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1.
5th International Conference on Communication, Device and Networking, ICCDN 2021 ; 902:223-232, 2023.
Article in English | Scopus | ID: covidwho-2048169

ABSTRACT

Now a days in EFL procedure of education the ability of reading became as significant belief and personal-efficacy reading as a basic understanding for students. By monitoring the acknowledged participates under the ballpark figure of large studying and methods of understanding, the impact of their observation is premeditated on reading of each one’s personal-efficacy. On a daily routine all these things are comparatively considered which are put into effect by teachers of handful in number. Approach towards exhibiting Extensive reading (ER) is inspected to be “more expensive, difficult, and time-consuming”. Method of recognition of elements in a various way for effective impact in putting its efforts to utilize for its empowerment. Paper has been segregated into two contexts: Association with attitude is considered as primary one and attitude is considered as secondary one. Whether knowledge work is understood by student or not is considered as the impact of ER by the first review. Procedure which are convenient is taken as the observations of student and is analysed as second one. The examinations are quantifiable to utilize the observations as information in terms of subjective way taken from students who belong to first academic year of reading course in a systematic way and 603 details of undergraduate students from KLEF of Guntur were chosen as participants for extant examination. In ER programme of includes and excludes “comprehension reading work” is treated as fundamental in the proposal of disclosures. In case of any, “the programme appeared to positively affect contributing students”. Techniques of classification like “decision tree and Mixed Model Database Miner (MMDBM)” are employed in this paper which leads to improvements of post-test to pre-test in ER group. Observations of students in ER results as optimistic and algorithm of MMDBM which leads to accuracy in higher rate in pre-test and post-test detection. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

2.
Journal of NeuroInterventional Surgery ; 14:A47-A48, 2022.
Article in English | EMBASE | ID: covidwho-2005437

ABSTRACT

Background The mechanisms and outcomes in COVID-19- associated stroke are unique from those of non-COVID-19 stroke. Objectives The purpose of this study is to describe the efficacy and outcomes of acute revascularization of large vessel occlusion (LVO) in the setting of COVID-19 in an international cohort. Methods We conducted an international multicenter retrospective study of consecutively admitted COVID-19 patients with concomitant acute large vessel occlusion (LVO) across 50 comprehensive stroke centers. Our control group constituted historical controls of patients presenting with LVO and receiving a MT between January 2018 to December 2020.Results: The total cohort was 575 patients with acute LVO, 194 had COVID-19 while 381 patients did not. Patients in the COVID-19 group were younger (62.5 vs. 71.2;p<0.001), and lacked vascular risk factors (49, 25.3% vs. 54, 14.2%;p =0.001). mTICI 3 revascularization was less common in the COVID-19 group (74, 39.2% vs. 252, 67.2%;p < 0.001). Poor functional outcome at discharge (defined as mRS 3-6) was more common in the COVID-19 group (150, 79.8% vs.132, 66.7%;p =0.004). COVID-19 was independently associated with a lower likelihood of achieving mTICI 3 (OR: 0.4, 95% CI: 0.2 -0.7;p<0.001), and unfavorable outcomes (OR: 2.5, 95% CI: 1.4 - 4.5;p=0.002). Conclusion COVID-19 was an independent predictor of incomplete revascularization and poor outcomes in patients with stroke due to LVO. COVID-19 patients with LVO patients were younger, had fewer cerebrovascular risk factors, and suffered from higher morbidity/mortality rates. (Figure Presented).

