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1.
Mol Med ; 28(1):153, 2022.
Article in English | PubMed | ID: covidwho-2162292

ABSTRACT

BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as a hyper inflammatory process with multiorgan involvement in predominantly healthy children in the weeks following mild or asymptomatic coronavirus disease 2019 (COVID-19). However, host monogenic predisposing factors to MIS-C remain elusive. METHODS: Herein, we used whole exome sequencing (WES) on 16 MIS-C Brazilian patients to identify single nucleotide/InDels variants as predisposition factors associated with MIS-C. RESULTS: We identified ten very rare variants in eight genes (FREM1, MPO, POLG, C6, C9, ABCA4, ABCC6, and BSCL2) as the most promising candidates to be related to a higher risk of MIS-C development. These variants may propitiate a less effective immune response to infection or trigger the inflammatory response or yet a delayed hyperimmune response to SARS-CoV-2. Protein-Protein Interactions (PPIs) among the products of the mutated genes revealed an integrated network, enriched for immune and inflammatory response mechanisms with some of the direct partners representing gene products previously associated with MIS-C and Kawasaki disease (KD). In addition, the PPIs direct partners are also enriched for COVID-19-related gene sets. HLA alleles prediction from WES data allowed the identification of at least one risk allele in 100% of the MIS-C patients. CONCLUSIONS: This study is the first to explore host MIS-C-associated variants in a Latin American admixed population. Besides expanding the spectrum of MIS-C-associated variants, our findings highlight the relevance of using WES for characterising the genetic interindividual variability associated with COVID-19 complications and ratify the presence of overlapping/convergent mechanisms among MIS-C, KD and COVID-19, crucial for future therapeutic management.

2.
RSC Medicinal Chemistry ; 2022.
Article in English | Scopus | ID: covidwho-2160356

ABSTRACT

An Ugi-Zhu three-component reaction (UZ-3CR) coupled in one pot manner to a cascade process (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones in 45 to 82% overall yields using ytterbium triflate as a catalyst, toluene as a solvent, and microwaves as a heat source. The synthesized molecules were evaluated in vitro against human SARS-CoV-2 through a time-of-addition approach, finding that compound 1e, at a concentration of 10.0 μM, exhibited a significant reduction at the initial infection stages, thus showing prophylactic potential. On the other hand, it was found that compound 1d, at the same concentration, was significantly active when applied post-infection, thus exhibiting a therapeutic profile. Moreover, compound 1f showed both, prophylactic and therapeutic activity. Then, to understand interactions between synthesized compounds and the main proteins related to the virus, docking studies were performed on spike-glycoprotein, main-protease, and Nsp3 protein, finding moderate to strong binding energies, matching accurately with the in vitro results. Additionally, a pharmacophore model was computed behind further rational drug design. © 2022 RSC.

4.
Pharmacy Education ; 22(1):843-855, 2022.
Article in English | Scopus | ID: covidwho-2146613

ABSTRACT

Background: The multimedia capturing of live lectures has increased within higher education institutions, even in the pre-COVID-19 period. Despite student satisfaction, the video lecture capture (VLC) influence on students' attainment and achievement of intended learning outcomes is controversial. Methods: To explore the impact of VLC, a cross-sectional study across 2016/17 (n=209 students) and 2017/18 (n=206 students) was conducted in the course of Mechanistic Toxicology in Pharmaceutical Education. Results: The results showed that 73% and 90% of the assessed students entirely viewed the videos of theoretical (550 minutes) and practical/laboratory classes (250 minutes), respectively. VLC impacted student attainment and the achievement of intended learning outcomes on the capacity to understand the subjects and apply knowledge. Conclusion: The effectiveness of VLC is to be considered under the framework of constructive alignment and the specificities of the course. © 2022 FIP.

