Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 24
Filter
1.
Social Skills: Influencing Factors, Gender Differences and Impact of COVID-19 ; : 19-40, 2021.
Article in English | Scopus | ID: covidwho-1877363

ABSTRACT

With the emergence of the COVID-19 pandemic, social distancing became necessary to reduce the possibility of contagion by the virus. However, in this context the number of social interactions has decreased. Given this situation, this chapter aims to present an instructional material entitled “Social skills for better interpersonal relationships while facing COVID-19.” The material presents the main classes of social skills that can contribute to coping with the pandemic situation. The classes of social skills are Civility, Communication, Empathy, Empathy, Interpersonal Problem Solving, Self-Control, Emotional expressiveness. Finally, the chapter presents some practical guidelines for coping and developing social skills. We believe that the development and competent use of social skills can improve interpersonal relationships, resulting in a life with better mental health during the pandemic. © 2021 by Nova Science Publishers, Inc.

2.
Social Skills: Influencing Factors, Gender Differences and Impact of COVID-19 ; : 91-122, 2021.
Article in English | Scopus | ID: covidwho-1877362

ABSTRACT

Considering the high number of conflicts in the classroom between students and teachers, the present study aimed to evaluate the effects of a remote Social Skills Training program on Middle School Teachers. The study included 19 teachers aged between 29 and 63 (M = 43.95;SD = 10.57) years, who taught in public and private schools. The enrolled participants were divided between the experimental Social Skills Training group and a control group identified as Cycle of Lectures for Middle School Teachers. Two instruments were used: the Social Skills Inventory - 2 and the Educational Social Skills Inventory - teacher version. The project was submitted to the University’s Ethics Committee and data collection took place in an online format due to the new coronavirus pandemic. Ten virtual meetings were held with days and times scheduled in advance, with the provision of a link to access the virtual room. In these meetings, participants were trained to acquire social skills and educational social skills for better management of situations considered difficult. The difficult situations encompassed four specific themes: Indiscipline, Psychosocial Difficulties, Violence and Discrimination. For data analysis, the JT Method was used using the reliable change indices as the standard to consider individual improvements of the subjects. Regarding Social Skills, the participants in the experimental group presented gains, reliable changes, in all five dimensions of the social skills inventory. Concerning educational social skills, 27.3% of the participants in the experimental group showed significant improvements in all dimensions. The intervention led to the acquisition of a more elaborate repertoire of social skills and educational social skills in the teachers, which could help them to establish more favorable learning environments. © 2021 by Nova Science Publishers, Inc.

3.
J Hosp Infect ; 124: 37-46, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1814717

ABSTRACT

BACKGROUND: The COVID-19 pandemic increased the use of broad-spectrum antibiotics due to diagnostic uncertainty, particularly in critical care. Multi-professional communication became more difficult, weakening stewardship activities. AIM: To determine changes in bacterial co-/secondary infections and antibiotics used in COVID-19 patients in critical care, and mortality rates, between the first and second waves. METHODS: Prospective audit comparing bacterial co-/secondary infections and their treatment during the first two waves of the pandemic in a single-centre teaching hospital intensive care unit. Data on demographics, daily antibiotic use, clinical outcomes, and culture results in patients diagnosed with COVID-19 infection were collected over 11 months. FINDINGS: From March 9th, 2020 to September 2nd, 2020 (Wave 1), there were 156 patients and between September 3rd, 2020 and February 1st, 2021 (Wave 2) there were 235 patients with COVID-19 infection admitted to intensive care. No significant difference was seen in mortality or positive blood culture rates between the two waves. The proportion of patients receiving antimicrobial therapy (93.0% vs 81.7%; P < 0.01) and the duration of meropenem use (median (interquartile range): 5 (2-7) vs 3 (2-5) days; P = 0.01) was lower in Wave 2. However, the number of patients with respiratory isolates of Pseudomonas aeruginosa (4/156 vs 21/235; P < 0.01) and bacteraemia from a respiratory source (3/156 vs 20/235; P < 0.01) increased in Wave 2, associated with an outbreak of infection. There was no significant difference between waves with respect to isolation of other pathogens. CONCLUSION: Reduced broad-spectrum antimicrobial use in the second wave of COVID-19 compared with the first wave was not associated with significant change in mortality.