3.
Journal of Applied Pharmaceutical Science ; 12(5):104-119, 2022.
Article in English | Scopus | ID: covidwho-1863256

ABSTRACT

In the current scenario of the severe acute respiratory syndrome caused by novel coronavirus 2 (SARS-CoV-2) pandemic, the repurposing of the Food and Drug Administration (FDA)-approved antiviral drugs for the possibility of treating SARS-CoV-2 is an unavoidable scientific method. It further exemplifies the physical interactions between the target protein and the chosen drugs. In this study, the main protease (Mpro) structure of SARS-CoV-2 Protein Data Bank ID: 7BUY with 42 FDA-approved antiviral drugs was analyzed by molecular docking using PyRx-Vina, and the amino acids involved in docking are analyzed using Discovery Studio Visualizer. The protein–drug complex stability was analyzed by molecular dynamics simulation (MDS) using GROMACS. The results showed that ledipasvir showed the maximum binding affinity (−10.4 kcal/mol) with Mpro of SARS-CoV-2 followed by paritaprevir (−9.1 kcal/mol) and velpatasvir (−8.8 kcal/mol). These three compounds are found to have a significant number of interactions. Moreover, ledipasvir and velpatasvir showed similar interactions at GLU240, PRO241, ILE249, PRO293, and VAL202. MDS showed that the top ligands had formed stable complexes with Mpro. Molecular Mechanics Poisson–Boltzmann Surface Area calculation revealed thermodynamically stable binding energies of −195.370 ± 1.119 kJ/mol and −180.778 ± 0.868 kJ/mol for ledipasvir and velpatasvir, respectively. Paritaprevir showed stable binding energy of −75.679 ± 0.922 kJ/mol with Mpro of SARS-CoV-2. © 2022. Subramaniam Sivakumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

4.
2nd International Workshop on Best-Worst Method (BWM) ; : 238-251, 2021.
Article in English | Web of Science | ID: covidwho-1756705

ABSTRACT

COVID-19's Infection and the mortality rates pushed the governments to impose lockdowns that caused huge economical losses. This pandemic also changed our social and personal life and causes severe psychological problems. Continuous mutations of the COVID-19 virus and unabated transmission rate made it unsustainable to continue the lockdowns. Discovery of suitable vaccine brings a glimmer of hope to the race against this virus. However, the real task is to manufacture, distribute and vaccinate the world's entire population within a reasonable time. Considering the state of healthcare infrastructure and vaccine cold storage facilities, this is going to be a challenge. This paper collected the opinion of 17 decision makers representing the various levels of Covid-19 vaccination programme such as vaccine manufacturer and vaccine administrator. Then, Best Worst Method, a Multi-Criteria Decision Making method was applied to understand the critical factors for the success of this vaccination programme in India. This method elicited consistent pairwise comparisons from the decision makers. Results signify the immediate need to scale up the investment in the vaccine cold storage and the need to reduce vaccine wastage for the success of this vaccination programme.

5.
2nd IEEE International Power and Renewable Energy Conference, IPRECON 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1672793

ABSTRACT

The idea of this work is to create an interaction between people to keep them connected emotionally during the Covid crisis. The goal is to provide two interactive boards(i-Boards) and to let people communicate using it wireless. The device embodies digital information in physical space and aims to go beyond the limits of graphical user interfaces. It also expands the affordances of simple physical objects (e.g cubes) and surfaces (board). It provides a tangible interface and also has its own elements of fun to keep the interaction as intuitive and as fun as possible. The user interface design choices and the limitations were also investigated. © 2021 IEEE.

6.
Materials Today: Proceedings ; 2021.
Article in English | ScienceDirect | ID: covidwho-1313330

ABSTRACT

We are developed in the green activity of silver nitrate nanoparticles and are used materials of Mentha (M), Azadirachta indica (A) leaves, and have been implemented as the agent for stabilizing the poly-leaf extracts (LE) / pig liver acetone powder (PL) with complexes. An optimal extract absorption of LE/PL has been used in 500 mg then 200 mg individually, by attraction about 0.841%. Since the PL satisfied with an energetic mediator of the MA leaf extracts are 92.1667 ± 0.3626%. The antibacterial movement on made silver nanoparticles is Escherichia coli, then Staphylococcus aureus. These samples are calculated to additional the antimicrobial movement counter to verified in a pathogenic way in a gram of positive, negative with microbial and fungiform straining. It was made with fast production to Natural Garden Pest Control (non-toxic method) for the mixture of silver nanoparticles are showed hopeful to the movement of all the established microbial straining. The trend is improved through an augmented quantity echelon.