5.
Frontiers in Sustainable Food Systems ; 6, 2022.
Article in English | Web of Science | ID: covidwho-2142382

ABSTRACT

The COVID-19 pandemic pushed a large number of workers out of their offices and to their homes for a significant period of time for teleworking. However, some workers continued to work in their offices and others went home only partially. This arguably exogenous shock to the way in which workers performed their jobs opened the opportunity to evaluate whether work environments are ideal for promoting healthier diets and reducing overweight among office workers. We explore the results of two consecutive surveys (pre- and during-COVID-19) to examine whether workers working from home perceived their situation as more favorable in terms of healthy eating habits and weight gains. Our results show that workers did perceive their homes as places where they can follow healthier eating habits, but this was not accompanied by weight loss. On the contrary, workers fully teleworking were more likely to perceive weight gains and diet-related health problems than their in-office counterparts. Among teleworkers, those only partially teleworking were the most affected. This study opens many questions about food environments at work that remain unanswered. More studies in this area are needed to understand how the food at work affects the worker's health.

6.
European Psychiatry ; 64(Supplement 1):S294, 2021.
Article in English | EMBASE | ID: covidwho-2140022

ABSTRACT

Introduction: As disorders of thought, delusions are modified by patients' background, and so their content varies widely according to location and throughout the ages. The COVID-19 pandemic has shown its global impact on society and mental health of the population, thus becoming a new delusional topic. Objective(s): We report a case where the COVID-19 pandemic has been integrated into a patient's delusion in an attempt to raise professional awareness for this new psychotic presentation. Method(s): Review of clinical notes and literature review. Result(s): A 38-year-old female patient with no prior psychiatric history presented with psychotic symptoms characterized by selfreferential ideas, feelings of guilt and delusions of ruin, with a sudden onset of less than 24 hours prior to observation. The patient claimed that she was the coronavirus and, as such, she was a common topic of conversation in both television and social media, and the reported deaths caused by COVID-19 were her own doing. As a result of this, the patient was asking doctors to kill her in order to save everyone else affected by the virus. After evaluation, a diagnosis of Acute and Transient Psychotic Disorder was considered. The patient was initially treated with paliperidone, but due to hyperprolactinemia and menstrual changes this was switched to aripiprazole. Symptoms remitted fully after 21 days of treatment, and six months later no recurrences have been described. Conclusion(s): This case illustrates the potential of the coronavirus pandemic outbreak as a new delusional topic. Possible side effects of treatment are also discussed.

7.
Pharmacy Education ; 22(1):843-855, 2022.
Article in English | Web of Science | ID: covidwho-2111670

ABSTRACT

Background: The multimedia capturing of live lectures has increased within higher education institutions, even in the pre-COVID-19 period. Despite student satisfaction, the video lecture capture (VLC) influence on students' attainment and achievement of intended learning outcomes is controversial. Methods: To explore the impact of VLC, a cross-sectional study across 2016/17 (n=209 students) and 2017/18 (n=206 students) was conducted in the course of Mechanistic Toxicology in Pharmaceutical Education. Results: The results showed that 73% and 90% of the assessed students entirely viewed the videos of theoretical (550 minutes) and practical/laboratory classes (250 minutes), respectively. VLC impacted student attainment and the achievement of intended learning outcomes on the capacity to understand the subjects and apply knowledge. Conclusion: The effectiveness of VLC is to be considered under the framework of constructive alignment and the specificities of the course.

8.
Boletin Medico del Hospital Infantil de Mexico ; 79(Supplement 2):1-56, 2022.
Article in Spanish | EMBASE | ID: covidwho-2100845

ABSTRACT

The aim of this COVID-19 Practical Manual for the prevention, detection, control and surveillance of SARS-CoV-2 is to standardize and regulate the best strategy for the prevention and control of SARS-CoV-2 infections. All of this to provide better care quality to patients and their families/caregivers, and to promote a safe working environment for health personnel within the institution. The manual has been prepared with the aim of guiding health personnel in decision-making for the prevention, detection, control and surveillance of SARS-CoV-2 infections. This document describes various multidisciplinary care algorithms in different scenarios, considering the recommendations for isolation, use of personal protective equipment, transfer within various services in the hospital, admission to procedures and recommendations for healthcare personnel. Copyright © 2022 Hospital Infantil de Mexico Federico Gomez. Publicado por Permanyer.

