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1.
Indian Journal of Critical Care Medicine ; 26:S128, 2022.
Article in English | EMBASE | ID: covidwho-2006415

ABSTRACT

Aim and background: Cytokine storm caused by the release of proinflammatory mediators, e.g., IL-6, TNF-, IL2, IL10, G-CSF, etc., is the hallmark of COVID-19 disease. This cytokine storm is characterized by immuno-thrombomodulation. C-Reactive Protein (CRP) and d-dimer are markers of proinflammatory state, which can also be used as a prognostic marker for the underlying disease processes. Objective: To determine the clinical utility of raised C-reactive protein (CRP) and d-Dimer levels as prognostic markers in patients with the diagnosis of COVID-19. Materials and methods: This retrospective observational study will be conducted at Max Super speciality Hospital I.P. Extension, Delhi after ethical committee clearance. Adult (age > 18 years) patients with confirmed diagnosis of COVID-19 admitted to COVID-ICU between 1st April 2021 till 30th June 2021 will be included and checked for CRP and d-Dimer values retrospectively. Correlation between raised CRP and d-dimer on presentation and rising trend of markers with 28-day mortality, Average length of ICU stay, need for invasive mechanical ventilation, and need for Renal Replacement Therapy will be seen. Results: Results will be shared after the completion of the study.

2.
7th IEEE International conference for Convergence in Technology, I2CT 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1992612

ABSTRACT

As a result of the Covid-19 outbreak, a trustworthy health care system for remote surveillance was required, particularly in care facilitieas for the elderly. Many studies have been done in this subject, however they still have security, latency, extended time of execution and response delay. An intelligent Healthcare infrastructure termed Remote Health Monitoring (RHM) is introduced in this study to overcome these constraints. The framework uses high-level fog layer services including locally storage, native real-time data processing with combined mining of information in handling certain cloud and sensor network loads and transformed in a decision taker entity. This systems uses a body and camera sensors to diagnose, increasing accuracy and efficiency while protecting privacy. The suggested framework was tested using the iFogSim toolbox. It may minimise latency, energy usage, network connectivity and total reaction time. This work will assist develop a high performing, secure, and dependable intelligent Medical infrastructure. © 2022 IEEE.

3.
Journal of the Association of Physicians of India ; 69(5):14-15, 2021.
Article in English | MEDLINE | ID: covidwho-1287199
4.
Annals of Medical and Health Sciences Research ; 11(3):1331-+, 2021.
Article in English | Web of Science | ID: covidwho-1271490

ABSTRACT

Background: Prevailing conditions of COVID-19 has hit all sectors of society including dentistry. Both personal and professional lives of dentists have been influenced. Several studies have been undertaken regarding aspects likes influence of clinical practices, awareness regarding the pandemic among patients and dentists. Only a few studies have been conducted in Saudi Arabia. The present study evaluates the impact of COVID-19 on Fear, anxiety, socioeconomic status and performance of clinical practices of dental professionals in Riyadh. Methods: A Questionnaire was designed as Google form and sent to 400 dental professionals and responses were statistically evaluated. Results: 244 males and 156 females' dental professionals participated in study. Most of the clinical practices were found to be open but with lower patient volumes. There was decline in both monthly volumes of patients and volumes of collections. Majority of dental professionals were in fear of getting COVID-19 and transmitting to their families. They were afraid of getting quarantined also. In general, all agreed that it will take more than a year for their practices to come back to normal but most of them did not want to shift their profession. There was found to be significant association between designation and effects of COVID-19. Conclusion: There was definite negative impact of COVID-19 on socioeconomic status and performance of clinical practices along with increase in Fear and anxiety among dental professionals.

