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1.
European Journal of Molecular and Clinical Medicine ; 9(4):3249-3256, 2022.
Article in English | EMBASE | ID: covidwho-2030822

ABSTRACT

Background: Corona pandemic and its resultant lockdown have caused a devastated effect of life of human beings. We conducted this study during Covid-19 period to analyze the effects of lockdown on pediatric trauma variations in injury pattern and its severity among children in a tertiary hospital. Materials and Methods: Patients of less than 16 year presented to orthopedic trauma were defined in this study. The study has been divided into three time periods. Patients presented from March 2019 to July 2019 (base line period), March 2020 to July 2020 (Lockdown period) and March 2021 to July 2021 (post lockdown period) were identified and compared in this retrospective cross sectional study. The children included in this study were either requiring manipulation under anesthesia or surgical intervention in operation theatre. We conducted unadjusted bivariate analyses of injury patterns during these periods. Segmented linear regression models were used to evaluate the rates of injuries before, during and after pandemic period. The one way analysis of variance (ANOVA) was used to evaluate the differences in means of three independent groups. Results: A total of 231 numbers of children with orthopedic trauma were presented to our tertiary hospital. Out of these, 111 were admitted during pre-pandemic period and 45 in the pandemic period with 75 children during post pandemic period. During lockdown period, mean age of children with significant orthopedic trauma has decreased to 7.5 years in comparison to base line which was about 8.5 years and post lockdown period 9.25 years. Boys outnumbered the girls during this study. The outdoor injury has drastically decreased from 65.75% in base line to 35.65% in lockdown period, but this pattern has increased to 85.25% in post lockdown period. Conclusion: Our study has shown that during lock down in Covid pandemic, there was a decrease of 59.46% cases of pediatric trauma patients in which surgical intervention or manipulation in operation theatre was required. These changes in epidemiology may be due to modified approach followed by surgeon while following strict Covid guidelines. Our study has also mentioned increase in domestic injuries requiring surgical intervention which may be due to lock down implications by national protocols. We recommend to create a safe environment for children during indoor and outdoor activities and creating awareness among parents to safe guard their siblings. All above these measures may reduce the burden on health care facilities.

2.
RMD Open ; 8(2), 2022.
Article in English | MEDLINE | ID: covidwho-2029524

ABSTRACT

OBJECTIVE: We investigated prolonged COVID-19 symptom duration, defined as lasting 28 days or longer, among people with systemic autoimmune rheumatic diseases (SARDs). METHODS: We analysed data from the COVID-19 Global Rheumatology Alliance Vaccine Survey (2 April 2021-15 October 2021) to identify people with SARDs reporting test-confirmed COVID-19. Participants reported COVID-19 severity and symptom duration, sociodemographics and clinical characteristics. We reported the proportion experiencing prolonged symptom duration and investigated associations with baseline characteristics using logistic regression. RESULTS: We identified 441 respondents with SARDs and COVID-19 (mean age 48.2 years, 83.7% female, 39.5% rheumatoid arthritis). The median COVID-19 symptom duration was 15 days (IQR 7, 25). Overall, 107 (24.2%) respondents had prolonged symptom duration (>=28 days);42/429 (9.8%) reported symptoms lasting >=90 days. Factors associated with higher odds of prolonged symptom duration included: hospitalisation for COVID-19 vs not hospitalised and mild acute symptoms (age-adjusted OR (aOR) 6.49, 95% CI 3.03 to 14.1), comorbidity count (aOR 1.11 per comorbidity, 95% CI 1.02 to 1.21) and osteoarthritis (aOR 2.11, 95% CI 1.01 to 4.27). COVID-19 onset in 2021 vs June 2020 or earlier was associated with lower odds of prolonged symptom duration (aOR 0.42, 95% CI 0.21 to 0.81). CONCLUSION: Most people with SARDs had complete symptom resolution by day 15 after COVID-19 onset. However, about 1 in 4 experienced COVID-19 symptom duration 28 days or longer;1 in 10 experienced symptoms 90 days or longer. Future studies are needed to investigate the possible relationships between immunomodulating medications, SARD type/flare, vaccine doses and novel viral variants with prolonged COVID-19 symptoms and other postacute sequelae of COVID-19 among people with SARDs.