9.
Nutricion Clinica Y Dietetica Hospitalaria ; 42(3):152-159, 2022.
Article in English | Web of Science | ID: covidwho-2100424

ABSTRACT

Introduction: Skipping meals has been associated with cardiometabolic risk factors such as overweight and insulin re-sistance. Despite this, data on the frequency of meals and the influence on the nutritional and metabolic status of individu-als with type 2 Diabetes Mellitus (DM2) are scarce.Objective: To investigate the correlation between missed meals, body mass index (BMI) and metabolic profile of DM2 patients during the COVID-19 pandemic.Methodology: Cross-sectional study with 107 individuals followed at a Nutrition outpatient clinic of a reference hospi-tal in Fortaleza, Ceara. Socioeconomic, clinical, anthropomet-ric and biochemical data were collected. Meal omission was verified using a 24-hour dietary recall. The correlation be-tween the variables was verified by the Spearman and Chi -Square test, considering p<0.05 as significant.Results: The mean age of participants was 62 +/- 11.34 years, where most were women (57.9%). The mean BMI was 28.67 +/- 5.13 kg/m2 and most were overweight (68%). Participants ate an average of 5 +/- 0.94 meals per day. The median number of meals skipped was 1 (0 -3) and 60.7% skipped at least 1 meal. The most missed meals were supper (41%) and a morning snack (38%). There was a significant positive correlation between the number of skipped meals with BMI and weight.Conclusion: The number of skipped meals is directly cor-related with the nutritional status of older adults and elderly people with DM2.

10.
Saude e Pesquisa ; 14(2):333-340, 2021.
Article in Portuguese, English | CAB Abstracts | ID: covidwho-2056619

ABSTRACT

The aim of this study was to identify the incidence of COVID-19 according to the positivity of the rapid tests and the associated factors in the population of the state of Para. This is a cross-sectional, analytical, retrospective study, developed with cases of COVID-19 in individuals notified and residing in the state of Para. Information was collected on the State Transparency Portal. Positivity for rapid tests of the disease was considered as the outcome variable. Logistic regression analysis was applied to identify associations between variables. The incidence of COVID-19 was 46% (95% CI: 45.7-46.2). Being male, over 80 years old and waiting 22 days or more to perform the tests after the onset of symptoms increased the chances for a positive result. It can be concluded that there is a high incidence of COVID-19 in the state. Non-pharmacological measures and case tracking strategies are important alternatives to mitigate the pandemic.

11.
Saude e Pesquisa ; 14(2):247-259, 2021.
Article in Portuguese, English | CAB Abstracts | ID: covidwho-2056618

ABSTRACT

This study aimed to assess the quality of life (QOL) of dental students in the 2019 Coronavirus Disease pandemic (COVID-19). A cross-sectional study was carried out with undergraduate students in Dentistry from Higher Education Institutions (HEIs) in the state of Ceara, Brazil. Data collection took place in May 2020, online, using questionnaires with sociodemographic, course-related and behavioral variables, in addition to the World Health Organization Questionnaire for Quality of Life-bref (WHOQOL-bref). Multinomial logistic regression was performed. 864 students participated in this study. Variables such as higher income (p = 0.034), having religion (p = 0.010), having health insurance (p = 0.005), satisfaction with sleep quality (p < 0.001), absence of insomnia (p < 0.001) and practicing physical activity always (p < 0.001) were associated with greater satisfaction regarding QOL. The QoL of dental students was classified in the dissatisfaction category, being perhaps impacted by the pandemic of COVID-19. Variables that reflected a more economically favorable living condition were associated with satisfaction with the quality of life of this public in the COVID-19 pandemic.

