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1.
Cell Host and Microbe ; 30(12):1788, 2022.
Article in English | EMBASE | ID: covidwho-2158586

ABSTRACT

Main text: (Cell Host & Microbe 29, 1076-1092;July 14, 2021) In the originally published version of this article, the supplemental table contained numbered references, while the main article contained Harvard-style references. An updated version of the table with Harvard-style references is now available online. The authors and production staff apologize for any confusion. Copyright © 2022 Elsevier Inc.

2.
Journal of the National Medical Association ; 112(5):S15-S15, 2020.
Article in English | PMC | ID: covidwho-1386083

ABSTRACT

Background: Due to the limited availability of rapid testing for SARS-CoV-2 infection, these tests are often reserved for those requiring urgent procedures or hospital admission and are often not available to emergency department (ED) patients. Complete blood count (CBC), C-reactive protein (CRP) and Ferritin levels can be easily obtained in the ED. Lymphopenia and high C-reactive protein and Ferritin levels are associated with poor outcome in COVID-19 illness. However, it is not known whether these biomarkers are useful for identifying persons with SARS-CoV-2 infection. Methods: We performed a cross-sectional study of patients 18 years or older who were evaluated at an academic ED for suspected SARS-CoV-2 infection from March to May 2020. CBC, CRP and Ferritin levels were ordered at clinician’s discretion in patients who were suspected to have SARS-CoV-2 infection. SARS-CoV-2 infection was diagnosed using a number of PCR-based tests including the Cepheid Xpert Xpress and the Diasorin Simplexa. The discriminative values of the candidate biomarkers were estimated using the area under the receiver operating characteristic curve (AUC). Results: We studied a total of 1082 patients who had a median age of 59.5 (IQR: 46.0 – 71.0) years. A total of 431 (39.8%) of the subjects had PCR confirmed SARS-CoV-2 infection. The median absolute lymphocyte count was 0.9 (IQR: 0.7 – 1.3) and 1.0 (0.7 – 1.6) in those with and those without SARS-CoV-2 infection respectively (p=0.0004). The median CRP level in mg/L was 8.9 (IQR: 4.6 – 17.3) and 6.1 (IQR: 1.6 – 14.0) in those with and those without SARS-CoV-2 infection respectively (p=0.0001). The median ferritin level in ng/mL was 782 (IQR: 299 – 1479) and 312 (IQR: 106 – 1015) in those with and those without SARS-CoV-2 infection respectively (p=0.0001). Lymphocyte count, CRP and Ferritin levels distinguished between those with and those without SARS-CoV-2 infection with AUCs of 0.56 (IQR: 0.53 – 0.60), 0.61 (IQR: 0.58 – 0.64) and 0.66 (IQR: 0.62 – 0.68). Conclusion: Although patients with SARS-CoV-2 infection have lymphopenia and elevated CRP and ferritin levels, the levels of these biomarkers are not useful for identifying persons under investigation who have SARS-CoV-2 infection.

3.
ClinicalTrials.gov; 24/06/2021; TrialID: NCT04944095
Clinical Trial Register | ICTRP | ID: ictrp-NCT04944095
4.
Journal of the American College of Cardiology ; 77(18, Supplement 1):3073, 2021.
Article in English | ScienceDirect | ID: covidwho-1213725
5.
Journal of the National Medical Association ; 112(5):S15, 2020.
Article in English | EMBASE | ID: covidwho-988445

ABSTRACT

Background: Due to the limited availability of rapid testing for SARS-CoV-2 infection, these tests are often reserved for those requiring urgent procedures or hospital admission and are often not available to emergency department (ED) patients. Complete blood count (CBC), C-reactive protein (CRP) and Ferritin levels can be easily obtained in the ED. Lymphopenia and high C-reactive protein and Ferritin levels are associated with poor outcome in COVID-19 illness. However, it is not known whether these biomarkers are useful for identifying persons with SARS-CoV-2 infection. Methods: We performed a cross-sectional study of patients 18 years or older who were evaluated at an academic ED for suspected SARS-CoV-2 infection from March to May 2020. CBC, CRP and Ferritin levels were ordered at clinician’s discretion in patients who were suspected to have SARS-CoV-2 infection. SARS-CoV-2 infection was diagnosed using a number of PCR-based tests including the Cepheid Xpert Xpress and the Diasorin Simplexa. The discriminative values of the candidate biomarkers were estimated using the area under the receiver operating characteristic curve (AUC). Results: We studied a total of 1082 patients who had a median age of 59.5 (IQR: 46.0 – 71.0) years. A total of 431 (39.8%) of the subjects had PCR confirmed SARS-CoV-2 infection. The median absolute lymphocyte count was 0.9 (IQR: 0.7 – 1.3) and 1.0 (0.7 – 1.6) in those with and those without SARS-CoV-2 infection respectively (p=0.0004). The median CRP level in mg/L was 8.9 (IQR: 4.6 – 17.3) and 6.1 (IQR: 1.6 – 14.0) in those with and those without SARS-CoV-2 infection respectively (p=0.0001). The median ferritin level in ng/mL was 782 (IQR: 299 – 1479) and 312 (IQR: 106 – 1015) in those with and those without SARS-CoV-2 infection respectively (p=0.0001). Lymphocyte count, CRP and Ferritin levels distinguished between those with and those without SARS-CoV-2 infection with AUCs of 0.56 (IQR: 0.53 – 0.60), 0.61 (IQR: 0.58 – 0.64) and 0.66 (IQR: 0.62 – 0.68). Conclusion: Although patients with SARS-CoV-2 infection have lymphopenia and elevated CRP and ferritin levels, the levels of these biomarkers are not useful for identifying persons under investigation who have SARS-CoV-2 infection.

6.
Journal of Environmental Chemical Engineering ; : 104708, 2020.
Article in English | ScienceDirect | ID: covidwho-896823

ABSTRACT

This research study reports the formation of flexible and multifunctional organic-inorganic hybrid membranes (BC-SiO2-TiO2/Ag) based on bacterial cellulose (BC) that contain photoactive (TiO2) and antibacterial (Ag) components, rendering them photocatalytic, self-cleaning and UV-shielding properties (due to TiO2) as well as antibacterial activity. Coating of BC with sol-gel derived silica and titania particles was achieved through hydrolysis-polycondensation of tetraethyl orthosilicate and titanium (IV) isopropoxide and a soft hydrothermal treatment (140 °C, 20 h) was used to obtain well-crystalline TiO2. The prepared BC-SiO2-TiO2/Ag photoactive membranes were characterized by an array of analytical techniques including XRD, XRF, SEM-EDS, electronic absorption spectroscopy and vibrational spectroscopy. The morphology of TiO2 coatings changes from a homogenous film-like smooth one to a rougher one consisting of randomly oriented titania particles (170 ± 35 nm) upon increasing the TiO2 loading of the membranes. These prepared photoactive BC-SiO2-TiO2 membranes exhibited excellent TiO2-loading dependent photocatalytic/self-cleaning activity towards crystal violet dye deposited as an over-layer on the surface of the membranes, degrading 97% of the dye within 50 min of UV illumination. In addition to good photoactivity, the BC-SiO2-TiO2/Ag membranes demonstrated reasonable antibacterial activity against five different bacterial strains under dark conditions. These flexible BC-based hybrid membranes with photocatalytic, self-cleaning, antibacterial properties have the potential to be used in the design of self-cleaning and antibacterial surfaces, filters and facemasks that could be easily disinfected under UV irradiation from a lamp or natural sunlight and safely discarded and even recycled.

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