Subject(s)
Anti-Infective Agents , Bacterial Infections , COVID-19 , Coinfection , Anti-Bacterial Agents/therapeutic use , Anti-Infective Agents/therapeutic use , Bacterial Infections/epidemiology , COVID-19/drug therapy , Coinfection/drug therapy , Humans , Intensive Care Units , Pandemics , SARS-CoV-2
4.
Mater Today Chem ; 24: 100817, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1796291

ABSTRACT

The rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion in humans is crucial for suitable infection control. In this sense, many studies have focused on increasing the sensibility, lowering the detection limits and minimizing false negative/positive results. Thus, biosensors based on nanoarchitectures of conducting polymers are promising alternatives to more traditional materials since they can hold improved surface area, higher electrical conductivity and electrochemical activity. In this work, we reported the analytical comparison of two different conducting polymers morphologies for the development of an impedimetric biosensor to monitor SARS-CoV-2 seroconversion in humans. Biosensors based on polypyrrole (PPy), synthesized in both globular and nanotubular (NT) morphology, and gold nanoparticles are reported, using a self-assembly monolayer of 3-mercaptopropionic acid and covalently linked SARS-CoV-2 Nucleocapsid protein. First, the novel hybrid materials were characterized by electron microscopy and electrochemical measurements, and the biosensor step-by-step construction was characterized by electrochemical and spectroscopic techniques. As a proof of concept, the biosensor was used for the impedimetric detection of anti-SARS-CoV-2 Nucleocapsid protein monoclonal antibodies. The results showed a linear response for different antibody concentrations, good sensibility and possibility to quantify 7.442 and 0.4 ng/mL of monoclonal antibody for PPy in the globular and NT morphology, respectively. The PPy-NTs biosensor was able to discriminate serum obtained from COVID-19 positive versus negative clinical samples and is a promising tool for COVID-19 immunodiagnostic, which can contribute to further studies concerning rapid, efficient, and reliable detections.

6.
The Journal of hospital infection ; 2022.
Article in English | EuropePMC | ID: covidwho-1755587

ABSTRACT

Background The COVID-19 pandemic increased the use of broad-spectrum antibiotics due to diagnostic uncertainty, particularly in critical care. Multiprofessional communication became more difficult, weakening stewardship activities. Aim To determine changes in bacterial co-/secondary infections and antibiotics used in COVID-19 patients in critical care, and mortality rates, between the first and second waves. Methods Prospective audit comparing bacterial co-/secondary infections and their treatment during the first two waves of the pandemic in a single centre teaching hospital ICU. Data on demographics, daily antibiotic use, clinical outcomes, and culture results in patients diagnosed with COVID-19 infection were collected over 11 months. Findings From 9/3/20 to 2/9/20 (Wave 1), there were 156 patients and between 3/9/20 and 1/2/21 (Wave 2) there were 235 patients with COVID-19 infection admitted to intensive care. No significant difference was seen in mortality or positive blood culture rates between the two waves. The proportion of patients receiving antimicrobial therapy (93.0% vs 81.7%;p<0.01), and the duration of meropenem use (median (interquartile range): 5 (2-7) vs 3 (2-5) days;p=0.01) was lower in Wave 2. However, the number of patients with respiratory isolates of Pseudomonas aeruginosa (4/156 vs 21/235;p<0.01) and bacteraemia from a respiratory source (3/156 vs 20/235 p<0.01) increased in Wave 2, associated with an outbreak of infection. There was no significant difference between waves with respect to isolation of other pathogens. Conclusions Reduced broad spectrum antimicrobial use in the second wave of COVID-19 compared with the first wave was not associated with significant change in mortality.

