACT

Green bonds are becoming increasingly important in sustainable investments since their environmental protection attributes allow them to benefit from environmental degradation. However, the mechanism of environmental degradation on green bonds has not yet been studied. This study proposes a mediation model to analyze air pollution's influence on green bonds. Theoretically, air pollution leads to increased public concern through public environmental awareness and perceptions of physical health risks. Enhanced public concern drives investors' green preference and environmental responsibility, thus expanding green bond demand, in which public concern plays an important mediation role. To verify the mediating effect, causal stepwise regression and bootstrap methods are used. The empirical results confirm this theoretical mechanism. Air pollution is significantly positively related to public concern. Public concern is positively linked with green bond investment willingness, resulting in increased volatility. The total positive effect of air pollution on green bonds is partly absorbed by the mediating effect of public concern that is significantly positive and reaches 30.21% of the total effect. In addition, major crisis events (e.g., COVID-19) may hinder the positive mediation process by generating a negative trend and distracting the public. This means that the government could propose appropriate measures to minimize the negative aspects in order to promote green finance. The mediation model is also useful for investors wishing to increase green assets in their portfolios and provides an incentive for businesses to promote green finance. Copyright © 2022 Elsevier Ltd

4.
Journal of Behavioral Addictions ; 11:201-202, 2022.
Article in English | EMBASE | ID: covidwho-2009759

ABSTRACT

Background: Video gaming revenues have increased dramatically during the COVID-19 pandemic. Trending social games and hyper-casual games are attracting new audiences that require further study. While engaging in video games and Internet-related behaviors inherently may help promote social connection and alleviate stress during the pandemic, a small proportion of individuals develop problematic habits that interfere with daily functioning. Therefore, the aim of this study is to examine the impact of COVID-19 lockdowns on the number of helpline calls for gaming disorder and problematic Internet use in the province of Ontario, Canada. Methods: Helpline calls were collected from a provincial mental health & addiction treatment service hotline from January 2019 to December 2021. This free and confidential service is for people who experience problems with alcohol, drugs, mental illness, and behavioral disorders. Growth modeling will be employed to examine the links between the number of calls received, the number of COVID-19 cases reported province-wide and the accumulated lockdown days across the different months. Results: The associations between the linear, quadratic and cubic growth/change curve factors of the number of calls received in relation to the progress of the pandemic will be reported for time variant, time-invariant and parallel growth moderators. Conclusions: Helpline calls are expected to increase during lockdowns and decrease when restrictions are lifted. This study serves to inform preventive measures that should be considered with the implementation of lockdown during a pandemic to prevent problematic forms of gaming or Internet use.

6.
Environmental Science-Nano ; : 10, 2022.
Article in English | Web of Science | ID: covidwho-1978025

ABSTRACT

Since the emergence of coronavirus disease 2019 (COVID-19), this highly contagious disease has ravaged the world, cumulatively causing millions of deaths and huge economic losses. As the culprit of COVID-19, severe acute respiratory syndrome beta-coronavirus 2 (SARS-CoV-2) is highly infectious and pathogenic, which has caused extreme panic worldwide. Early and rapid monitoring of SARS-CoV-2 has a significant role in suppressing the pandemic and reducing the virus's lethality. In our work, we prepared a self-enhanced ruthenium complex linked to zeolitic imidazole framework-8 (ZIF-8) and used it as an electrochemiluminescence (ECL) emitter. Additionally, a double-stranded specific nuclease (DSN)-assisted target RNA cycling with catalytic hairpin assembly (CHA) signal amplification technology was used to achieve the conversion of target RNA concentration to double-stranded DNA (dsDNA) output which significantly improved the detection sensitivity of target RNA under environmental conditions and in real human serum samples. In addition, we also combined the trans-cleavage property of CRISPR-Cas12a with the adsorption property of C3N4 on a ferrocene (Fc)-labeled DNA probe and obtained target RNA-dependent ECL signals. The reliable detection protocol achieved the transformation of SARS-CoV-2 RNA concentration to ECL responses, obtaining a limit of detection (LOD) of 0.67 fM with high specificity and reproducibility, which was of guiding significance for current detection methods of mutant SARS-CoV-2 and universal RNA.

