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1.
Indonesian Journal of Electrical Engineering and Computer Science ; 29(2):1095-1101, 2023.
Article in English | Scopus | ID: covidwho-2164232

ABSTRACT

Makespan and cost are the major factors in the current scenario and they generally upgrade the results to optimize the upcoming task processing by implementing the scheduling within the specified cloud platform. A new proposed agenda is being considered for a health care system to make the world healthier. The paper is designed to identify prior work as a health evaluator for the end user and act accordingly. It also satisfies the end user by providing demanded results and can establish trust between the system and the customer within a global era. By analyzing the COVID-pandemic situation in the digital world, things should be implemented in conjunction with healthcare and technology to serve things better. The proposed algorithm works on priority basis by analyzing the current patient condition and then implemented in CloudSim Toolkit. As per the results, the proposed steps are performing 50-70% better in terms of makespan and cost. Notable optimization has been accomplished by the proposed healthcare evaluator. © 2023 Institute of Advanced Engineering and Science. All rights reserved.

2.
International Journal of Pharmaceutical Sciences and Research ; 13(12):4890-4900, 2022.
Article in English | EMBASE | ID: covidwho-2155831

ABSTRACT

The recent emergence of the Omicron variant (B.1.1.529) of SARS-CoV-2 has added alarm to the eternal flame of the global COVID-19 pandemic. Omicron was first identified in Botswana in November 2021. The omicron is thought to be at least three times more infectious than the previous variants. Omicron can cause diseases varying from asymptomatic, mild, and severe infection and people have died from omicron in a second pandemic wave that occurred in March-May 2021. This variant has been detected in more than 77 countries worldwide as per WHO until January 2022. The spike protein is the target of most COVID-19 vaccines and is what the virus uses to unlock access to our body's immune cells, many of which (69-70del (deletion), T95I, G142D/143-145del, K417N, N679K, T478K, N501Y, N655Y, and P681H) overlap with Alpha, Beta, Gamma, or Delta variants. Some spike protein mutations include A67V, DELTA69-70, T95I, G142D/DELTA143-145, DELTA211/L212I, ins214EPE G339D, S371L, S373P, S375F, etc. Remarkable mutations in the furin cleavage site may increase transmissibility and replication as in Alpha (P681H) and Gamma (H655Y, N679K) and affect the binding affinity of ACE-2 receptor. Though, after many ongoing mutations and adaptation, omicron can efficiently breach the host immunity, leading to prolonged, severe infection, causing more mortality and rapid spread. There is still substantial uncertainty based on ongoing genomic changes, the effectiveness of current and upcoming vaccines, and treatment against omicron. Thus omicron has forced on the world a chance to explore the intricacies of the complex immunological mechanism. Copyright © 2022 are reserved by International Journal of Pharmaceutical Sciences and Research. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

3.
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics ; : 49-76, 2022.
Article in English | Scopus | ID: covidwho-2149125

ABSTRACT

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) is one of the worst human health problems faced by humanity in recent centuries. An end to this health crisis relies on our ability to monitor viral transmission dynamics to check spread, develop therapeutics and preventatives for treatment of SARS-CoV-2 infection and understand the pathophysiology of the disease for better management of the patients. Omics technologies have played a crucial part in understanding the different aspects of COVID-19 disease. While whole-genome sequencing of SARS-CoV-2 isolates from across the globe has aided in the development of molecular diagnostic assays and informed about the viral evolution, knowledge of structure and function of viral proteome fueled the development of small molecule and biologicals therapeutics as well as vaccines. Concurrently, metabolomic profiling of samples from COVID-19 patients experiencing a varying level of disease severity has provided a snapshot of the pathophysiology of the disease helping device effective treatment regimen. This chapter deals with genomic, proteomic, and metabolomic profiling of SRAS-CoV-2. © 2022 Elsevier Inc. All rights reserved.

