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1.
Pharmacy Education ; 22(1):336-347, 2022.
Article in English | Web of Science | ID: covidwho-1887462

ABSTRACT

Context: In response to the COVID-19 pandemic, many educational adjustments had to be made to move in-person teaching to online classrooms. This report showcases the use of the software GastroPlus at an undergraduate level pharmacy course. Programme description: This course aimed for the students to learn how to perform mechanistically based simulation to predict the oral absorption pattern, pharmacokinetics and biopharmaceutics properties of compounds in humans. The computer simulation offered the opportunity to teach concepts about bioavailability providing all kinds of experience with major biopharmaceutic determinants that affect systemic drug exposure. Evaluation: The advantage of this approach was seen by the enhanced performance on the biopharmaceutics questions on the final exam compared with the previous year where the laboratory was not implemented: An increase from 2019 (where no laboratory was implemented) through 2021 in correct scores from 52, 76 to 75%, respectively. Conclusion: There is great benefit in using computer programs and simulations as a technique to enhance active learning and to educate pharmacy students in salient aspects of biopharmaceutics.

2.
Topics in Antiviral Medicine ; 30(1 SUPPL):350, 2022.
Article in English | EMBASE | ID: covidwho-1880027

ABSTRACT

Background: Sexually transmitted infection (STI) diagnosis serves as an important linkage to HIV testing and pre-exposure prophylaxis (PrEP) for adolescents. The COVID-19 pandemic disrupted sexual health services for young people, with a potential consequence of increasing undiagnosed STIs. This study aimed to describe STI testing changes and estimate undiagnosed STI cases during the pandemic. Methods: We analyzed electronic medical records for chlamydia, gonorrhea, and trichomonas testing encounters from six pediatric primary care clinics in Philadelphia, July 2014-November 2020. We assessed whether testing was asymptomatic screening, risk-based testing, or symptomatic testing, and whether any result was positive. We evaluated STI trends over time, comparing pre-pandemic (before March 1st, 2020) and pandemic periods (after March 1st, 2020). Missed STI cases during the pandemic were estimated using decreases in patient volume and asymptomatic screening as compared to the previous year. Generalized linear mixed-effects models estimated the effects of patient-level and neighborhood-level characteristics on STI outcomes. Results: 35,548 STI testing encounters were analyzed, including 2,958 during the pandemic period. The median patient age was 17.5 years, 57% of patients were female, and 84% were Black/African American. Mean monthly STI testing encounters decreased from 479/month pre-pandemic to 329/month during the pandemic. Test positivity increased from 12.5% pre-pandemic to a peak of 27.5% in April 2020. The percent of STI tests performed as asymptomatic screening dropped from 72.5% pre-pandemic to a nadir of 54.5% in April 2020 (Figure). We estimate that the decrease in asymptomatic screening in the pandemic period would be associated with 159 missed cases (23.8% of expected cases) based on patient volume from the previous year. In multivariate models controlling for testing type (asymptomatic screening, risk-based testing, or symptomatic testing), the odds of test positivity were 50% higher during the pandemic (OR: 1.50, p<0.001). Conclusion: STI test positivity increased during the pandemic while asymptomatic screening decreased. Test positivity was higher for asymptomatic patients, suggesting increased STI prevalence. These changes likely resulted in a substantial number of undiagnosed STIs, representing missed opportunities for PrEP linkage. Efforts are needed to re-establish and sustain access to STI services for adolescents in response to disruptions caused by the pandemic.

3.
Brazilian Archives of Biology and Technology ; 65(e22210648), 2022.
Article in English | CAB Abstracts | ID: covidwho-1875203

ABSTRACT

COVID-19 rapidly spread across the world in an unprecedented outbreak with a massive number of infected and fatalities. The pandemic was heavily discussed and searched on the internet, which generated big amounts of data related to it. This led to the possibility of attempting to forecast coronavirus indicators using the internet data. For this study, Google Trends statistics for 124 selected search terms related to pandemic were used in an attempt to find which keywords had the best Spearman correlations with a lag, as well as a forecasting model. It was found that keywords related to coronavirus testing among some others, such as "I have contracted covid", had high correlations (0.7) with few weeks of lag (4 weeks). Besides that, the ARIMAX model using those keywords had promising results in predicting the increase or decrease of epidemiological indicators, although it was not able to predict their exact values. Thus, we found that Google Trends data may be useful for predicting outbreaks of coronavirus a few weeks before they happen, and may be used as an auxiliary tool in monitoring and forecasting the disease in Brazil.

