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1.
Cogent Medicine ; 8, 2021.
Article in English | EMBASE | ID: covidwho-1617059

ABSTRACT

Background: Coronavirus disease 19 (COVID-19) tends to be milder in children, but severe cases have been reported. We described a case report of a toddler admitted to our department with additional findings, highlighting the importance of assessing the patient as a whole. Case Presentation: A previously healthy, 15-month-year-old girl presented with fever and dry cough for 10 days, respiratory distress and PCR SARS-CoV-2 was positive. At admission, she presented with hypoxemia (SpO2 89-90% in room air), global retraction and bilateral bronchospasm. She was treated with bronchodilators, methylprednisolone, remdesivir and also amoxicillin/clavulanic acid. Her complete blood count revealed leucocytosis 16,160x109/L, 41% lymphocytes, C-reactive protein 57,9 mg/L, procalcitonin 0,13 ng/mL, sedimentation rate 44 mm/h, ferritin 218,4 ng/mL. Chest computed tomography (CT) scan revealed bilateral peripheral areas of ground glass, coexisting consolidation areas at inferior lobes but also revealed a 6 cm supra-renal mass. Abdominal ultrasound and CT confirmed an heterogeneous right supra-renal gland mass of 5,5cm along the greatest diameter with diffuse calcifications, evolving the inferior vena cava and the renal vascular pedicle, no signs of liver, bone, cutaneous or ganglionic metastization. These features were suggestive of neuroblastoma in stage L2. Vanillylmandelic acid, normetanephrine/creatinine ratio and metanephrine/creatinine ratio were elevated. The metaiodobenzylguanidine (Mibg) scan showed a localized disease. The total excision of the tumour mass was performed, and the histology confirmed neuroblastoma with no N-myc oncogene amplification, nor other bad prognosis chromosomal abnormalities. She is currently under oncological surveillance, with no signs of recurrence. Learning Points Discussion: Neuroblastoma is the most common extracranial solid tumour of childhood. It is known for its broad spectrum of clinical behaviour and outcome. In this case, although this toddler was admitted due to COVID-19 pneumonia, it allowed to identify a localized tumour, perform excision and due to the favourable biology tumour, she has a very good chances of being cured and free of disease.

3.
Gestao E Desenvolvimento ; 18(3):51-79, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1576845

ABSTRACT

The new coronavirus pandemic has changed the lives of people around the world. From performing simple tasks to more complex ones, such as work and study relationships, they were somehow affected by this new scenario. Among the activities/relationships that have undergone changes are consumption and consumer behavior. The entertainment sector, both at home and away from home, was one of those activities that most felt these changes, as several studies have shown. Thus, this article aims to verify and analyze whether there was a change in the purchasing behavior of undergraduate students at the Federal University of Santa Catarina regarding the use of streaming services after the start of the pandemic. For this, a structured online questionnaire was developed, which was answered by 574 students from different phases and courses. With the results, it was found that there was a change regarding the use of these students from the period before the pandemic to the time when there was a pandemic and suggestion of isolation measures. Among these changes, we can mention the knowledge and subscription of new streaming platforms, as well as the increase in the number of hours and changes in the days, periods and places in which these contents started to be consumed.

4.
Revista Rol De Enfermeria ; 44(11-12):13-16, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1576661

ABSTRACT

Introduction: In December 2019, China reported to the World Health Organization a cluster of pneumonia in March 2020 has classified as pandemic. Given the situation, ESEnfC, based on the rules and guidelines sent by DGS, reorganized teaching activities, face-to-face work and adapted spaces to minimize the impact of COVID-19, adopting preventive measures and control procedures at the level of risk. Objectives: Describe the implementation of preventive measures at ESEnfC. Methodology: Experience report. Results: number of cases retrieved 141 students (9.51%);13 employees (6.81%);active surveillance 244 students (16.45%);24 employees (12.57%) - 1557 tests. Conclusions: the implementation of guidelines, actions and correction of applied measures impact in the epidemiological control of COVID-19. The unexpected risk led ESEnfC to adjust its operation to the established permissions, safeguarding the interests of students in carrying out their academic year with the least possible harm. Encouraging the sharing of information and adopting a positive change in relation to the culture of safety and prevention of COVID-19 infection was the purpose of ESEnfC.