4.
Indian Journal of Community Health ; 34(3):341-347, 2022.
Article in English | Scopus | ID: covidwho-2081595

ABSTRACT

Introduction: For curbing Covid-19 disease, adequate knowledge, attitude, and practices of both rural and urban population for Covid-19 disease prevention is required along with busting of the associated myths. Objectives: To assess the Knowledge, Attitude and Practices of urban and rural residents of Lucknow district regarding covid-19 preventive behaviour and associated myths. Methodology: A community-based study was conducted among 420 rural and 421 urban residents of Lucknow. Multistage random sampling was done to select the study subjects. A pre-designed pretested semi-structured questionnaire was used to collect the information regarding the Knowledge, Attitude and Practices of the residents for covid-19 disease causes, prevention, and treatment. Further, KAP scoring was done to compare the two groups. Results: The mean age of the rural and urban residents was 31.48 ± 12.05 and 30.93 ± 11.96 years respectively. Only 40.4 % urban and 25.5 % rural people had correct knowledge about social distancing (p<0.0001). Knowledge regarding quarantine for covid-19 disease prevention was less among the urban residents (64.6%) as compared to rural (70.5%) (p=0.035). More than one-third (37.6%) of the rural resident believed in the myth that alcohol can prevent the covid-19 disease (p=0.003). 68.8 and 70.5 percent rural and urban residents had positive attitude towards the Indian government’ efforts in curbing the disease. Majority of the urban (90%) and rural (87.6%) residents wore mask when they went out. Only one-fourth of the urban (24.7%) and rural (22.9%) had correct practices for the duration of hand washing. Conclusion: The knowledge was more among the urban people, attitude and practices were almost similar among both the rural and urban residents while myths were more observed among the rural residents. © 2022, Indian Association of Preventive and Social Medicine. All rights reserved.

5.
3rd International Conference on Emerging Technologies in Data Mining and Information Security, IEMIS 2022 ; 490:651-659, 2023.
Article in English | Scopus | ID: covidwho-2059761

ABSTRACT

Each zone could be very well investigated and ability packages, social and financial affects, and limitations to mass rehabilitation are discussed in greater detail. It describes in element the demanding situations and opportunities for IoE framework solutions inside the post-COVID-19 generation. The COVID-19 epidemic has furnished a far-wanted check of IoE-stimulated frameworks and answers. IoE solutions together with a ways flung fitness monitoring and phone tracking have supplied the guide of authorities to successfully manage to unfold the corona contamination. The principle contribution of this compare paper is the in-intensity analysis and segmentation of vicinity-unique IoE technology, which have the potential to be remarkable applications inside the new present day. So far, privacy worries and the protection of IoE applications are thoroughly analyzed with rising standards, and the code for multitasking practices is likewise being mentioned. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

6.
International Conference on Advances and Innovations in Recycling Engineering, AIR 2021 ; 275:85-101, 2023.
Article in English | Scopus | ID: covidwho-2059755

ABSTRACT

The whole world is presently battling against the Coronavirus pandemic, which has tested every aspect of life. The virus spread has severe implications on the global economy. In the face of a deteriorating economic environment brought on by globalisation, Indian industries must bear the significant economic brunt and suffer severe consequences. One among the seriously affected industry is the well-reputed Indian IT industry. During COVID 19 era, employees from the IT sector have faced various troublesome situations. In the present study, a web-based survey consisting of questions concerning WFH during pandemic has been conducted to visualise the repercussions caused due to COVID 19 pandemic. This paper studies the benefits, challenges, and implications for IT firms moving forward while also analysing employees’ perceptions of the current work situation to improve the current systems. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

7.
Journal of Reliability and Statistical Studies ; 15(2):535-552, 2022.
Article in English | Web of Science | ID: covidwho-2033429