3.
2022 International Conference on Machine Learning, Big Data, Cloud and Parallel Computing, COM-IT-CON 2022 ; : 317-321, 2022.
Article in English | Scopus | ID: covidwho-2029191

ABSTRACT

Tourism industry is a significant industries in the world. It increases the revenue of the economy by creating thousands of jobs and developing the infrastructures of a country. With the normalcy returning in the lives of people around the world after the brutal waves of COVID19, it might be a high time people would be looking forward to visiting new places. Many types of research have been done in the direction of the use of machine learning to analyze the sentiments in the field of the tourism industry while very little research has been done on using machine learning in predicting the growth of the tourism industry. Thus, the present research has tried to explore the area of predicting the growth of the tourism industry using machine learning. The growth has been estimated by using footfall as the parameter. The research has applied four models namely Random Forest, Linear Regression, Gradient Boosting Machine (GBM), and Decision Tree. R-square along with RMSE, MAPE, and MAE has been used as the metrics for assessing the best fit model. GBM comes out on top in every category with R-square value of 96.84, MAPE of 15.96%, RMSE of 6017.74, and MAE of 4780.32. © 2022 IEEE.

4.
Pediatric Infectious Disease Journal ; 07:07, 2022.
Article in English | MEDLINE | ID: covidwho-2029114

ABSTRACT

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related complication that has disproportionately affected racial/ethnic minority children. We conducted a pilot study to investigate risk factors for MIS-C aiming to understand MIS-C disparities. METHODS: This case-control study included MIS-C cases and SARS-CoV-2-positive outpatient controls aged less than 18 years frequency-matched 4:1 to cases by age group and site. Patients hospitalized with MIS-C were admitted between March 16 and October 2, 2020, across 17 pediatric hospitals. We evaluated race, ethnicity, social vulnerability index (SVI), insurance status, weight-for-age and underlying medical conditions as risk factors using mixed effects multivariable logistic regression. RESULTS: We compared 241 MIS-C cases to 817 outpatient SARS-CoV-2-positive at-risk controls. Cases and controls had similar sex, age and U.S. census region distribution. MIS-C patients were more frequently previously healthy, non-Hispanic Black, residing in higher SVI areas, and in the 95th percentile or higher for weight-for-age. In the multivariable analysis, the likelihood of MIS-C was higher among non-Hispanic Black children [adjusted odds ratio (aOR): 2.07;95% CI: 1.23-3.48]. Additionally, SVI in the 2nd and 3rd tertiles (aOR: 1.88;95% CI: 1.18-2.97 and aOR: 2.03;95% CI: 1.19-3.47, respectively) were independent factors along with being previously healthy (aOR: 1.64;95% CI: 1.18-2.28). CONCLUSIONS: In this study, non-Hispanic Black children were more likely to develop MIS-C after adjustment for sociodemographic factors, underlying medical conditions, and weight-for-age. Investigation of the potential contribution of immunologic, environmental, and other factors is warranted.

5.
Sci Rep ; 12(1):15517, 2022.
Article in English | PubMed | ID: covidwho-2028729

ABSTRACT

Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage display human antibody library approach to rapidly identify neutralizing antibodies (nAbs) against SARS-CoV-2. We demonstrate the binding and neutralization capability of two nAbs, STI-2020 and STI-5041, against the SARS-CoV-2 WA-1 strain as well as the Alpha and Beta variants. STI-2020 and STI-5041 were protective when administered intravenously or intranasally in the golden (Syrian) hamster model of COVID-19 challenged with the WA-1 strain or Beta variant. The ability to administer nAbs intravenously and intranasally may have important therapeutic implications and Phase 1 healthy subjects clinical trials are ongoing.