7.
Frontiers in Pharmacology ; 13:926189, 2022.
Article in English | MEDLINE | ID: covidwho-1974672

ABSTRACT

Background: The coronavirus disease 2019 (COVID-19) continues to spread globally. Due to the higher risk of mortality, the treatment of severe or critical patients is a top priority. Traditional Chinese medicine (TCM) treatment has played an extremely important role in the fight against COVID-19 in China;a timely evidence summary on TCM in managing COVID-19 is crucial to update the knowledge of healthcare for better clinical management of COVID-19. This study aimed to assess the effects and safety of TCM treatments for severe/critical COVID-19 patients by systematically collecting and synthesizing evidence from randomized controlled trials (RCTs) and observational studies (e.g., cohort). Methods: We searched nine databases up to 19th March 2022 and the reference lists of relevant publications. Pairs of reviewers independently screened studies, extracted data of interest, and assessed risk of bias. We performed qualitative systematic analysis with visual presentation of results and compared the direction and distribution of effect estimates for each patient's important outcome. We performed sensitivity analyses to observe the robustness of results by restricting analysis to studies with low risk of bias.

8.
IEEE Transactions on Intelligent Transportation Systems ; : 1-15, 2022.
Article in English | Scopus | ID: covidwho-1948850

ABSTRACT

The COVID-19 pandemic calls for contactless deliveries. To prevent the further spread of the disease and ensure the timely delivery of supplies, this paper investigates a collaborative truck-drone routing problem for contactless parcel delivery (CRP-T&D), which allows multiple trucks and multiple drones to deliver parcels cooperatively in epidemic areas. We formulate a mixed-integer programming model that minimizes the delivery time, with the consideration of the energy consumption model of drones. To solve CRP-T&D, we develop an improved variable neighborhood descent (IVND) that combines the Metropolis acceptance criterion of Simulated Annealing (SA) and the tabu list of Tabu Search (TS). Meanwhile, the integration of K-means clustering and Nearest neighbor strategy is applied to generate the initial solution. To evaluate the performance of IVND, experiments are conducted by comparing IVND with VND, SA, TS, variants of VND, and large neighborhood search (LNS) on instances with different scales. Several critical factors are tested to verify the robustness of IVND. Moreover, the experimental results on a practical instance further demonstrate the superior performance of IVND. IEEE

9.
SUSTAINABILITY ; 14(13), 2022.
Article in English | Web of Science | ID: covidwho-1938971

ABSTRACT

Currently, urban crises are spreading, even tending to be magnified along the urban networks. Improving urban network resilience can effectively reduce the loss and cope with sudden disasters. Based on the dimensions of regional resilience and the framework of urban network, a new evaluation system of network resilience, including economic, social, and engineering networks, was established to assess the network resilience of the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) from a structural perspective. We analyzed the spatial characteristics and influencing factors of network resilience using social network analysis and quadratic assignment procedure. The results were as follows: (1) regional difference was biggest in GBA's economic network strength while smallest in its transportation network strength, and the east bank of the Pearl River represented an extremely resilient connection axis;(2) the structures of network resilience and its subsystems were heterogeneous, and the connection paths of network resilience were more heterogeneous and diversified than those of the subsystems;(3) network resilience presented an obvious core-edge structure, and the spatial correlation and spillover effect between blocks were substantial;and (4) geographical proximity, as well as differences in economic development, urban agglomeration, and market development, had a significant impact on network resilience. This study provides a more systematic approach to evaluate the regional network resilience, and the results provide references for the construction of bay areas in developing countries.