6.
Blood Cells Mol Dis ; 88: 102548, 2021 05.
Article in English | MEDLINE | ID: covidwho-1086789

ABSTRACT

BACKGROUND: Convalescent plasma (CP) is being used as a treatment option in hospitalized patients with COVID-19. Till date, there is conflicting evidence on efficacy of CP in reducing COVID-19 related mortality. OBJECTIVE: To evaluate the effect of CP on 28-day mortality reduction in patients with COVID-19. METHODS: We did a multi-centre, retrospective case control observational study from 1st May 2020 to 31st August 2020. A total of 1079 adult patients with moderate and severe COVID-19 requiring oxygen, were reviewed. Of these, 694 patients were admitted to ICU. Out of these, 333 were given CP along with best supportive care and remaining 361 received best supportive care only. RESULTS: In the overall group of 1079 patients, mortality in plasma vs no plasma group was statistically not significant (22.4% vs 18.5%; p = 0.125; OR = 1.27, 95% CI: 0.94--1.72). However, in patients with COVID-19 admitted to ICU, mortality was significantly lower in plasma group (25.5% vs 33.2%; p = 0.026; OR = 0.69, 95%CI: 0.50-0.96). This benefit of reduced mortality was most seen in age group 60 to 74 years (26.7% vs 43.0%; p = 0.004; OR = 0.48, 95% CI: 0.29-0.80), driven mostly by females of this age group (23.1% vs 53.5%; p = 0.013; OR = 0.26, 95% CI: 0.09-0.78). Significant difference in mortality was observed in patients with one comorbidity (22.3% vs 36.5%; p = 0.004; OR = 0.50, 95% CI: 0.31-0.80). Moreover, patients on ventilator had significantly lower mortality in the plasma arm (37.2% vs 49.3%; p = 0.009; OR = 0.61, 95% CI: 0.42-0.89); particularly so for patients on invasive mechanical ventilation (63.9% vs 82.9%; p = 0.014; OR = 0.37, 95% CI: 0.16-0.83). CONCLUSION: The use of CP was associated with reduced mortality in COVID-19 elderly patients admitted in ICU, above 60 years of age, particularly females, those with comorbidities and especially those who required some form of ventilation.


Subject(s)
COVID-19/therapy , Adult , Age Factors , Aged , COVID-19/epidemiology , COVID-19/mortality , Case-Control Studies , Female , Humans , Immunization, Passive , India/epidemiology , Male , Middle Aged , Retrospective Studies , SARS-CoV-2/isolation & purification
7.
Annals of Rheumatic Diseases ; 79(Suppl 1):216, 2020.
Article in English | ProQuest Central | ID: covidwho-1017137

ABSTRACT

Background:The COVID-19 pandemic has resulted in uncertainty and negative psychological outcomes for patients with autoimmune rheumatic diseases for several reasons.1 The anxiety is due to “underlying conditions” that are expected to increase the risk of infection and / or severe complications. Patients with rheumatological disorders fall into this group as they are believed to be immunosuppressed due to disease or the treatment. It is essential to understand the level of anxiety among the rheumatic disease patients at the current situation of COVID-19.Objectives:To study difference in Anxiety score (Mean/Avg Score) among following groups-underlying rheumatic disease, age, gender, marital status, educational status, employment status, medications, those who were on steroids/not, those who are Biologicals / Not.Methods:A web-based cross-sectional multi-centre survey was done across 5 rheumatology centres in India. The study duration was between 9th May and 16th May 2020.The questionnaire included consent, demographic details, medication history, opinion about tele rheumatology services and anxiety score measured by Beck Anxiety Inventory (BAI) 2.Results:The survey was sent to 2987 patients, there were 933 responses and 581 were complete (Male =175). Complete responses were considered for data analysis. Most respondents were less than 50 years of age (70.6%). Rheumatoid arthritis (RA) was the most frequent (50.6%) diagnosis followed by other conditions. Most of the patients (43%) were on combination DMARD therapy, 12.7% of patients were on biological drugs and 23.9% of patients were on glucocorticoids. Statistically significant higher anxiety scores were observed in females, patients suffering from fibromyalgia, patients on glucocorticoids and biological agents. There was no difference in the anxiety scores with regard to age, educational status, and employment status.Difficulty in meeting rheumatologists and getting medications was expressed by 327 (56.2%) and 73 (29.7%) respondents respectively. Majority of respondents (86.6 %) agreed/strongly agreed regarding use of telemedicine to access health care during the crisis.Conclusion:The findings of the study revealed that anxiety is a major concern in patients with autoimmune rheumatic diseases. Fibromyalgia patients and those who were on glucocorticoids and biological drugs were found to have more anxiety levels compared to other groups of patients. In such periods of public health crises, telemedicine is a great tool for patients to access healthcare without fear of going to hospital. There is a need to intensify the awareness and address the mental health issues of rheumatology patients during this COVID-19 pandemic.References:[1]Pope, J.E. What Does the COVID-19 Pandemic Mean for Rheumatology Patients?. Curr Treat Options in Rheum (2020). https://doi.org/10.1007/s40674-020-00145-y.[2]Oh H, Park K, Yoon S, Kim Y, Lee SH, Choi YY, et al. Clinical utility of beck anxiety inventory in clinical and nonclinical Korean samples. Front Psychiatry.2018;9:666. https://doi.org/10.3389/fpsyt.2018.00666Disclosure of Interests:None declared

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