6.
International Journal of Health Sciences ; 6:11653-11672, 2022.
Article in English | Scopus | ID: covidwho-2026867

ABSTRACT

Domestic workers are one of the most unprotected groups of the global workforce in informal employment who remain outside the ambit of social security and legal protection. Despite their significant contribution to the economy and society, they are often invisible and undervalued. The pre-existing adversities and vulnerabilities became all the more evident during the recent health crisis. While different groups of workers faced constraints to support their livelihood, the women domestic workers were hardest hit, facing total or near unemployment, job losses and economic distress. This paper attempts to analyse the impact of pandemic on the lives and livelihoods of female domestic workers in five Indian cities including Pune, Lucknow, Jhansi, Katni and Bhopal. The analytical findings from the random sample survey of 250 female domestic worker provides a temporal analysis of the impact of covid-19 on the nature of work, income, expenditure and consumption across the various cities of India. Our findings not only increase our understanding on the impact of the crisis for domestic worker but also informal workers in general. This also help inform the policy response of authorities towards addressing the exclusion of domestic workers from the ambit of the privileges that workers employ in the formal sector. © International Journal of Health Sciences 2022.

7.
Journal of Anaesthesiology Clinical Pharmacology ; 38(Suppl 1):S132-S133, 2022.
Article in English | MEDLINE | ID: covidwho-2024780
8.
Journal of Anaesthesiology Clinical Pharmacology ; 38(Suppl 1):S52-S57, 2022.
Article in English | MEDLINE | ID: covidwho-2024767

ABSTRACT

Background and Aims: There is a marked inclination towards cesarean sections as the preferred mode of delivery in parturients with COVID-19 disease. However, the challenges associated with planning and performing a surgery in the COVID-19 setup are considerable. These factors may lead to widespread changes in obstetric decision-making, operative planning, and perioperative outcomes. Thus, our study aimed to study the clinical and logistical factors involved in cesarean sections in COVID-19 parturients. Material and Methods: This was a retrospective observational study performed at a dedicated COVID-19 tertiary care center in India. All women undergoing cesarean section in the specially earmarked operating room between 1st May 2020 and 31st December 2020 were included in the study. The clinical characteristics, operative details, and neonatal details, along with maternal and fetal outcomes were noted and analyzed. Results: A total of 44 women underwent cesarean section during the study period, with elective and emergency surgeries numbering 22 each. No indication, apart from COVID-19 status, was listed in over one-fourth of the women (13/44). The most common preoperative comorbidity was hypothyroidism (12/44). Median surgical duration was 117.5 min (IQR 100-133), with a median of 7.5 (IQR 6-8.25) healthcare personnel in the OT. Over one-fourth (12/44) of the delivered babies had low birth weight, while 4.5% (2/44) tested positive for SARS-CoV-2. Conclusion: COVID-19 status alone continues to be a common indication for cesarean section. Operative time is increased, but the number of healthcare personnel involved can be trimmed with proper planning. Maternal and fetal outcomes are largely positive, with low transmission rates, but a considerable proportion of low-birth-weight neonates.

9.
Journal of Anaesthesiology Clinical Pharmacology ; 38(Suppl 1):S151-S153, 2022.
Article in English | MEDLINE | ID: covidwho-2024760
10.
Oxid Med Cell Longev ; 2022:3012778, 2022.
Article in English | PubMed | ID: covidwho-2020490