10.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 33(6): 606-614, 2021 Dec 14.
Article in Chinese | MEDLINE | ID: covidwho-1893446

ABSTRACT

OBJECTIVE: To analyze the epidemiological characteristics of reported imported malaria cases in Zhengzhou City from 2016 to 2020, so as to provide insights into the management of imported malaria in the city. METHODS: All data pertaining to cases with definitive diagnosis of malaria in Zhengzhou City from 2016 to 2020 were captured from the National Notifiable Disease Report System and the Information Management System for Parasitic Disease Control in China, including individual demographic data, and malaria onset, initial diagnosis and definitive diagnosis data. All data were descriptively analyzed. The duration from malaria onset to initial diagnosis, from initial diagnosis to definitive diagnosis and from onset to definitive diagnosis was compared among cases. In addition, the diagnoses of imported malaria cases in which definitive diagnosis was made were compared with the reexaminations by Zhengzhou Municipal Malaria Diagnosis Reference Laboratory. RESULTS: A total of 302 cases with definitive diagnosis of malaria were reported in Zhengzhou City from 2016 to 2020, and all were imported cases, with Plasmodium falciparum malaria as the predominant type (230 cases, 76.2%). There were 293 malaria cases imported from Africa (293 cases, 97.0%), which mainly included Nigeria (48 cases, 15.9%), Angola (40 cases, 13.2%), and the Democratic Republic of the Congo (29 cases, 9.6%). There was no obvious seasonality found in the date of malaria onset and time of reporting malaria. The ratio of male to female malaria cases was 49.3:1, and there were 103 cases (34.1%) with the current residency address in Zhengzhou City, 193 cases (63.9%) with the current residency address in other cities of Henan Province and 6 cases (2.0%) in other provinces of China. There were 271 cases (89.7%) seeking initial diagnosis in medical institutions, and the diagnostic accuracy of malaria was 56.6% (171/302) at initial diagnosis institutions. A total of 122 cases (40.4%) sought medical care on the day of malaria onset, and 252 cases (86.4%) within 3 days; however, only 22 cases (7.3%) were definitively diagnosed on the day of onset, and 162 cases (53.6%) diagnosed within 3 days. There were no significant differences between malaria cases seeking initial diagnosis at medical institutions and disease control and prevention institutions in terms of the duration from malaria onset to initial diagnosis (Z = -1.663, P > 0.05), from initial diagnosis to definitive diagnosis (Z = -0.413, P > 0.05) or from malaria onset to definitive diagnosis (Z = -0.838, P > 0.05). The median duration (interquartile range) from initial diagnosis to definitive diagnosis of malaria was 3.00 (2.00), 3.00 (6.00), 2.00 (4.00) d and 1.00 (1.00) d among cases seeking medical care at township-level and lower, county-, city- and province-level medical institutions, and the median duration from initial diagnosis to definitive diagnosis of malaria was significantly longer among cases seeking medical care at township-level and lower medical institutions than at city (Z = -3.286, P < 0.008 33) and province-level medical institutions (Z = -9.119, P < 0.008 33), while the median duration from initial diagnosis to definitive diagnosis [1.00 (3.00) d vs. 2.00 (4.00) d; Z = -4.099, P < 0.016] and from malaria onset to definitive diagnosis [3.00 (4.00) d vs. 4.00 (5.00) d; Z = -2.868, P < 0.016] among malaria cases with the current residency address in Zhengzhou City was both shorter than in other cities of Henan Province. The diagnostic accuracy was 89.1% (269/302) among malaria cases in which definitive diagnosis was made, and the accuracy of malaria reexaminations was 94.0% (284/302) in Zhengzhou Municipal Malaria Diagnosis Reference Laboratory. CONCLUSIONS: P. falciparum malaria was predominant among reported imported malaria cases in Zhengzhou City from 2016 to 2020, and these imported malaria cases were predominantly diagnosed at medical institutions; however, the diagnostic capability of malaria is poor in township-level and lower medical institutions. Strengthening the collaboration between medical institutions and disease control and prevention institutions and improving the diagnostic capability building at medical institutions are recommended to consolidate malaria elimination achivements.