5.
Allergy: European Journal of Allergy and Clinical Immunology ; 76(SUPPL 110):479-480, 2021.
Article in English | EMBASE | ID: covidwho-1570382

ABSTRACT

Background: During the COVID-19 pandemic, the Portuguese government implemented several stringent measures and all the health care sectors were reorganized. The goal of this study was to assess the antiallergic prescription tendency in outpatient settings in Portugal, including in public primary health care (PC) and hospital care (HC) centers, and to evaluate potential changes during the COVID-19 pandemic. Method: The data on antiallergic prescription, in the form of monthly Defined Daily Doses (DDD), prescribed by physicians of the public health sector, were retrieved from the System of Information and Monitoring of the Portuguese National Health System (SIM@SNS) public-access platform, from January 2018 to October 2020. We used the student's t-test with 95% confidence level to compare antiallergics' prescription between the analyzed years. Results: Antiallergics' prescription in outpatient settings of PC/HC (Figure 1) presented a seasonal pattern: with increased peaks being observed throughout autumn and winter and decreased peaks in summer, with the exception of an usual spike occurring in May. In 2020, the monthly average prescription (PC= 2 747 409 ± 824 538;HC= 1 237 395 ± 289 133) was found to be lower than in 2018 (PC= 3 185 220 ± 605 702;HC =1 392 217 ± 159 337) and 2019 (PC= 3 327 975 ± 688 781;HC=1 489 159 ± 213 014), p>0.05 (in PC and HC when comparing with 2018 and 2019). In 2020, upon COVID-19 emergence, an overall decrease on antiallergics' prescription was observed, being particularly noticeable and statistically significant (p>0.05) on PC (p = 0,028) and HC (p = 0,037) centers after May. Conclusion: A significant decline on antiallergics' prescription was detected in 2020, mainly over the spring/summer months following COVID-19 emergence, probably due to the reduction in all non-essential health care activity, especially in HC. Another interesting outcome is the absence of the usual spike in May 2020, as this period was coincident with the home confinement and routine mask use, which may have reduced patients contact with outdoor allergens. (Table Presented).

8.
Revista de Saude Publica ; 55:01-10, 2021.
Article in English | Scopus | ID: covidwho-1551890

ABSTRACT

OBJECTIVE: To analyze adverse events following immunization (AEFI) against SARS-CoV-2 (covid-19) in the state of Minas Gerais (MG), Brazil. METHODS: Epidemiological, descriptive study, with data from e-SUS Notifica (e-SUS Notification) in the state of Minas Gerais from January 20 to March 5, 2021. All suspected cases of AEFI of the covid-19 vaccine in the state were analyzed, totaling 7,305 cases. In this study, we verified the possible correlation between AEFI and the possible immunobiological administered causalities. The variables analyzed for AEFI cases were the immunobiological agent administered (AstraZeneca or Coronavac), the type of event, the evolution of the case, and the time in days since the administration of the immunobiological agent and the onset of symptoms and causality. The incidence rate (IT) was calculated for 100,000 doses applied. RESULTS: The occurrence of AEFI as a result of the covid-19 vaccine was frequent (TI: 777.12) in the state. However, only 3% were classified as a severe AEFI, with a 20.85 IT, and 4.71% of them evolved to deaths (8.19 deaths per 100,000 doses applied). Among the deaths analyzed, 84.4% were classified as preexisting conditions caused by factors other than vaccines. Regarding non-serious AEFI, 1.11% occurred by immunization errors (TI: 8.62 EI for every 100 thousand doses applied). CONCLUSION: This work encourages the discussion about the importance of recording AEFI related to covid-19 vaccines, demonstrating its safety for the population. DESCRIPTORS: Coronavirus Infections, prevention & control. Vaccines, adverse effects. Clinical Trials Data Monitoring Committees. © 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided that the original author and source are credited.