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronavirus (HCoV) that has created a pandemic situation worldwide as COVID-19. This virus can invade human cells via angiotensin-converting enzyme 2 (ACE2) receptor-based mechanisms, affecting the human respiratory tract. However, several reports of neurological symptoms suggest a neuroinvasive development of coronavirus. SARS-CoV-2 can damage the brain via several routes, along with direct neural cell infection with the coronavirus. The chronic inflammatory reactions surge the brain with proinflammatory elements, damaging the neural cells, causing brain ischemia associated with other health issues. SARS-CoV-2 exhibited neuropsychiatric and neurological manifestations, including cognitive impairment, depression, dizziness, delirium, and disturbed sleep. These symptoms show nervous tissue damage that enhances the occurrence of neurodegenerative disorders and aids dementia. SARS-CoV-2 has been seen in brain necropsy and isolated from the cerebrospinal fluid of COVID-19 patients. The associated inflammatory reaction in some COVID-19 patients has increased proinflammatory cytokines, which have been investigated as a prognostic factor. Therefore, the immunogenic changes observed in Parkinson's and Alzheimer's patients include their pathogenetic role. Inflammatory events have been an important pathophysiological feature of neurodegenerative diseases (NDs) such as Parkinson's and Alzheimer's. The neuroinflammation observed in AD has exacerbated the Aβ burden and tau hyperphosphorylation. The resident microglia and other immune cells are responsible for the enhanced burden of Aβ and subsequently mediate tau phosphorylation and ultimately disease progression. Similarly, neuroinflammation also plays a key role in the progression of PD. Several studies have demonstrated an interplay between neuroinflammation and pathogenic mechanisms of PD. The dynamic proinflammation stage guides the accumulation of α-synuclein and neurodegenerative progression. Besides, few viruses may have a role as stimulators and generate a cross-autoimmune response for α-synuclein. Hence, neurological complications in patients suffering from COVID-19 cannot be ruled out. In this review article, our primary focus is on discussing the neuroinvasive effect of the SARS-CoV-2 virus, its impact on the blood-brain barrier, and ultimately its impact on the people affected with neurodegenerative disorders such as Parkinson's and Alzheimer's.

11.
1st International Conference on Advances in Computing and Future Communication Technologies, ICACFCT 2021 ; : 231-236, 2021.
Article in English | Scopus | ID: covidwho-2018769

ABSTRACT

Internet of the Everything (IoE) along with different technologies like Cloud and Arduino UNO is of great use throughout the disaster. We have used the MLX90614 Sensor to send the temperature of the person on the cloud with the help of Arduino UNO. This sensor can assist in discovering all of the humans who have come into touch with the infected people. This IoE generation is also useful in tracking sufferers. For those who are having a high probability of getting infected, their information can be supplied to the healthcare workforce to take further action. The COVID-19 epidemic can be controlled by IoE-stimulated frameworks. IoE answers at the side of far-flung health monitoring. If the disease is found in a suspected person then this information is passed through IoE to the health care team. IoE technology which is used here can be a fantastic way to control epidemics. Here we have maintained the privacy and protection issues in our project. IoE is very well analyzed with growing requirements and for multi-tasking practices. © 2021 IEEE.

12.
Journal of Craniofacial Surgery ; 26:26, 2022.
Article in English | MEDLINE | ID: covidwho-2018394

ABSTRACT

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has posed another serious threat, mucormycosis infection, affecting the maxilla and orbitocerebral region. This condition has not spared world population from its merciless claws. This article addresses the challenges faced by the maxillofacial surgeons in setting the protocols from preoperative diagnosis, surgical management to postoperative care, including short-term and long-term rehabilitation. To manage this relentlessly progressing condition, a multispecialty team approach is to be activated in diagnosing, managing, and rehabilitating the patients. PURPOSE: The purpose of this clinical study is to document and analyze the clinical and demographic data, presentation of the lesion, the diagnostic methods followed for early clinical detection, and management of post COVID-19 midface mucormycosis. The article also discusses postoperative medical management and prosthetic rehabilitation. RESULTS: Most of the mucormycosis cases reporting to our center were treated and recovered patients of Severe Acute Respiratory Syndrome Coronavirus 2 infection. Thirty-four (n=34) case were operated for post COVID-19 midface mucormycosis between October 2020 and December 2021. Male to Female ratio is 1:42. The average age of the patients was 57.5 years. Maximum patients were in fifth and sixth decade of life. Maxilla was the involved bone. Treatment was primarily surgical debridement to extended or radical maxillectomy. All patients were treated with Liposomal Amphotericin B and tab posaconazole for 3 to 4 weeks depending upon the age, weight, and physiological state of the patients to attain an optimal cumulative load. Three patients succumbed to illness postoperatively (n=3, 1.02%). Average duration of hospital stay was 47 days. The average review period was 5.1 months.