ABSTRACT

Corona viruses, commonly called COVID-19, are a large family of viruses that can cause diseases ranging from the common cold to Severe Acute Respiratory Syndrome (SARS). Worldwide Covid-19 is affecting 210 countries and territories around the world and two international conveyances. As of 2 June 2020, there are 6,408,869 confirmed 2,935,368 recovered and 378,317 deaths cases has been reported in world of Coronavirus diseases, India is not untouched from this situation. Currently, it has reported infected 190,535 and 5,394 death cases due to COVID-19 in India. (https://covid19.who.in t/region/searo/country/in). The COVID-19 pandemic was first confirmed in the Indian state of Uttar Pradesh on 4 March 2020, with the first positive case in Ghaziabad. As of 1 June 2020, the state has 8361 confirmed cases, resulting in 222 deaths and 5030 recoveries. The situation is getting worst day by day as COVID-19 outbreaks and patients are increasing by every minute and become the most important issue for the whole world and So accessing knowledge and awareness among the people is very important. The present study using the exploratory data analysis we tried to demonstrate the knowledge and awareness of individuals about the COVID-19 pandemic in Uttar Pradesh, the most populous state of India. The findings of the present study can be utilized by the researchers and policy makers to handle this worst situation.

8.
J Anaesthesiol Clin Pharmacol ; 38(Suppl 1): S52-S57, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-2024767

ABSTRACT

Background and Aims: There is a marked inclination towards cesarean sections as the preferred mode of delivery in parturients with COVID-19 disease. However, the challenges associated with planning and performing a surgery in the COVID-19 setup are considerable. These factors may lead to widespread changes in obstetric decision-making, operative planning, and perioperative outcomes. Thus, our study aimed to study the clinical and logistical factors involved in cesarean sections in COVID-19 parturients. Material and Methods: This was a retrospective observational study performed at a dedicated COVID-19 tertiary care center in India. All women undergoing cesarean section in the specially earmarked operating room between 1st May 2020 and 31st December 2020 were included in the study. The clinical characteristics, operative details, and neonatal details, along with maternal and fetal outcomes were noted and analyzed. Results: A total of 44 women underwent cesarean section during the study period, with elective and emergency surgeries numbering 22 each. No indication, apart from COVID-19 status, was listed in over one-fourth of the women (13/44). The most common preoperative comorbidity was hypothyroidism (12/44). Median surgical duration was 117.5 min (IQR 100-133), with a median of 7.5 (IQR 6-8.25) healthcare personnel in the OT. Over one-fourth (12/44) of the delivered babies had low birth weight, while 4.5% (2/44) tested positive for SARS-CoV-2. Conclusion: COVID-19 status alone continues to be a common indication for cesarean section. Operative time is increased, but the number of healthcare personnel involved can be trimmed with proper planning. Maternal and fetal outcomes are largely positive, with low transmission rates, but a considerable proportion of low-birth-weight neonates.

9.
1st International Conference on Advances in Computing and Future Communication Technologies, ICACFCT 2021 ; : 231-236, 2021.
Article in English | Scopus | ID: covidwho-2018769

ABSTRACT

Internet of the Everything (IoE) along with different technologies like Cloud and Arduino UNO is of great use throughout the disaster. We have used the MLX90614 Sensor to send the temperature of the person on the cloud with the help of Arduino UNO. This sensor can assist in discovering all of the humans who have come into touch with the infected people. This IoE generation is also useful in tracking sufferers. For those who are having a high probability of getting infected, their information can be supplied to the healthcare workforce to take further action. The COVID-19 epidemic can be controlled by IoE-stimulated frameworks. IoE answers at the side of far-flung health monitoring. If the disease is found in a suspected person then this information is passed through IoE to the health care team. IoE technology which is used here can be a fantastic way to control epidemics. Here we have maintained the privacy and protection issues in our project. IoE is very well analyzed with growing requirements and for multi-tasking practices. © 2021 IEEE.