5.
1st IEEE International Conference on Smart Technologies and Systems for Next Generation Computing, ICSTSN 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1861111

ABSTRACT

The rapid increase in posting personal information on social media has been noticed over last two years especially due to heavy use of smart phones and restrictions imposed on face-to-face meeting due to the current Covid-19 pandemic. Often, user information and user status updates on social media platforms provide valuable insights in determining personality traits. Scraping and analyzing this social media content and accurate prediction of user personality bring many benefits for enterprises including delivering personalized services, product recommendation and improving performance of recruitment system. This study was carried out based on digital footprints left on social media and the Myers-Briggs Type Indicator (MBTI), one of the most reliable personality inventories, was used to identify and predict the personality traits in mobile applications. Long Short-Term memory (LSTM) architecture-based sentiment classifier was proposed in this paper to predict personality and obtained a convincing model performance with overall 78% accuracy for personality traits. © 2022 IEEE.

6.
Hematology, Transfusion and Cell Therapy ; 43:S540-S541, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859758

ABSTRACT

Objetivos: A pandemia da COVID-19, doença causada pelo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), já ultrapassou 200 milhões de casos no mundo e mais de 4 milhões de óbitos. Os indivíduos podem apresentar-se assintomático, com sintomas leves ou graves associados às infecções do trato respiratório. Pacientes com COVID-19 apresentam anticorpos do tipo IgG em média duas semanas após a infecção, e persistem em níveis estáveis por alguns meses. Ainda não foi completamente elucidada a influência dos níveis desses anticorpos e o tempo de permanência em circulação, com a proteção e gravidade da doença em reinfecções. O objetivo deste trabalho foi avaliar a presença de anticorpos anti-SARS-CoV-2 IgG em pacientes assintomáticos ou com sintomas leves em um período de 3 meses. Material e métodos: Estudo prospectivo em que indivíduos adultos de ambos os sexos, participantes do projeto EpiSergipe e que apresentaram resultado positivo ao teste rápido para IgG/IgM confirmado por sorologia, foram convidados a continuar participando da pesquisa durante o período de 3 meses. Para as análises foram coletadas amostras de sangue periférico, sendo a amostra inicial descrita como D+0 e a final como D+90. A análise sorológica foi realizada por meio do kit comercial, de imunoensaio fluorescente (IchromaTM COVID-19 Ab) e os procedimentos foram realizados de acordo com as recomendações do fabricante. Resultados: Foram analisadas amostras dos 20 indivíduos, sendo 9 do sexo masculino e 11 do sexo feminino. A idade variou de 28 a 73 anos. Os sintomas mais comumente relatados foram mal-estar, febre, cefaleia e dor de garganta. Os níveis de IgG no D+0 variaram de 19,4 a 45,7, média de 34,47 (± 7,12), e no D+90 a variaram de 1,2 a 45,6, com média de 20,64 (± 12,18). Após 3 meses foi observada uma diminuição significativa (p < 0,0001) dos níveis de IgG em 85% dos indivíduos com média de 52,74%, e apenas 15% apresentaram aumento significativo (p < 0,05) com média de 27,47%. Discussão: Estudos descrevem que os níveis de IgG permanecem por apenas 3-4 meses no organismo dos indivíduos que tiveram contato prévio com o SARS-CoV-2, entretanto neste estudo inicial foi observado que a maioria dos indivíduos apresentou uma diminuição significativa e gradual de anticorpos IgG anti- SARS-CoV-2 circulantes, antes mesmo de completos os 3 meses após a exposição ao vírus. Conclusão: A partir destes resultados preliminares é possível compreender que os indivíduos, sejam eles assintomáticos ou sintomáticos leves, apresentaram soroconversão, produzindo IgG e estes anticorpos permaneceram em circulação por um período mínimo de 3 meses. Este estudo apresenta dados mais extensivos, ainda em análises, que futuramente corroborarão com a compreensão desta manutenção de anticorpos, e ainda assim, serão necessários mais estudos com o mesmo objetivo.