7.
Stroke ; 52(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1234375

ABSTRACT

Introduction: Underlying biological, genetic, or epigenetic characteristics may predispose to health differences and outcomes with COVID-19 associated stroke. Social determinants of health, access and geographical differences pertaining both to population density and other location-based factors may also be important. Methods: We report 69 cases of acute stroke in patients positive for SARS-CoV-2, in a dichotomized analysis of ischemic stroke outcomes between patients of African American background versus all other backgrounds. All patients presented to 14 major hospitals in the United States and Canada, from March 14-April 14, 2020. All patients had nasopharyngeal swab samples that were positive for SARS-CoV-2 on qualitative RT-PCR assays. Results: We found no significant difference in age (64.4 versus 62.9 years) or the proportion of females (51.9% versus 38.1%) (table 1). Diabetes mellitus was present significantly less in African American cases versus others (37% vs. 66.7%). The African American cohort had a similar mean NIHSS score of 16.3 compared with 14.9 in other races (p=0.63). The door-to-CT time was also similar (23 versus 19 minutes). The proportion of patients presenting with a large vessel occlusion was not significantly different (40.7% versus 47%). We noted 14.8% of African American cases received intravenous tPA compared to 31% in other races but was not significantly different. The proportion of thrombectomy cases mirrored this (14.8% versus 31%). Regarding stroke functional outcomes, there was no difference between African Americans and other races with respect to discharge mRS or proportion of favorable outcome (mRS 0-2). Symptomatic intracranial hemorrhage (sICH) was significantly higher for African Americans (11.1% versus 3%, p<0.001).Mortality was significantly higher in African Americans compared to other races (51.9% vs. 28.6%,p=0.03). Discussion: The reasons for increased mortality in African Americans with COVID-19-associatedstroke are unknown. The finding in this study that mortality rate of COVID-19 positive stroke patientsis greater than that previously reported in either COVID-19 respiratory infection alone or acuteischemic stroke alone, suggests an interaction that also warrants further study.

9.
Journal of Contemporary Issues in Business and Government ; 26(2):980-986, 2020.
Article in English | Web of Science | ID: covidwho-1106781

ABSTRACT

Online banking is increasingly becoming popular because of convenience and flexibility. The present paper explores the major factors responsible for internet banking based on respondents' perception on various internet applications. It also provides a framework of the factors which are taken to assess the internet banking perception. The banking industry has been rapidly developing the use of online banking as an efficient and viable tool to create customer value. It is one of the popular services offered by the traditional banks to provide speedier and reliable services to online users. With the rapid development of computer technology as a commercial tool, Internet banking can be used to attract more customers to perform banking transactions in related banks. However, the main problem of Internet banking faced by the providers is that a large number of the banks' customers are not willing to use the Internet banking services offered. This happened due to the services offered through Internet banking have yet to satisfy their customers. Customer satisfaction is an important factor to help banks to sustain competitive advantages. Therefore, the purpose of this research is to search and examine the factors which influence customer satisfaction towards Internet banking.

10.
Journal of NeuroInterventional Surgery ; 12(Suppl 1):A162, 2020.
Article in English | ProQuest Central | ID: covidwho-824457