10.
Eur Arch Otorhinolaryngol ; 2022 Sep 02.
Article in English | MEDLINE | ID: covidwho-2007141

ABSTRACT

BACKGROUND: Rhino-orbital-cerebral mucor mycosis (ROCM) is a relatively rare opportunistic infection caused by the Mucorales species. While ROCM suggests involvement of the paranasal sinuses, orbit and brain ROM (rhino-orbital-Mucormycosis) stands for the fungal invasion in sinuses and orbit sans cerebral involvement. In India with the outbreak of the second COVID wave and the delta variant of the virus, there has been a steep increase in this opportunistic fulminant fungal infection, named COVID-associated Mucor mycosis (CAM). The most critical question in orbital management is when to go ahead with an exenteration. Our study aims to design a pertinent minimal invasive surgical protocol for surgeons to manage such cases based on our surgical experience and mitigate the need for exenteration and save the eyes wherever possible. METHODS: The study is a retrospective analysis of patients of ROM with and without brain involvement, who underwent minimal surgical management between March 2021 to March 2022 along with their follow-up. RESULTS: There were 184 eyes of 148 patients diagnosed with CAM. The mean age was 51.7 years with a male predominance of 103 (70%). All patients developed ROM following the COVID-19 infection and the duration between diagnosis of COVID-19 and ROM was 36 ± 23 days. 18 cases (12%) were bilateral. 76 eyes (41%) had no vision at the presentation. Imaging revealed paranasal sinus involvement (100%), orbital apex involvement (61%), cavernous sinus involvement (53%), and central nervous system (CNS) involvement (47%). All the patients (100%) were treated with systemic Liposomal amphotericin-B and sinus debridement. Endoscopic debridement of the orbital disease was performed in 45 (30.4%) cases, 15(8.1%) eyes underwent exenteration and were later rehabilitated with a customized ocular prosthesis, 103 (56%) eyes underwent transcutaneous retrobulbar amphotericin-B. At a mean follow-up of 13.1 months; the complete resolution was seen in 25 (17%) cases, the residual stable lesion was seen in 77(52%) of the cases and new lesions were developed in 13(9%) of the cases. Mortality was seen in 33 (22%) patients and all of them had CNS involvement. CONCLUSIONS: Systemic and protocol-based management can save the life and salvage the eyes.

11.
Indian Journal of Critical Care Medicine ; 26:S84, 2022.
Article in English | EMBASE | ID: covidwho-2006372

ABSTRACT

Cytomegalovirus infection is a common occurrence in the immunocompromised host and can affect any organ of the human body. Clinical presentation is extremely variable and nonspecific, which makes diagnosis difficult. Post COVID patients are immunocompromised due to viral infection, uncontrolled diabetes, poor nutrition, hyper-catabolic state, and use of immunosuppressive drugs like steroids and tocilizumab. We are presenting a clinical spectrum of seven post COVID patients who were readmitted to the hospital with variable clinical spectrums. Early suspicion and appropriate pharmacological interventions were necessary to make the right diagnosis and achieve a positive outcome. Materials and methods: This is a retrospective analysis of seven post COVID patients admitted in our hospital since 15th January to 1 August 2021. All post COVID patients were investigated and only those were positive by PCR and serology for CMV was analyzed. Results: All seven patients were previously treated in hospital for severe COVID associated pneumonia and readmitted with various CMV related complications. Three out of seven patients died and four survived. All patients were having multisystem involvement with predominantly affected respiratory system in the form of pneumonia and reappearance of ground glass lesions in HRCT and increased demand of oxygen. Conclusion: CMV-associated complications are underdiagnosed in post COVID patients and this is one of the etiologies of re-hospitalization of such patients. Clinical spectrum is wide and nonspecific therefore strong clinical suspicion and early investigation can provide an opportunity for optimal therapeutic intervention for the suffering patient.

13.
2nd International Conference on Advance Computing and Innovative Technologies in Engineering, ICACITE 2022 ; : 909-914, 2022.
Article in English | Scopus | ID: covidwho-1992625

ABSTRACT

Across India, offline educational system facilities were forced to collapse and students' access to education was severely curtailed due to the Covid-19 pandemic. During COVID-19 many educational institutes abruptly shifted to virtual classrooms for learning with numerous gaps to maintain the academic activities and provide remote lessons to their students. This has impacted the education system in contrary forces. The huge gap is anonymously costing students by taking away their knowledge growth. On the other hand, faculties are scrambling to adapt to the usability of online learning platforms. Faculties are finding innovative ways to interact with the students, but the loss remains incomparable. Therefore, the concept of a smart attendance system governs a significant role in covering at least one gap by replacing the time-consuming traditional method of taking attendance in the virtual classroom. The system takes attendance by recognizing the face of the student and marking attendance automatically with zero errors. Hence, the goal of an online attendance system is achieved with high accuracy. © 2022 IEEE.