13.
Scientific Reports ; 12(1):14534, 2022.
Article in English | MEDLINE | ID: covidwho-2016828

ABSTRACT

To date, more than 263 million people have been infected with SARS-CoV-2 during the COVID-19 pandemic. In many countries, the global spread occurred in multiple pandemic waves characterized by the emergence of new SARS-CoV-2 variants. Here we report a sequence and structural-bioinformatics analysis to estimate the effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike receptor binding domain (RBD) to the human receptor hACE2. This is done through qualitative electrostatics and hydrophobicity analysis as well as molecular dynamics simulations used to develop a high-precision empirical scoring function (ESF) closely related to the linear interaction energy method and calibrated on a large set of experimental binding energies. For the latest variant of concern (VOC), B.1.1.529 Omicron, our Halo difference point cloud studies reveal the largest impact on the RBD binding interface compared to all other VOC. Moreover, according to our ESF model, Omicron achieves a much higher ACE2 binding affinity than the wild type and, in particular, the highest among all VOCs except Alpha and thus requires special attention and monitoring.

14.
Jama Network Open ; 5(8), 2022.
Article in English | Web of Science | ID: covidwho-2013234

ABSTRACT

IMPORTANCE Widespread distribution of rapid antigen tests is integral to the US strategy to address COVID-19;however, it is estimated that few rapid antigen test results are reported to local departments of health. OBJECTIVE To characterize how often individuals in 6 communities throughout the United States used a digital assistant to log rapid antigen test results and report them to their local departments of health. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study is based on anonymously collected data from the beneficiaries of the Say Yes! Covid Test program, which distributed more than 3 000 000 rapid antigen tests at no cost to residents of 6 communities (Louisville, Kentucky;Indianapolis, Indiana;Fulton County, Georgia;O'ahu, Hawaii;Ann Arbor and Ypsilanti, Michigan;and Chattanooga, Tennessee) between April and October 2021. A descriptive evaluation of beneficiary use of a digital assistant for logging and reporting their rapid antigen test results was performed. INTERVENTIONS Widespread community distribution of rapid antigen tests. MAIN OUTCOMES AND MEASURES Number and proportion of tests logged and reported to the local department of health through the digital assistant. RESULTS A total of 313 000 test kits were distributed, including 178 785 test kits that were ordered using the digital assistant. Among all distributed kits, 14 398 households (4.6%) used the digital assistant, but beneficiaries reported three-quarters of their rapid antigen test results to their state public health departments (30 965 tests reported of 41 465 total test results [75.0%]). The reporting behavior varied by community and was significantly higher among communities that were incentivized for reporting test results vs those that were not incentivized or partially incentivized (90.5%[95% CI, 89.9%-91.2%] vs 70.5%;[95% CI, 70.0%-71.0%]). In all communities, positive tests were less frequently reported than negative tests (60.4%[95% CI, 58.1%-62.8%] vs 75.5%[95% CI, 75.1%-76.0%]). CONCLUSIONS AND RELEVANCE These results suggest that application-based reporting with incentives may be associated with increased reporting of rapid tests for COVID-19. However, increasing the adoption of the digital assistant may be a critical first step.