ABSTRACT

IntroductionThere has been limited evidence on the influence of racial background in stroke outcomes in COVID-19. Underlying biological, genetic, or epigenetic characteristics may predispose to health differences and outcomes. Social determinants of health, access and geographical differences pertaining both to population density and other location-based factors may also be important.MethodsWe report 69 cases of acute stroke in patients positive for SARS-CoV-2, including 27 of African American background and 42 of other racial backgrounds, including Caucasian, Hispanic, and Asian. All patients presented to 14 major hospitals in the United States and Canada, from March 14-April 14, 2020. All patients had nasopharyngeal swab samples that were positive for SARS-CoV-2 on qualitative RT-PCR assays. We present a dichotomized analysis of ischemic stroke outcomes between patients of African American background as reported on hospital intake questionnaire versus all other backgrounds.ResultsComparison between Caucasian, Hispanic and Asian backgrounds did not show disparities in stroke outcomes. We found no significant difference in age (64.4 versus 62.9 years) or the proportion of females (51.9% versus 38.1%) (table 1). Diabetes mellitus was present significantly less in African American cases versus others (37% vs. 66.7%). No significant difference between groups was found regarding other comorbidities including smoking, atrial fibrillation, prior anticoagulation, coronary artery disease, congestive heart failure, hypertension, hyperlipidemia, cerebrovascular accident, peripheral vascular disease, or chronic kidney disease. With respect to presenting SARS-CoV-2 symptoms, we found no difference in exposure history, asymptomatic cases, fever, cough, dyspnea, nausea or vomiting, chills, malaise, or lethargy. The African American cohort had a similar mean NIHSS score of 16.3 compared with 14.9 in other races (p=0.63). The door-to-CT time was also similar (23 versus 19 minutes). The proportion of patients presenting with a large vessel occlusion was not significantly different (40.7% versus 47%). We noted 14.8% of African American cases received intravenous tPA compared to 31% in other races, but this was not significantly different in this sample. The proportion of thrombectomy cases mirrored this (14.8% versus 31%). Laboratory findings were not significantly different between African Americans and all others. Regarding stroke functional outcomes, there was no difference between African Americans and other races in terms of discharge mRS (p=0.27). For mRS 0–2, there was no significant difference noted (14.8% versus 16.7%). Symptomatic intracranial hemorrhage (sICH) was significantly higher for African Americans (11.1% versus 3%, p0.001). Mortality was significantly higher in African Americans compared to other races (51.9% vs. 28.6%, p=0.03).DiscussionOur preliminary data suggest that there may be a mortality difference amongst stroke patients of African American background afflicted with COVID-19. The reasons for increased mortality in African Americans with COVID-19-associated stroke are unknown. Racial disparities in case counts and outcomes during the COVID-19 pandemic have been highlighted, particularly regarding African American communities. In addition, the finding in this study that mortality rate of COVID-19 positive stroke patients is greater than that previously reported in either COVID-19 respiratory infection alone or acute ischemic stroke alone, suggests an interaction that also warrants further study.DisclosuresA. Dmytriw: None. K. Phan: None. C. Schirmer: None. F. Settecase: None. M. Heran: None. A. Efendizade: None. A. Kuhn: None. A. Puri: None. B. Menon: None. M. Dibas: None. S. Sivakumar: None. A. Mowla: None. L. Leung: None. A. Malek: None. B. Voetsch: None. S. Segal: None. A. Wakhloo: None. H. Wu: None. A. Xavier: None. A. Tiwari: None.

11.
Annals of Oncology ; 31:S1004, 2020.
Article in English | EMBASE | ID: covidwho-805713

ABSTRACT

Background: The COVID-19 pandemic required a rapid response and need for real-world data in cancer patients. The nationwide, real-time coordinated UKCCMP reporting network provided an immediate solution. Methods: The ability to set up an interdisciplinary multi-organisational team quickly, covering expert knowledge from clinical, legal, statistical, and computer science was essential. The technical infra-structure allows clinician-led anonymised data entry and rapid dissemination of results with a clinical (RedCap) database as core. However the development of a national cancer reporting network was crucial for the viability of the project. From its inception in March 2020 the reporting network was established via 4 iterative phases. Results: Within the first 4 weeks, >50 centres were involved with coverage throughout the UK. Expansion has continued with >70 centres within 6 weeks reporting over 1200 COVID positive cancer patients. This was achieved through a 4-phase approach: phase 1 - Outline: This involved project protocol development where key data and timelines were confirmed by a small project team followed by whole-team sign-off. phase 2 - Engagement: This involved identification and engagement of existing groups to establish an initial network. Professional body endorsement led to increased recognition and utilisation of their membership networks. Finally regional leads were identified. phase 3 - Invitation: The third phase involved the distribution of a formal invite letter via identified networks. Project specific email and standard mailing lists were created to enhance network identity and communication. phase 4 - Consolidation: Early development of an interactive project website and focus on communication via social media with varied content consolidated interest and led to further extension. Conclusions: Real-time reporting of real world data can be achieved with clearly defined project phases, standardised documentation and an iterative recruitment process. The COVID-19 pandemic necessitated a rapid response, proving that similar reporting networks can be set up quickly and robustly to react to the evidence-based needs of the oncology community in the drive for implementation of change. Legal entity responsible for the study: The authors. Funding: Has not received any funding. Disclosure: A.C. Olsson-Brown: Honoraria (self): Roche;Honoraria (institution): Roche;Honoraria (self): Bristol Myers Squibb;Research grant/Funding (institution): Bristol Myers Squibb;Research grant/Funding (institution): USB Pharma;Research grant/Funding (institution): Eli Lily;Research grant/Funding (institution): Novartis. D.J. Hughes: Honoraria (self): Novartis;Research grant/Funding (self): NanoMab Technology LtD. S. Sivakumar: Research grant/Funding (self): Celgene. All other authors have declared no conflicts of interest.

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