14.
Computer Applications in Engineering Education ; : 20, 2022.
Article in English | Web of Science | ID: covidwho-1981597

ABSTRACT

Four-dimensional (4D) printing has received an amplified consideration in the research community for fabrication and manufacturing in industry, medical field, and smart flood management. Disruptive technologies such as Internet of Things, Artificial Intelligence, and 4D printing are highly recommended during disaster management activities. The 4D printing technology is an evolving field that is an advancement of three-dimensional printing technologies in which the materials are programmed to change shape over time responding to external stimulus without human intervention, thereby adding a fourth dimension. The technology had a great impact during the coronavirus disease 2019 pandemic and flood management activities. This paper, with the aim of a scientometric review, recognizes the recent research hotspots, trends, and worldwide scope of 4D printing for the period of 2007-2021. The bibliographic data fetched from the Scopus in comma-separated values format is used in the study for extracting the masked information by discussing the in-depth visualization of the attributes of the index documents. The study examines the growth of publications, subject categorizations, global distributions, citation analysis, and the influence of the institutions and authors using the bibliographic data. VOSviewer, a java-based tool, is used to study the keyword co-occurrence, which yields hotspots and emerging trends in the various applications of 4D printing, including smart flood management. This study provides the implementation, latest trends, and universal research topography over the past decade, which assists to recognize primitive research and also provides supervision for the upcoming research.

15.
Arab Gulf Journal of Scientific Research ; 39(Special Issue (2):48-59, 2021.
Article in English | GIM | ID: covidwho-1929360

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) associated inflammatory cytokine storm that worsens COVID-19, relies heavily on the inflammatory response. IL-6, a TH1 cytokine, PCT and CRP have been linked to serious illness and a higher mortality rate. We further tried to evaluate the role of these indicators and their association with clinical severity in COVID-19 patients. Material and Methods: Eighty-three consecutive patients with age 18 years with RT-PCR test positive for SARS-CoV-2 were included in the study. Demographic characteristics (age and sex), underlying co-morbidities, symptoms, physical findings, and laboratory tests of the patients were recorded. All patients were categorized as having mild, moderate, and severe COVID-19 disease, according to the Indian Council of Medical Research (ICMR). The levels of IL-6 and PCT were estimated by electrochemiluminescence immunoassay (ECLIA) using Cobas-e411 Immunoassay System, and Quantitative CRP was done by Unicorn-230 automated biochemistry analyzer to find out their correlation with disease severity and outcome. Multiple Regression was performed to find out factors associated with the adverse outcome of the disease. Result: Mean age of patients was 51 years. IL-6, CRP, and PCT levels increased in 73%, 68.0%, and 8.2% patients on admission, respectively. The most common co-morbidity associated with the disease was hypertension (25%), followed by diabetes (24%) and respiratory disease (15%). Increased IL-6, CRP, and PCT levels were found in 77 percent, 79 percent, and 20 percent of patients, respectively. We found that IL-6 (P0.05), CRP (P0.05), and PCT (P0.05) were significantly raised in COVID-19 patients with increasing severity of the disease. The Area under the receiver operating characteristic (AUROC) of these parameters ranged between 0.65 and 0.8 (IL-6, 0.828;CRP, 0.809;and PCT, 0.658), indicating a reliable biomarker to assess clinical severity.

16.
18.
Endocrinology, and Diabetes & Metabolism ; 4(1):e00176, 2021.
Article in English | MEDLINE | ID: covidwho-1898651