7.
Hematology, Transfusion and Cell Therapy ; 43:S512-S513, 2021.
Article in English | EMBASE | ID: covidwho-1859709

ABSTRACT

Objetivos: A COVID-19, oriunda do novo coronavírus (SARS-CoV-2) se espalhou como uma pandemia, causando mais de 4 milhão de mortes globalmente, tornando-se uma emergência de saúde pública. O número de casos de pacientes recuperados é crescente, o que pode ser crucial sobre o curso da doença. Na forma grave da doença é possível observar linfopenia e leucopenia. Estes achados podem ser auxiliares como indicadores clínicos para avaliação e progressão da doença. Desta forma, este trabalho teve como objetivo descrever o perfil leucocitário dos indivíduos positivos na sorologia para o SARS-CoV-2. Material e métodos: Trata-se de um estudo prospectivo em que indivíduos adultos de ambos os sexos, participantes do projeto EpiSergipe e que apresentaram resultado positivo ao teste rápido para IgG/IgM confirmado por sorologia. Foram coletadas amostras de sangue periférico para realização do hemograma e análise sorológica utilizando o kit comercial de imunoensaio fluorescente (IchromaTM COVID-19 Ab) em que os procedimentos foram realizados de acordo com as recomendações do fabricante. Resultados: Foram analisadas amostras de 847 pacientes com sorologia positiva para o SARS-CoV-2, assintomáticos ou com sintomas leves, sendo 275 do sexo masculino (32,47%) e 572 do sexo feminino (67,53%). Do total de hemogramas analisados, 9,33% apresentaram leucocitose e 2,01% leucopenia (média leucócitos totais = 7.370/mm3 /±2,10). A linfocitose foi observada em 23,61% dos indivíduos e a linfopenia foi observada em apenas 1,18% (média linfócitos = 2.550/mm3/±772). A neutrofilia foi observada em 5,90% dos participantes e a neutropenia em 5,31% (média neutrófilos = 4.280/mm3/±1,67). A maioria dos hemogramas analisados (67,41%) apresentaram todos os parâmetros normais. Discussão: A linfocitose, de acordo com estudos, pode auxiliar na previsão e acompanhamento da progressão da COVID-19, neste estudo foi observada em 23,61% dos hemogramas analisados, enfatizando que os participantes do presente estudo eram assintomáticos e sintomáticos leves, o que pode justificar o porquê grande parte dos pacientes apresentaram parâmetros dentro da normalidade. Além disso um estudo publicado em 2021, comparou os achados hematológicos de óbitos por COVID-19 com os de sobreviventes, nos indivíduos que morreram havia maior contagem de neutrófilos e leucócitos, e uma diminuição nos linfócitos, quando comparados aos sobreviventes. Neste estudo, não houveram óbitos, as taxas encontradas de leucocitose e neutrofilia foram de 9,33% e 5,90% respectivamente, e a linfopenia 1,18%. Conclusão: A partir dos resultados prévios encontrados, observa-se alterações no perfil leucocitário em indivíduos com COVID-19, condizentes com os descritos recentemente na literatura.