12.
Brazilian Journal of Occupational Therapy ; 30, 2022.
Article in English | Scopus | ID: covidwho-2054628

ABSTRACT

This experience report is a theoretical deepening of the practices of remote internship in Occupational Therapy (OT) at the Social Assistance Reference Center (CRAS) of territory in the municipality of Pelotas, State of Rio Grande do Sul, Brazil. The practices are based on the Occupational Therapy of the South and decolonial feminist perspectives. During the internship, individual interventions, a virtual group with women users of the CRAS, and a training group focused on workers from the same institution were carried out. Through these interventions, we had access to life stories marked by gender oppression. Supported by Patricia Hill Collins's theory, we understood how the images of control impacted those women's daily activities, especially those related to care. The interventions found support in the Amerindian paradigm of translation, underlining misunderstanding as the foundation of care in OT. We proposed Cultural Translation Activities as a method of occupational-therapeutic intervention that foresees and uses the cultural difference in favor of new forms of experimentation, awareness, collectivization, and incitement to face oppression. © 2022 Universidade Federal de Sao Carlos. All rights reserved.

13.
Revista Cubana de Informacion en Ciencias de la Salud ; 33, 2022.
Article in Portuguese | Scopus | ID: covidwho-2046958

ABSTRACT

Brazil is one of the biggest movements of resistance to mandatory vaccination since the Vaccine Uprising and has experienced leadership rates in the number of deaths by COVID-19. From this perspective, this study seeks to investigate, by a bibliographic search in Information Science databases and in Brazilian laws, compulsory vaccination in the context of COVID-19. The objective is to contribute to the Brazilian discussions about compulsory vaccination in relation to COVID-19, in the scope of Information Science and its subareas. The results point that Information Science can base this type of conflict, because its sub work areas lead to rethinking the meanings that knowledge receives in society. It is concluded that clarifying and guideding the population of the efficacy and need for vaccination can be an even greater challenge than overcoming the disease itself. Therefore, educating society about the legal provisions that lead to vaccination and that dispel anti-vaccine and anti-scientific discourses is a theme to be incorporated into the scope of investigation of Information Science, mainly in areas such as Knowledge Organization, Information and Knowledge Management, Information Literacy, and Information Mediation. © 2022, Centro Nacional de Informacion de Ciencias Medicas. All rights reserved.

14.
European psychiatry : the journal of the Association of European Psychiatrists ; 64(Suppl 1):S532-S532, 2021.
Article in English | EuropePMC | ID: covidwho-2046745

ABSTRACT

Introduction OPEN is a structured intervention program for patients who present with untreated psychosis at an early stage, under the guidance of a case manager and a periodic evaluation performed by a multidisciplinary team. Objectives The aim of the OPEN program is to create an individual care plan, promoting recovery, functionality, quality of life and prevent relapses. One year after implementation of the program, we present the first results. Methods We performed a retrospective review of the patients’ clinical profiles included in the OPEN program. Results Nine patients were included in the program. The most frequent diagnosis was schizophrenia (n=5). By the time of inclusion in the program, 5 patients used cannabis frequently;one patient kept substance use. At the 6th month assessment, 4 in 5 patients showed an improvement in social functioning (Personal and Social Performance Scale;± 16 points), and a decrease in symptom severity in all (Brief Psychiatric Rating Scale;± 11 points). Due to COVID-19 pandemics, group interventions were suspended, and some visits were performed by teleconsultation. No patients lost follow-up. Conclusions We observed an overall positive result of the first months of this program, regarding both functionality and clinical outcomes. The main obstacle so far is the impossibility of performing group interventions since the start of the contingency measures regarding COVID-19 pandemics. We expect further results of the OPEN program with the inclusion of more patients.

15.
European psychiatry : the journal of the Association of European Psychiatrists ; 64(Suppl 1):S294-S294, 2021.
Article in English | EuropePMC | ID: covidwho-2045127