Subject(s)
Malaria, Falciparum , Malaria , Africa , China/epidemiology , Cities , Female , Humans , Malaria/diagnosis , Malaria/epidemiology , Male
11.
International Journal of Low-Carbon Technologies ; 17:678-685, 2022.
Article in English | Web of Science | ID: covidwho-1886438

ABSTRACT

Windows are the communication medium between indoor and outdoor, but their influence and the corresponding landscape outside the window are often ignored due to the outdoor frequent activities of people. The coronavirus disease 2019 (COVID-19) has been a better choice to show the window performance, especially for the anxiety level alleviation of people isolated at home. A national survey was conducted on the anxiety of self-separation people and the window influence. The results showed that the average anxiety level was 1.54, between a little anxious and anxious, due to the COVID-19. The best satisfaction with the landscape outside the window was waterscape (2.98), followed by green plants (2.33) and buildings (0.83). During the COVID-19, the average number of overlook times increased by 1.49 times/day, which is higher 0.42 ties/day than the normal condition. The landscape types had the certain influence on the overlook frequency, the window opening times and even the anxiety level. The average anxiety levels are 1.36 and 1.68 with natural landscapes and human landscapes, respectively. Optimizing the landscapes outside the window plays an important role in alleviating the anxiety of residents and improving their mental health.

12.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-337380

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although unprecedented efforts are underway to develop therapeutic strategies against this disease, scientists have acquired only a little knowledge regarding the structures and functions of the CoV replication and transcription complex (RTC) and 16 non-structural proteins, named NSP1-16. Results: In the present study, we proposed a two-route model to answer how the RTC functions in the jumping transcription of CoVs. The key step leading to this model was that the motif AAACH for METTL3 recognition flanking the transcription regulatory sequence (TRS) motif was discovered to determine the m6A methylation of SARS-CoV-2 RNAs, by reanalyzing public Nanopore RNA-seq data. As the most important finding, TRS hairpins were reported for the first time to interpret NSP15 cleavage, RNA methylation of CoVs and their association at the molecular level. In addition, we reported canonical TRS motifs of all CoVs to prove the importance of our findings. Conclusions: The main conclusions are: (1) TRS hairpins can be used to identify recombination regions in CoV genomes;(2) RNA methylation of CoVs participates in the determination of the RNA secondary structures by affecting the formation of base pairing;and (3) The eventual determination of the CoV RTC global structure needs to consider METTL3 in the experimental design. Our findings enrich fundamental knowledge in the field of gene expression and its regulation, providing a crucial basis for future studies.

13.
International Journal of Information and Education Technology ; 12(6):565-570, 2022.
Article in English | Scopus | ID: covidwho-1847909

ABSTRACT

Distance education has been widely used in universities due to the outbreak of Covid-19. SPOCs (Small Private Online Courses) have high enrollment and completion rates in higher education due to their ability to provide students with personalized deep learning. This study aims to investigate the learning effect of SPOCs and further explores the reasons that affect its effectiveness. The study found that: a) there is a certain difference in the learning effect between SPOCs and face-to-face courses;b) the learning effect in SPOCs can be effectively improved by enhancing the interest in learning, and c) the teacher’s internal and external assistance can significantly improve the learning effect. The study suggested that the “Hard-Pure” SPOCs needs more detailed course design, enhancing students’ motivations and learning interests in SPOC courses, and strengthening teachers’ assistance to students in and out of class. © 2022, International Journal of Information and Education Technology. All rights reserved.