15.
Potato Journal ; 49(1):48-55, 2022.
Article in English | Scopus | ID: covidwho-2011690

ABSTRACT

Seed is an essential input for the potato crop. Much of the efforts and investment would be infructuous if the farmers did not get the quality seeds. Only the seed with assured purity-genetic and physical can be expected to respond to fertilizers and other inputs in a respected manner. The present study attempted to analyze the source, SRR of potato seed and assess the effect on potato crop yield by using certified seed in the Jalandhar district of Punjab. The current study was conducted on primary data collected from 120 farmers during the 2020-21 agricultural year. The data were analyzed using simple tabular analysis and other suitable statistical techniques. The study found that the most preferred source of seed was the self-retained seed which came out to be 48 per cent, the second most preferred source was private seed dealers, as 17 per cent procured seed from these dealers. The high use of self-retained seed was due to the high cost of purchased seed, and the other reason was that farmers had more confidence in the self-retained seed. The study found that large farmers’ Seed Replacement Rate (SRR) was higher. It was 11.2 per cent for small farmers, 19.5 per cent for medium farmers and 27.5 per cent for large farmers. The yield of potato crop using certified seed was higher than non-certified seed. The per cent difference in yield of potato grown by certified and non-certified seed among small and medium farmers was 17 per cent, 11 per cent among large farmers and 15 per cent overall in the Jalandhar district of Punjab. The study highlighted that the primary constraint faced by potato seed growers were high prices of certified seed (69.1 per cent), high cost of pesticides and insecticides (65.8 per cent), fluctuations in the price of potato seed (55 per cent), lack of public procurement at MSP (53.3 per cent), covid related restrictions (52.5 per cent) and lack of extension facilities (48.3 per cent). The study suggested that the government should provide certified seed to the farmers at the lowest cost to increase the seed replacement rate. Awareness regarding the use of certified seed should be given to farmers through extension services. Government institutes like Central Potato Research Station (CPRS) (ICAR), the Centre of Excellence (Dogri) and the Department of Horticulture should expand the production of certified seeds as only 18 per cent of potato growers purchased seeds from these agencies in the study area. The minimum support price of potatoes should be fixed to promote the production of potatoes in the state. © 2022, Indian Potato Association. All rights reserved.

16.
HemaSphere ; 6(Suppl), 2022.
Article in English | EuropePMC | ID: covidwho-2011466
18.
Current pharmaceutical design ; 2022.
Article in English | MEDLINE | ID: covidwho-2009796

ABSTRACT

Heat shock protein 90 (Hsp90) is a chaperone protein that prevents many other proteins from aggregating by folding them in a certain way. Hsp90 consists of three structural domains: N-terminal, middle and C-terminal domains. Hsp90 has many activities in numerous proteins and signaling pathways like chimeric fusion proteins, steroid hormone receptors, tumor suppressor genes, and cell cycle regulatory proteins. The role of Hsp90 is not only in cancer but also in other diseases like COVID-19, leishmaniasis, diabetes, flavi virus, systemic sclerosis, grass carp reovirus, psoriasis, malaria, cardiac fibrosis, and alcohol-related liver diseases. This review is a compilation of the pharmacological profile of Hsp90 inhibitors, problems associated with them, and suggested remedies for the same.