7.
Open Forum Infectious Diseases ; 8(SUPPL 1):S576-S577, 2021.
Article in English | EMBASE | ID: covidwho-1746340

ABSTRACT

Background. Brazillian authorities reported a total of 16.3 million cases and 454. 000 deaths during COVID-19 pandemic in Brazil by may 2021. It became necessary to educate healthcare professionals on diagnosis and treatment of the syndrome. Game based learning surfaced as an effective alternative, since it promotes critical thinking and problem solving skills. A team of Brazilian and Peruvian students, physicians, designers and programmers gathered to create a decision based computer game that simulates a hospital scenario and allows medical students to analise, make decisions and receive feedback. This work describes the creative process and showcase the initial version of the software. Methods. Professors and students of Medicine, Information Technology (IT), Design and Architecture from Brazil and Peru assembled a team in order to develop the computer game. Clinical cases were created by the medical students and professors, comprising medical procedures for the treatment and management of COVID 19, and a video game script was developed exploring gamification principles of challenge, objectivity, persistence, failure, reward and feedback. Algorithms (image 1) were created, under supervision of professors of Medicine, to define possible courses of action and outcomes (e.g. gain or loss of points, improvement or worsening of the patient). Students of Design created artistic elements, and IT students programmed with a game engine software. This fluxogram, written in portuguese, describes in detail all the possible courses of actions that can be exercised by the player. It is created by a team of Professors of Medicine and medical students, in accordance with evidence-based guidelines. Primarily, this document guides the programmers and designers throughout the development phase of the game. Results. Initially, an expandable minimum viable product was obtained. The game, visualized on image 2, consists in a non-playable character and a playable character (i.e. doctor), with a scenario and a dialogue script simulating a clinical examination of a COVID 19 patient. The player can interact with certain elements within the game, e.g. the computer and other characters, to retrieve test results or start dialogues with relevant information. Hospital scenario and dialogue window between doctor (player in black) and patient (non playable character) are displayer in the game engine software (Unity 2D). On the bottom half of the screen, the dialogue box allows the player to collect the patient's medical history. The player can interact with certain elements to obtain relevant information to make decision and progress in the game. Conclusion. The game allows medical students to practice diagnosis and treatment of COVID 19. Future versions will include assessment reports of player's actions, and a new score system will be implemented. New diseases will be incorporated in the gameplay to match the variety of scenarios offered by real hospitals and patients. Artificial intelligence will be employed to optimize gameplay, feedback and learning.

8.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-296972

ABSTRACT

The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. This enzyme is a promising antiviral target because catalytic mutations render viruses non-pathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. Crystallographic screening of diverse fragment libraries resulted in 214 unique macrodomain-binding fragments, out of 2,683 screened. An additional 60 molecules were selected from docking over 20 million fragments, of which 20 were crystallographically confirmed. X-ray data collection to ultra-high resolution and at physiological temperature enabled assessment of the conformational heterogeneity around the active site. Several crystallographic and docking fragment hits were validated for solution binding using three biophysical techniques (DSF, HTRF, ITC). Overall, the 234 fragment structures presented explore a wide range of chemotypes and provide starting points for development of potent SARS-CoV-2 macrodomain inhibitors.

9.
Arquivos Brasileiros de Oftalmologia ; 29:29, 2021.
Article in English | MEDLINE | ID: covidwho-1547643

ABSTRACT

We report the case of a previously healthy 48-year-old man who developed an isolated abducens nerve palsy 18 days after presenting with coronavirus disease (COVID-19) confirmed by reverse transcriptase polymerase chain reaction. His main complaint at arrival was double vision. Ocular examination revealed a sixth cranial nerve palsy in the left eye. The incomitant esotropia at arrival was 30 prism diopters. Abduction was markedly limited, while adduction was normal in the left eye. The patient underwent complete clinical, neurological, and neuroimaging investigations, including cerebrospinal fluid sample analysis to rule out infectious causes. A conservative approach with orthoptic therapy and Fresnel prism was opted. Eight months after the onset of COVID-19, regression of the strabismus was observed, and the patient reported complete recovery of the diplopia. This case suggests that isolated abducens nerve palsy caused by severe acute respiratory syndrome coronavirus 2 infection may improve with a conservative approach.

10.
1st International Conference on Bioengineering and Biomedical Signal and Image Processing, BIOMESIP 2021 ; 12940 LNCS:350-358, 2021.
Article in English | Scopus | ID: covidwho-1499348

ABSTRACT

In March 2020 the WHO announced the pandemic due to the new coronavirus nCoV-19, which uses the ACE-2 enzyme, present in several body tissues, to infect the host. The presence of ACE-2 in the corneal limbus makes the eyeball an important route of infection for the virus, which is why corneal transplantation is precluded in cases of suspected COVID-19 donors. Also in 2020, The Global Alliance of Eye Bank Association (GAEBA) developed restrictive measures aimed at preventing the spread of the new coronavirus between eye tissue donors and recipient patients, consequently, there was a reduction in effective donors and a global increase in the waiting lines for corneal transplantation worldwide. On the other hand, artificial corneal implantation presents itself as a positive alternative for the current moment, since it makes it impossible for the donor and the recipient of the eye tissue to become infected. In this sense, the present study aims to describe the use of artificial corneas in keratoplasties, considering this a safe and effective method for restoring vision during the COVID-19 pandemic. © 2021, Springer Nature Switzerland AG.