14.
2022 zh Conference on Human Factors in Computing Systems, zh EA 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1846568

ABSTRACT

The World Health Organization (WHO) and other public health agencies have identified vaccine hesitancy as a critical challenge in reducing future cases and deaths from COVID-19. The current study has investigated ways to improve a widely circulated vaccine infographic video by Centers for Disease Control and Prevention. After gathering qualitative feedback on properties of the message that could be improved (from online crowdworkers), we conducted a randomized experiment to investigate different combinations of these attributes. Our results suggest participants were more likely to share the video which was: (1) played more slowly;(2) had a female speaker;(3) did not have background music. The study demonstrates potential of user studies for improving existing communication strategies for encouraging vaccinations and alleviating vaccine hesitancy on social media platforms. Our contribution also includes a repository of messages to encourage vaccination, generated by online crowdworkers, which could be utilized by future studies. © 2022 ACM.

15.
Huanjing Kexue/Environmental Science ; 43(5):2557-2565, 2022.
Article in Chinese | Scopus | ID: covidwho-1835958

ABSTRACT

To reveal the spatiotemporal distribution and risks of plastic additives in Taihu Lake during the COVID-19 pandemic, the occurrences of typical bisphenols, phthalate esters, and benzotriazoles in the surface water of Taihu Lake were investigated. The plastic additives in 19 sites in Taihu Lake were monitored in four seasons, and their potential ecological risks were evaluated. Diethylphthalate (DEP), dimethoxyethyl phthalate (DMEP), benzyl butyl phthalate (BBP), bisphenol A (BPA), and 2-(2H-benzotriazol-2-yl)-4, 6-di-tert-pentylphenol (UV-328) were detected, with detection rates of 100%, 97%, 58%, 98%, and 7%, respectively. During the COVID-19 pandemic, the sharply increasing usage of plastic products did not result in a significant increase in the plastic additives pollution in Taihu Lake. Conversely, the pollution of plastic additives showed a decreasing trend due to reduced human activities. There were significant seasonal differences in the concentrations of plastic additives in Taihu Lake. The average concentrations of plastic additives in spring and summer were 104.7 and 100.3 ng•L-1, respectively, which were higher than those in autumn (30.7 ng•L-1) and winter (29.9 ng•L-1). The plastic additive pollution also showed some differences in spatial distribution. The concentrations of plastic additives near the southwest coast of Taihu Lake were higher than those in other monitoring sites. The presence of plastic additives in Taihu Lake showed low risks to algae with the proportion of 30%. The risks in autumn and winter were higher than those in spring and summer. BPA and UV-328 may have been the main risk factors, which should be of concern. © 2022, Science Press. All right reserved.

16.
Journal of Allergy and Clinical Immunology ; 149(2):AB56-AB56, 2022.
Article in English | Web of Science | ID: covidwho-1798171
17.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 43(2):273-277, 2022.
Article in Chinese | EMBASE | ID: covidwho-1791918

ABSTRACT

Objective: To evaluate the ability of different disinfection methods to remove nucleic acid pollution in 2019-nCoV so as to obtain the best removal scheme. Methods: 2019-nCoV positive quality control nucleic acid of 50 μL was applied to plastic, metal and glass with medical cotton swabs, respectively. After drying, we dropped 50 μL of 750 mL/L alcohol (ethanol), chlorine-containing disinfectant (2 000 mg/L and 5 500 mg/L), and PCR Cleaner, respectively. After 1 min, the contaminated area was wiped with medical cotton swabs and soaked in 300 μL of pure water. After shaking and mixing, 5 μL was taken as a template. The Ct values of ORF1ab and N genes and IC genes of internal standard fragment in the amplified target area of 2019-nCoV after wiping with different disinfection methods were compared to evaluate the effect of eliminating nucleic acid pollution, and each experiment was repeated for three times. Similarly, the effects of ultraviolet irradiation for 0, 1, 2, 3, 4, and 5 hours on the removal of nucleic acid pollution were compared. Results: After 2 000 mg/L and 5 500 mg/L chlorine-containing disinfectant wiped the contaminated area, the Ct values of ORF1ab and N genes and IC genes of internal standard fragment in the amplified target area in 2019-nCoV were all 0, and the Ct values of all genes in the contaminated area in groups 3, 4 and 5 h after UV irradiation were all 0, which completely cleared the pollution and had a strong effect. The effect of PCR Cleaner was second, and 750 mL/L ethanol was the worst. Conclusion: 2 000 mg/L and 5 500 mg/L chlorine-containing disinfectant and ultraviolet irradiation for 3 hours have the best effect of eliminating nucleic acid pollution, which is worth popularizing under appropriate conditions.

