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1.
The COVID-19 Pandemic and Risks in East Asia: Media, Social Reactions, and Theories ; : 62-84, 2022.
Article in English | Scopus | ID: covidwho-2120821
2.
Journal of the American Academy of Dermatology ; 87(3):AB170, 2022.
Article in English | EMBASE | ID: covidwho-2031394

ABSTRACT

Introduction: Hand dermatitis causes significant physical, psychosocial, and economic burden. The internet is a major source of health education for patients. Here, we evaluate the readability, quality, and comprehensiveness of online health resources on hand dermatitis. Methods: On July 27th 2021, a Google search was conducted with terms “hand dermatitis” and “hand eczema” and the first 40 items were evaluated. Articles that were advertisements, blogs, intended for professionals, scientific papers, or irrelevant were excluded. Contents of articles were evaluated using several validated grading tools/criteria for readability and quality and Pearson’s correlation assessed the relationship between readability and quality. Results: Twenty-three articles met inclusion criteria. Average readability was at the 11th-grade level (range 7.7-15.6). University-level reading comprehension (≥13th grade) was required for 5/23 websites. The highest quality website based on the Discern instrument was Medical News Today (55.5);nearly half of the websites (48%, 11/23) rated as poor or very poor. The average JAMA benchmark score was only 1.4/4. Nineteen websites contained images (83%) and only 4 websites (21%) included images representing hand dermatitis in skin of color (SOC). Quality and readability of the articles were significantly correlated (P =.02). Conclusion: Our results demonstrate that generally, articles were too difficult to read, have low quality, and lack representation of SOC images. With increases in hand dermatitis in the setting of frequent hand-hygiene practices during the COVID-19 pandemic, it is important for online health information to improve in readability, quality, and inclusion of SOC images to optimize online patient education.

3.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE ; 5(6):400-412, 2022.
Article in English | Web of Science | ID: covidwho-1908094

ABSTRACT

The rampageous transmission of SARS-CoV-2 has been devastatingly impacting human life and public health since late 2019. The waves of pandemic events caused by distinct coronaviruses at present and over the past decades have prompted the need to develop broad-spectrum antiviral drugs against them. In this study, our Pentarlandir ultrapure and potent tannic acids (UPPTA) showed activities against two coronaviral strains, SARSCoV-2 and HCoV-OC43, the earliest-known coronaviruses. The mode of inhibition of Pentarlandir UPPTA is likely to act on 3-chymotrypsin-like protease (3CLpro) to prevent viral replication, as supported by results of biochemical analysis, a 3CLpro assay, and a "gain-of-function" 3CLpro overexpressed cell-based method. Even in the 3CLpro overexpressed environment, Pentarlandir UPPTA remained its antiviral characteristic. Utilizing cell-based virucidal and cytotoxicity assays, the 50% effective concentrations (EC50) and 50% cytotoxicity concentration (CC50) of Pentarlandir UPPTA were determined to be similar to 0.5 and 52.5 mu M against SARS-CoV-2, while they were 1.3 and 205.9 mu M against HCoV-OC43, respectively. In the pharmacokinetic studies, Pentarlandir UPPTA was distributable at a high level to the lung tissue with no accumulation in the body, although the distribution was affected by the food effect. With further investigation in toxicology, Pentarlandir UPPTA demonstrated an overall safe toxicology profile. Taking these findings together, Pentarlandir UPPTA is considered to be a safe and efficacious pancoronal antiviral drug candidate that has been advanced to clinical development.

4.
14th International Conference on Knowledge and Smart Technology, KST 2022 ; : 1-6, 2022.
Article in English | Scopus | ID: covidwho-1794815

ABSTRACT

With the restrictions in our daily life activities under the current situation of the covid-19 pandemic worldwide, billions of people rely on social media platforms to share and obtaining covid-19 related news information. This made social media platforms easily be used as a source of myths and disinformation, which can cause severe public risks. It is thus of vital importance to constraint the spread of misinformation to the public. Although many works have shown promising results on the misinformation detection problem, only a few studies focus on the infodemic detection during the covid-19 pandemic, especially in the low resource language like Thai. Therefore, in this paper, we conduct extensive experiments on the real-world social network datasets to detect misinformation about covid-19 targeting both English and Thai languages. In particular, we perform an exploratory data analysis to get the statistic and characteristics of real and fake content. Also, we evaluate a series of three feature extraction, seven traditional machine learning, and eleven deep learning methods in detecting the fabricated content on social media platforms. The experimental results demonstrate that the transformer-based model significantly outperforms other deep learning and traditional machine learning methods in all metrics, including accuracy and F-measure. © 2022 IEEE.

5.
NTIS; 2020.
Non-conventional in English | NTIS | ID: grc-753746

ABSTRACT

The overall goal of this award is to find ways to prolong the efficacy of cabazitaxel chemotherapy in patients with castration resistant prostate cancer (CRPC) who have previously been treated with and developed resistance to Abiraterone Acetate (ABI) or enzalutamide (ENZ). In months 1-12 of this award, we aimed to determine whether a novel galectin-1 (Gal-1) inhibitor, S-LLS30 developed by the applicant, prevents ABI/ENZ resistance and/or sensitizes the cells to cabazitaxel (Major task 1). We have shown that indeed S-LLS30 sensitizes CRPC cells to ENZ and strongly affected cells expressing Gal-1. The experiments with cabazitaxel are continuing despite prolonged operational shutdown at the University due to COVID-19 restrictions. We have also started to investigate the role of Gal-1 nuclear localization, and its binding partners Gemin4 and HSP90 in this process (Major task 2, subtask 1). It appears that Gemin4 plays a substantial role in Gal-1 activity in this context but the role of HSP90 is unclear. Finally, we conducted preliminary experiments to evaluate the toxicity of S-LLS30 and determine the maximum tolerated dose (Major task 3, subtask 1). S-LLS30 was deemed to be of limited toxicity and very well tolerated in mice up to 30 mg/Kg doses. S-LLS30 is a viable potential drug candidate to overcome resistance to ABI/ENZ in models of CRPC.

6.
Mass Communication Research ; 148:153-196, 2021.
Article in Chinese | Scopus | ID: covidwho-1558948

ABSTRACT

The COVID-19 pandemic seriously struck the world in early 2020 and has exerted great impacts on every aspect of human life. Whether the disease can be contained or not depends greatly on how well people take preventive measures over an extended period of time. This study thus integrates theories from risk communication and media effects to understand the predictors of preventive measures, with a specific focus on the interplay among media, risk perception, and emotion. Based on a representative, dual-frame telephone survey (N = 1,073), the current study finds that people’s ways of living have changed quite drastically during the pandemic. More than 8 out of 10 Taiwanese expressed wearing face masks (82.9%) and washing hands (83.1%) more frequently than the usual level, while 63.6% of people indicated that they have tried to avoid going out, unless it is necessary, such as going to work or school. More than one-third of Taiwanese had canceled a planned trip (35.7%) and about a quarter are considering to do so (23.0%). Results of regression analyses suggest that risk perception is not directly predictive of people’s preventive behaviors, but it does positively affect behaviors by increasing people’s level of fear, lending support to the “emotion mediation model.” The results also indicate an amplifying effect of television on the relationship between risk perception and fear. Conversely, social media use exerts an attenuating effect that mitigates the impact of risk perception on preventive behaviors. The results extend the applicability of the social amplification of the risk framework from risk perception to subsequent emotional and behavioral responses. Further implications are discussed. © 2021 National Chengchi University. All rights reserved.

7.
International Journal of Gerontology ; 14(4):349, 2020.
Article in English | EMBASE | ID: covidwho-1006841
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