8.
Hematology, Transfusion and Cell Therapy ; 43:S485, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859691

ABSTRACT

Introdução: De acordo com o Instituto Nacional de Câncer (INCA) para cada ano, entre 2020 e 2022, são diagnosticados 10.810 novos casos de leucemias no Brasil. A leucemia mieloide aguda é um dos tipos mais comuns de leucemia em adultos, mas mesmo assim é bem rara. A leucemia mieloide aguda (LMA) é uma doença caracterizada pela expansão clonal, heterogênea e progressiva, com proliferação anormal de células progenitoras da linhagem mieloide, associada à perda da capacidade de diferenciação, ocasionando produção insuficiente de células sanguíneas maduras normais, com consequente substituição do tecido normal. Acomete frequentemente idosos acima de 60 anos de idade e é rara em menores de 45 anos, representando cerca de 15% a 20% das leucemias agudas na infância e 80% nos adultos. A doença também pode ser manifestar com formas extramedulares, onde células leucêmicas saem da medula e se infiltram em outros tecidos, como a pele, gânglios e sistema nervoso, levando a um aumento da gravidade. Relato de caso: Paciente, 14 anos, masculino, foi diagnosticado com LMA com acometimento extramedular. Iniciou quadro com mialgia intensa em MMII, progredindo com paraparesia, sensibilidade tátil, térmica e dolorosa preservadas, além de retenção urinária, conferindo uma mielite torácica. RM de coluna evidenciou lesões expansivas extramedulares e extradurais desde o nível T3 até o nível T9. Hemograma apresentava anemia (Hb 9,9g/dl), leucócitos totais 26.700, segmentados 500, linfócitos 3200, blastos 76% e plaquetas 120.000. Realizado estudo de medula óssea que diagnosticou a leucemia mieloide aguda. O cariótipo era 45, X, -Y, t (8:21) (q22;q22), 9qh+c [18], 9qh+c [2]. Paciente realizou radioterapia em região de coluna torácica e quimioterapia de indução “3+7”com remissão completa e DRM negativa. Sem doadores compatíveis na família, foi inscrito no REREME e seguiu com consolidação com ARA-C altas doses. Após o 4°ciclo de consolidação, paciente evoluiu com neutropenia febril secundária e pneumonia por COVID-19. Ficou internado por mais de 30 dias na UTI com piora do status performance e dificuldade de seguir tratamento da leucemia pela complicação clínica, apresentando recidiva da doença extra e intra-medular, evoluindo para óbito. Discussão: Neste caso o paciente abriu o quadro clínico com sintomas neurológicos sugestivos de mielite de causa desconhecida, após realização de RNM foi identificado lesão expansiva comprimido coluna torácica. Assim, feito o diagnóstico de LMA com acometimento extramedular pelo hemograma e estudo de medula óssea. LMA com sarcoma granulocítico é uma doença de pior prognóstico, com necessidade de tratamento intensivo e transplante de medula óssea alogênico. Nosso paciente acabou recidivando a doença antes do transplante devido complicação infecciosa por neutropenia febril secundária a pneumonia viral (COVID), evoluindo para óbito.

9.
Hematology, Transfusion and Cell Therapy ; 43:S352, 2021.
Article in English | EMBASE | ID: covidwho-1859653

ABSTRACT

A doação de sangue representa um importante ato voluntário e altruísta de saúde pública em todo o país, embora tenhamos uma grande população de 211.755.692 pessoas estimada em 2020, o número de pessoas que doam sangue é baixo e de acordo com o Ministério da Saúde representa apenas 2% do total da população. Com a pandemia da COVID-19 cria um receio na população ao ato de doação de sangue e a necessidade de isolamento social só dificulta este ato. No início de 2021 o Ministério da Saúde estimou uma redução da doação de sangue no nosso país entre 15% e 20% em comparação com o ano que antecedeu a pandemia. O objetivo deste estudo foi avaliar o perfil dos doadores novos que compareceram para doação na Sede do Hemocentro de Ribeirão Preto, de acordo com a idade, sexo, tipo de doação e os motivos que aprovam ou reprovam estes novos doadores de acordo com os critérios da triagem clínica comparando os dados antes e durante a pandemia. Foi realizado um estudo observacional e retrospectivo dos números referente às doações de sangue na Sede Hemocentro de Ribeirão Preto, por meio da coleta dos dados do sistema informatizado no período de janeiro de 2019 a dezembro de 2020. As doações de sangue total dos novos doadores aprovados nos critérios de triagem clínica foram reduzidas de 3681 para 3348, representando uma diminuição de 9% desse tipo de doação. A coleta de plaquetas por aférese aumentou de 42 para 82 doações, o que significa um aumento de 51,2% destes doadores. Mesmo com o aumento das doações por aférese, o estoque continua crítico devido à grande demanda desses hemocomponentes. Os motivos que mais incentivam os doadores novos a comparecerem ao Hemocentro de Ribeirão Preto são: vontade própria (37,9%), doadores vinculados transfundidos (23,2%) e Campanhas (15,3%) em relação ao total de doadores novos. A faixa etária de 18 a 29 anos foi a mais representativa com 51% e 47,5%, respectivamente nos anos de 2019 e 2020. Não há diferenças significativas entre os sexos dos doadores novos. Durante o período de estudo houve uma queda de 10% na inaptidão dos novos doadores. Os principais motivos para essa queda foram uma redução de 3,2% do Estado Gripal e 2,5% do Uso de Medicamento. Já o motivo HB/HT Baixo apresentou aumento de 2,1%, apesar de que em número absoluto houve uma redução de 12,7% (2019: 102 candidatos e 2020: 89 candidatos). Outro aspecto interessante é que apenas 9,9% (19) dos inaptos por HB/HT Baixo foram do sexo masculino. Esta redução situa-se na faixa etária de 18 a 29 anos com 4,5%. Não há diferenças de redução entre o sexo dos doadores novos. Mesmo com o aumento do número de doações por aférese o nível do estoque continua crítico. Pode-se observar que a pandemia alterou o perfil de reprovação (inaptidão) e número dos candidatos novos, sendo fundamental o estabelecimento de rotinas adequadas às normas de biossegurança aumentando a segurança e confiança dos doadores.