ABSTRACT

Introduction As disorders of thought, delusions are modified by patients’ background, and so their content varies widely according to location and throughout the ages. The COVID-19 pandemic has shown its global impact on society and mental health of the population, thus becoming a new delusional topic. Objectives We report a case where the COVID-19 pandemic has been integrated into a patient’s delusion in an attempt to raise professional awareness for this new psychotic presentation. Methods Review of clinical notes and literature review. Results A 38-year-old female patient with no prior psychiatric history presented with psychotic symptoms characterized by self-referential ideas, feelings of guilt and delusions of ruin, with a sudden onset of less than 24 hours prior to observation. The patient claimed that she was the coronavirus and, as such, she was a common topic of conversation in both television and social media, and the reported deaths caused by COVID-19 were her own doing. As a result of this, the patient was asking doctors to kill her in order to save everyone else affected by the virus. After evaluation, a diagnosis of Acute and Transient Psychotic Disorder was considered. The patient was initially treated with paliperidone, but due to hyperprolactinemia and menstrual changes this was switched to aripiprazole. Symptoms remitted fully after 21 days of treatment, and six months later no recurrences have been described. Conclusions This case illustrates the potential of the coronavirus pandemic outbreak as a new delusional topic. Possible side effects of treatment are also discussed.

16.
Icsbt: Proceedings of the 19th International Conference on Smart Business Technologies ; : 93-100, 2022.
Article in English | Web of Science | ID: covidwho-2044125

ABSTRACT

With the significant increase of technology-based newer competitors and the digital economy reshaping the global economic environment, it is undoubtful that the market is becoming aggressively more demanding for small and medium enterprises, which is a strong driver of their need to adopt new digital technologies and transform their businesses. Events such as the COVID-19 pandemic have accelerated the online engagement of consumers, and that also means that digital transformation might not only be about the digitalisation of internal processes and reshaping of business models but as well, and not least relevant, the Strategies used by SMEs to position themselves in the market and maximise the value of digital marketing to regain competitiveness and reposition their products.

17.
Cadernos CEDES ; 42(118):232-247, 2022.
Article in Portuguese | Scopus | ID: covidwho-2022167

ABSTRACT

The article aims at understanding the challenges and risks that arise for remote research-intervention with children and adolescents as digital devices during the Covid-19 pandemic are used. The method consisted of interviews by means of cell phones and computers with 18 children and adolescents during the months of March to September 2020. The results indicate that the relationship established between the researcher and the child is affected, above all, by the limitations due to face-to-face contact. On the other hand, it was noted that both researcher and child were highly committed to develop a relationship of trust. As conclusion, it is highlighted the expansion of the use of two digital devices, above all, of video and voice calls. © 2022, Centro de Estudos Educacao e Sociedade - CEDES. All rights reserved.

18.
Arquivos Brasileiros De Cardiologia ; 119(2):362-362, 2022.
Article in English | Web of Science | ID: covidwho-2003442
19.
Rbne-Revista Brasileira De Nutricao Esportiva ; 16(98):135-142, 2022.
Article in English | Web of Science | ID: covidwho-1995253

ABSTRACT

Good nutrition is one of the pillars for energy and general well-being, as well as disease prevention and physical development. This article aimed to evaluate the eating habits of medical students at the University Center for the Development of Alto Vale do Itajai (UNIDAVI) which occurred between the pre-pandemic and post-pandemic periods caused by COVID-19. For the research, classes comprised between the third and eighth semesters were selected, totaling 154 students. Eating habits were assessed using the questionnaire "Markers of Food Consumption", made available by the Ministry of Health. The results showed a number of students who rated their health as good and a decrease in those who rated it as very good. There was an increase in the average consumption of lunch, afternoon snack and dinner, and a decrease in the average intake of breakfast, morning snack and supper, maintaining an average of four meals a day in both periods. Regarding the food consumed, there was an increase in the intake of fruits and vegetables, as well as hamburgers/sausages, sweetened drinks, sweets and sweets and frozen/fast food. The reduction in global intake was restricted to the alternatives of beans and snacks/biscuits. Finally, there was a decrease in the evaluation of distractions such as TV and cell phone permeating meals. In conclusion, there was a worsening in the perception of global health, an increase in general food consumption, a decrease in the frequency of morning meals and an increase in evening meals, and conservation of the average number of daily meals.

20.
Journal of the Academy of Nutrition & Dietetics ; 122(9):A58-A58, 2022.
Article in English | CINAHL | ID: covidwho-1991119
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