19.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009556

ABSTRACT

Background: Burnout is a psychological syndrome defined by the Maslach Burnout Inventory (MBI) as emotional exhaustion, depersonalization, and a low sense of personal accomplishment. Risk of job-related burnout for early-career medical oncologists can significantly impact career longevity and health outcomes for providers and patients alike. Because little is known about burnout specific to early-career academic oncologists, we sought to characterize the prevalence of burnout and associated factors among Assistant Professors at MD Anderson Cancer Center (MDACC). Methods: For this IRB-approved retrospective study, an electronic survey was developed for Assistant Professors in medical oncology at MDACC. Participants were all involved directly in patient care with at least some clinical effort. Our survey included nine questions validated in the MBI addressing equally the 3 aforementioned domains of burnout. An additional 31 questions were formulated to assess personal and professional factors that may contribute to burnout at our institution (clinical workload, research expectations, communication, COVID, and home-life). Each question was scored on a scale of 1 to 5, with higher scores correlating to higher levels of burnout. Descriptive statistics were used to describe the prevalence of burnout, and logistic regression analyses were performed to identify characteristics associated with burnout. Results: Among 70 (of 86 total) Assistant Professors who responded, mean duration on faculty was 3.1 years (standard deviation +/-1.8). Mean clinical effort was 67% (range, 19-95). Gender identifications were 44% female, 54% male, and 2% non-binary. 54% of respondents reported symptoms of burnout already, including 21% endorsing severe burnout. Severe burnout was more common for solid tumor providers than liquid tumor providers (55% vs 13%, p =.03). Using the MBI, severe emotional exhaustion (25%) was more prevalent (p <.0001) than depersonalization (6%) or lack of personal accomplishment (17%). Sentiments of being “emotionally drained” (20%), fatigue to face another day on the job” (37%), and “becoming more callous” (30%) were especially concerning among early-career faculty. Emotional exhaustion was associated with a feeling of less autonomy over personal decision making (p =.03) and female gender (p =.04). Conclusions: Burnout exists with high prevalence among early-career medical oncologists in this single-institution analysis. Emotional exhaustion was the specific manifestation of burnout in this population. Further validation of these data nationwide is anticipated. Interventions focusing on reducing emotional exhaustion are under development to reduce medical oncology-specific burnout in an academic setting for faculty retention and for deliverance of optimal care to patients with cancer.

20.
Annals of the Rheumatic Diseases ; 81:965-966, 2022.
Article in English | EMBASE | ID: covidwho-2009096

ABSTRACT

Background: Rheumatologists recommend vaccination in rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) patients, but there are few studies on the occurrence of adverse events (AEs), particularly worsening disease related activity and unrelated immune reactions in these groups. Objectives: To evaluate the uptake of COVID vaccination in RA and axSpA patients, compare the frequency of AEs, and identify risk factors associated with vaccine AEs in two prospective cohorts comprised of these patients. Methods: The IMPACT study is a monthly survey of two prospective cohorts of established RA and axSpA patients in northern Alberta, Canada from November 2020-2021 who answered at least one or more Redcap surveys through de-iden-tifed email link surveying demographics, disease characteristics, COVID symptoms, treatment of RA and axSpA, health care utilization, vaccination status, vaccine AEs and use of cannabis. Univariate analyses evaluated independent variables associated with the dependent variables of (1) any AE, (2) any severe AE, (3) any arthritis fare, and (4) any severe arthritis fare, followed by multi-variate analyses of these four dependant variables using all clinically relevant variables from the univariate analysis. Results: 773/2167 patients (RA 574, axSpA 197) responded to at least one survey. 32/663 (5%) were single vaccinated, 631 (95%) double vaccinated and 230 (54%) triple vaccinated with 80% receiving Pfzer, 24% Moderna, 28% Astra-Zeneca and 30% 'other'. 456 (69%) reported at least one AE (Figure 1) with 21 (3%) patients seeing a physician for their AE. Increased age was associated with all AEs. RA patients had lower reported AEs versus axSpA patients for all AE defnitions except for severe arthritis fares. Generally, males reported worse AEs (Table 1). 'Any arthritis fare' was lower in patients reporting cannabis use. Conclusion: RA and axSpA patients showed high uptake of COVID vaccination with largely minor AEs. Older age and male gender were associated with more general and arthritis specifc AEs. The association of any AE and/or arthritis-spe-cifc AEs in SpA versus RA patients is a novel fnding which may correlate with the male predominance of SpA. The association of cannabis with fewer arthritis AEs may refect the nociceptive properties of cannabis.

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