10.
Hematology, Transfusion and Cell Therapy ; 43:S312, 2021.
Article in English | EMBASE | ID: covidwho-1859635

ABSTRACT

Objetivo: Relatar um caso de tetraparesia flácida após início do esquema vacinal em paciente submetida a transplante de medula óssea (TMO) autólogo para tratamento de linfoma não Hodgkin. Relato do caso: Trata-se de uma mulher parda, de 32 anos, com histórico de linfoma não Hodgkin, hipertensão arterial e diabetes mellitus tipo 2, submetida a TMO em abril/2020 que, após iniciar regime vacinal de rotina pós-TMO, em outubro/2020, evoluiu com sintomas sistêmicos inespecíficos, caracterizados por febre não aferida, náuseas e vômitos. Nenhum quadro infeccioso foi detectado naquele momento. Cerca de 12 dias mais tarde, a paciente passou a apresentar quadro sensitivo-motor caracterizado por parestesia e paresia ascendentes, inicialmente em pés, com progressão para o abdome e mãos em 24 horas, além de disfagia para líquidos e diplopia. Familiares relatavam ainda alguns episódios de síncope nos últimos dois dias anteriores à consulta médica e sudorese extrema e intermitente na região da face. A paciente foi admitida em unidade de terapia intensiva onde foram verificadas hipotonia generalizada, arreflexia global, disautonomia e dissociação proteíno-citológica na análise do líquido cefalorraquidiano, estabelecendo-se o diagnóstico de Síndrome de Guillain-Barré (SGB). Foram descartados quadros infecciosos, inclusive COVID-19, assim como a recidiva do linfoma. Três dias depois houve deterioração da função respiratória com necessidade de intubação orotraqueal e ventilação mecânica. Optou-se por tratamento com plasmaférese (cinco sessões em dias alternados com troca de uma volemia plasmática por sessão). Os efeitos colaterais ao procedimento foram um pequeno hematoma em local de inserção do acesso venoso e distúrbios eletrolíticos moderados, corrigidos sem dificuldade. A recuperação motora foi rápida e a paciente recebeu alta hospitalar após 20 dias de internação, deambulando sem apoio e mantendo-se livre de quaisquer sequelas sensitivo-motoras durante o seguimento. Discussão: paralisias flácidas progressivas são condições frequentes em departamentos de urgência, mas que ainda constituem relevante desafio diagnóstico. Na maioria das vezes a SGB está associada a uma resposta imunológica a um estado infeccioso prévio, porém, em alguns raros casos, pode se desenvolver após imunizações ou transplante de medula óssea. A plasmaférese é tão efetiva quanto a infusão de imunoglobulinas no tratamento da SGB, embora com mais efeitos colaterais em potencial como hipotensão, sepse, reações transfusionais e problemas relacionados ao acesso vascular. Os resultados tendem a ser superiores quando a plasmaférese é iniciada nos primeiros sete dias do surgimento dos sintomas, melhorando a força muscular, diminuindo a necessidade de ventilação mecânica e acelerando a recuperação dos pacientes com SGB grave. Conclusão: a rápida progressão sintomática apresentada pela paciente e a excelente resposta clínica após a instituição da plasmaférese reforçam a importância de um diagnóstico precoce pois, com a terapia adequada é possível atingir uma reversão completa das manifestações e evitar danos neurológicos permanentes.