9.
IEEE Congress on Evolutionary Computation (IEEE CEC) ; : 1296-1303, 2021.
Article in English | Web of Science | ID: covidwho-1541649

ABSTRACT

The COVID-19 pandemic has created an urgency for studies to understand the spread of the virus, in particular, to predict the number of daily cases. This type of investigation depends heavily on the data collected and made available manually. Therefore, data are susceptible to human errors which can cause anomalies in the dataset. Understanding and correcting anomalies in real-world application data is an important task to ensure the reliability of the data analysis and prediction tools. This paper presents a spectral anomaly detection and correction strategy that uses concepts from the graph signal processing (GSP) theory. The main advantage of the introduced strategy is to analyze the variation in the daily number of cases with the proximity relation between the investigated locations. Experiments were carried out with real meteorological and mobility data for predicting the number of COVID-19 cases by the classic prediction model known as autoregressive integrated moving average exogenous (ARIMAX). Then, the anomaly detection method was applied to determine the relationship between the prediction errors and the anomalous variations identified by the tool. The results show a strong relationship between the anomalous variations and the errors made by the model and attest to the increase in the accuracy of the prediction model after the normalization of the anomalies.

10.
British Journal of Surgery ; 108:73-73, 2021.
Article in English | Web of Science | ID: covidwho-1537514
12.
Ars Veterinaria ; 37(3):128-133, 2021.
Article in Portuguese | CAB Abstracts | ID: covidwho-1478721

ABSTRACT

The pandemic caused by SARS-CoV-2 brought to society a health crisis that drastically affected the global economy and brought more restrictive measures to food supply establishments, which are classified as essential activities. However, they had to adapt to the new hygienic-sanitary operating protocol, established through regulations published by the Federal and State Governments in order to reduce the chances of viral spread. The objective of the study was to evaluate the hygienic and sanitary conditions of fish sold in fish markets in the city of Nova Iguacu/RJ, through questionnaires on the application of good marketing and handling practices, during the lockdown related to the coronavirus pandemic. An observational "checklist" type questionnaire was used to assess the hygienic and sanitary conditions of fish in 13 fish markets located in 7 districts of Nova Iguacu/RJ. It was observed that in 92% of the establishments visited had materials and equipment in disuse in the outdoor area, had failures in conservation, sanitation and adequate maintenance, without vector and pest control, without a suitable container for waste collection, lack of personal cleanliness and did not present the amount of flaky ice adequate to coat the fish. Thus, it was possible to check that the establishments did not follow the basic rules of hygiene and safety of the fish to reduce the dissemination of the coronavirus, confirming that the commercialization of fish in the fish markets visited in the municipality of Nova Iguacu/RJ does not meet the recommended standards of hygiene and packaging of the products sold. Therefore, the relevance of this study is to provide fishmongers in the municipality of Nova Iguacu, practical and viable guidelines for adapting to the legislation, with the main objective of updating and favoring the reinforcement of Good Handling Practices through an illustrative folder distributed later on visits to establishments.

14.
Journal of Clinical Rheumatology ; 27(SUPPL 1):S19, 2021.
Article in English | EMBASE | ID: covidwho-1368233

ABSTRACT

Objectives: To determine the main risk factors associated with COVID-19 in SLE patients. Methods: The Reuma CoV Brazil is a multicenter, observational, prospective cohort designed to monitor immune-mediated rheumatic diseases patients during SARS-CoV-2 pandemic in Brazil. SLE adult patients according to SLE SLICC criteria classification (2012), with and without (control group-CG) COVID-19 diagnosis were matched. Demographic data, managing of COVID-19, comorbidities, clinical characteristics (disease activity: Patient Report Outcomes-PROs, Physician Global Assessment and SLEDAI-2 K)were collected. Results: From May 2020 to January 2021, 604 SLE patients were included, 317 (52.4%) with COVID-19 and 287 (47.6%) in the CG. Both groups were homogeneous and comparable regarding sex and comorbidities. SLE patients with COVID-19 declared a lower level of social isolation (49.5% vs. 61.9%;p = 0.002), worked more commonly in health professions (10.4% vs. 3.5%;p = 0.002), presented more frequently joint (32.5% vs. 22.0%;p = 0.004) and hematological manifestations (18.0% vs. 11.5%;p = 0.025). SLEDAI-2 K did not differ among groups prior and after COVID-19 infection. However, considering the mean duration of COVID-19 symptoms (12.1 ± 8.8 days), infected patients had more severe disease activity's PROs after resolution of COVID-19 symptoms (2.9 ± 2.9 vs. 2.3 ± 2.6;p = 0.031). The hospitalization rate was 20.5% (n = 65), of whom 23 (7.2%) needed intensive care unit and 14 (4.4%) patients died. Hypertension [5,26 (1,9714,07);p = 0.001] and recently cyclophosphamide pulses [39,21 (4,17-368,53);p = 0.001] were associated with hospitalization and patients who received telemedicine medical care presented 72% less chance of hospitalization [0.28 (0.09-0.83);p = 0.023). Conclusion: COVID-19 was associated with a lower level of declared social isolation and more severe disease activity perception after SARS-CoV-2 infection according to PROs. Hypertension and cyclophosphamide were associated with hospitalization and telemedicine can be a useful tool for SLE patients with COVID-19. These data should be considered to perform public health policy and national guidelines to manage SLE patients during the pandemic, as well as to prioritize some special groups for the immunization program.