18.
International Journal of Wireless and Mobile Computing ; 21(4):342-348, 2021.
Article in English | Scopus | ID: covidwho-1789217

ABSTRACT

In recent years, public security emergencies such as COVID-19, rainstorm and waterlogging have occurred frequently, posing a great threat to personal and property safety. At the same time, the panic buying behaviour induced by public security incidents, i.e., synchronous buying behaviour, further strengthens the harm caused by the event. For example, simultaneous panic buying of face masks amid the pandemic has sparked fears of a shortage. The food rush after the rainstorm caused food shortage in some groups and the price soared, which easily led to the extreme behaviour of the people. Based on this, this paper constructs a game model of synchronous buying under public emergencies, analyses the psychological incentive of synchronous buying behaviour and the formation mechanism of synchronous panic buying behaviour, and puts forward effective measures to alleviate synchronous buying behaviour. Finally, we verify the model and its application through an actual case. Copyright © 2021 Inderscience Enterprises Ltd.

19.
Frontiers in Communication ; 7:12, 2022.
Article in English | Web of Science | ID: covidwho-1771029

ABSTRACT

Scientific and moderate exercise is an effective remedy to boost the immune system and minimize the risk of infection in coronavirus disease 2019 (COVID-19) epidemic period. In this context, social media platforms play an essential role in communicating scientific fitness at home. Based on the integrated analysis of communication, physical geography, and health geography, this article takes short fitness-based videos on TikTok as the research object and comprehensively uses text analysis, mathematical statistics, and spatial analysis to reveal the characteristics of communication elements, fitness preferences, and the spatiotemporal evolution of these short videos, and to explore the communication mechanism and optimization path of short videos. The results show that: (1) the communication information focusing on "fighting against the epidemic and keeping fit at home" is made into short videos by female youth. Through the communication channels mainly composed of texts, pictures, and audio, the communication subjects carry out multilevel interactive communication with the communication objects;(2) fitness preferences are mainly composed of dances, unarmed fitness, and fitness with equipment;(3) from the perspective of time, taking February 20 as the node, the daily number of released short videos shows a trend of "increase before decrease";from the perspective of space, the distribution is significantly unbalanced across provinces, and the direction is not apparent;and (4) this article explores the communication mechanism and targeted optimization countermeasures of short fitness-based videos on TikTok in China's COVID-19 epidemic period.