11.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-337462

ABSTRACT

Background: Since the beginning of the COVID-19 pandemic, health professionals have been working under extreme conditions, increasing the risk of physical and mental illness. We evaluated the prevalence of burnout and its associated factors among postgraduate student residents in health professions during the global health crisis. Methods: Healthcare residents were recruited from all across Brazil between July and September 2020 through digital forms containing instruments for assessing burnout (Oldenburg Burnout Inventory (OLBI)), resilience (brief resilient coping scale (BRCS)) and anxiety, stress and depression (depression, anxiety and stress scale (DASS-21) and Patient Health Questionnaire (PHQ-9)). Additionally, the relationships between burnout and chronic diseases, autonomy and educational adequacy in the residency programme, personal protective equipment (PPE), workload and care for patients with COVID-19 were evaluated. The chi-square test, Student’s t test, Pearson’s correlation test and logistic regression were performed. Results: A total of 1,313 participants were included: mean (standard deviation) age, 27.8 (4.4) years;female gender, 78.1%;white race, 59.3%;and physicians, 51.3%. The overall prevalence of burnout was 33.4%. The odds (odds ratio [95% confidence interval]) of burnout were higher in the presence of pre-existing diseases (1.76 [1.26–2.47]) and weekly work > 60 h (1.36 [1.03–1.79]) and were lower in the presence of high resilience (0.84 [0.81–0.88]), autonomy (0.87 [0.81–0.93]), and educational structure (0.77 [0.73–0.82]), adequate availability of PPE (0.72 [0.63–0.83]) and non-white race (0.63 [0.47–0.83]). Burnout was correlated with anxiety (r = 0.47;p < 0.05), stress (r: 0.58;p < 0.05) and depression (r: 0.65;p < 0.05). Conclusions: We observed a high prevalence of burnout among residents during the COVID-19 pandemic. Individual characteristics and conditions related to the work environment were associated with a higher or lower occurrence of the syndrome.

12.
Pasos-Revista De Turismo Y Patrimonio Cultural ; 20(3):601-614, 2022.
Article in Portuguese | Web of Science | ID: covidwho-1856602

ABSTRACT

Brazilian tourism has experienced the restrictions on mobility and new rigid health procedures as a result of the COVID-19. pandemic The present research aimed at analysing the impacts of coronavirus on tourism as based on the perceptions of specialists in the area, as given live on the social network In eta gram and in interviews. In order to study the impacts, an exploratory qualitative approach was chosen, using the techniques of net(h)nography. Thus, of the results obtained, the study highlights the understanding that post-COVID-19 tourism will recover at a slower pace than other sectors of the economy acquiring formats that privilege domestic tourism, requiring public managers to exercise perspicacity in development and management processes that allow tourist destinations to adapt to the new market demands.

13.
Int J Environ Sci Technol (Tehran) ; : 1-22, 2022 May 03.
Article in English | MEDLINE | ID: covidwho-1821019

ABSTRACT

The Covid-19 pandemic has negatively disrupted the way our economy and society functions. Nonetheless, there have also been some positive externalities of the pandemic on the environment. This paper aims to evaluate the concentration of nitrogen dioxide in Brazilian metropolitan regions after the policies adopted to confront Covid-19. In terms of methodological approach, the study employs cross-sectional quantitative analyses to compare the period of 36 days, i.e., 12 March to 16 April-before (in 2019) and after (in 2020) the pandemic declaration. The data were obtained from the Sentinel 5-P low-Earth polar satellite concerning Brazilian metropolitan regions (n = 24). Thorough spatial and statistical analyses were undertaken to identify the pre- and during pandemic nitrogen dioxide concentrations. Complementarily, Spearman's correlation test was performed with variables that impact air quality. The study results a fall in nitrogen dioxide concentration levels in 21 of the 24 metropolitan regions which was observed. The Spearman's correlation coefficient between the nitrogen dioxide variation and the vehicle density was 0.485, at a significance level of 0.05. With these findings in mind, the paper advocates that while the pandemic has a significant negative consequence on the health of population globally, a series of measures that result in a new social organization directly interfere in the reduction of air pollution that contributes to the quality of the air we breathe.