11.
Child Abuse Negl ; : 105345, 2021 Oct 05.
Article in English | MEDLINE | ID: covidwho-1458748

ABSTRACT

Families' health, safety, and economic stability were jeopardized during the pandemic. Parental stress is a risk factor for hostile and less supportive parenting. Parenting styles are a set of attitudes, feelings and behaviors related to parenting that modulate the child's psychosocial functioning and might impact on the adaptability to a stressful time. OBJECTIVE: To investigate the group differences among children raised by negative and positive parenting families during COVID-19 pandemic. METHODS: We have done an online survey with 329 parents. Parents answer about parenting strategies and styles, children's behavior, Covid related questions, socio-economic information, sleep and gaming disorders. RESULTS: Parents' frequent use of negative strategies were a risk factor to have a negative outcome related to mental health, games, sleep, and children behavior. DISCUSSION: Parenting strategies are some targets pointed in this study for intervention. Parents' styles and strategies training to better manage children might be even more important to avoid negative consequences for children in stressful times.

12.
Revista De Ciencias Humanas Da Universidade De Taubate ; 14(2):88-99, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1365964

ABSTRACT

The interest in the potential of cinema as extensible to the scope of education dates back to the beginning of the seventh art and has followed the evolution of society. In line with this vision, the Portuguese National Film Plan (PNFP) emerges nowadays as a government program for film literacy among school audiences, awakening in young people the habit of watching cinema and valuing it as an art. This essay has the purpose of taking a look at the presence of the PNFP on digital social networks during the closure of schools decreed for Portugal as one of the responses to the COVID-19 pandemic. Characterized by in-presence and collective activities, the Plan faced the impossibility of developing them as before, since the school space was transferred to online settings. We observed that pandemic times have come to reveal some of the virtues of the new media and ways of living the cinema, which, not excluding others, are a contribution to the future of the relationship between cinema and education, a dynamic that the PNFP has been developing. We conclude that social web tools such as the digital social networks can be a valid asset for the Plan, in a virtualization that is complementary to its physical presence in schools.

13.
Journal of General Internal Medicine ; 36(SUPPL 1):S182-S182, 2021.
Article in English | Web of Science | ID: covidwho-1349095
15.
Arquivos Brasileiros de Psicologia ; 72(Special Issue):139-155, 2020.
Article in English, Portuguese, Spanish | Scopus | ID: covidwho-1348921

ABSTRACT

Taking Covid-19 Pandemic as a context and analyzer, this article discusses the historical links between racism and the medicalized management of the right to life and death in Brazil. It is based on the understanding that listening and clinical management of situations of psychological distress in the context of the medicalization of life (in Pandemic, and even outside it) necessarily imply making social criticism as well. To this end, we propose a debate that encapsulates clinical theory, the histories of social medicine and psychoanalysis in Brazil, and the concepts of bio and necropoli-tics. Our hypothesis is that if, on the one hand, on its arrival in Brazil, psychoanalysis was “co-opted” by a hygienist medical tradition (which for years polarized the way it was seen in our country), on the other, by its conceptual structure, by the initial counterpoint with Brazilian modernism, and by its current debate on segregation, this praxis can make explicit its anti-racist power and vocation. © 2020. All Rights Reserved.