ABSTRACT

Background: Obesity accompanied by excess ectopic fat storage has been postulated as a risk factor for severe disease in people with SARS-CoV-2 through the stimulation of inflammation, functional immunologic deficit and a pro-thrombotic disseminated intravascular coagulation with associated high rates of venous thromboembolism. Methods: Observational studies in COVID-19 patients reporting data on raised body mass index at admission and associated clinical outcomes were identified from MEDLINE, Embase, Web of Science and the Cochrane Library up to 16 May 2020. Mean differences and relative risks (RR) with 95% confidence intervals (CIs) were aggregated using random effects models. Results: Eight retrospective cohort studies and one cohort prospective cohort study with data on of 4,920 patients with COVID-19 were eligible. Comparing BMI >= 25 vs <25 kg/m2, the RRs (95% CIs) of severe illness and mortality were 2.35 (1.43-3.86) and 3.52 (1.32-9.42), respectively. In a pooled analysis of three studies, the RR (95% CI) of severe illness comparing BMI > 35 vs <25 kg/m2 was 7.04 (2.72-18.20). High levels of statistical heterogeneity were partly explained by age;BMI >= 25 kg/m2 was associated with an increased risk of severe illness in older age groups (>=60 years), whereas the association was weaker in younger age groups (<60 years). Conclusions: Excess adiposity is a risk factor for severe disease and mortality in people with SARS-CoV-2 infection. This was particularly pronounced in people 60 and older. The increased risk of worse outcomes from SARS-CoV-2 infection in people with excess adiposity should be taken into account when considering individual and population risks and when deciding on which groups to target for public health messaging on prevention and detection measures. Systematic review registration: PROSPERO 2020: CRD42020179783.

19.
7th International Conference on Computing in Engineering and Technology, ICCET 2022 ; 303 SIST:705-719, 2022.
Article in English | Scopus | ID: covidwho-1877804

ABSTRACT

Technology is one of the modes of education to optimize teaching and learning methodologies in imparting knowledge. Talking about higher educational institutes, one can see the same pedagogy as it used to be a decade ago. However, these Institutes are plagued by many challenges like lack of infrastructure and inadequate technology access, and it is essential to see how these burgeoning technologies (ICT) are fostering and bridging this massive gap of teaching and learning and keeping pace with the rest of the part of the globe. ICT has revolutionized almost every sphere of society. The education system is one of the sectors that has also undergone a massive change with ICT incorporation. After the arrival of the worldwide covid pandemic, the use of ICT in education has increased extensively. This paper has performed a comparative analysis on ICT usage by the students and teachers of engineering institutions in pre-covid age and post-covid age. The survey method of data collection has been used in this research work. Analysis of results has revealed that the usage of ICT by the students and teachers has been significantly increased after the arrival of covid. Moreover, the presented work has highlighted the issues raised by the students and teachers in the post-covid time. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

20.
Journal of Clinical and Experimental Hepatology ; 12:S40-S41, 2022.
Article in English | EMBASE | ID: covidwho-1859849

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) is a respiratory system trophic disease. Liver involvement is emerging from recent data. Studies describing liver function test (LFT) abnormalities are sparse from our population. Aims: We studied LFT abnormalities in different categories of COVID-19 and its significance in relation to primary outcomes of in-hospital mortality. Methods: It was a retrospective study from a single center of a metropolitan city. All consecutive patients with proven COVID19 by reverse transcriptase-polymerase chain reaction from 23rd March 2020 till 31stOctober 2020 were enrolled. Of 3280 case records profiled, 1474 cases were included in the study. Clinical characteristics, biochemical parameters and outcomes were recorded. Results: Deranged LFTs were present in 681/1474 (46%) patients. Hepatocellular type of injury was most common (93%). Patients with deranged LFTs had more probability of developing severe disease (P<0.001) and mortality (P<0.001). Higher mean age (P<0.001), male gender (P<0.001), diabetes mellitus (P<0.001), chronic kidney disease (P<0.02) cirrhosis (P<0.001), lower oxygen saturation (SpO2) levels at admission (P<0.001), higher serum creatinine (P value<0.001), D-dimer levels (P<0.001) and positive radiological findings on Chest X-ray (P<0.001) were associated with deranged LFTs. Acute liver injury was seen in 65 (4.33%) cases on admission and 57(3.5%) cases during hospital stay. On admission, raised serum bilirubin, aspartate and alanine transaminases, international normalized ratio and low serum albumin were found to be significant. However, on multivariate analysis for predicting mortality, age, serum creatinine, and PaO2/FiO2 ratio only were found to be significant (P<0.001). Conclusion: In COVID-19, LFT abnormalities are common and multifactorial. As severity of disease progresses, derangement in LFT’s increase. However, it is not associated with in- hospital mortality.

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