14.
Asia-Pacific Journal of Business Administration ; : 20, 2022.
Article in English | Web of Science | ID: covidwho-1799406

ABSTRACT

Purpose Companies' relationship with their customers through e-commerce platforms has increased considerably in the past few years, bringing new challenges concerning service guarantees (SG). This study aims to propose a framework of the relations between customers' expectations on SG, their negative experiences and their attitudes and behavioural intentions towards an e-commerce platform. Design/methodology/approach The research had a qualitative and descriptive approach. Testimonials from clients of an online e-commerce platform were obtained through interviews via videoconference and non-participant observation on a complaints website in Brazil. The testimonies were analysed through content analysis. Findings The customer expectations regarding the SG offered by the e-commerce platform are congruent with the five categories of the theory that support this research. Customer testimonials on the complaints site show that their negative experiences with the e-commerce platform generated negative emotional, cognitive and behavioural responses towards the company. A framework was proposed, including customers' expectations regarding SG, their negative experiences and their repercussions on clients' attitudes and behavioural intentions. Originality/value This article is the only that contemplates customers' expectations about SG in an e-commerce platform, relating them to attitudes and behavioural intentions. Thus, its framework demonstrates the relationships between customer expectations about SGs, their negative experiences and attitudinal and behavioural repercussions. This article brings academic and managerial contributions for companies and managers of e-commerce platforms. It contributes to clients and consumer protection associations by revealing problems they face with SG on e-commerce platforms. This research can be used by those responsible for elaborating laws and public policies to regulate and inspect the relationships between e-commerce platforms and their customers.

15.
European Heart Journal Cardiovascular Imaging ; 23(SUPPL 1):i143, 2022.
Article in English | EMBASE | ID: covidwho-1795324

ABSTRACT

Introduction: The impact of acute infection by SARS-COV2 on the cardiovascular system has been previously reported in the literature, with a higher propensity in patients with more serious pattern of disease and pro-inflammatory status. Nevertheless, the long-term burden and sequels of COVID-19 on the cardiovascular system is still unknown. Purpose: To evaluate the long-term impact of COVID-19 on left ventricular function in patients with severe clinical presentation requiring intensive care hospitalization. Methods: This was a single-center observational, prospective study which included patients requiring admission to the Intensive Care Unit (ICU) due to COVID-19 infection from January to November 2020. All discharged patients were contacted to perform a clinical, electrocardiographic and echocardiographic evaluation and those who accepted were included on the protocol. Baseline and clinical characteristics were collected from clinical reports. For the global longitudinal strain (GLS) analysis all patients with significant wall motion abnormalities and valvular cardiopathy were excluded. Statistical analysis was performed with Mann-Whitney and a safety cut-off was established with ROC curve analysis. Results: A total of 43 patients were included (mean age 64 ± 12, 67.4% males). During SARS-COV2 infection 49% presented with severe ARDS and 51% with moderate, 35% required invasive mechanical ventilation, 14% noninvasive mechanical ventilation and 52% with high nasal flow cannula. On the follow-up analysis, fatigue was the most reported in symptom (52% patients) and the majority did not present other signs or symptoms suggestive of heart failure, with the mean NT-proBNP of 49 ± 389 pg/dL. The standard ECG and echocardiogram did not show significant changes with a mean LVEF of 58 ± 7.8 and mean TAPSE of 21 ± 4. The strain analysis showed low value of GLS (mean GLS of -17.14 ± 2.36) for a reference cut-off of -18%, suggesting subclinical left ventricular dysfunction in this subset of patients with preserved ejection fraction. Maximum CPR values during ICU did not correlate either with the extent of disease evolvement in CT (p= NS) or ARDS severity (p= NS). Nevertheless, maximum CPR correlated significantly with GLS reduction (R = 0.44, p = 0.019). A CPR value higher than iger30mg/ dL had 100% specificity for GLS reduction and a cut-off of 14gm/dL reported a sensitivity of 65% and specificity pf 75% for reduction in GLS. Conclusion: In our study, we reported subclinical impairment in left ventricular function detected with global longitudinal strain after serious infection with SARS-COV2. The detected myocardial dysfunction was related with higher inflammatory as expressed by CPR values. Longterm monitoring of these patients should be undertaken in order to timely detect late complications.