16.
Materials Chemistry Frontiers ; 5(15):13, 2021.
Article in English | Web of Science | ID: covidwho-1324438

ABSTRACT

We report on genosensors to detect an ssDNA sequence from the SARS-CoV-2 genome, which mimics the GU280 gp10 gene (coding the viral nucleocapsid phosphoprotein), using four distinct principles of detection and treating the data with information visualization and machine learning techniques. Genosensors were fabricated on either gold (Au) interdigitated electrodes for electrical and electrochemical measurements or on Au nanoparticles on a glass slide for optical measurements. They contained a matrix of 11-mercaptoundecanoic acid (11-MUA) self-assembled monolayer (SAM) onto which a layer of capture probe (cpDNA) sequence was immobilized. Detection was performed using electrical and electrochemical impedance spectroscopies and localized surface plasmon resonance (LSPR). The highest sensitivity was reached with impedance spectroscopy, including using a low-cost (US$ 100) homemade impedance analyzer. Complementary ssDNA sequences were detected with a detection limit of 0.5 aM (0.3 copy per mu L). This performance may be attributed to the high sensitivity of the electrical impedance technique combined with an appropriate arrangement of the sequences on the electrodes and hybridization between the complementary sequences, as inferred from polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS). The selectivity of the genosensor was confirmed by plotting the impedance spectroscopy data with a multidimensional projection technique (interactive document mapping, IDMAP), where a clear separation was observed among the samples of the complementary DNA sequence at various concentrations and from buffer samples containing a non-complementary sequence and other DNA biomarkers. The diagnosis of SARS-CoV-2 mimicking sequences was also achieved with machine learning techniques applied to scanning electron microscope images taken from genosensors exposed to distinct concentrations of the complementary ssDNA sequences. In summary, the genosensors proposed here are promising for detecting SARS-CoV-2 genetic material (RNA) in biological fluids in point-of-care settings.

17.
Humanidades & Inovacao ; 8(35):53-70, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1312077

ABSTRACT

This article aims to outline an overview of the adoption of traffic restriction measures and the political, economic and social responses in Brazil and countries of five continents in coping with the Covid-19 pandemic. This describes the outbreak of the Covid-19 epidemic in China and its rapid geographical progression, as well as the central role of cases of asymptomatic people or people with mild symptoms in the spread of the virus worldwide. There is an overview of the restriction measures adopted in countries on five continents. Next, a synthesis of the main political, economic and social responses to the pandemic adopted in 19 selected countries, with the representation of all continents, is presented. It is observed that in most of the countries analyzed some type of movement restriction measure were adopted by national governments, as well as measures to help workers and vulnerable groups.

18.
Water and Environment Journal ; 35(1):6, 2021.
Article in English | EMBASE | ID: covidwho-1177481
19.
Research on Biomedical Engineering ; 2021.
Article in English | Scopus | ID: covidwho-1141545

ABSTRACT

Purpose: The aim of this study was to carry out a systematic review of telemedicine technology and to discuss the role of legislation in the application of telemedicine technology within the scope of COVID-19. Methods: The search for papers was conducted in the databases Cochrane Central, MEDLINE, and Embase. The keywords considered for this systematic review were (coronavirus OR “2019-nCoV” OR 2019nCoV OR nCoV2019 OR “nCoV-2019” OR “COVID-19” OR COVID19 OR “HCoV-19” OR HCoV19 OR CoV OR “2019 novel*” OR Ncov OR “n-cov” OR “SARS-CoV-2” OR “SARSCoV-2” OR “SARSCoV2” OR “SARSCoV2” OR SARSCov19 OR “SARS-Cov19” OR “SARS-Cov-19” OR “severe acute respiratory syndrome*” OR ((corona* OR corono*) AND (virus* OR viral* OR virinae*))) AND ((telemedicine OR telehealth OR “remote assessment” OR telemonitoring)). The review process was carried out by six independent reviewers, using the PRISMA-P method. Results: As a result, a total of 34 papers were selected, which addressed the study of telemedicine technologies used in times of endemics, epidemics, and pandemics, focusing on COVID-19. Conclusion: Telemedicine allows for care in remote areas and at a lower cost to the patient and, in the current situation, it can reduce the number of contagions as well as the occupation of beds in health facilities. Telemedicine may suffer from limitations, mainly due to current legislation, but in this pandemic era of COVID-19, several countries around the world have made their laws more flexible to allow more widespread use of telemedicine. © 2021, Sociedade Brasileira de Engenharia Biomedica.

20.
Oncology-New York ; 34(9):370-376, 2020.
Article in English | Web of Science | ID: covidwho-1061724
SELECTION OF CITATIONS
SEARCH DETAIL