15.
Enfermeria Global ; 20(3):530-543, 2021.
Article in English | Scopus | ID: covidwho-1362726

ABSTRACT

Objective: To analyze, describe and explain the impact of the pandemic on the role of nursing, according to literature. Method: Narrative review of the literature based on searches in databases (Pubmed, BDENF, Scielo, Google Scholar), on the references of articles, and official websites. The search used the combination of descriptors: COVID-19 and Enfermagem and Pandemia and only COVID- 19. Results: 44 references were selected, according to the inclusion criteria. It was shown that the pandemic impact the routines of nursing work in many ways, affecting the updating of measures to prevent occupational infections and protective equipment-related pressure injuries, mental health care, the proportion of infection among nurses, although it brings more visibility and recognition to the importance of nursing workers in health care. Conclusion: The pandemic forced nurses to submit to new working conditions, which caused personal and labor issues that are associated with the quality of health care. © COPYRIGHT Servicio de Publicaciones - Universidad de Murcia

16.
Annals of the Rheumatic Diseases ; 80(SUPPL 1):876-877, 2021.
Article in English | EMBASE | ID: covidwho-1358729

ABSTRACT

Background: Telemedicine was widely utilised to complement face-to-face (F2F) care in 2020 during the COVID-19 pandemic, but the impact of this on patient care is poorly understood. Objectives: To investigate the impact of telemedicine during COVID-19 on outpatient rheumatology services. Methods: We retrospectively audited patient electronic medical records from rheumatology outpatient clinics in an urban tertiary rheumatology centre between April-May 2020 (telemedicine cohort) and April-May 2019 (comparator cohort). Differences in age, sex, primary diagnosis, medications, and proportion of new/review appointments were assessed using Mann-Whitney U and Chi-square tests. Univariate analysis was used to estimate associations between telemedicine usage and the ability to assign a diagnosis in patients without a prior rheumatological diagnosis, the frequency of changes to immunosuppression, subsequent F2F review, planned admissions or procedures, follow-up phone calls, and time to next appointment. Results: 3,040 outpatient appointments were audited: 1,443 from 2019 and 1,597 from 2020. There was no statistically significant difference in the age, sex, proportion of new/review appointments, or frequency of immunosuppression use between the cohorts. Inflammatory arthritis (IA) was a more common diagnosis in the 2020 cohort (35.1% vs 31%, p=0.024). 96.7% (n=1,444) of patients seen in the 2020 cohort were reviewed via telemedicine. In patients without an existing rheumatological diagnosis, the odds of making a diagnosis at the appointment were significantly lower in 2020 (28.6% vs 57.4%;OR 0.30 [95% CI 0.16-0.53];p<0.001). Clinicians were also less likely to change immunosuppressive therapy in 2020 (22.6% vs 27.4%;OR 0.78 [95% CI 0.65-0.92];p=0.004). This was mostly driven by less de-escalation in therapy (10% vs 12.6%;OR 0.75 [95% CI 0.59-0.95];p=0.019) as there was no statistically significant difference in the escalation or switching of immunosuppressive therapies. There was no significant difference in frequency of follow-up phone calls, however, patients seen in 2020 required earlier follow-up appointments (p<0.001). There was also no difference in unplanned rheumatological presentations but significantly fewer planned admissions and procedures in 2020 (1% vs 2.6%, p=0.002). Appointment non-attendance reduced in 2020 to 6.5% from 10.9% in 2019 (OR 0.57 [95% CI 0.44-0.74];p<0.001), however the odds of discharging a patient from care were significantly lower in 2020 (3.9% vs 6%;OR 0.64 [95% CI 0.46-0.89];p=0.008), although there was no significance when patients who failed to attend were excluded. Amongst patients seen via telemedicine in 2020, a subsequent F2F appointment was required in 9.4%. The predictors of needing a F2F review were being a new patient (OR 6.28 [95% CI 4.10-9.64];p<0.001), not having a prior rheumatological diagnosis (OR 18.43 [95% CI: 2.35-144.63];p=0.006), or having a diagnosis of IA (OR 2.85 [95% CI: 1.40-5.80];p=0.004) or connective tissue disease (OR 3.22 [95% CI: 1.11-9.32];p=0.031). Conclusion: Most patients in the 2020 cohort were seen via telemedicine. Telemedicine use during the COVID-19 pandemic was associated with reduced clinic non-attendance, but with diagnostic delay, reduced likelihood of changing existing immunosuppressive therapy, earlier requirement for review, and lower likelihood of discharge. While the effects of telemedicine cannot be differentiated from changes in practice related to other aspects of the pandemic, they suggest that telemedicine may have a negative impact on the timeliness of management of rheumatology patients.