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IAF Space Education and Outreach Symposium 2021 at the 72nd International Astronautical Congress, IAC 2021 ; E1, 2021.
Article in English | Scopus | ID: covidwho-1787058

ABSTRACT

Astrotourism and related citizen science activities are becoming a major trend of a sustainable, high-quality tourism segment, core elements to the protection of Dark skies in many countries. In the Summer of 2020, in the middle of COVID pandemics, we started an initiative to train young students - Cyber-Cosmos - using an Unistellar eVscope, a smart, compact and user-friendly digital telescope that offers unprecedented opportunities for deep-sky observation and citizen science campaigns. Sponsored by the Ciência Viva Summer program, this was probably the first continuous application of this equipment in a pedagogical and citizen-science context, and in a pandemic context. Pampilhosa da Serra, home to a certified Dark Sky destination (Aldeias do Xisto) in central Portugal, was the chosen location for this project, where we expect astrotourism and citizen science to flourish and contribute to space sciences education. Copyright © 2021 by the International Astronautical Federation (IAF). All rights reserved.

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6th Latin American Conference on Learning Technologies, LACLO 2021 ; : 506-509, 2021.
Article in Portuguese | Scopus | ID: covidwho-1784538

ABSTRACT

The Covid-19 pandemic imposed technological challenges so that education could continue during the imposed social isolation. One of the challenges of this pandemic is online assessments. This work presents experimental results of two plugins, one for facial verification and another for access reporting, both open source, available in the Moodle Learning Management System. The first plugin was tested with 31 users. The results show the feasibility of use, with an average approval rate of 76% through a questionnaire applied to 16 users in optional online activities performed in Moodle at the end of 2020 and beginning of 2021. © 2021 IEEE.

18.
Humanidades & Inovacao ; 8(63):12-25, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1766741

ABSTRACT

This text seeks to present the data of a research carried out in the Territory of Identity of the Southwest Bahia - TISOBA on the conditions of teaching work in times of pandemic of CoWd-19. To this end, it used on online questionnaire disseminated among teachers who work in municipal schools belonging to TISOBA and who adhered to the research. The data were presented and reveal the reality experienced by teachers who hod to adopt to the remote teaching model mediated by technologies applied to education and which demonstrate the difficulties faced.

19.
Revista Cient..fica Multidisciplinar RECIMA21 ; 3(1), 2022.
Article in Portuguese | CAB Abstracts | ID: covidwho-1761751

ABSTRACT

OBJECTIVE: to analyze the scientific evidence available in the literature on therapeutic interventions applied to Burnout Syndrome in health professionals during the COVID-19 pandemic. METHOD: An integrative review was carried out between August and October 2021, in which the databases and portals PubMed, BVS, SciELO, Google Scholar and CAPES Journal Portal were consulted, resulting in eleven articles analyzed. RESULTS: The analysis of the articles included in the study showed that self-care and organizational interventions in health professionals contributed to the reduction of symptoms of Burnout Syndrome. The studies reported that the measures of therapeutic interventions that were implemented, including aromatherapy, music therapy, the application of EFT, LMX strategies, minimize the effects of factors that contribute to the increase in Burnout Syndrome in health professionals, as well as the reorganization of the working day and improvements in the work environment that favor a more positive perception of professional practice. CONCLUSION: The COVID-19 pandemic contributed to the increased prevalence of Burnout Syndrome in healthcare professionals. Thus, measures such as mental health education, as well as therapeutic interventions for those already affected by the disease, are essential for professionals to maintain their physical and mental well-being.

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