20.
Achdout, H.; Aimon, A.; Bar-David, E.; Barr, H.; Ben-Shmuel, A.; Bennett, J.; Bilenko, V. A.; Bilenko, V. A.; Boby, M. L.; Borden, B.; Bowman, G. R.; Brun, J.; Bvnbs, S.; Calmiano, M.; Carbery, A.; Carney, D.; Cattermole, E.; Chang, E.; Chernyshenko, E.; Chodera, J. D.; Clyde, A.; Coffland, J. E.; Cohen, G.; Cole, J.; Contini, A.; Cox, L.; Cvitkovic, M.; Dias, A.; Donckers, K.; Dotson, D. L.; Douangamath, A.; Duberstein, S.; Dudgeon, T.; Dunnett, L.; Eastman, P. K.; Erez, N.; Eyermann, C. J.; Fairhead, M.; Fate, G.; Fearon, D.; Fedorov, O.; Ferla, M.; Fernandes, R. S.; Ferrins, L.; Foster, R.; Foster, H.; Gabizon, R.; Garcia-Sastre, A.; Gawriljuk, V. O.; Gehrtz, P.; Gileadi, C.; Giroud, C.; Glass, W. G.; Glen, R.; Glinert, I.; Godoy, A. S.; Gorichko, M.; Gorrie-Stone, T.; Griffen, E. J.; Hart, S. H.; Heer, J.; Henry, M.; Hill, M.; Horrell, S.; Huliak, V. D.; Hurley, M. F. D.; Israely, T.; Jajack, A.; Jansen, J.; Jnoff, E.; Jochmans, D.; John, T.; De Jonghe, S.; Kantsadi, A. L.; Kenny, P. W.; Kiappes, J. L.; Kinakh, S. O.; Koekemoer, L.; Kovar, B.; Krojer, T.; Lee, A.; Lefker, B. A.; Levy, H.; Logvinenko, I. G.; London, N.; Lukacik, P.; Macdonald, H. B.; MacLean, B.; Malla, T. R.; Matviiuk, T.; McCorkindale, W.; McGovern, B. L.; Melamed, S.; Melnykov, K. P.; Michurin, O.; Mikolajek, H.; Milne, B. F.; Morris, A.; Morris, G. M.; Morwitzer, M. J.; Moustakas, D.; Nakamura, A. M.; Neto, J. B.; Neyts, J.; Nguyen, L.; Noske, G. D.; Oleinikovas, V.; Oliva, G.; Overheul, G. J.; Owen, D.; Pai, R.; Pan, J.; Paran, N.; Perry, B.; Pingle, M.; Pinjari, J.; Politi, B.; Powell, A.; Psenak, V.; Puni, R.; Rangel, V. L.; Reddi, R. N.; Reid, S. P.; Resnick, E.; Ripka, E. G.; Robinson, M. C.; Robinson, R. P.; Rodriguez-Guerra, J.; Rosales, R.; Rufa, D.; Saar, K.; Saikatendu, K. S.; Schofield, C.; Shafeev, M.; Shaikh, A.; Shi, J.; Shurrush, K.; Singh, S.; Sittner, A.; Skyner, R.; Smalley, A.; Smeets, B.; Smilova, M. D.; Solmesky, L. J.; Spencer, J.; Strain-Damerell, C.; Swamy, V.; Tamir, H.; Tennant, R.; Thompson, W.; Thompson, A.; Tomasio, S.; Tsurupa, I. S.; Tumber, A.; Vakonakis, I.; Van Rij, R. P.; Vangeel, L.; Varghese, F. S.; Vaschetto, M.; Vitner, E. B.; Voelz, V.; Volkamer, A.; Von Delft, F. f, Von Delft, A.; Walsh, M.; Ward, W.; Weatherall, C.; Weiss, S.; White, K. M.; Wild, C. F.; Wittmann, M.; Wright, N.; Yahalom-Ronen, Y.; Zaidmann, D.; Zidane, H.; Zitzmann, N..
Embase; 2020.
Preprint in English | EMBASE | ID: ppcovidwho-330569

ABSTRACT

The COVID-19 pandemic is a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Future pandemics could be prevented by accessible, easily deployable broad-spectrum oral antivirals and open knowledge bases that derisk and accelerate novel antiviral discovery and development. Here, we report the results of the COVID Moonshot, a fully open-science structure-enabled drug discovery campaign targeting the SARS-CoV-2 main protease. We discovered a novel chemical scaffold that is differentiated to current clinical candidates in terms of toxicity and pharmacokinetics liabilities, and developed it into orally-bioavailable inhibitors with clinical potential. Our approach leverages crowdsourcing, high throughput structural biology, machine learning, and exascale molecular simulations. In the process, we generated a detailed map of the structural plasticity of the main protease, extensive structure-activity relationships for multiple chemotypes, and a wealth of biochemical activity data. In a first for a structure-based drug discovery campaign, all compound designs (>18,000 designs), crystallographic data (>500 ligand-bound X-ray structures), assay data (>10,000 measurements), and synthesized molecules (>2,400 compounds) for this campaign were shared rapidly and openly, creating a rich open and IP-free knowledgebase for future anti-coronavirus drug discovery.

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