17.
Salusvita ; 39(4):1045-1060, 2020.
Article in Portuguese | CAB Abstracts | ID: covidwho-1342712

ABSTRACT

Introduction: Responsible for the disease COVID-19, the new coronavirus, called SARS-CoV-2, was discovered in China. Its rapid spread caused astonishment and concern in the population, and it ended up causing one of the largest pandemics ever recorded in history. Some professionals suggest using Chloroquine and Hydroxychloroquine, medicines that have been used to fight various diseases for more than 70 years, to treat this infection. Their effectiveness in controlling COVID-19 has not been confirmed, though. Objectives: This study aims to collect information in the scientific literature on the risks and benefits of the drugs Chloroquine and Hydroxychloroquine used as drug therapy for patients affected by the disease. Method: An integrative literature review was carried out, on three online databases (LILACS, SCIELO, and PUBMED) to describe the effects of Chloroquine and Hydroxychloroquine when used in the treatment of the disease, allowing the critical evaluation of certain knowledge on the subject, and gathering multiple studies and their main outcomes.

18.
European Journal of Neurology ; 28(SUPPL 1):473, 2021.
Article in English | EMBASE | ID: covidwho-1307755

ABSTRACT

Background and aims: Until the 1st week of January / 2021, Brazil is the 3rd country with the highest number of confirmed cases of Coronavirus Disease- 2019 (COVID- 19). Annually, neurological diseases and their complications culminate in approximately 200,000 hospitalisations in the Brazilian public health system. This work intends to investigate the relation between COVID-19 and its effect on the condition of neurological patients. Methods: The research used the descriptors: Coronavirus Infections, Brazil, Nervous System Diseases;in PubMed, Scielo and Virtual Health Library databases. Through DataSUS, epidemiological data was collected about: Parkinson's disease, Multiple Sclerosis and Epilepsy. Results: It was expected an increase in urgent hospitalisations related to the neurological diseases scanned. According to studies carried out in other countries, the exacerbation of neurological symptoms is possible. Contrariwise, there was a significant reduction in hospitalizations related to these diseases (DataSUS), especially between April and October 2020, when the number of COVID-19 cases increased dramatically in Brazil. The cause of reduction in hospitalisations may come from a scenario of systematic underreporting triggered by the pandemic. Hospitalisation due to coronavirus infection, in the Brazilian context, allows complications of pre-existing neurological diseases, resulting from COVID-19, to not be properly registered and notified in the integrated system. Conclusion: Brazil, due to its integrated health system, is able to provide full data collected from all its territory. Had there not been a noticeable reduction in hospital care due to fear of infection, this would enable further research and understanding of the effects of COVID-19 on pre-existing neurological conditions. (Figure Presented).

19.
International Journal of Clinical Pharmacy ; 43(3):797-797, 2021.
Article in English | Web of Science | ID: covidwho-1303141
20.
International Journal of Clinical Pharmacy ; 43(3):790-791, 2021.
Article in English | Web of Science | ID: covidwho-1303042
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